Published in Diabetes on September 12, 2011
Calpain-1 regulation of matrix metalloproteinase 2 activity in vascular smooth muscle cells facilitates age-associated aortic wall calcification and fibrosis. Hypertension (2012) 1.04
Urinary podocyte microparticles identify prealbuminuric diabetic glomerular injury. J Am Soc Nephrol (2014) 1.00
Regulation and physiological roles of the calpain system in muscular disorders. Cardiovasc Res (2012) 0.97
Protective effects of Acyl-coA thioesterase 1 on diabetic heart via PPARα/PGC1α signaling. PLoS One (2012) 0.95
Deficiency of Capn4 gene inhibits nuclear factor-κB (NF-κB) protein signaling/inflammation and reduces remodeling after myocardial infarction. J Biol Chem (2012) 0.94
Calpain 2 activation of P-TEFb drives megakaryocyte morphogenesis and is disrupted by leukemogenic GATA1 mutation. Dev Cell (2013) 0.92
Electrophysiological Mechanisms of Bayés Syndrome: Insights from Clinical and Mouse Studies. Front Physiol (2016) 0.92
Molecular and Cellular Mechanisms of Cardiovascular Disorders in Diabetes. Circ Res (2016) 0.92
Inhibition of calpain reduces oxidative stress and attenuates endothelial dysfunction in diabetes. Cardiovasc Diabetol (2014) 0.90
Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL/6 mice. Diabetologia (2015) 0.88
Calpain-dependent cleavage of junctophilin-2 and T-tubule remodeling in a mouse model of reversible heart failure. J Am Heart Assoc (2014) 0.88
Histone deacetylase (HDAC) inhibition improves myocardial function and prevents cardiac remodeling in diabetic mice. Cardiovasc Diabetol (2015) 0.86
Chronic Inhibition of PDE5 Limits Pro-Inflammatory Monocyte-Macrophage Polarization in Streptozotocin-Induced Diabetic Mice. PLoS One (2015) 0.82
Molecular Determinants of Calpain-dependent Cleavage of Junctophilin-2 Protein in Cardiomyocytes. J Biol Chem (2015) 0.82
Prognostic significance of Capn4 overexpression in intrahepatic cholangiocarcinoma. PLoS One (2013) 0.82
Calpain research for drug discovery: challenges and potential. Nat Rev Drug Discov (2016) 0.82
Calpain-1 induces endoplasmic reticulum stress in promoting cardiomyocyte apoptosis following hypoxia/reoxygenation. Biochim Biophys Acta (2015) 0.81
Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy. Diabetes (2015) 0.80
Updating experimental models of diabetic cardiomyopathy. J Diabetes Res (2015) 0.80
Myocardial remodeling in diabetic cardiomyopathy associated with cardiac mast cell activation. PLoS One (2013) 0.78
Altered sympathetic nervous system signaling in the diabetic heart: emerging targets for molecular imaging. Am J Nucl Med Mol Imaging (2012) 0.78
Aldosterone signaling through transient receptor potential melastatin 7 cation channel (TRPM7) and its α-kinase domain. Cell Signal (2013) 0.78
Cardiac protective effects of dexrazoxane on animal cardiotoxicity model induced by anthracycline combined with trastuzumab is associated with upregulation of calpain-2. Medicine (Baltimore) (2015) 0.78
Role of Calpain in Pathogenesis of Human Disease Processes. J Nat Sci (2016) 0.77
Over-expression of calpastatin inhibits calpain activation and attenuates post-infarction myocardial remodeling. PLoS One (2015) 0.76
Deletion of capn4 Protects the Heart Against Endotoxemic Injury by Preventing ATP Synthase Disruption and Inhibiting Mitochondrial Superoxide Generation. Circ Heart Fail (2015) 0.76
Relevance of mouse models of cardiac fibrosis and hypertrophy in cardiac research. Mol Cell Biochem (2016) 0.76
Heat stress prevents lipopolysaccharide-induced apoptosis in pulmonary microvascular endothelial cells by blocking calpain/p38 MAPK signalling. Apoptosis (2016) 0.75
Disruption of calpain reduces lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stress. Biochim Biophys Acta (2016) 0.75
Critical role of calpain in inflammation. Biomed Rep (2016) 0.75
Metabolic and Biochemical Stressors in Diabetic Cardiomyopathy. Front Cardiovasc Med (2017) 0.75
The calpain system. Physiol Rev (2003) 9.95
Diabetic cardiomyopathy revisited. Circulation (2007) 6.76
Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy. Circ Res (2003) 5.30
Diabetic cardiomyopathy: evidence, mechanisms, and therapeutic implications. Endocr Rev (2004) 3.69
Diabetic cardiomyopathy: the search for a unifying hypothesis. Circ Res (2006) 3.27
Diabetes patients requiring glucose-lowering therapy and nondiabetics with a prior myocardial infarction carry the same cardiovascular risk: a population study of 3.3 million people. Circulation (2008) 3.23
Adaptation and maladaptation of the heart in diabetes: Part I: general concepts. Circulation (2002) 2.61
Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload. J Clin Invest (2009) 2.46
Disruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and division. Mol Cell Biol (2000) 2.23
Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart. J Clin Invest (1999) 2.22
Structure, activation, and biology of calpain. Diabetes (2004) 2.16
The pathogenesis of myocardial fibrosis in the setting of diabetic cardiomyopathy. J Am Coll Cardiol (2006) 2.03
Reduced cell migration and disruption of the actin cytoskeleton in calpain-deficient embryonic fibroblasts. J Biol Chem (2001) 1.91
Stimulation of collagen production by transforming growth factor-beta1 during differentiation of cardiac fibroblasts to myofibroblasts. Hypertension (2002) 1.87
Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin. Nature (2008) 1.84
Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface. Nat Rev Drug Discov (2007) 1.83
Calpain and mitochondria in ischemia/reperfusion injury. J Biol Chem (2002) 1.62
NF-kappaB activation is required for the development of cardiac hypertrophy in vivo. Am J Physiol Heart Circ Physiol (2004) 1.54
NFATc2 is a necessary mediator of calcineurin-dependent cardiac hypertrophy and heart failure. J Biol Chem (2008) 1.50
Prevention of cardiac hypertrophy and heart failure by silencing of NF-kappaB. J Mol Biol (2007) 1.46
Cardiomyocyte NF-κB p65 promotes adverse remodelling, apoptosis, and endoplasmic reticulum stress in heart failure. Cardiovasc Res (2010) 1.45
Role of nuclear factor kappaB in cardiovascular health and disease. Clin Sci (Lond) (2010) 1.44
Targeting the calpain/calpastatin system as a new strategy to prevent cardiovascular remodeling in angiotensin II-induced hypertension. Circ Res (2008) 1.40
Contributions of inflammation and cardiac matrix metalloproteinase activity to cardiac failure in diabetic cardiomyopathy: the role of angiotensin type 1 receptor antagonism. Diabetes (2007) 1.39
Hyperglycemia in streptozotocin-induced diabetic rat increases infarct size associated with low levels of myocardial HO-1 during ischemia/reperfusion. Diabetes (2005) 1.37
Ca2+ oscillation frequency decoding in cardiac cell hypertrophy: role of calcineurin/NFAT as Ca2+ signal integrators. Proc Natl Acad Sci U S A (2008) 1.34
Requirement of nuclear factor of activated T-cells in calcineurin-mediated cardiomyocyte hypertrophy. J Biol Chem (2002) 1.23
Deficiency of rac1 blocks NADPH oxidase activation, inhibits endoplasmic reticulum stress, and reduces myocardial remodeling in a mouse model of type 1 diabetes. Diabetes (2010) 1.20
Inhibition of p38 MAPK decreases myocardial TNF-alpha expression and improves myocardial function and survival in endotoxemia. Cardiovasc Res (2003) 1.16
Myocardial infarction and heart failure in the db/db diabetic mouse. Am J Physiol Heart Circ Physiol (2005) 1.14
Homocysteine-mediated activation and mitochondrial translocation of calpain regulates MMP-9 in MVEC. Am J Physiol Heart Circ Physiol (2006) 1.13
Conditional disruption of ubiquitous calpains in the mouse. Genesis (2006) 1.13
Over-expression of calpastatin inhibits calpain activation and attenuates myocardial dysfunction during endotoxaemia. Cardiovasc Res (2009) 1.12
Taurine prevents cardiomyocyte death by inhibiting NADPH oxidase-mediated calpain activation. Free Radic Biol Med (2008) 1.07
Calpain activation and secretion promote glomerular injury in experimental glomerulonephritis: evidence from calpastatin-transgenic mice. J Am Soc Nephrol (2006) 1.06
