| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity.
|
J Hepatol
|
2012
|
3.15
|
|
2
|
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
|
Arch Toxicol
|
2013
|
3.00
|
|
3
|
Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes.
|
Hepatology
|
2004
|
2.92
|
|
4
|
The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation.
|
J Clin Invest
|
2012
|
2.65
|
|
5
|
Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic necrosis?
|
Toxicol Sci
|
2002
|
2.42
|
|
6
|
Peroxynitrite-induced mitochondrial and endonuclease-mediated nuclear DNA damage in acetaminophen hepatotoxicity.
|
J Pharmacol Exp Ther
|
2005
|
2.41
|
|
7
|
Activation of autophagy protects against acetaminophen-induced hepatotoxicity.
|
Hepatology
|
2011
|
2.15
|
|
8
|
Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine.
|
Hepatology
|
2010
|
2.15
|
|
9
|
Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetyl cysteine.
|
Toxicol Sci
|
2004
|
2.07
|
|
10
|
Neutrophils aggravate acute liver injury during obstructive cholestasis in bile duct-ligated mice.
|
Hepatology
|
2003
|
2.00
|
|
11
|
Role of neutrophils in the pathogenesis of acute inflammatory liver injury.
|
Toxicol Pathol
|
2007
|
1.99
|
|
12
|
Nuclear translocation of endonuclease G and apoptosis-inducing factor during acetaminophen-induced liver cell injury.
|
Toxicol Sci
|
2006
|
1.94
|
|
13
|
Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis.
|
Am J Pathol
|
2010
|
1.91
|
|
14
|
Farnesoid X receptor critically determines the fibrotic response in mice but is expressed to a low extent in human hepatic stellate cells and periductal myofibroblasts.
|
Am J Pathol
|
2009
|
1.87
|
|
15
|
HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity.
|
Hepatology
|
2011
|
1.86
|
|
16
|
c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity.
|
Toxicol Appl Pharmacol
|
2010
|
1.84
|
|
17
|
Peroxynitrite is a critical mediator of acetaminophen hepatotoxicity in murine livers: protection by glutathione.
|
J Pharmacol Exp Ther
|
2002
|
1.73
|
|
18
|
Bile acids trigger cholemic nephropathy in common bile-duct-ligated mice.
|
Hepatology
|
2013
|
1.71
|
|
19
|
Mitochondrial bax translocation accelerates DNA fragmentation and cell necrosis in a murine model of acetaminophen hepatotoxicity.
|
J Pharmacol Exp Ther
|
2007
|
1.70
|
|
20
|
A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis.
|
Am J Pathol
|
2007
|
1.70
|
|
21
|
Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis.
|
Pharm Res
|
2013
|
1.62
|
|
22
|
24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice.
|
Gastroenterology
|
2006
|
1.54
|
|
23
|
Mechanisms of immune-mediated liver injury.
|
Toxicol Sci
|
2010
|
1.48
|
|
24
|
Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications.
|
Toxicol Appl Pharmacol
|
2013
|
1.46
|
|
25
|
Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury.
|
Free Radic Res
|
2010
|
1.45
|
|
26
|
Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity.
|
Toxicol Appl Pharmacol
|
2012
|
1.45
|
|
27
|
Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice.
|
Hepatology
|
2013
|
1.41
|
|
28
|
Functional importance of ICAM-1 in the mechanism of neutrophil-induced liver injury in bile duct-ligated mice.
|
Am J Physiol Gastrointest Liver Physiol
|
2003
|
1.40
|
|
29
|
Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury.
|
Toxicol Sci
|
2012
|
1.38
|
|
30
|
Role of caspase-1 and interleukin-1beta in acetaminophen-induced hepatic inflammation and liver injury.
|
Toxicol Appl Pharmacol
|
2010
|
1.38
|
|
31
|
Pathophysiological role of the acute inflammatory response during acetaminophen hepatotoxicity.
