Published in Proc Natl Acad Sci U S A on October 04, 2011
The absence of intrarenal ACE protects against hypertension. J Clin Invest (2013) 2.31
Regulation of NKCC2 activity by inhibitory SPAK isoforms: KS-SPAK is a more potent inhibitor than SPAK2. Am J Physiol Renal Physiol (2013) 1.41
SPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner. J Biol Chem (2012) 1.21
Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport. Physiol Rev (2012) 1.18
SPAK differentially mediates vasopressin effects on sodium cotransporters. J Am Soc Nephrol (2013) 1.16
Effects of ACE inhibition and ANG II stimulation on renal Na-Cl cotransporter distribution, phosphorylation, and membrane complex properties. Am J Physiol Cell Physiol (2012) 1.05
Sympathetic stimulation of thiazide-sensitive sodium chloride cotransport in the generation of salt-sensitive hypertension. Hypertension (2014) 0.97
Adenylyl cyclase 6 enhances NKCC2 expression and mediates vasopressin-induced phosphorylation of NKCC2 and NCC. Am J Pathol (2012) 0.96
Physiology and pathophysiology of SLC12A1/2 transporters. Pflugers Arch (2013) 0.96
Novel diuretic targets. Am J Physiol Renal Physiol (2013) 0.93
Regulation of the renal Na+-Cl- cotransporter by phosphorylation and ubiquitylation. Am J Physiol Renal Physiol (2012) 0.90
Cullin 3 as a novel target in diverse pathologies. Redox Biol (2013) 0.89
Discovery of Novel SPAK Inhibitors That Block WNK Kinase Signaling to Cation Chloride Transporters. J Am Soc Nephrol (2014) 0.88
SPAK-mediated NCC regulation in response to low-K+ diet. Am J Physiol Renal Physiol (2015) 0.86
WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade. J Biol Chem (2013) 0.85
Calcium-binding protein 39 facilitates molecular interaction between Ste20p proline alanine-rich kinase and oxidative stress response 1 monomers. Am J Physiol Cell Physiol (2012) 0.85
Thick ascending limb of the loop of Henle. Clin J Am Soc Nephrol (2014) 0.85
Hypotonicity stimulates potassium flux through the WNK-SPAK/OSR1 kinase cascade and the Ncc69 sodium-potassium-2-chloride cotransporter in the Drosophila renal tubule. J Biol Chem (2014) 0.81
Short forms of Ste20-related proline/alanine-rich kinase (SPAK) in the kidney are created by aspartyl aminopeptidase (Dnpep)-mediated proteolytic cleavage. J Biol Chem (2014) 0.80
SPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation. PLoS One (2013) 0.80
Phosphorylation regulates NCC stability and transporter activity in vivo. J Am Soc Nephrol (2013) 0.80
Deletion of the WNK3-SPAK kinase complex in mice improves radiographic and clinical outcomes in malignant cerebral edema after ischemic stroke. J Cereb Blood Flow Metab (2016) 0.78
Calcineurin and Sorting-Related Receptor with A-Type Repeats Interact to Regulate the Renal Na+-K+-2Cl- Cotransporter. J Am Soc Nephrol (2015) 0.78
SPAK and OSR1 play essential roles in potassium homeostasis through actions on the distal convoluted tubule. J Physiol (2016) 0.78
SPAK and OSR1 sensitivity of voltage-gated K+ channel Kv1.5. J Membr Biol (2014) 0.77
OSR1 and SPAK cooperatively modulate Sertoli cell support of mouse spermatogenesis. Sci Rep (2016) 0.75
WNK signalling pathways in blood pressure regulation. Cell Mol Life Sci (2016) 0.75
Albuminuria enhances NHE3 and NCC via stimulation of mitochondrial oxidative stress/angiotensin II axis. Oncotarget (2016) 0.75
In silico analysis and experimental verification of OSR1 kinase - Peptide interaction. J Struct Biol (2014) 0.75
PharmGKB summary: Diuretics pathway, pharmacodynamics. Pharmacogenet Genomics (2013) 0.75
Emerging Targets of Diuretic Therapy. Clin Pharmacol Ther (2017) 0.75
The role of renal transporters and novel regulatory interactions in the TAL that control blood pressure. Physiol Genomics (2017) 0.75
Regulation of renal Na-(K)-Cl cotransporters by vasopressin. Pflugers Arch (2017) 0.75
WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats. J Cereb Blood Flow Metab (2016) 0.75
Human hypertension caused by mutations in WNK kinases. Science (2001) 8.71
Gitelman's variant of Bartter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter. Nat Genet (1996) 5.95
Molecular physiology and pathophysiology of electroneutral cation-chloride cotransporters. Physiol Rev (2005) 4.29
Hyperplasia of the juxtaglomerular complex with hyperaldosteronism and hypokalemic alkalosis. A new syndrome. Am J Med (1962) 4.20
Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2. Nat Genet (1996) 3.84
The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases. Biochem J (2005) 3.52
From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene. Proc Natl Acad Sci U S A (2008) 3.39
WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. J Biol Chem (2005) 3.26
Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model. Cell Metab (2007) 2.88
Cation chloride cotransporters interact with the stress-related kinases Ste20-related proline-alanine-rich kinase (SPAK) and oxidative stress response 1 (OSR1). J Biol Chem (2002) 2.87
SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction. J Am Soc Nephrol (2010) 2.73
Role of the WNK-activated SPAK kinase in regulating blood pressure. EMBO Mol Med (2010) 2.36
SPAK and OSR1: STE20 kinases involved in the regulation of ion homoeostasis and volume control in mammalian cells. Biochem J (2008) 2.18
Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone. Kidney Int (2008) 1.92
Effect of the Na-K-2Cl cotransporter NKCC1 on systemic blood pressure and smooth muscle tone. Am J Physiol Heart Circ Physiol (2007) 1.81
SPAK, a STE20/SPS1-related kinase that activates the p38 pathway. Oncogene (2000) 1.59
Uncompensated polyuria in a mouse model of Bartter's syndrome. Proc Natl Acad Sci U S A (2000) 1.59
Distribution and diversity of Na-K-Cl cotransport proteins: a study with monoclonal antibodies. Am J Physiol (1995) 1.59
Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure. Hum Mol Genet (2009) 1.56
Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways. J Cell Sci (2011) 1.55
WNK4 diverts the thiazide-sensitive NaCl cotransporter to the lysosome and stimulates AP-3 interaction. J Biol Chem (2009) 1.44
Decreased blood pressure and vascular smooth muscle tone in mice lacking basolateral Na(+)-K(+)-2Cl(-) cotransporter. Am J Physiol Heart Circ Physiol (2002) 1.32
Expression of the mouse Na-K-2Cl cotransporter, mBSC2, in the terminal inner medullary collecting duct, the glomerular and extraglomerular mesangium, and the glomerular afferent arteriole. J Clin Invest (1996) 1.28
Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p22-21.3. J Hum Genet (1999) 1.23
Mechanism of regulation of renal ion transport by WNK kinases. Curr Opin Nephrol Hypertens (2008) 1.15
Salt-sensing mechanisms in blood pressure regulation and hypertension. Am J Physiol Heart Circ Physiol (2007) 1.10
Renal function in mice with targeted disruption of the A isoform of the Na-K-2Cl co-transporter. J Am Soc Nephrol (2007) 1.07
Hypotension in NKCC1 null mice: role of the kidneys. Am J Physiol Renal Physiol (2005) 1.04
Generation and analysis of the thiazide-sensitive Na+ -Cl- cotransporter (Ncc/Slc12a3) Ser707X knockin mouse as a model of Gitelman syndrome. Hum Mutat (2010) 1.01
Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse models. Hum Mol Genet (2010) 0.98
Macula densa control of renin secretion and preglomerular resistance in mice with selective deletion of the B isoform of the Na,K,2Cl co-transporter. J Am Soc Nephrol (2006) 0.97
Molecular pathogenesis of Bartter's and Gitelman's syndromes. Kidney Int (1998) 0.94
Salt sensitivity of blood pressure in NKCC1-deficient mice. Am J Physiol Renal Physiol (2008) 0.94
NKCC1 and hypertension: a novel therapeutic target involved in the regulation of vascular tone and renal function. Curr Opin Nephrol Hypertens (2010) 0.89