Calpain inhibition reduces infarct size and improves global hemodynamics and left ventricular contractility in a porcine myocardial ischemia/reperfusion model. Eur J Pharmacol (2005) 1.05
NF-kappaB activation is required for adaptive cardiac hypertrophy. Cardiovasc Res (2009) 1.03
Calpain contributes to silica-induced I kappa B-alpha degradation and nuclear factor-kappa B activation. Arch Biochem Biophys (1997) 1.01
Increased expression of calpain and elevated activity of calcineurin in the myocardium of patients with congestive heart failure. Int J Mol Med (2010) 1.00
Gelatinase B(MMP-9) an apoptotic factor in diabetic transgenic mice. Diabetologia (2003) 1.00
Inhibition of NF-{kappa}B improves left ventricular remodeling and cardiac dysfunction after myocardial infarction. Am J Physiol Heart Circ Physiol (2006) 1.00
Calpain activation contributes to hyperglycaemia-induced apoptosis in cardiomyocytes. Cardiovasc Res (2009) 0.99
JNK1/c-fos inhibits cardiomyocyte TNF-alpha expression via a negative crosstalk with ERK and p38 MAPK in endotoxaemia. Cardiovasc Res (2008) 0.98
Protective action of doxycycline against diabetic cardiomyopathy in rats. Br J Pharmacol (2008) 0.94
Growth properties and biochemical characterization of collagens synthesized by adult rat heart fibroblasts in culture. J Mol Cell Cardiol (1992) 0.92
Calpain inhibition preserves myocardial structure and function following myocardial infarction. Am J Physiol Heart Circ Physiol (2009) 0.90
Myocardial remodelling and matrix metalloproteinases in heart failure: turmoil within the interstitium. Ann Med (2001) 0.90
Calcium, calpains, and cardiac hypertrophy: a new link. Circ Res (2009) 0.84
Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21
Diabetic cardiomyopathy revisited. Circulation (2007) 6.76
PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol (2005) 5.80
Analyses of pig genomes provide insight into porcine demography and evolution. Nature (2012) 5.58
Cistrome: an integrative platform for transcriptional regulation studies. Genome Biol (2011) 4.13
Comparative and demographic analysis of orang-utan genomes. Nature (2011) 3.83
Impact of tobacco control policies and mass media campaigns on monthly adult smoking prevalence. Am J Public Health (2008) 3.72
Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity. Circulation (2005) 3.22
Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins. Diabetes (2007) 3.20
Bone marrow-derived stem cells initiate pancreatic regeneration. Nat Biotechnol (2003) 3.02
Mulan: multiple-sequence local alignment and visualization for studying function and evolution. Genome Res (2004) 2.91
Ceramide is a cardiotoxin in lipotoxic cardiomyopathy. J Lipid Res (2008) 2.88
Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance. PLoS Biol (2006) 2.86
Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure. J Clin Invest (2004) 2.76
Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5. Circ Res (2012) 2.74
Minimally invasive aortic banding in mice: effects of altered cardiomyocyte insulin signaling during pressure overload. Am J Physiol Heart Circ Physiol (2003) 2.57
Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression. J Clin Invest (2002) 2.53
Transcript annotation in FANTOM3: mouse gene catalog based on physical cDNAs. PLoS Genet (2006) 2.48
Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity. Endocrinology (2005) 2.43
Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts. Diabetes (2004) 2.39
The yak genome and adaptation to life at high altitude. Nat Genet (2012) 2.34
Recipes for creating animal models of diabetic cardiovascular disease. Circ Res (2007) 2.34
Vitamin D insufficiency is associated with challenge-proven food allergy in infants. J Allergy Clin Immunol (2013) 2.31
Cardiac resynchronization therapy: a meta-analysis of randomized controlled trials. CMAJ (2011) 2.28
The feasibility of voluntary counselling and HIV testing for pregnant women using community volunteers in Zimbabwe. Int J STD AIDS (2005) 2.27
Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis. Mol Cell Biol (2007) 2.22
