Published in J Biol Chem on April 21, 2006
The calpain system and cancer. Nat Rev Cancer (2011) 2.10
Increased μ-Calpain Activity in Blasts of Common B-Precursor Childhood Acute Lymphoblastic Leukemia Correlates with Their Lower Susceptibility to Apoptosis. PLoS One (2015) 1.39
Development of α-helical calpain probes by mimicking a natural protein-protein interaction. J Am Chem Soc (2012) 1.18
SerpinB2 protection of retinoblastoma protein from calpain enhances tumor cell survival. Cancer Res (2008) 1.16
Protective actions of ovarian hormones in the serotonin system of macaques. Front Neuroendocrinol (2009) 1.11
Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease. J Clin Invest (2011) 1.11
Subcellular localization and functional domain studies of DEFECTIVE KERNEL1 in maize and Arabidopsis suggest a model for aleurone cell fate specification involving CRINKLY4 and SUPERNUMERARY ALEURONE LAYER1. Plant Cell (2007) 1.08
Appl1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling in murine embryonic fibroblasts. J Biol Chem (2009) 1.06
GPS-CCD: a novel computational program for the prediction of calpain cleavage sites. PLoS One (2011) 1.04
A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome. Proc Natl Acad Sci U S A (2014) 0.99
Calcium efflux from the endoplasmic reticulum leads to β-cell death. Endocrinology (2013) 0.97
Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma. J Biol Chem (2012) 0.97
Lack of beta3 integrin signaling contributes to calpain-mediated myocardial cell loss in pressure-overloaded myocardium. J Cardiovasc Pharmacol (2010) 0.92
Preventing the autophagic survival response by inhibition of calpain enhances the cytotoxic activity of bortezomib in vitro and in vivo. Cancer Chemother Pharmacol (2013) 0.92
Calpain inhibition preserves myocardial structure and function following myocardial infarction. Am J Physiol Heart Circ Physiol (2009) 0.90
The role of the Hsp90/Akt pathway in myocardial calpain-induced caspase-3 activation and apoptosis during sepsis. BMC Cardiovasc Disord (2013) 0.90
Control of cellular Bcl-xL levels by deamidation-regulated degradation. PLoS Biol (2013) 0.86
Tamoxifen increases nuclear respiratory factor 1 transcription by activating estrogen receptor beta and AP-1 recruitment to adjacent promoter binding sites. FASEB J (2011) 0.85
Helicobacter pylori activates calpain via toll-like receptor 2 to disrupt adherens junctions in human gastric epithelial cells. Infect Immun (2011) 0.83
Calpain protects the heart from hemodynamic stress. J Biol Chem (2011) 0.82
Thioamide-based fluorescent protease sensors. J Am Chem Soc (2014) 0.81
Calpain 4 is not necessary for LFA-1-mediated function in CD4+ T cells. PLoS One (2010) 0.80
Calpain interacts with class IA phosphoinositide 3-kinases regulating their stability and signaling activity. Proc Natl Acad Sci U S A (2011) 0.80
Regional Health and Function in the hippocampus: Evolutionary compromises for a critical brain region. Biosci Hypotheses (2009) 0.79
Expression of calpain-calpastatin system (CCS) member proteins in human lymphocytes of young and elderly individuals; pilot baseline data for the CALPACENT project. Immun Ageing (2013) 0.78
A novel benzofuran derivative, ACDB, induces apoptosis of human chondrosarcoma cells through mitochondrial dysfunction and endoplasmic reticulum stress. Oncotarget (2016) 0.77
Disruption of cellular homeostasis induces organelle stress and triggers apoptosis like cell-death pathways in malaria parasite. Cell Death Dis (2015) 0.76
Calpain Cleaves Most Components in the Multiple Aminoacyl-tRNA Synthetase Complex and Affects Their Functions. J Biol Chem (2015) 0.75
The calpain system as a potential target for pelvic muscle reinforcement. Cent European J Urol (2011) 0.75
Calpain Genetic Disruption and HSP90 Inhibition Combine To Attenuate Mammary Tumorigenesis. Mol Cell Biol (2016) 0.75
Neuroprotection mediated by inhibition of calpain during acute viral encephalitis. Sci Rep (2016) 0.75
MiR-99a and MiR-491 Regulate Cisplatin Resistance in Human Gastric Cancer Cells by Targeting CAPNS1. Int J Biol Sci (2016) 0.75
Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis. Mol Cell Biol (2007) 2.22