Hypocalciuria in patients with Gitelman syndrome: role of blood volume. Am J Kidney Dis (2007) 0.88
Genetic and biochemical determinants of abnormal monovalent ion transport in primary hypertension. Am J Physiol (1999) 0.88
Roles of the kidneys and fluid volumes in arterial pressure regulation and hypertension. Chin J Physiol (1989) 0.81
A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. Nat Genet (2010) 3.86
WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. J Biol Chem (2005) 3.26
Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model. Cell Metab (2007) 2.88
What is the learning curve associated with double-balloon enteroscopy? Technical details and early experience in 6 U.S. tertiary care centers. Gastrointest Endosc (2006) 2.78
SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction. J Am Soc Nephrol (2010) 2.73
Implications of the aquaporin-4 structure on array formation and cell adhesion. J Mol Biol (2005) 2.50
TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis. Genesis (2010) 2.31
Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins. Proc Natl Acad Sci U S A (2004) 2.10
Expression and phosphorylation of the Na+-Cl- cotransporter NCC in vivo is regulated by dietary salt, potassium, and SGK1. Am J Physiol Renal Physiol (2009) 2.03
Myeloperoxidase serves as a marker of oxidative stress during single haemodialysis session using two different biocompatible dialysis membranes. Nephrol Dial Transplant (2005) 1.98
Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone. Kidney Int (2008) 1.92
Cisplatin-induced macroautophagy occurs prior to apoptosis in proximal tubules in vivo. Clin Exp Nephrol (2009) 1.74
Single nucleotide polymorphism at Fas promoter is associated with cervical carcinogenesis. Int J Cancer (2003) 1.71
Celecoxib and radioresistant glioblastoma-derived CD133+ cells: improvement in radiotherapeutic effects. Laboratory investigation. J Neurosurg (2010) 1.70
ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation. J Biol Chem (2004) 1.61
Progressive adipocyte hypertrophy in aquaporin-7-deficient mice: adipocyte glycerol permeability as a novel regulator of fat accumulation. J Biol Chem (2005) 1.60
Development of enzyme-linked immunosorbent assays for urinary thiazide-sensitive Na-Cl cotransporter measurement. Am J Physiol Renal Physiol (2013) 1.59
Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure. Hum Mol Genet (2009) 1.56
Therapeutic effects of hypertonic saline on peritonitis-induced septic shock with multiple organ dysfunction syndrome in rats. Crit Care Med (2008) 1.56
Assessment and significance of abdominal aortic calcification in chronic kidney disease. Nephrol Dial Transplant (2010) 1.54
Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice. Am J Physiol Renal Physiol (2005) 1.53
Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension. Cell Rep (2013) 1.52
Generation and analyses of R8L barttin knockin mouse. Am J Physiol Renal Physiol (2011) 1.52
Retracted Evidence for the early involvement of interleukin 17 in human and experimental renal allograft rejection. J Pathol (2002) 1.52
Enhanced angiotensin receptor-associated protein in renal tubule suppresses angiotensin-dependent hypertension. Hypertension (2013) 1.52
Neuromyelitis optica and anti-aquaporin-4 antibodies measured by an enzyme-linked immunosorbent assay. J Neuroimmunol (2008) 1.51
Progressive renal distortion by multiple cysts in transgenic mice expressing artificial microRNAs against Pkd1. J Pathol (2010) 1.51
Early diagnosis of thyrotoxic periodic paralysis: spot urine calcium to phosphate ratio. Crit Care Med (2006) 1.51
Laboratory tests to determine the cause of hypokalemia and paralysis. Arch Intern Med (2004) 1.49
Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule. Mol Cell Biol (2005) 1.48
