Published in Proc Natl Acad Sci U S A on November 01, 1979
3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc Natl Acad Sci U S A (1982) 8.71
Internalization and processing of transferrin and the transferrin receptor in human carcinoma A431 cells. J Cell Biol (1983) 6.17
Quantitation of membrane receptor distributions by image correlation spectroscopy: concept and application. Biophys J (1993) 4.88
Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes. Cell (2010) 4.19
Diffusion of low density lipoprotein-receptor complex on human fibroblasts. J Cell Biol (1982) 3.16
Receptor-mediated endocytosis. Biochem J (1985) 2.73
Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking. Mol Biol Cell (2001) 2.66
Meeting of the apical and basolateral endocytic pathways of the Madin-Darby canine kidney cell in late endosomes. J Cell Biol (1989) 2.51
Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system. J Cell Biol (1988) 2.31
Lysomotropic amines cause intracellular accumulation of receptors for epidermal growth factor. Proc Natl Acad Sci U S A (1980) 2.22
Epidermal growth factor inhibits growth of A431 human epidermoid carcinoma in serum-free cell culture. J Cell Biol (1982) 2.17
Down regulation of epidermal growth factor receptors: direct demonstration of receptor degradation in human fibroblasts. J Cell Biol (1984) 2.12
Receptor-mediated endocytosis of epidermal growth factor by hepatocytes in the perfused rat liver: ligand and receptor dynamics. J Cell Biol (1984) 1.99
Endocytosis and intracellular trafficking of ErbBs. Exp Cell Res (2008) 1.96
Tyrosine phosphorylation of specific proteins after mitogen stimulation of chicken embryo fibroblasts. Mol Cell Biol (1983) 1.92
Transport of macrophage Fc receptors and Fc receptor-bound ligands to lysosomes. J Exp Med (1986) 1.91
Receptor-mediated internalization and degradation of urokinase is caused by its specific inhibitor PAI-1. EMBO J (1990) 1.87
Rapid rounding of human epidermoid carcinoma cells A-431 induced by epidermal growth factor. J Cell Biol (1981) 1.52
Receptor-mediated endocytosis of asialoglycoproteins by rat liver hepatocytes: biochemical characterization of the endosomal compartments. J Cell Biol (1985) 1.50
Localization of the epidermal growth factor (EGF) receptor within the endosome of EGF-stimulated epidermoid carcinoma (A431) cells. J Cell Biol (1986) 1.43
Endocytic control of growth factor signalling: multivesicular bodies as signalling organelles. Nat Rev Mol Cell Biol (2011) 1.43
Increased EGF receptors on human squamous carcinoma cell lines. Br J Cancer (1986) 1.36
Colloidal gold--low density lipoprotein conjugates as membrane receptor probes. Proc Natl Acad Sci U S A (1981) 1.36
Epidermal growth factor-induced centrosomal separation: mechanism and relationship to mitogenesis. J Cell Biol (1982) 1.35
Saturable binding sites for vesicular stomatitis virus on the surface of Vero cells. J Virol (1982) 1.34
Mobility, clustering, and transport of nerve growth factor in embryonal sensory cells and in a sympathetic neuronal cell line. Proc Natl Acad Sci U S A (1980) 1.33
Distribution of an asialoglycoprotein receptor on rat hepatocyte cell surface. J Cell Biol (1982) 1.29
Correlative fluorescence microscopy and scanning transmission electron microscopy of quantum-dot-labeled proteins in whole cells in liquid. ACS Nano (2010) 1.28
Evidence for insulin-induced internalization and degradation of insulin receptors in rat adipocytes. Proc Natl Acad Sci U S A (1982) 1.27
Direct visualization of the phosphorylated epidermal growth factor receptor during its internalization in A-431 cells. J Cell Biol (1987) 1.19