Guidelines for the diagnosis and management of cow's milk protein allergy in infants. Arch Dis Child (2007) 2.19
Residential radon and lung cancer--detailed results of a collaborative analysis of individual data on 7148 persons with lung cancer and 14,208 persons without lung cancer from 13 epidemiologic studies in Europe. Scand J Work Environ Health (2006) 2.18
Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression. Am J Physiol Heart Circ Physiol (2007) 2.17
Infant feeding tube as rescue endotracheal tube in an infant with an aerodigestive foreign body. J Anesth (2013) 1.98
Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart. Circulation (2009) 1.91
Focal atrial tachycardia originating from the non-coronary aortic sinus: electrophysiological characteristics and catheter ablation. J Am Coll Cardiol (2006) 1.88
Akt signaling mediates postnatal heart growth in response to insulin and nutritional status. J Biol Chem (2002) 1.86
Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase. J Card Fail (2006) 1.79
Mammalian target of rapamycin is a critical regulator of cardiac hypertrophy in spontaneously hypertensive rats. Hypertension (2009) 1.78
Apicomplexan parasites co-opt host calpains to facilitate their escape from infected cells. Science (2009) 1.77
Preferential electrical coupling regulates neocortical lineage-dependent microcircuit assembly. Nature (2012) 1.75
Cardiac metabolism in heart failure: implications beyond ATP production. Circ Res (2013) 1.72
Persistent and relapsing babesiosis in immunocompromised patients. Clin Infect Dis (2008) 1.71
Allergenicity assessment of genetically modified crops--what makes sense? Nat Biotechnol (2008) 1.67
A susceptibility locus at chromosome 3p21 linked to familial nasopharyngeal carcinoma. Cancer Res (2004) 1.65
WorfDB: the Caenorhabditis elegans ORFeome Database. Nucleic Acids Res (2003) 1.65
PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation. J Clin Invest (2010) 1.63
Development of heart failure and congenital septal defects in mice lacking endothelial nitric oxide synthase. Circulation (2002) 1.63
Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure. Circ Res (2009) 1.60
Lipotoxicity in the heart. Biochim Biophys Acta (2009) 1.60
microRNA-141 is involved in a nasopharyngeal carcinoma-related genes network. Carcinogenesis (2010) 1.59
Preoperative use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers is associated with increased risk for acute kidney injury after cardiovascular surgery. Clin J Am Soc Nephrol (2008) 1.57
Rodent models of diabetic cardiomyopathy. Dis Model Mech (2009) 1.56
Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3. Diabetes (2008) 1.55
Ubiquitous calpains promote caspase-12 and JNK activation during endoplasmic reticulum stress-induced apoptosis. J Biol Chem (2006) 1.54
Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes. Physiology (Bethesda) (2006) 1.53
Molecular mechanisms of diabetic cardiomyopathy. Diabetologia (2014) 1.53
Repair of damaged supraglottic airway devices: A novel method. Scand J Trauma Resusc Emerg Med (2010) 1.51
The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis. Am J Physiol Heart Circ Physiol (2008) 1.51
Mitochondria in the diabetic heart. Cardiovasc Res (2010) 1.50
Increasing melanoma cell death using inhibitors of protein disulfide isomerases to abrogate survival responses to endoplasmic reticulum stress. Cancer Res (2008) 1.50
Nuclear receptor SHP, a death receptor that targets mitochondria, induces apoptosis and inhibits tumor growth. Mol Cell Biol (2010) 1.50
RNA interference knockdown of DNA methyl-transferase 3 affects gene alternative splicing in the honey bee. Proc Natl Acad Sci U S A (2013) 1.49
17beta-estradiol and tamoxifen stimulate rapid and transient ERK activationin MCF-7 cells via distinct signaling mechanisms. Cancer Biol Ther (2006) 1.49
The management of early breast carcinoma before and after the introduction of clinical practice guidelines. Cancer (2004) 1.47
Mechanisms for increased myocardial fatty acid utilization following short-term high-fat feeding. Cardiovasc Res (2009) 1.46