Telomere lengthening early in development. Nat Cell Biol (2007) 2.02
Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2. J Clin Invest (2008) 1.89
Apicomplexan parasites co-opt host calpains to facilitate their escape from infected cells. Science (2009) 1.77
Vaccination against hepatitis B: the Chinese experience. Chin Med J (Engl) (2009) 1.67
Ubiquitous calpains promote caspase-12 and JNK activation during endoplasmic reticulum stress-induced apoptosis. J Biol Chem (2006) 1.54
17beta-estradiol and tamoxifen stimulate rapid and transient ERK activationin MCF-7 cells via distinct signaling mechanisms. Cancer Biol Ther (2006) 1.49
Germline stem cells and neo-oogenesis in the adult human ovary. Dev Biol (2007) 1.48
Helicobacter pylori-induced Th17 responses modulate Th1 cell responses, benefit bacterial growth, and contribute to pathology in mice. J Immunol (2010) 1.42
m-Calpain is required for preimplantation embryonic development in mice. BMC Dev Biol (2006) 1.37
Actin depolymerization-induced tyrosine phosphorylation of cortactin: the role of Fer kinase. Biochem J (2004) 1.31
Lnk constrains myeloproliferative diseases in mice. J Clin Invest (2010) 1.29
Fer-mediated cortactin phosphorylation is associated with efficient fibroblast migration and is dependent on reactive oxygen species generation during integrin-mediated cell adhesion. Mol Cell Biol (2007) 1.22
Control of vesicle fusion by a tyrosine phosphatase. Nat Cell Biol (2004) 1.21
Identification and characterization of HTD2: a novel gene negatively regulating tiller bud outgrowth in rice. Planta (2009) 1.21
Human antibody responses to avian influenza A(H7N9) virus, 2013. Emerg Infect Dis (2014) 1.19
Calpain activation is not required for AIF translocation in PARP-1-dependent cell death (parthanatos). J Neurochem (2009) 1.16
cAMP response element-binding protein promotes gliomagenesis by modulating the expression of oncogenic microRNA-23a. Proc Natl Acad Sci U S A (2012) 1.15
Targeted inhibition of calpain reduces myocardial hypertrophy and fibrosis in mouse models of type 1 diabetes. Diabetes (2011) 1.15
Conditional disruption of ubiquitous calpains in the mouse. Genesis (2006) 1.13
Birth of parthenote mice directly from parthenogenetic embryonic stem cells. Stem Cells (2009) 1.13
Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease. J Clin Invest (2011) 1.11
13C-tracer and gas chromatography-mass spectrometry analyses reveal metabolic flux distribution in the oleaginous microalga Chlorella protothecoides. Plant Physiol (2010) 1.10
Double CO(2) fixation in photosynthesis-fermentation model enhances algal lipid synthesis for biodiesel production. Bioresour Technol (2009) 1.08
Constructing disease-specific gene networks using pair-wise relevance metric: application to colon cancer identifies interleukin 8, desmin and enolase 1 as the central elements. BMC Syst Biol (2008) 1.08
In vivo targeted deletion of calpain small subunit, Capn4, in cells of the osteoblast lineage impairs cell proliferation, differentiation, and bone formation. J Biol Chem (2008) 1.06
Fer kinase is required for sustained p38 kinase activation and maximal chemotaxis of activated mast cells. Mol Cell Biol (2002) 1.06
Appl1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling in murine embryonic fibroblasts. J Biol Chem (2009) 1.06
Calcium-dependent plasma membrane repair requires m- or mu-calpain, but not calpain-3, the proteasome, or caspases. Biochim Biophys Acta (2009) 1.06
Culture-negative subacute bacterial endocarditis masquerades as granulomatosis with polyangiitis (Wegener's granulomatosis) involving both the kidney and lung. BMC Nephrol (2012) 1.04
Phosphorylation of N-cadherin-associated cortactin by Fer kinase regulates N-cadherin mobility and intercellular adhesion strength. Mol Biol Cell (2005) 1.04
Nucleoprotein of influenza A virus is a major target of immunodominant CD8+ T-cell responses. Immunol Cell Biol (2013) 1.03
Calpains mediate p53 activation and neuronal death evoked by DNA damage. J Biol Chem (2003) 1.02
Absence of Fer protein-tyrosine kinase exacerbates leukocyte recruitment in response to endotoxin. J Immunol (2002) 1.00