Multivesicular bodies in neurons: distribution, protein content, and trafficking functions. Prog Neurobiol (2011) 1.14
Consumption of EGF by A431 cells: evidence for receptor recycling. J Cell Biol (1993) 1.13
Recycling of epidermal growth factor-receptor complexes in A431 cells: identification of dual pathways. J Cell Biol (1991) 1.12
Ligand-mediated autophosphorylation activity of the epidermal growth factor receptor during internalization. J Cell Biol (1989) 1.11
Isolation and characterization of multivesicular bodies from rat hepatocytes: an organelle distinct from secretory vesicles of the Golgi apparatus. J Cell Biol (1985) 1.11
Subfractionation of hepatic endosomes in Nycodenz gradients and by free-flow electrophoresis. Separation of ligand-transporting and receptor-enriched membranes. Biochem J (1985) 1.10
Association of the tyrosine phosphorylated epidermal growth factor receptor with a 55-kD tyrosine phosphorylated protein at the cell surface and in endosomes. J Cell Biol (1992) 1.10
Lysosomotropic amines inhibit mitogenesis induced by growth factors. Proc Natl Acad Sci U S A (1981) 1.10
Regulation of insulin receptors: evidence for involvement of an endocytotic internalization pathway. Proc Natl Acad Sci U S A (1980) 1.10
Perinuclear location and recycling of epidermal growth factor receptor kinase: immunofluorescent visualization using antibodies directed to kinase and extracellular domains. J Cell Biol (1986) 1.09
A tubular endosomal fraction from rat liver: biochemical evidence of receptor sorting by default. Proc Natl Acad Sci U S A (1999) 1.09
Antibodies against a lysosomal membrane antigen recognize a prelysosomal compartment involved in the endocytic pathway in cultured prolactin cells. J Cell Biol (1985) 1.05
Transport of epidermal growth factor by rat liver: evidence for a nonlysosomal pathway. J Cell Biol (1984) 1.01
Receptor-mediated insulin degradation and insulin-stimulated glycogenesis in cultured foetal hepatocytes. Biochem J (1982) 1.00
Restricted mobility of membrane constituents in cell-substrate focal contacts of chicken fibroblasts. J Cell Biol (1982) 0.99
Hepatic binding and internalization of low density lipoprotein-gold conjugates in rats treated with 17 alpha-ethinylestradiol. J Cell Biol (1981) 0.99
Ultrastructural basis for chloroquine-induced increase in intracellular insulin in adipocytes: alteration of lysosomal function. Proc Natl Acad Sci U S A (1982) 0.96
Electric field-induced redistribution and postfield relaxation of epidermal growth factor receptors on A431 cells. J Cell Biol (1987) 0.93
Heterogeneity of epidermal growth factor binding kinetics on individual cells. Biophys J (1997) 0.90
Three-dimensional locations of gold-labeled proteins in a whole mount eukaryotic cell obtained with 3nm precision using aberration-corrected scanning transmission electron microscopy. J Struct Biol (2011) 0.88
Effects of lysosomotropic amines on human polymorphonuclear leucocyte function. Immunology (1984) 0.88
Two populations of prelysosomal structures transporting asialoglycoproteins in rat liver. Proc Natl Acad Sci U S A (1984) 0.88
Saccharin and cyclamate inhibit binding of epidermal growth factor. Proc Natl Acad Sci U S A (1981) 0.84
Electric field-induced redistribution and postfield relaxation of low density lipoprotein receptors on cultured human fibroblasts. J Cell Biol (1985) 0.83
Functional state of the epidermal growth factor-receptor complexes during their internalization in A-431 cells. Mol Cell Biol (1990) 0.82
Microtubules and microfilaments in fixed and permeabilized cells are selectively decorated by nerve growth factor. Proc Natl Acad Sci U S A (1982) 0.82
Structural characterization and exposure of aromatic residues in epidermal growth factor from the rat. Biochem J (1986) 0.80
