Organotypic slice culture from human adult ventricular myocardium.

PubWeight™: 1.78‹?› | Rank: Top 3%

🔗 View Article (PMID 21972180)

Published in Cardiovasc Res on October 04, 2011

Authors

Matthias Brandenburger1, Jan Wenzel, Roman Bogdan, Doreen Richardt, Filomain Nguemo, Michael Reppel, Jürgen Hescheler, Heinrich Terlau, Andreas Dendorfer

Author Affiliations

1: Department of Experimental and Clinical Pharmacology and Toxicology, Medical University of Lübeck, Germany.

Articles citing this

Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes. Biomaterials (2013) 1.97

In vivo activation of a conserved microRNA program induces mammalian heart regeneration. Cell Stem Cell (2014) 1.61

Screening drug-induced arrhythmia [corrected] using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays. Circulation (2013) 1.54

Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window. Sci Transl Med (2015) 1.25

Human stem cells for modeling heart disease and for drug discovery. Sci Transl Med (2014) 1.24

Human iPSC-based cardiac microphysiological system for drug screening applications. Sci Rep (2015) 1.04

Cross talk between cardiac myocytes and fibroblasts: from multiscale investigative approaches to mechanisms and functional consequences. Am J Physiol Heart Circ Physiol (2012) 1.02

Finding the rhythm of sudden cardiac death: new opportunities using induced pluripotent stem cell-derived cardiomyocytes. Circ Res (2015) 0.96

Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation. Hepatology (2013) 0.91

Engineered heart tissues and induced pluripotent stem cells: Macro- and microstructures for disease modeling, drug screening, and translational studies. Adv Drug Deliv Rev (2015) 0.91

Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation. J Clin Invest (2014) 0.87

Maturing human pluripotent stem cell-derived cardiomyocytes in human engineered cardiac tissues. Adv Drug Deliv Rev (2015) 0.83

A Myocardial Slice Culture Model Reveals Alpha-1A-Adrenergic Receptor Signaling in the Human Heart. JACC Basic Transl Sci (2016) 0.81

A novel ex vivo culture method for the embryonic mouse heart. J Vis Exp (2013) 0.80

Human Organotypic Cultured Cardiac Slices: New Platform For High Throughput Preclinical Human Trials. Sci Rep (2016) 0.79

Cardiac tissue slices: preparation, handling, and successful optical mapping. Am J Physiol Heart Circ Physiol (2015) 0.77

Myocyte-fibroblast communication in cardiac fibrosis and arrhythmias: Mechanisms and model systems. J Mol Cell Cardiol (2016) 0.76

Explant culture of adult zebrafish hearts for epicardial regeneration studies. Nat Protoc (2016) 0.76

A novel adult human ventricle slice preparation for cardiac drug discovery and safety pharmacology. Cardiovasc Res (2011) 0.76

Human ex-vivo action potential model for pro-arrhythmia risk assessment. J Pharmacol Toxicol Methods (2016) 0.75

Medium-chain fatty acids modulate myocardial function via a cardiac odorant receptor. Basic Res Cardiol (2017) 0.75

21st Century Cardio-Oncology: Identifying Cardiac Safety Signals in the Era of Personalized Medicine. JACC Basic Transl Sci (2016) 0.75

Articles by these authors

Retracted Generation of pluripotent stem cells from adult human testis. Nature (2008) 5.49

Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation. Nat Med (2004) 4.59

Monitoring of implanted stem cell migration in vivo: a highly resolved in vivo magnetic resonance imaging investigation of experimental stroke in rat. Proc Natl Acad Sci U S A (2002) 3.27

Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection. Arterioscler Thromb Vasc Biol (2004) 3.18

Generation of functional murine cardiac myocytes from induced pluripotent stem cells. Circulation (2008) 3.11

Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol (2012) 2.17

Retracted Cav 2.3 (R-type) calcium channels are critical for mediating anticonvulsive and neuroprotective properties of lamotrigine in vivo. Epilepsia (2013) 2.05

Host-dependent tumorigenesis of embryonic stem cell transplantation in experimental stroke. J Cereb Blood Flow Metab (2003) 2.01

Electrophysiological maturation and integration of murine fetal cardiomyocytes after transplantation. Circ Res (2007) 1.73

Effective engraftment but poor mid-term persistence of mononuclear and mesenchymal bone marrow cells in acute and chronic rat myocardial infarction. J Mol Cell Cardiol (2006) 1.72

Differential expression of AT1 receptors in the pituitary and adrenal gland of SHR and WKY. Hypertension (2003) 1.61

Modulation of ventricular repolarization in patients with transient left ventricular apical ballooning: a case control study. J Cardiovasc Electrophysiol (2006) 1.59

Effects of selective angiotensin II receptor blockade on sympathetic nerve activity in primary hypertensive subjects. J Hypertens (2002) 1.54

Brain nitric oxide synthase activity in spontaneously hypertensive rats during the development of hypertension. J Hypertens (2003) 1.53

Estimation of action potential changes from field potential recordings in multicellular mouse cardiac myocyte cultures. Cell Physiol Biochem (2003) 1.50