High-performance single-crystalline arsenic-doped indium oxide nanowires for transparent thin-film transistors and active matrix organic light-emitting diode displays. ACS Nano (2009) 0.98
Bioreducible hyperbranched poly(amido amine)s for gene delivery. Biomacromolecules (2009) 0.98
Novel risk loci for rheumatoid arthritis in Han Chinese and congruence with risk variants in Europeans. Arthritis Rheumatol (2014) 0.98
Therapeutic efficacy of oral immunization with attenuated Salmonella typhimurium expressing Helicobacter pylori CagA, VacA and UreB fusion proteins in mice model. Vaccine (2011) 0.98
Conditional disruption of calpain in the CNS alters dendrite morphology, impairs LTP, and promotes neuronal survival following injury. J Neurosci (2013) 0.97
Detection of hepatitis B virus DNA among accepted blood donors in Nanjing, China. Virol J (2010) 0.97
Isolation and genetic characteristics of human genotype 1 Japanese encephalitis virus, China, 2009. PLoS One (2011) 0.97
Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma. J Biol Chem (2012) 0.97
Effect of innate glutathione levels on activity of redox-responsive gene delivery vectors. J Control Release (2009) 0.96
Differential seroprevalence of human bocavirus species 1-4 in Beijing, China. PLoS One (2012) 0.96
Therapeutic efficacy of a multi-epitope vaccine against Helicobacter pylori infection in BALB/c mice model. Vaccine (2009) 0.96
Separated carbon nanotube macroelectronics for active matrix organic light-emitting diode displays. Nano Lett (2011) 0.95
The receptor for parathyroid hormone and parathyroid hormone-related peptide is hydrolyzed and its signaling properties are altered by directly binding the calpain small subunit. Endocrinology (2005) 0.95
DOSim: an R package for similarity between diseases based on Disease Ontology. BMC Bioinformatics (2011) 0.95
The implications of relationships between human diseases and metabolic subpathways. PLoS One (2011) 0.94
Deficiency of Capn4 gene inhibits nuclear factor-κB (NF-κB) protein signaling/inflammation and reduces remodeling after myocardial infarction. J Biol Chem (2012) 0.94
Fps/Fes and Fer protein-tyrosinekinases play redundant roles in regulating hematopoiesis. Exp Hematol (2003) 0.93
Newcastle disease virus-vectored Nipah encephalitis vaccines induce B and T cell responses in mice and long-lasting neutralizing antibodies in pigs. Virology (2012) 0.93
Small-animal SPECT and SPECT/CT: application in cardiovascular research. Eur J Nucl Med Mol Imaging (2010) 0.93
Observation of pH-, solvent-, spin-, and excitation-dependent blue photoluminescence from carbon nanoparticles. Chem Commun (Camb) (2010) 0.92
The Fps/Fes kinase regulates the inflammatory response to endotoxin through down-regulation of TLR4, NF-kappaB activation, and TNF-alpha secretion in macrophages. J Leukoc Biol (2006) 0.92
A nonsynonymous LNK polymorphism associated with idiopathic erythrocytosis. Am J Hematol (2011) 0.92
Large-scale seroprevalence analysis of human metapneumovirus and human respiratory syncytial virus infections in Beijing, China. Virol J (2011) 0.92
Genome-wide gene expression profiling reveals aberrant MAPK and Wnt signaling pathways associated with early parthenogenesis. J Mol Cell Biol (2010) 0.92
Targeted deletion of Capn4 in cells of the chondrocyte lineage impairs chondrocyte proliferation and differentiation. Mol Cell Biol (2010) 0.91
The correlation of expression levels of HIF-1α and HIF-2α in hepatocellular carcinoma with capsular invasion, portal vein tumor thrombi and patients' clinical outcome. Jpn J Clin Oncol (2013) 0.91
Identification and fine mapping of a thermo-sensitive chlorophyll deficient mutant in rice (Oryza sativa L.). Planta (2007) 0.90
Identification of a highly conserved H1 subtype-specific epitope with diagnostic potential in the hemagglutinin protein of influenza A virus. PLoS One (2011) 0.90
Sharing insights and H7N9 patient clinical data. Am J Respir Crit Care Med (2013) 0.90
A highly ordered meso@microporous carbon-supported sulfur@smaller sulfur core-shell structured cathode for Li-S batteries. ACS Nano (2014) 0.90