Recent progress on lipid lateral heterogeneity in plasma membranes: From rafts to submicrometric domains. Prog Lipid Res (2015) 0.80
My journey into the world of sphingolipids and sphingolipidoses. Proc Jpn Acad Ser B Phys Biol Sci (2012) 0.79
Processing of calcitonin and epidermal growth factor after binding to receptors in human breast cancer cells (T 47D). Biochem J (1982) 0.79
Endogenous sphingomyelin segregates into submicrometric domains in the living erythrocyte membrane. J Lipid Res (2014) 0.78
Origins of growth factors: NGF and EGF. J Biol Chem (2008) 0.78
Uptake of lectins by pulmonary alveolar type II cells: subsequent deposition into lamellar bodies. Proc Natl Acad Sci U S A (1984) 0.77
Increased ammoniagenesis and the renal tubular effects of potassium depletion. J Clin Pathol (1984) 0.76
Epidermal growth factor stimulation of ornithine decarboxylase activity in a human hepatoma cell line. Proc Natl Acad Sci U S A (1981) 0.75
Receptor-linked degradation of 125I-insulin is mediated by internalization in isolated rat hepatocytes. Yale J Biol Med (1982) 0.75
Rapid endocytosis of soluble immune complexes by Fc receptors of normal human neutrophils. Immunology (1982) 0.75
Binding of tissue plasminogen activator to human aortic endothelial cells. Biochem J (1990) 0.75
Epidermal growth factor. Annu Rev Biochem (1979) 11.82
125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts. J Cell Biol (1976) 10.88
Epidermal growth factor and a new derivative. Rapid isolation procedures and biological and chemical characterization. J Biol Chem (1972) 10.86
Ruthenium red and violet. I. Chemistry, purification, methods of use for electron microscopy and mechanism of action. Anat Rec (1971) 9.73
Freeze-etching nomenclature. Science (1975) 7.41
Nerve growth factor receptors on human melanoma cells in culture. Proc Natl Acad Sci U S A (1977) 6.62
Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells. Proc Natl Acad Sci U S A (1978) 6.59
Visualization by fluorescence of the binding and internalization of epidermal growth factor in human carcinoma cells A-431. Proc Natl Acad Sci U S A (1978) 5.91
Direct visualization of the binding and internalization of a ferritin conjugate of epidermal growth factor in human carcinoma cells A-431. J Cell Biol (1979) 5.62
Molecular mechanism of mitogen action: processing of receptor induced by epidermal growth factor. Proc Natl Acad Sci U S A (1978) 4.31
Epidermal growth factor: morphological demonstration of binding, internalization, and lysosomal association in human fibroblasts. Proc Natl Acad Sci U S A (1978) 4.03
Collection of insulin, EGF and alpha2-macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization. Cell (1978) 3.90
Rapid stimulation of pinocytosis in human carcinoma cells A-431 by epidermal growth factor. J Cell Biol (1979) 2.88
Hormonal regulation of peptide receptors and target cell responses. Nature (1979) 2.79
Epidermal growth factor. Relationship between receptor regulation and mitogenesis in 3T3 cells. J Biol Chem (1978) 2.54
Amines inhibit the clustering of alpha2-macroglobulin and EGF on the fibroblast cell surface. Nature (1979) 2.41
An ultrastructural staining method for enhancing the size and electron opacity of ferritin in thin sections. J Histochem Cytochem (1972) 2.12
Fluorescent labeling of hormone receptors in viable cells: preparation and properties of highly fluorescent derivatives of epidermal growth factor and insulin. Proc Natl Acad Sci U S A (1978) 2.03
Cytochemical staining of multivesicular body and golgi vesicles. J Cell Biol (1969) 1.88