|
Toxicol Appl Pharmacol
|
2006
|
1.37
|
|
32
|
Effect of bile duct ligation on bile acid composition in mouse serum and liver.
|
Liver Int
|
2011
|
1.34
|
|
33
|
Translocation of iron from lysosomes into mitochondria is a key event during oxidative stress-induced hepatocellular injury.
|
Hepatology
|
2008
|
1.31
|
|
34
|
Novel insight into mechanisms of cholestatic liver injury.
|
World J Gastroenterol
|
2012
|
1.31
|
|
35
|
Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice.
|
Am J Pathol
|
2006
|
1.30
|
|
36
|
Acetaminophen-induced hepatic neutrophil accumulation and inflammatory liver injury in CD18-deficient mice.
|
Liver Int
|
2010
|
1.29
|
|
37
|
Parkin and mitofusins reciprocally regulate mitophagy and mitochondrial spheroid formation.
|
J Biol Chem
|
2012
|
1.25
|
|
38
|
Scavenging peroxynitrite with glutathione promotes regeneration and enhances survival during acetaminophen-induced liver injury in mice.
|
J Pharmacol Exp Ther
|
2003
|
1.25
|
|
39
|
NADPH oxidase-derived oxidant stress is critical for neutrophil cytotoxicity during endotoxemia.
|
Am J Physiol Gastrointest Liver Physiol
|
2004
|
1.23
|
|
40
|
The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity.
|
Toxicol Appl Pharmacol
|
2011
|
1.23
|
|
41
|
Generation of hypochlorite-modified proteins by neutrophils during ischemia-reperfusion injury in rat liver: attenuation by ischemic preconditioning.
|
Am J Physiol Gastrointest Liver Physiol
|
2005
|
1.22
|
|
42
|
Oxidative stress and the pathogenesis of cholestasis.
|
Semin Liver Dis
|
2010
|
1.22
|
|
43
|
Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury.
|
Toxicol Appl Pharmacol
|
2011
|
1.21
|
|
44
|
Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity.
|
Toxicol Sci
|
2011
|
1.16
|
|
45
|
Serum glutamate dehydrogenase--biomarker for liver cell death or mitochondrial dysfunction?
|
Toxicol Sci
|
2013
|
1.15
|
|
46
|
Lysosomal iron mobilization and induction of the mitochondrial permeability transition in acetaminophen-induced toxicity to mouse hepatocytes.
|
Toxicol Sci
|
2010
|
1.15
|
|
47
|
Pathophysiological relevance of neutrophils in acetaminophen hepatotoxicity.
|
Hepatology
|
2013
|
1.14
|
|
48
|
Reduced oncotic necrosis in Fas receptor-deficient C57BL/6J-lpr mice after bile duct ligation.
|
Hepatology
|
2004
|
1.13
|
|
49
|
Plasminogen activator inhibitor-1 limits liver injury and facilitates regeneration after acetaminophen overdose.
|
Toxicol Sci
|
2008
|
1.11
|
|
50
|
Acetaminophen toxicity in mice lacking NADPH oxidase activity: role of peroxynitrite formation and mitochondrial oxidant stress.
|
Free Radic Res
|
2003
|
1.10
|
|
51
|
Role of lipid peroxidation as a mechanism of liver injury after acetaminophen overdose in mice.
|
Toxicol Sci
|
2003
|
1.09
|
|
52
|
Role of heme oxygenase 1 in TNF/TNF receptor-mediated apoptosis after hepatic ischemia/reperfusion in rats. Shock 39: 380-388, 2013.
|
Shock
|
2013
|
1.09
|
|
53
|
Plasma biomarkers of liver injury and inflammation demonstrate a lack of apoptosis during obstructive cholestasis in mice.
|
Toxicol Appl Pharmacol
|
2013
|
1.08
|
|
54
|
Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans.
|
Arch Toxicol
|
2013
|
1.08
|
|
55
|
Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome.
|
Hepatology
|
2014
|
1.07
|
|
56
|
Purinergic receptor antagonist A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation.
