Published in Nature on April 19, 1979
Hormone receptor topology and dynamics: morphological analysis using ferritin-labeled epidermal growth factor. Proc Natl Acad Sci U S A (1979) 3.54
Down regulation of epidermal growth factor receptors: direct demonstration of receptor degradation in human fibroblasts. J Cell Biol (1984) 2.12
The binding of human complement component C4 to antibody-antigen aggregates. Biochem J (1980) 1.83
Released protease-nexin regulates cellular binding, internalization, and degradation of serine proteases. Proc Natl Acad Sci U S A (1981) 1.53
Biosynthesis of the epidermal growth factor receptor in A431 cells. EMBO J (1984) 1.43
Hepatic sequestration and biliary secretion of epidermal growth factor: evidence for a high-capacity uptake system. Proc Natl Acad Sci U S A (1983) 1.05
Functional receptors for epidermal growth factor in an epithelial-cell line derived from the rat small intestine. Biochem J (1985) 1.01
Keratin filaments of mouse epithelial cells are rapidly affected by epidermal growth factor. J Cell Biol (1981) 0.92
Effect of cell density on thrombin binding to a specific site on bovine vascular endothelial cells. J Cell Biol (1981) 0.83
Serum factors modify the cellular requirement for Ca2+, K+, Mg2+, phosphate ions, and 2-oxocarboxylic acids for multiplication of normal human fibroblasts. Proc Natl Acad Sci U S A (1980) 0.82
Bradykinin stimulates bone resorption and lysosomal-enzyme release in cultured mouse calvaria. Biochem J (1984) 0.82
Transport changes rapidly initiated by serum addition to "contact inhibited" 3T3 cells. Proc Natl Acad Sci U S A (1969) 3.98
Sequence of the promoter region of the gene for human X-linked 3-phosphoglycerate kinase. Gene (1984) 3.67
The endocytotic rate constant. A cellular parameter for quantitating receptor-mediated endocytosis. J Biol Chem (1982) 3.41
Protease-nexin: a cellular component that links thrombin and plasminogen activator and mediates their binding to cells. Cell (1980) 2.76
Modulation of airway inflammation in cystic fibrosis. In vivo suppression of interleukin-8 levels on the respiratory epithelial surface by aerosolization of recombinant secretory leukoprotease inhibitor. J Clin Invest (1992) 2.33
Red blood cells are a sink for interleukin 8, a leukocyte chemotaxin. J Clin Invest (1991) 2.32
Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor. Nature (1989) 2.17
No .NO from NO synthase. Proc Natl Acad Sci U S A (1996) 2.14
Intravascular IL-8. Inhibitor of polymorphonuclear leukocyte accumulation at sites of acute inflammation. J Immunol (1991) 2.10
Human monocyte-derived growth factor(s) for mesenchymal cells: activation of secretion by endotoxin and concanavalin A. Cell (1981) 2.06
Scanning mutagenesis of interleukin-8 identifies a cluster of residues required for receptor binding. J Biol Chem (1991) 1.89
Stimulation of division of density inhibited fibroblasts by glucocorticoids. Nature (1973) 1.79
Selective radiolabeling of cell surface proteins to a high specific activity. Biochemistry (1987) 1.74
A steady state model for analyzing the cellular binding, internalization and degradation of polypeptide ligands. Cell (1981) 1.74
Isolation of a cDNA clone for human X-linked 3-phosphoglycerate kinase by use of a mixture of synthetic oligodeoxyribonucleotides as a detection probe. Proc Natl Acad Sci U S A (1983) 1.71
Endothelial and leukocyte forms of IL-8. Conversion by thrombin and interactions with neutrophils. J Immunol (1990) 1.69
Structure-function analysis of hepatocyte growth factor: identification of variants that lack mitogenic activity yet retain high affinity receptor binding. EMBO J (1992) 1.68
Protease nexin. Properties and a modified purification procedure. J Biol Chem (1985) 1.66
Thrombin active site regions required for fibroblast receptor binding and initiation of cell division. J Biol Chem (1980) 1.56
Relationship between epidermal growth factor receptor occupancy and mitogenic response. Quantitative analysis using a steady state model system. J Biol Chem (1984) 1.56
Released protease-nexin regulates cellular binding, internalization, and degradation of serine proteases. Proc Natl Acad Sci U S A (1981) 1.53