A comparison of the binding of epidermal growth factor to cultured granulosa and luteal cells. J Biol Chem (1978) 1.53
Thrombin and epidermal growth factor become linked to cell surface receptors during mitogenic stimulation. Nature (1979) 1.23
Direct linkage of epidermal growth factor to its receptor. Nature (1979) 1.11
A global measure of perceived stress. J Health Soc Behav (1983) 56.90
Stress, social support, and the buffering hypothesis. Psychol Bull (1985) 19.28
Socioeconomic status and health. The challenge of the gradient. Am Psychol (1994) 13.59
Epidermal growth factor. Annu Rev Biochem (1979) 11.82
125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts. J Cell Biol (1976) 10.88
Epidermal growth factor and a new derivative. Rapid isolation procedures and biological and chemical characterization. J Biol Chem (1972) 10.86
Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein. N Engl J Med (1997) 8.65
Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes. J Biol Chem (1980) 7.71
Beta Alanine as a Growth Accessory for the Diphtheria Bacillus. J Bacteriol (1937) 7.51
Visualization by fluorescence of the binding and internalization of epidermal growth factor in human carcinoma cells A-431. Proc Natl Acad Sci U S A (1978) 5.91
Direct visualization of the binding and internalization of a ferritin conjugate of epidermal growth factor in human carcinoma cells A-431. J Cell Biol (1979) 5.62
Does hiatus hernia affect competence of the gastroesophageal sphincter? N Engl J Med (1971) 5.44
Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells. J Biol Chem (1980) 5.24
Epidermal growth factor-receptor-protein kinase interactions. Co-purification of receptor and epidermal growth factor-enhanced phosphorylation activity. J Biol Chem (1980) 5.19
Epidermal growth factor. J Biol Chem (1990) 4.79
Prophylactic vs therapeutic blood patch for obstetric patients with accidental dural puncture--a randomised controlled trial. Anaesthesia (2014) 4.75
IMMUNITY IN MUMPS : II. THE DEVELOPMENT OF COMPLEMENT-FIXING ANTIBODY AND DERMAL HYPERSENSITIVITY IN HUMAN BEINGS FOLLOWING MUMPS. J Exp Med (1945) 4.69
The primary structure of epidermal growth factor. J Biol Chem (1972) 4.41
Epidermal growth factor: morphological demonstration of binding, internalization, and lysosomal association in human fibroblasts. Proc Natl Acad Sci U S A (1978) 4.03
Human epidermal growth factor and the proliferation of human fibroblasts. J Cell Physiol (1976) 3.91
A native 170,000 epidermal growth factor receptor-kinase complex from shed plasma membrane vesicles. J Biol Chem (1982) 3.81
IN VITRO AND IN VIVO EFFECTS OF A NERVE GROWTH-STIMULATING AGENT ISOLATED FROM SNAKE VENOM. Proc Natl Acad Sci U S A (1956) 3.64
THE INFLUENCE OF PROTEIN INTAKE ON THE UREA CLEARANCE IN NORMAL MAN. J Clin Invest (1934) 3.60
Transformation by murine and feline sarcoma viruses specifically blocks binding of epidermal growth factor to cells. Nature (1976) 3.56
Epidermal growth factor stimulates phosphorylation in membrane preparations in vitro. Nature (1978) 3.54
Glycosyltransferase activity of Fringe modulates Notch-Delta interactions. Nature (2000) 3.51
Characterization of the binding of 125-I-labeled epidermal growth factor to human fibroblasts. J Biol Chem (1975) 3.48
Induction by EGF and interferon-gamma of tyrosine phosphorylated DNA binding proteins in mouse liver nuclei. Science (1993) 3.30
Heterogeneity of the peptide chains of gamma-globulin. Biochem J (1964) 3.25
Action of malarial antibody in vitro. Nature (1969) 3.24
Rapid enhancement of protein phosphorylation in A-431 cell membrane preparations by epidermal growth factor. J Biol Chem (1979) 3.18
Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Leflunomide Rheumatoid Arthritis Investigators Group. Arch Intern Med (1999) 3.10
