Mammalian Target of Rapamycin: A Target for (Lung) Diseases and Aging.

mTOR signaling in growth control and disease. Cell (2012) 29.21

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature (2009) 19.56

The hallmarks of aging. Cell (2013) 14.29

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J Cell Biol (2004) 9.71

Efficacy and safety of sirolimus in lymphangioleiomyomatosis. N Engl J Med (2011) 6.74

Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J Antibiot (Tokyo) (1975) 4.37

mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci Signal (2009) 3.94

Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. J Biol Chem (2001) 3.19

The tuberous sclerosis complex. Ann N Y Acad Sci (2010) 2.51

Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction. Aging Cell (2014) 2.35

Geroscience: linking aging to chronic disease. Cell (2014) 2.13

Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival. Sci Transl Med (2012) 1.98

mTOR inhibition improves immune function in the elderly. Sci Transl Med (2014) 1.78

An investigator-driven study of everolimus in surgical lung biopsy confirmed idiopathic pulmonary fibrosis. Respirology (2011) 1.58

Common toxicities of mammalian target of rapamycin inhibitors. Target Oncol (2011) 1.34

Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutation. Sci Transl Med (2012) 1.19

The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging. Cell Metab (2016) 1.10

Accelerated ageing of the lung in COPD: new concepts. Thorax (2015) 1.06

Metformin as a Tool to Target Aging. Cell Metab (2016) 1.03

Drug-induced pneumonitis in cancer patients treated with mTOR inhibitors: management and insights into possible mechanisms. Expert Opin Drug Saf (2014) 0.97

IPF fibroblasts are desensitized to type I collagen matrix-induced cell death by suppressing low autophagy via aberrant Akt/mTOR kinases. PLoS One (2014) 0.93

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice. Elife (2016) 0.92

Geroprotectors as a novel therapeutic strategy for COPD, an accelerating aging disease. Int J Chron Obstruct Pulmon Dis (2012) 0.87

Rapamycin Regulates Bleomycin-Induced Lung Damage in SP-C-Deficient Mice. Pulm Med (2011) 0.86

mTOR in health and in sickness. J Mol Med (Berl) (2015) 0.85

Profiling sirolimus-induced inflammatory syndrome: a prospective tricentric observational study. PLoS One (2013) 0.81

Clinical significance of mTOR, ZEB1, ROCK1 expression in lung tissues of pulmonary fibrosis patients. BMC Pulm Med (2014) 0.80

Rapamycin decreases airway remodeling and hyperreactivity in a transgenic model of noninflammatory lung disease. J Appl Physiol (1985) (2011) 0.80

Restoration of Corticosteroid Sensitivity in Chronic Obstructive Pulmonary Disease by Inhibition of Mammalian Target of Rapamycin. Am J Respir Crit Care Med (2016) 0.80

A critical role for the mTORC2 pathway in lung fibrosis. PLoS One (2014) 0.79

mTORC1 activation decreases autophagy in aging and idiopathic pulmonary fibrosis and contributes to apoptosis resistance in IPF fibroblasts. Aging Cell (2016) 0.78

Rapamycin attenuates bleomycin-induced pulmonary fibrosis in rats and the expression of metalloproteinase-9 and tissue inhibitors of metalloproteinase-1 in lung tissue. Chin Med J (Engl) (2014) 0.78

mTOR treatment in lymphangioleiomyomatosis: the role of everolimus. Expert Rev Respir Med (2016) 0.77

Immunohistochemical evidence for the association between attenuated mTOR signaling and diffuse alveolar damage, a fatal lung complication. Tohoku J Exp Med (2014) 0.77

Insight into Tor2, a budding yeast microdomain protein. Eur J Cell Biol (2014) 0.77

Preparing for an Aging World: Engaging Biogerontologists, Geriatricians, and the Society. J Gerontol A Biol Sci Med Sci (2015) 1.16

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse. Cancer Discov (2016) 0.87