|
Toxicol Sci
|
2012
|
1.05
|
|
57
|
The oxygen tension modulates acetaminophen-induced mitochondrial oxidant stress and cell injury in cultured hepatocytes.
|
Toxicol Sci
|
2010
|
1.05
|
|
58
|
Oxidant stress-induced liver injury in vivo: role of apoptosis, oncotic necrosis, and c-Jun NH2-terminal kinase activation.
|
Am J Physiol Gastrointest Liver Physiol
|
2009
|
1.02
|
|
59
|
Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients.
|
Expert Opin Drug Metab Toxicol
|
2014
|
1.02
|
|
60
|
Acetaminophen-induced inhibition of Fas receptor-mediated liver cell apoptosis: mitochondrial dysfunction versus glutathione depletion.
|
Toxicol Appl Pharmacol
|
2002
|
1.02
|
|
61
|
Inflammation in response to hepatocellular apoptosis.
|
Hepatology
|
2002
|
1.01
|
|
62
|
Mechanism of protection by metallothionein against acetaminophen hepatotoxicity.
|
Toxicol Appl Pharmacol
|
2009
|
1.00
|
|
63
|
Hepatic neutrophil infiltration in the pathogenesis of alcohol-induced liver injury.
|
Toxicol Mech Methods
|
2007
|
0.98
|
|
64
|
Innate immunity and acetaminophen-induced liver injury: why so many controversies?
|
Hepatology
|
2008
|
0.98
|
|
65
|
Zonated induction of autophagy and mitochondrial spheroids limits acetaminophen-induced necrosis in the liver.
|
Redox Biol
|
2013
|
0.97
|
|
66
|
Biomarkers distinguish apoptotic and necrotic cell death during hepatic ischemia/reperfusion injury in mice.
|
Liver Transpl
|
2014
|
0.96
|
|
67
|
No evidence for caspase-dependent apoptosis in acetaminophen hepatotoxicity.
|
Hepatology
|
2010
|
0.95
|
|
68
|
The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal kinase activation.
|
Toxicol Appl Pharmacol
|
2013
|
0.95
|
|
69
|
Neutrophil depletion protects against murine acetaminophen hepatotoxicity: another perspective.
|
Hepatology
|
2007
|
0.95
|
|
70
|
Reduced inflammatory response and increased microcirculatory disturbances during hepatic ischemia-reperfusion injury in steatotic livers of ob/ob mice.
|
Am J Physiol Gastrointest Liver Physiol
|
2007
|
0.94
|
|
71
|
Generation and functional significance of CXC chemokines for neutrophil-induced liver injury during endotoxemia.
|
Am J Physiol Gastrointest Liver Physiol
|
2004
|
0.94
|
|
72
|
The role of osteopontin and tumor necrosis factor alpha receptor-1 in xenobiotic-induced cholangitis and biliary fibrosis in mice.
|
Lab Invest
|
2010
|
0.94
|
|
73
|
Mouse strain-dependent caspase activation during acetaminophen hepatotoxicity does not result in apoptosis or modulation of inflammation.
|
Toxicol Appl Pharmacol
|
2011
|
0.94
|
|
74
|
Mitochondrial protein thiol modifications in acetaminophen hepatotoxicity: effect on HMG-CoA synthase.
|
Toxicol Lett
|
2008
|
0.93
|
|
75
|
Hepatic sinusoidal cells in health and disease: update from the 14th International Symposium.
|
Liver Int
|
2009
|
0.93
|
|
76
|
The BH3-only protein bid does not mediate death-receptor-induced liver injury in obstructive cholestasis.
|
Am J Pathol
|
2009
|
0.92
|
|
77
|
Recovery of hepatocellular ATP and "pericentral apoptosis" after hemorrhage and resuscitation.
|
FASEB J
|
2003
|
0.91
|
|
78
|
Development of an adverse outcome pathway from drug-mediated bile salt export pump inhibition to cholestatic liver injury.