Linkage of extracellular plasminogen activator to the fibroblast cytoskeleton: colocalization of cell surface urokinase with vinculin. J Cell Biol (1988) 1.49
Inhibition of tumor-cell-mediated extracellular matrix destruction by a fibroblast proteinase inhibitor, protease nexin I. Proc Natl Acad Sci U S A (1986) 1.47
Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities. J Neurosci (1997) 1.45
Solution structure of the cyclosporin A/cyclophilin complex by NMR. Nature (1993) 1.44
Effects of intravenous IL-8 administration in nonhuman primates. J Immunol (1992) 1.44
Thrombin modulates and reverses neuroblastoma neurite outgrowth. Proc Natl Acad Sci U S A (1988) 1.40
Direct linkage of 125I-EGF to cell surface receptors. A useful artifact of chloramine-T treatment. J Biol Chem (1982) 1.38
Cellular localization of thrombin receptor mRNA in rat brain: expression by mesencephalic dopaminergic neurons and codistribution with prothrombin mRNA. J Neurosci (1995) 1.37
Conditions which affect initiation of animal cell division by trypsin and thrombin. J Cell Physiol (1978) 1.26
In vitro inhibitory effect of IL-8 and other chemoattractants on neutrophil-endothelial adhesive interactions. J Immunol (1992) 1.26
Protease nexin-II (amyloid beta-protein precursor): a platelet alpha-granule protein. Science (1990) 1.26
Cell surface action of thrombin is sufficient to initiate division of chick cells. Cell (1978) 1.25
Purification of human fibroblast urokinase proenzyme and analysis of its regulation by proteases and protease nexin. J Biol Chem (1984) 1.24
Intravenous interleukin-8 inhibits granulocyte emigration from rabbit mesenteric venules without altering L-selectin expression or leukocyte rolling. J Immunol (1993) 1.24
Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults. J Neurosci (1995) 1.22
Cryptic urokinase binding sites on human foreskin fibroblasts. Biochem Biophys Res Commun (1985) 1.22
Initiation of check cell division by trypsin action at the cell surface. Nature (1977) 1.19
Epidermal growth factor immunoreactive material in the central nervous system: location and development. Science (1984) 1.17
Dexamethasone modulates binding and action of epidermal growth factor in serum-free cell culture. Proc Natl Acad Sci U S A (1978) 1.15
Immunopurification and protease inhibitory properties of protease nexin-2/amyloid beta-protein precursor. J Biol Chem (1990) 1.14
X-ray crystallographic structure of ABT-378 (lopinavir) bound to HIV-1 protease. Bioorg Med Chem (2002) 1.13
Molecular cloning of a gene belonging to the carcinoembryonic antigen gene family and discussion of a domain model. Proc Natl Acad Sci U S A (1987) 1.12
Epidermal growth factor stimulates fluid phase endocytosis in human fibroblasts through a signal generated at the cell surface. J Cell Biochem (1982) 1.12
Purification of human protease nexin. J Biol Chem (1983) 1.11
Cells regulate their mitogenic response to thrombin through release of protease nexin. Nature (1982) 1.10
Regulation of extracellular plasminogen activator by human fibroblasts. The role of protease nexin. J Biol Chem (1983) 1.09
Evidence that a variety of cultured cells secrete protease nexin and produce a distinct cytoplasmic serine protease-binding factor. J Cell Physiol (1983) 1.09
Herniated cerebellar tonsils and cough syncope. J Neurosurg (1974) 1.05
Affinity purification of HIV-1 and HIV-2 proteases from recombinant E. coli strains using pepstatin-agarose. Biochem Biophys Res Commun (1990) 1.04
Reciprocal modulation of astrocyte stellation by thrombin and protease nexin-1. J Neurochem (1990) 1.03
Creatine kinase, an ATP-generating enzyme, is required for thrombin receptor signaling to the cytoskeleton. Proc Natl Acad Sci U S A (2000) 1.02
Role of specific cell surface receptors in thrombin-stimulated cell division. Cell (1978) 1.01
Cellular mechanism of the insulin-like effect of growth hormone in adipocytes. Rapid translocation of the HepG2-type and adipocyte/muscle glucose transporters. Biochem J (1992) 1.01
Intracellular processing of epidermal growth factor and its effect on ligand-receptor interactions. J Biol Chem (1985) 0.99
Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neurites in Alzheimer's disease. Neuroscience (1992) 0.99