Finding the missing honey bee genes: lessons learned from a genome upgrade. BMC Genomics (2014) 1.46
Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice. Diabetes (2009) 1.45
GoArrays: highly dynamic and efficient microarray probe design. Bioinformatics (2004) 1.44
The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation. Genes Dev (2012) 1.43
Modulation of glucose transporter 1 (GLUT1) expression levels alters mouse mammary tumor cell growth in vitro and in vivo. PLoS One (2011) 1.43
The role of mPer2 clock gene in glucocorticoid and feeding rhythms. Endocrinology (2009) 1.43
Akt1 in the cardiovascular system: friend or foe? J Clin Invest (2005) 1.43
The intrinsic circadian clock within the cardiomyocyte. Am J Physiol Heart Circ Physiol (2005) 1.42
A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy. Cell Metab (2007) 1.42
FusionHunter: identifying fusion transcripts in cancer using paired-end RNA-seq. Bioinformatics (2011) 1.41
Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome. Clin Sci (Lond) (2008) 1.41
Distinct transcriptional regulation of long-chain acyl-CoA synthetase isoforms and cytosolic thioesterase 1 in the rodent heart by fatty acids and insulin. Am J Physiol Heart Circ Physiol (2006) 1.41
miR-216b suppresses tumor growth and invasion by targeting KRAS in nasopharyngeal carcinoma. J Cell Sci (2011) 1.41
Changes in the management of ductal carcinoma in situ before the release of clinical practice recommendations in Australia: the case in Victoria. ANZ J Surg (2006) 1.39
Derivation of euploid human embryonic stem cells from aneuploid embryos. Stem Cells (2008) 1.38
Rac1 is required for cardiomyocyte apoptosis during hyperglycemia. Diabetes (2009) 1.38
m-Calpain is required for preimplantation embryonic development in mice. BMC Dev Biol (2006) 1.37
Targeting myocardial substrate metabolism in heart failure: potential for new therapies. Eur J Heart Fail (2012) 1.36
Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells. J Immunol (2014) 1.35
Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents. J Clin Invest (2010) 1.34
Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy. Mol Endocrinol (2008) 1.33
MicroRNA-195 promotes palmitate-induced apoptosis in cardiomyocytes by down-regulating Sirt1. Cardiovasc Res (2011) 1.32
Loss of lipoprotein lipase-derived fatty acids leads to increased cardiac glucose metabolism and heart dysfunction. J Biol Chem (2006) 1.32
PGC-1β deficiency accelerates the transition to heart failure in pressure overload hypertrophy. Circ Res (2011) 1.31
Actin depolymerization-induced tyrosine phosphorylation of cortactin: the role of Fer kinase. Biochem J (2004) 1.31
Effect of SPLUNC1 protein on the Pseudomonas aeruginosa and Epstein-Barr virus. Mol Cell Biochem (2007) 1.31
Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex. Diabetes (2012) 1.31
Preferential oxidation of triacylglyceride-derived fatty acids in heart is augmented by the nuclear receptor PPARalpha. Circ Res (2010) 1.30
Endothelial nitric oxide synthase phosphorylation in treadmill-running mice: role of vascular signalling kinases. J Physiol (2009) 1.29
BRD7, a novel bromodomain gene, inhibits G1-S progression by transcriptionally regulating some important molecules involved in ras/MEK/ERK and Rb/E2F pathways. J Cell Physiol (2004) 1.27
BLESS: bloom filter-based error correction solution for high-throughput sequencing reads. Bioinformatics (2014) 1.27
Store-operated Ca2+ entry through ORAI1 is critical for T cell-mediated autoimmunity and allograft rejection. J Immunol (2010) 1.27
Reference-assisted chromosome assembly. Proc Natl Acad Sci U S A (2013) 1.26
Ubiquitous calpains promote both apoptosis and survival signals in response to different cell death stimuli. J Biol Chem (2006) 1.25
Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy. Cardiovasc Res (2013) 1.25
Target analysis by integration of transcriptome and ChIP-seq data with BETA. Nat Protoc (2013) 1.24
Cactus graphs for genome comparisons. J Comput Biol (2011) 1.24