Long-term results of 203 young and middle-aged patients with more than 10 years of follow-up after the original subcoronary Ross operation. Ann Thorac Surg (2011) 1.48

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. J Biol Chem (2007) 1.48

Comparison of contractile behavior of native murine ventricular tissue and cardiomyocytes derived from embryonic or induced pluripotent stem cells. FASEB J (2010) 1.45

Cardiac specific differentiation of mouse embryonic stem cells. Cardiovasc Res (2003) 1.44

In vitro modeling of ryanodine receptor 2 dysfunction using human induced pluripotent stem cells. Cell Physiol Biochem (2011) 1.43

Toxicogenomics directory of chemically exposed human hepatocytes. Arch Toxicol (2014) 1.43

Two cases of heart failure after implantation of a CoreValve prosthesis. N Engl J Med (2015) 1.38

Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species. FASEB J (2003) 1.36

Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines. J Neurosci (2009) 1.36

Remote preconditioning protects the heart by activating myocardial PKCepsilon-isoform. Cardiovasc Res (2002) 1.31

Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family. Structural and functional characterization. J Biol Chem (2005) 1.27

Global transcriptional profiles of beating clusters derived from human induced pluripotent stem cells and embryonic stem cells are highly similar. BMC Dev Biol (2010) 1.21

Acute reduction of myocardial infarct size by a hydroxymethyl glutaryl coenzyme A reductase inhibitor is mediated by endothelial nitric oxide synthase. J Cardiovasc Pharmacol (2003) 1.19

Phosphatidylinositol 3-kinase-dependent membrane recruitment of Rac-1 and p47phox is critical for alpha-platelet-derived growth factor receptor-induced production of reactive oxygen species. J Biol Chem (2007) 1.19

The high mobility group protein HMGA2: a co-regulator of chromatin structure and pluripotency in stem cells? Stem Cell Rev (2009) 1.18

Sodium channel toxins--receptor targeting and therapeutic potential. Curr Med Chem (2004) 1.18

Simvastatin acutely reduces myocardial reperfusion injury in vivo by activating the phosphatidylinositide 3-kinase/Akt pathway. J Cardiovasc Pharmacol (2004) 1.17

Disturbances in glucose-tolerance, insulin-release, and stress-induced hyperglycemia upon disruption of the Ca(v)2.3 (alpha 1E) subunit of voltage-gated Ca(2+) channels. Mol Endocrinol (2002) 1.17

Conventional light chains inhibit the autonomous signaling capacity of the B cell receptor. Immunity (2007) 1.17

Synthetic muO-conotoxin MrVIB blocks TTX-resistant sodium channel NaV1.8 and has a long-lasting analgesic activity. Biochemistry (2006) 1.17

The FunGenES database: a genomics resource for mouse embryonic stem cell differentiation. PLoS One (2009) 1.15

Global transcriptome analysis of murine embryonic stem cell-derived cardiomyocytes. Genome Biol (2007) 1.15

Chemoprotective mechanism of the natural compounds, epigallocatechin-3-O-gallate, quercetin and curcumin against cancer and cardiovascular diseases. Curr Med Chem (2009) 1.14

Mechano-sensitivity of epithelial sodium channels (ENaCs): laminar shear stress increases ion channel open probability. FASEB J (2007) 1.13

A novel conotoxin inhibitor of Kv1.6 channel and nAChR subtypes defines a new superfamily of conotoxins. Biochemistry (2006) 1.12

The WNT receptor FZD7 contributes to self-renewal signaling of human embryonic stem cells. Biol Chem (2008) 1.12

Activity of complex III of the mitochondrial electron transport chain is essential for early heart muscle cell differentiation. FASEB J (2004) 1.11

Anatomic and procedural predictors of paravalvular aortic regurgitation after implantation of the Medtronic CoreValve bioprosthesis. J Am Coll Cardiol (2010) 1.10

Retracted Silencing of B cell receptor signals in human naive B cells. J Exp Med (2002) 1.09

Hypoxia rapidly activates HIF-3alpha mRNA expression. FASEB J (2003) 1.09

Identification and functional analysis of novel THAP1 mutations. Eur J Hum Genet (2011) 1.08

Molecular interaction of delta-conotoxins with voltage-gated sodium channels. FEBS Lett (2005) 1.08

Pain perception in mice lacking the beta3 subunit of voltage-activated calcium channels. J Biol Chem (2002) 1.07

Serpin-6 expression protects embryonic stem cells from lysis by antigen-specific CTL. J Immunol (2007) 1.07

Involvement of reactive oxygen species in cardiotrophin-1-induced proliferation of cardiomyocytes differentiated from murine embryonic stem cells. Exp Cell Res (2004) 1.07

Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome. Hum Mol Genet (2012) 1.07

Four new bromotryptamine derivatives from the marine bryozoan Flustra foliacea. J Nat Prod (2002) 1.07

Induced pluripotent mesenchymal stromal cell clones retain donor-derived differences in DNA methylation profiles. Mol Ther (2012) 1.07

Markers of murine embryonic and neural stem cells, neurons and astrocytes: reference points for developmental neurotoxicity testing. ALTEX (2010) 1.06