Inhibition of membrane phosphotyrosyl-protein phosphatase activity by vanadate. Biochem Biophys Res Commun (1982) 3.01
ABC of intensive care. Withdrawal of treatment. BMJ (1999) 2.96
Human epidermal growth factor: isolation and chemical and biological properties. Proc Natl Acad Sci U S A (1975) 2.95
Bone density threshold and other predictors of vertebral fracture in patients receiving oral glucocorticoid therapy. Arthritis Rheum (2003) 2.94
Social support and smoking cessation and maintenance. J Consult Clin Psychol (1986) 2.92
Rapid stimulation of pinocytosis in human carcinoma cells A-431 by epidermal growth factor. J Cell Biol (1979) 2.88
The production of migration inhibition factor by B and T cells of the guinea pig. J Exp Med (1973) 2.86
Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas. Nat Genet (1999) 2.83
Vaccination trials in rhesus monkeys with a minor, invariant, Plasmodium knowlesi 66 kD merozoite antigen. Parasite Immunol (1988) 2.79
In vitro comparison of netilmicin, a semisynthetic derivative of sisomicin, and four other aminoglycoside antibiotics. Antimicrob Agents Chemother (1976) 2.75
Debunking myths about self-quitting. Evidence from 10 prospective studies of persons who attempt to quit smoking by themselves. Am Psychol (1989) 2.72
Properties of protective malarial antibody. Immunology (1970) 2.65
Rapid induction of morphological changes in human carcinoma cells A-431 by epidermal growth factors. J Cell Biol (1979) 2.61
Evidence for high-energy extraterrestrial neutrinos at the IceCube detector. Science (2013) 2.56
Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction. J Clin Invest (1994) 2.55
The Fab fragments of monoclonal IgG to a merozoite surface antigen inhibit Plasmodium knowlesi invasion of erythrocytes. Mol Biochem Parasitol (1984) 2.54
A simple technique to reduce the incidence of accidental dural puncture. Anaesthesia (2001) 2.53
Stress and immunity in humans: a meta-analytic review. Psychosom Med (1993) 2.52
Conjugational transfer of gentamicin resistance plasmids intra- and interspecifically in Staphylococcus aureus and Staphylococcus epidermidis. Antimicrob Agents Chemother (1983) 2.50
The distribution of antigenic and nonantigenic compounds within draining lymph nodes. Lab Invest (1966) 2.49
Identity and interspecific transfer of gentamicin-resistance plasmids in Staphylococcus aureus and Staphylococcus epidermidis. J Infect Dis (1980) 2.48
Enhancement of calcium uptake and phosphatidylinositol turnover by epidermal growth factor in A-431 cells. Biochemistry (1981) 2.46
Social support and adjustment to cancer: reconciling descriptive, correlational, and intervention research. Health Psychol (1996) 2.46
Nobel laureates' letter to President Bush. Washington Post (2001) 2.43
Inconsistent visual analyses of intrasubject data. J Appl Behav Anal (1979) 2.43
A merozoite vaccine effective against Plasmodium knowlesi malaria. Nature (1974) 2.39
Group support interventions for women with breast cancer: who benefits from what? Health Psychol (2000) 2.38
In vitro and in vivo activity of a lymphocyte and immune complex-dependent chemotactic factor for eosinophils. J Exp Med (1971) 2.36
Review of psychosocial stress and asthma: an integrated biopsychosocial approach. Thorax (1998) 2.33
Depression and immunity: a meta-analytic review. Psychol Bull (1993) 2.30
Investigation of benefits and costs of an ophthalmic outreach clinic in general practice. Br J Gen Pract (1995) 2.26
Absence of circular plasmid deoxyribonucleic acid attributable to a genetic determinant for methicillin resistance in Staphylococcus aureus. J Bacteriol (1973) 2.25