|
Toxicol Sci
|
2013
|
0.91
|
|
79
|
Oncotic necrosis and caspase-dependent apoptosis during galactosamine-induced liver injury in rats.
|
Toxicol Appl Pharmacol
|
2003
|
0.91
|
|
80
|
Osteopontin is an initial mediator of inflammation and liver injury during obstructive cholestasis after bile duct ligation in mice.
|
Toxicol Lett
|
2013
|
0.89
|
|
81
|
Heme oxygenase-1 induction in hepatocytes and non-parenchymal cells protects against liver injury during endotoxemia.
|
Comp Hepatol
|
2004
|
0.88
|
|
82
|
The strength of the Fas ligand signal determines whether hepatocytes act as type 1 or type 2 cells in murine livers.
|
Hepatology
|
2009
|
0.86
|
|
83
|
Argininosuccinate synthetase as a plasma biomarker of liver injury after acetaminophen overdose in rodents and humans.
|
Biomarkers
|
2014
|
0.86
|
|
84
|
Pathophysiological role of poly(ADP-ribose) polymerase (PARP) activation during acetaminophen-induced liver cell necrosis in mice.
|
Toxicol Sci
|
2004
|
0.85
|
|
85
|
Fas receptor-deficient lpr mice are protected against acetaminophen hepatotoxicity due to higher glutathione synthesis and enhanced detoxification of oxidant stress.
|
Food Chem Toxicol
|
2013
|
0.85
|
|
86
|
Differences in early acetaminophen hepatotoxicity between obese ob/ob and db/db mice.
|
J Pharmacol Exp Ther
|
2012
|
0.84
|
|
87
|
Tissue factor contributes to neutrophil CD11b expression in alpha-naphthylisothiocyanate-treated mice.
|
Toxicol Appl Pharmacol
|
2010
|
0.83
|
|
88
|
Reactive oxygen as modulator of TNF and fas receptor-mediated apoptosis in vivo: studies with glutathione peroxidase-deficient mice.
|
Antioxid Redox Signal
|
2002
|
0.83
|
|
89
|
Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells.
|
Xenobiotica
|
2015
|
0.83
|
|
90
|
How relevant are neutrophils for acetaminophen hepatotoxicity?
|
Hepatology
|
2006
|
0.83
|
|
91
|
Mechanisms and pathophysiological implications of sinusoidal endothelial cell gap formation following treatment with galactosamine/endotoxin in mice.
|
Am J Physiol Gastrointest Liver Physiol
|
2006
|
0.82
|
|
92
|
Hepatobiliary transporter expression in intercellular adhesion molecule 1 knockout and Fas receptor-deficient mice after common bile duct ligation is independent of the degree of inflammation and oxidative stress.
|
Drug Metab Dispos
|
2007
|
0.82
|
|
93
|
Herbal extracts as hepatoprotectants against acetaminophen hepatotoxicity.
|
World J Gastroenterol
|
2010
|
0.82
|
|
94
|
Lysosomal instability and cathepsin B release during acetaminophen hepatotoxicity.
|
Basic Clin Pharmacol Toxicol
|
2012
|
0.81
|
|
95
|
Regulation of apoptotic signaling pathways in hepatocytes in vivo.
|
Hepatology
|
2003
|
0.81
|
|
96
|
Chlorotyrosine protein adducts are reliable biomarkers of neutrophil-induced cytotoxicity in vivo.
|
Comp Hepatol
|
2004
|
0.81
|
|
97
|
Peroxynitrite formation and sinusoidal endothelial cell injury during acetaminophen-induced hepatotoxicity in mice.
|
Comp Hepatol
|
2004
|
0.79
|
|
98
|
Caveats of using acetaminophen hepatotoxicity models for natural product testing.
|
Toxicol Lett
|
2012
|
0.79
|
|
99
|
Targeting autophagy for drug-induced hepatotoxicity.