The isolated perfused bovine retina--a sensitive tool for pharmacological research on retinal function. Brain Res Brain Res Protoc (2005) 1.05

Establishment and characterization of a mouse embryonic heart slice preparation. Cell Physiol Biochem (2005) 1.05

Identification of thalidomide-specific transcriptomics and proteomics signatures during differentiation of human embryonic stem cells. PLoS One (2012) 1.05

Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol (2014) 1.03

Electrocorticographic and deep intracerebral EEG recording in mice using a telemetry system. Brain Res Brain Res Protoc (2005) 1.03

Cardiac myocytes derived from murine reprogrammed fibroblasts: intact hormonal regulation, cardiac ion channel expression and development of contractility. Cell Physiol Biochem (2009) 1.02

Effects of gender and aging on differential autonomic responses to orthostatic maneuvers. J Cardiovasc Electrophysiol (2008) 1.02

Embryonic stem cell transplantation after experimental traumatic brain injury dramatically improves neurological outcome, but may cause tumors. J Neurotrauma (2007) 1.02

Bradykinin, angiotensin-(1-7), and ACE inhibitors: how do they interact? Int J Biochem Cell Biol (2003) 1.01

The small EF-hand Ca2+ binding protein S100A1 increases contractility and Ca2+ cycling in rat cardiac myocytes. Basic Res Cardiol (2002) 1.01

Contractile properties of early human embryonic stem cell-derived cardiomyocytes: beta-adrenergic stimulation induces positive chronotropy and lusitropy but not inotropy. Stem Cells Dev (2012) 1.01

Comparison of outcomes in patients having isolated transcatheter aortic valve implantation versus combined with preprocedural percutaneous coronary intervention. Am J Cardiol (2011) 1.00

muO conotoxins inhibit NaV channels by interfering with their voltage sensors in domain-2. Channels (Austin) (2007) 1.00

Trauma-associated inflammatory response impairs embryonic stem cell survival and integration after implantation into injured rat brain. J Neurotrauma (2007) 1.00

Modulation of intrinsic P-glycoprotein expression in multicellular prostate tumor spheroids by cell cycle inhibitors. Biochim Biophys Acta (2002) 0.99

Remote vs. ischaemic preconditioning: the differential role of mitogen-activated protein kinase pathways. Cardiovasc Res (2007) 0.98

Embryonic stem cells: a promising tool for cell replacement therapy. J Cell Mol Med (2004) 0.98

Reconsidering pluripotency tests: do we still need teratoma assays? Stem Cell Res (2013) 0.98

Force measurements of human embryonic stem cell-derived cardiomyocytes in an in vitro transplantation model. Stem Cells (2006) 0.97

Cardiovascular and renal function of angiotensin II type-2 receptors. Cardiovasc Res (2004) 0.97

Biochemical characterization of kappaM-RIIIJ, a Kv1.2 channel blocker: evaluation of cardioprotective effects of kappaM-conotoxins. J Biol Chem (2010) 0.96

Transcriptomic and phenotypic analysis of murine embryonic stem cell derived BMP2+ lineage cells: an insight into mesodermal patterning. Genome Biol (2007) 0.96

Identification of differentially expressed genes involved in the formation of multicellular tumor spheroids by HT-29 colon carcinoma cells. Mol Ther (2007) 0.96

Gene expression signatures defining fundamental biological processes in pluripotent, early, and late differentiated embryonic stem cells. Stem Cells Dev (2012) 0.95

In vitro differentiation of murine embryonic stem cells into keratinocyte-like cells. Eur J Cell Biol (2007) 0.94

In vitro model for assessing arrhythmogenic properties of drugs based on high-resolution impedance measurements. Cell Physiol Biochem (2012) 0.94

Non-hypoxic induction of HIF-3alpha by 2-deoxy-D-glucose and insulin. Biochem Biophys Res Commun (2006) 0.94

Angiotensin II inhibition reduces stress sensitivity of hypothalamo-pituitary-adrenal axis in spontaneously hypertensive rats. Endocrinology (2006) 0.94

Functional expression of the Na+/Ca2+ exchanger in the embryonic mouse heart. J Mol Cell Cardiol (2006) 0.94

Ventricular slices of adult mouse hearts--a new multicellular in vitro model for electrophysiological studies. Cell Physiol Biochem (2006) 0.93

An optimized embryonic stem cell model for consistent gene expression and developmental studies: a fundamental study. Thromb Haemost (2005) 0.93

Direct current electrical fields induce apoptosis in oral mucosa cancer cells by NADPH oxidase-derived reactive oxygen species. Bioelectromagnetics (2008) 0.93

Lack of laminin gamma1 in embryonic stem cell-derived cardiomyocytes causes inhomogeneous electrical spreading despite intact differentiation and function. Stem Cells (2009) 0.93

Role of natural-killer group 2 member D ligands and intercellular adhesion molecule 1 in natural killer cell-mediated lysis of murine embryonic stem cells and embryonic stem cell-derived cardiomyocytes. Stem Cells (2009) 0.92