Impaired urea accumulation in the inner medulla of mice lacking the urea transporter UT-A2. Mol Cell Biol (2005) 1.47
Double balloon enteroscopy detects small bowel mass lesions missed by capsule endoscopy. Dig Dis Sci (2008) 1.46
Effects of diuretics on sodium-dependent glucose cotransporter 2 inhibitor-induced changes in blood pressure in obese rats suffering from the metabolic syndrome. J Hypertens (2016) 1.41
A novel genetic variant in the apolipoprotein A5 gene is associated with hypertriglyceridemia. Hum Mol Genet (2003) 1.37
Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells. Biochem Biophys Res Commun (2005) 1.37
Phenotype and genotype analysis in Chinese patients with Gitelman's syndrome. J Clin Endocrinol Metab (2005) 1.37
SFRP1 and SFRP2 suppress the transformation and invasion abilities of cervical cancer cells through Wnt signal pathway. Gynecol Oncol (2008) 1.28
Expression and function of the developmental gene Wnt-4 during experimental acute renal failure in rats. J Am Soc Nephrol (2003) 1.28
Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation. Free Radic Biol Med (2011) 1.28
Oxidized cellulose (Surgicel) granuloma mimicking a primary ovarian tumor. Int J Gynecol Pathol (2002) 1.27
Immunomodulatory properties of human adult and fetal multipotent mesenchymal stem cells. J Biomed Sci (2011) 1.20
CLC-3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis. Genes Cells (2002) 1.20
Diagnostic usefulness of bone mineral density and biochemical markers of bone turnover in predicting fracture in CKD stage 5D patients--a single-center cohort study. Nephrol Dial Transplant (2011) 1.19
Effect of angiotensin II on the WNK-OSR1/SPAK-NCC phosphorylation cascade in cultured mpkDCT cells and in vivo mouse kidney. Biochem Biophys Res Commun (2010) 1.19
Current status of the immunomodulation and immunomediated therapeutic strategies for multiple sclerosis. Clin Dev Immunol (2011) 1.18
Aquaporins in kidney pathophysiology. Nat Rev Nephrol (2010) 1.18
The expression level of septin12 is critical for spermiogenesis. Am J Pathol (2009) 1.18
Aquaporin-2 trafficking is regulated by PDZ-domain containing protein SPA-1. FEBS Lett (2004) 1.18
Water channel activities of Mimosa pudica plasma membrane intrinsic proteins are regulated by direct interaction and phosphorylation. FEBS Lett (2005) 1.17
Immunolocalization of WNK4 in mouse kidney. Histochem Cell Biol (2011) 1.17
SPAK differentially mediates vasopressin effects on sodium cotransporters. J Am Soc Nephrol (2013) 1.16
Reciprocal interaction with G-actin and tropomyosin is essential for aquaporin-2 trafficking. J Cell Biol (2008) 1.15
Aquaporin-11 containing a divergent NPA motif has normal water channel activity. Biochim Biophys Acta (2006) 1.15
Mechanism of regulation of renal ion transport by WNK kinases. Curr Opin Nephrol Hypertens (2008) 1.15
Gene transfer of Smad7 using electroporation of adenovirus prevents renal fibrosis in post-obstructed kidney. Kidney Int (2002) 1.15
Identification of a multiprotein "motor" complex binding to water channel aquaporin-2. Biochem Biophys Res Commun (2005) 1.14
Wnt4-transformed mouse embryonic stem cells differentiate into renal tubular cells. Biochem Biophys Res Commun (2005) 1.14
Attenuation of Th1 response through galectin-9 and T-cell Ig mucin 3 interaction inhibits autoimmune diabetes in NOD mice. Eur J Immunol (2009) 1.14
Mice deficient in collapsin response mediator protein-1 exhibit impaired long-term potentiation and impaired spatial learning and memory. J Neurosci (2007) 1.13
Regulation of aquaporin-2 trafficking and its binding protein complex. Biochim Biophys Acta (2006) 1.13
Acute insulin stimulation induces phosphorylation of the Na-Cl cotransporter in cultured distal mpkDCT cells and mouse kidney. PLoS One (2011) 1.13
Function of chloride channels in the kidney. Annu Rev Physiol (2005) 1.12