Surgical Treatment of Giant Liver Hemangioma Larger Than 10 cm: A Single Center's Experience With 86 Patients. Medicine (Baltimore) (2015) 0.90
Effects of monoamine oxidase inhibitor and cytochrome P450 2D6 status on 5-methoxy-N,N-dimethyltryptamine metabolism and pharmacokinetics. Biochem Pharmacol (2010) 0.89
Crystal structure of a micro-like calpain reveals a partially activated conformation with low Ca2+ requirement. Structure (2003) 0.89
Core-shell structured polystyrene/BaTiO3 hybrid nanodielectrics prepared by in situ RAFT polymerization: a route to high dielectric constant and low loss materials with weak frequency dependence. Macromol Rapid Commun (2012) 0.89
Interferon-alpha plus adefovir combination therapy versus interferon-alpha monotherapy for chronic hepatitis B treatment: A meta-analysis. Hepatol Res (2013) 0.88
Calpain is required for MMP-2 and u-PA expression in SV40 large T-antigen-immortalized cells. Biochem Biophys Res Commun (2002) 0.88
Fer kinase limits neutrophil chemotaxis toward end target chemoattractants. J Immunol (2013) 0.88
Lnk deficiency partially mitigates hematopoietic stem cell aging. Aging Cell (2012) 0.87
14-3-3 regulates the LNK/JAK2 pathway in mouse hematopoietic stem and progenitor cells. J Clin Invest (2012) 0.87
Template-assisted nanostructure fabrication by glancing angle deposition: a molecular dynamics study. Nanoscale Res Lett (2013) 0.87
A dominant CD4(+) T-cell response to Helicobacter pylori reduces risk for gastric disease in humans. Gastroenterology (2012) 0.87
Disease resistance in rice and the role of molecular breeding in protecting rice crops against diseases. Biotechnol Lett (2014) 0.87
Helicobacter pylori-infected macrophages induce Th17 cell differentiation. Immunobiology (2010) 0.87
The Fer tyrosine kinase regulates an axon retraction response to Semaphorin 3A in dorsal root ganglion neurons. BMC Dev Biol (2007) 0.86
Enhanced endotoxin sensitivity in fps/fes-null mice with minimal defects in hematopoietic homeostasis. Mol Cell Biol (2002) 0.86
Feline sarcoma-related protein expression correlates with malignant aggressiveness and poor prognosis in renal cell carcinoma. Cancer Sci (2013) 0.85
Potential role of phytohormones and plant growth-promoting rhizobacteria in abiotic stresses: consequences for changing environment. Environ Sci Pollut Res Int (2014) 0.85
Compound Astragalus and Salvia miltiorrhiza extracts suppress hepatocarcinogenesis by modulating transforming growth factor-β/Smad signaling. J Gastroenterol Hepatol (2014) 0.85
The calpain small subunit regulates cell-substrate mechanical interactions during fibroblast migration. J Cell Sci (2008) 0.85
Evaluation of pharmacokinetics of bioreducible gene delivery vectors by real-time PCR. Pharm Res (2009) 0.85
Effects of tire rubber ash and zinc sulfate on crop productivity and cadmium accumulation in five rice cultivars under field conditions. Environ Sci Pollut Res Int (2015) 0.85
Recent developments in therapeutic protein expression technologies in plants. Biotechnol Lett (2014) 0.84
Mutation of the Nrf2 gene in non-small cell lung cancer. Mol Biol Rep (2011) 0.84
An identity crisis for fps/fes: oncogene or tumor suppressor? Cancer Res (2005) 0.84
Computational drug repositioning through heterogeneous network clustering. BMC Syst Biol (2013) 0.84
Identification of H-2d restricted Th epitopes in Urease B subunit of Helicobacter pylori. Vaccine (2006) 0.83
From phenotype to gene: detecting disease-specific gene functional modules via a text-based human disease phenotype network construction. FEBS Lett (2010) 0.83
First isolation of dengue virus from Lao PDR in a Chinese traveler. Virol J (2013) 0.83
A systematic method for mapping multiple loci: an application to construct a genetic network for rheumatoid arthritis. Gene (2007) 0.83
The Fps/Fes kinase regulates leucocyte recruitment and extravasation during inflammation. Immunology (2007) 0.83
[Evaluation of the enzyme-linked immunosorbant assay in detecting circumsporozoite protein of anopheline vectors in Yunnan]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi (2004) 0.83
High dimensional biological data retrieval optimization with NoSQL technology. BMC Genomics (2014) 0.83