Phorbol ester and mitogens stimulate human fibroblast secretions of plasmin-activatable plasminogen activator and protease nexin, an antiactivator/antiplasmin. J Cell Biol (1983) 0.98
Purification of protease nexin II from human fibroblasts. J Biol Chem (1987) 0.98
Urokinase binding sites on human foreskin cells. Evidence for occupancy with endogenous urokinase. Biochem Biophys Res Commun (1985) 0.98
Preliminary characterization of a cloned neutral isoelectric form of the human peptidyl prolyl isomerase cyclophilin. J Biol Chem (1991) 0.97
Serum-stimulated release of cell contacts and the initiation of growth in contact-inhibited chick fibroblasts. Proc Natl Acad Sci U S A (1971) 0.96
Interleukin-8: a review. Cancer Invest (1993) 0.96
Signaling pathways involved in thrombin-induced cell protection. J Biol Chem (1998) 0.94
Modulation of thrombin-stimulated lipid responses in cultured fibroblasts. Evidence for two coupling mechanisms. Biochemistry (1987) 0.94
Protease nexin-1, an antithrombin with neurite outgrowth activity, is reduced in Alzheimer disease. Proc Natl Acad Sci U S A (1989) 0.93
Localization of protease nexin-1 on the fibroblast extracellular matrix. J Cell Physiol (1988) 0.92
Serum-stimulated phosphate uptake and initiation of fibroblast proliferation. J Cell Physiol (1977) 0.92
Photoaffinity labeling of a single receptor for alpha-thrombin on mouse embryo cells. J Biol Chem (1979) 0.92
Human fibroblasts accelerate the inhibition of thrombin by protease nexin. Proc Natl Acad Sci U S A (1986) 0.92
Regulation of protease nexin-1 synthesis and secretion in cultured brain cells by injury-related factors. J Biol Chem (1993) 0.92
Protease nexin-1. Localization in the human brain suggests a protective role against extravasated serine proteases. Am J Pathol (1990) 0.91
Turnover of molecules which maintain the normal surfaces of contact-inhibited cells. Science (1972) 0.91
Protection against endotoxic shock by bactericidal/permeability-increasing protein in rats. J Clin Invest (1995) 0.91
Injury-related factors and conditions down-regulate the thrombin receptor (PAR-1) in a human neuronal cell line. J Neurochem (1998) 0.90
Thrombin-stimulated cell division involves proteolysis of its cell surface receptor. Nature (1979) 0.90
Effect of acute inflammatory lung injury on the expression of monocyte chemoattractant protein-1 (MCP-1) in rat pulmonary alveolar macrophages. Am J Respir Cell Mol Biol (1992) 0.90
Epidermal growth factor carrier protein binds to cells via a complex with released carried protein nexin. Proc Natl Acad Sci U S A (1982) 0.89
Protease nexins and cellular regulation. Semin Thromb Hemost (1986) 0.89
A novel method for measuring cell surface-bound thrombin. Detection of iodination-induced changes in thrombin-binding affinity. J Biol Chem (1982) 0.89
Photoaffinity labeling of specific alpha-thrombin binding sites on Chinese hamster lung cells. J Biol Chem (1983) 0.89
Thrombin attenuates neuronal cell death and modulates astrocyte reactivity induced by beta-amyloid in vitro. J Neurochem (1996) 0.88
Thrombin interaction with platelets. Influence of a platelet protease nexin. J Biol Chem (1987) 0.88
Protease nexin-2/amyloid beta-protein precursor in blood is a platelet-specific protein. Biochem Biophys Res Commun (1991) 0.87
Cloning and expression of the adenosine kinase gene from rat and human tissues. Biochem Biophys Res Commun (1997) 0.87
Blocking Chk1 expression induces apoptosis and abrogates the G2 checkpoint mechanism. Neoplasia (2001) 0.87
Abrogation of G2 checkpoint specifically sensitize p53 defective cells to cancer chemotherapeutic agents. Anticancer Res (2001) 0.87
Phosphate uptake and control of fibroblasts growth. J Cell Physiol (1977) 0.87
Neurite outgrowth activity of protease nexin-1 on neuroblastoma cells requires thrombin inhibition. J Cell Physiol (1990) 0.87
Effects of EGF and thrombin on inositol-containing phospholipids of cultured fibroblasts: stimulation of phosphatidylinositol synthesis by thrombin but not EGF. J Cell Physiol (1985) 0.87
Glycosaminoglycans on fibroblasts accelerate thrombin inhibition by protease nexin-1. Biochem J (1987) 0.87