Bioengineered cardiac grafts: A new approach to repair the infarcted myocardium? Circulation (2000) 2.25
Our new President: Frank P. Brooks. Gastroenterology (1980) 2.24
Cytoplasmic pH regulation in thymic lymphocytes by an amiloride-sensitive Na+/H+ antiport. J Gen Physiol (1984) 2.23
In vitro isolation of Plasmodium knowlesi merozoites using polycarbonate sieves. Parasitology (1975) 2.23
Cimetidine in the treatment of symptomatic gastroesophageal reflux: a double blind controlled trial. Gastroenterology (1978) 2.21
Isolation of a calcium-dependent 35-kilodalton substrate for the epidermal growth factor receptor/kinase from A-431 cells. J Biol Chem (1984) 2.21
Merozoite vaccination against Plasmodium knowlesi malaria. Immunology (1975) 2.21
Mesiotemporal T2-weighted hyperintensity: neurosyphilis mimicking herpes encephalitis. AJNR Am J Neuroradiol (2001) 2.16
Structure and biological properties of immunoglobulins. Adv Immunol (1967) 2.08
Hormonal regulation of human lower esophageal sphincter competence: interaction of gastrin and secretin. J Clin Invest (1971) 2.07
Colonic myoelectric activity in the irritable bowel syndrome. Gastroenterology (1976) 2.05
Constitutive penicillinase formation in Staphylococcus aureus owing to a mutation unlinked to the penicillinase plasmid. J Bacteriol (1968) 2.03
A merozoite receptor protein from Plasmodium knowlesi is highly conserved and distributed throughout Plasmodium. J Biol Chem (1990) 2.02
Crystal structure of the annexin XII hexamer and implications for bilayer insertion. Nature (1995) 2.01
First observation of PeV-energy neutrinos with IceCube. Phys Rev Lett (2013) 2.00
Characterization of lipocortin I and an immunologically unrelated 33-kDa protein as epidermal growth factor receptor/kinase substrates and phospholipase A2 inhibitors. J Biol Chem (1987) 1.98
Rat monoclonal antibodies which inhibit the in vitro multiplication of Plasmodium knowlesi. Clin Exp Immunol (1982) 1.97
Merozoite vaccination of douroucouli monkeys against falciparum malaria. Lancet (1977) 1.95
Effect of the prophage and penicillinase plasmid of the recipient strain upon the transduction and the stability of methicillin resistance in Staphylococcus aureus. J Bacteriol (1973) 1.92
Epidermal growth factor. Location of disulfide bonds. J Biol Chem (1973) 1.90
Affinity labeling of the protein kinase associated with the epidermal growth factor receptor in membrane vesicles from A431 cells. J Biol Chem (1982) 1.89
Leukotactic factors elaborated by virus-infected tissues. J Exp Med (1972) 1.89
Antigenic variation and protective immunity in Plasmodium knowlesi malaria. Immunology (1972) 1.89
Structural and phenotypic varieties of gentamicin resistance plasmids in hospital strains of Staphylococcus aureus and coagulase-negative staphylococci. Antimicrob Agents Chemother (1982) 1.89
Co-localization of 125I-epidermal growth factor and ferritin-low density lipoprotein in coated pits: a quantitative electron microscopic study in normal and mutant human fibroblasts. J Cell Biol (1982) 1.88
Interaction of epidermal growth factor (EGF) with cultured fibroblasts. Adv Metab Disord (1975) 1.88
Epidermal growth factor: effects of androgens and adrenergic agents. Endocrinology (1974) 1.87
Impact of sample type on rapid detection of influenza virus A by cytospin-enhanced immunofluorescence and membrane enzyme-linked immunosorbent assay. J Clin Microbiol (2000) 1.86
Rituximab inhibits structural joint damage in patients with rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitor therapies. Ann Rheum Dis (2008) 1.84
Women's recall of obstetric complications in south Kalimantan, Indonesia. Stud Fam Plann (1997) 1.82