|
Autophagy
|
2012
|
0.79
|
|
100
|
Gender-specific reduction of hepatic Mrp2 expression by high-fat diet protects female mice from ANIT toxicity.
|
Toxicol Appl Pharmacol
|
2012
|
0.79
|
|
101
|
Pathophysiological relevance of proteomics investigations of drug-induced hepatotoxicity in HepG2 cells.
|
Toxicol Sci
|
2011
|
0.78
|
|
102
|
Building shared experience to advance practical application of pathway-based toxicology: liver toxicity mode-of-action.
|
ALTEX
|
2014
|
0.78
|
|
103
|
Comments on "glycogen synthase kinase-3 mediates acetaminophen-induced apoptosis in human hepatoma cells".
|
J Pharmacol Exp Ther
|
2005
|
0.77
|
|
104
|
Apoptosis or necrosis in acetaminophen-induced acute liver failure? New insights from mechanistic biomarkers*.
|
Crit Care Med
|
2013
|
0.77
|
|
105
|
The role of the c-Jun N-terminal kinases 1/2 and receptor-interacting protein kinase 3 in furosemide-induced liver injury.
|
Xenobiotica
|
2014
|
0.77
|
|
106
|
Xanthine oxidase-induced oxidant stress during hepatic ischemia-reperfusion: are we coming full circle after 20 years?
|
Hepatology
|
2002
|
0.77
|
|
107
|
Hepatitis C virus structural proteins can exacerbate or ameliorate acetaminophen-induced liver injury in mice.
|
Arch Toxicol
|
2015
|
0.77
|
|
108
|
Autophagy and acetaminophen hepatotoxicity: how useful are Atg7-deficient mice?
|
J Gastroenterol
|
2012
|
0.77
|
|
109
|
Heme oxygenase-1 and platelets in hepatic ischemia reperfusion injury.
|
J Gastroenterol Hepatol
|
2013
|
0.76
|
|
110
|
Critical role of CXC chemokines in endotoxemic liver injury in mice.
|
J Leukoc Biol
|
2004
|
0.76
|
|
111
|
Comment on "Cyclophilin A is a damage-associated molecular pattern molecule that mediates acetaminophen-induced liver injury".
|
J Immunol
|
2011
|
0.76
|
|
112
|
Reactive nitrogen species in acetaminophen-induced mitochondrial damage and toxicity in mouse hepatocytes: a cautionary note on the impact of cell culture conditions.
|
Chem Res Toxicol
|
2010
|
0.75
|
|
113
|
DAMPen danger signals: novel therapeutic strategies against postischemic inflammation.
|
Crit Care Med
|
2010
|
0.75
|
|
114
|
Therapeutic strategies against ischemia-reperfusion injury: stem cell therapy and beyond.
|
Crit Care Med
|
2012
|
0.75
|
|
115
|
Involvement of Kupffer cells in the interaction between neutrophils and sinusoidal endothelial cells in rats. Shock 18(2):152-157, 2002.
|
Shock
|
2003
|
0.75
|
|
116
|
Critical Factors in the Assessment of Cholestatic Liver Injury In Vitro.
|
Methods Mol Biol
|
2015
|
0.75
|
|
117
|
Sterile inflammation in acute liver injury: myth or mystery?
|
Expert Rev Gastroenterol Hepatol
|
2015
|
0.75
|
|
118
|
15th International Symposium on Cells of the Hepatic Sinusoid, 2010.
|
Liver Int
|
2011
|
0.75
|
|
119
|
Gene array analysis of the hepatic response to endotoxin in glutathione peroxidase-deficient mice.
|
Toxicol Lett
|
2003
|
0.75
|
|
120
|
Redox considerations in hepatic injury and inflammation.
|
Antioxid Redox Signal
|
2002
|
0.75
|
|
121
|
The Challenge of Drug-Induced Liver Injury (DILI) / Challenges and Management of Liver Cirrhosis. Preface.
|
Dig Dis
|
2015
|
0.75
|