Published in J Biol Chem on October 05, 2011
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The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1. Oncotarget (2015) 0.91
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Hypoxia upregulates the expression of the NDRG1 gene leading to its overexpression in various human cancers. BMC Genet (2004) 1.28
Identification of a novel class in the alpha/beta hydrolase fold superfamily: the N-myc differentiation-related proteins. Proteins (2002) 1.25
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Nickel carcinogenesis: epigenetics and hypoxia signaling. Mutat Res (2005) 1.19
PTEN up-regulates the tumor metastasis suppressor gene Drg-1 in prostate and breast cancer. Cancer Res (2004) 1.16
Molecular mechanisms of iron uptake by cells and the use of iron chelators for the treatment of cancer. Curr Med Chem (2005) 1.14
Nitric oxide-induced conversion of cellular chelatable iron into macromolecule-bound paramagnetic dinitrosyliron complexes. J Biol Chem (2008) 1.12
Overexpression of NDRG1 is an indicator of poor prognosis in hepatocellular carcinoma. Mod Pathol (2006) 1.12
Novel thiosemicarbazone iron chelators induce up-regulation and phosphorylation of the metastasis suppressor N-myc down-stream regulated gene 1: a new strategy for the treatment of pancreatic cancer. Mol Pharmacol (2011) 1.11
KAI1 gene is engaged in NDRG1 gene-mediated metastasis suppression through the ATF3-NFkappaB complex in human prostate cancer. J Biol Chem (2011) 1.07
Dinitrosyliron complexes are the most abundant nitric oxide-derived cellular adduct: biological parameters of assembly and disappearance. Free Radic Biol Med (2011) 1.06
Excessive production of nitric oxide in rat solid tumor and its implication in rapid tumor growth. Cancer (1996) 1.06
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Iron chelator-mediated alterations in gene expression: identification of novel iron-regulated molecules that are molecular targets of hypoxia-inducible factor-1 alpha and p53. Mol Pharmacol (2009) 1.05
The involvement of hypoxia-inducible transcription factor-1-dependent pathway in nickel carcinogenesis. Cancer Res (2003) 1.02
Heme proteins and nitric oxide (NO): the neglected, eloquent chemistry in NO redox signaling and regulation. Antioxid Redox Signal (2003) 1.02
Iron regulatory proteins as NO signal transducers. Sci STKE (2003) 1.01
The growth-inhibitory Ndrg1 gene is a Myc negative target in human neuroblastomas and other cell types with overexpressed N- or c-myc. Mol Cell Biochem (2003) 0.99
Crystal structure of the human N-Myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor. J Biol Chem (2011) 0.99
Downregulation of Cap43 gene by von Hippel-Lindau tumor suppressor protein in human renal cancer cells. Int J Cancer (2003) 0.99
Decreased expression of NDRG1 in glioma is related to tumor progression and survival of patients. J Neurooncol (2009) 0.98
Drg1 expression in 131 colorectal liver metastases: correlation with clinical variables and patient outcomes. Clin Cancer Res (2005) 0.98
Decreased expression of NDRG1 is correlated with tumor progression and poor prognosis in patients with esophageal squamous cell carcinoma. Dis Esophagus (2006) 0.97
N-Myc down-regulated gene 1 mediates proliferation, invasion, and apoptosis of hepatocellular carcinoma cells. Cancer Lett (2008) 0.93
Cap43/NDRG1/Drg-1 is a molecular target for angiogenesis and a prognostic indicator in cervical adenocarcinoma. Cancer Lett (2008) 0.93
Iron chelation by clinically relevant anthracyclines: alteration in expression of iron-regulated genes and atypical changes in intracellular iron distribution and trafficking. Mol Pharmacol (2007) 0.92
Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1). J Mol Biol (2011) 0.91
Non-heme iron protein: a potential target of nitric oxide in acute cardiac allograft rejection. Proc Natl Acad Sci U S A (2003) 0.89
Iron regulatory protein 1 outcompetes iron regulatory protein 2 in regulating cellular iron homeostasis in response to nitric oxide. J Biol Chem (2011) 0.88
N-myc downstream regulated gene 1 (NDRG1)/Cap43 enhances portal vein invasion and intrahepatic metastasis in human hepatocellular carcinoma. Oncol Rep (2008) 0.87
The leukemogenic transcription factor E2a-Pbx1 induces expression of the putative N-myc and p53 target gene NDRG1 in Ba/F3 cells. Leukemia (2001) 0.82
The peroxidase activity of mitochondrial superoxide dismutase. Free Radic Biol Med (2012) 2.14
Inhibition of c-Src tyrosine kinase prevents angiotensin II-mediated connexin-43 remodeling and sudden cardiac death. J Am Coll Cardiol (2011) 1.80
A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system. Proc Natl Acad Sci U S A (2003) 1.78
Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1. Proc Natl Acad Sci U S A (2005) 1.55
Nitrogen dioxide and carbonate radical anion: two emerging radicals in biology. Free Radic Biol Med (2002) 1.53
Inflammation and IGF-I activate the Akt pathway in breast cancer. Int J Cancer (2007) 1.38
The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations. Biol Chem (2004) 1.37
Focusing of nitric oxide mediated nitrosation and oxidative nitrosylation as a consequence of reaction with superoxide. Proc Natl Acad Sci U S A (2002) 1.33
The biphasic nature of nitric oxide responses in tumor biology. Antioxid Redox Signal (2006) 1.32
Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways. Proc Natl Acad Sci U S A (2007) 1.26
Mechanism of aerobic decomposition of Angeli's salt (sodium trioxodinitrate) at physiological pH. J Am Chem Soc (2005) 1.22
Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria. Nucleic Acids Res (2011) 1.21
Nitrated lipids decompose to nitric oxide and lipid radicals and cause vasorelaxation. Free Radic Biol Med (2005) 1.17
Nitric oxide-dependent Src activation and resultant caveolin-1 phosphorylation promote eNOS/caveolin-1 binding and eNOS inhibition. Mol Biol Cell (2012) 1.16
Direct real-time evaluation of nitration with green fluorescent protein in solution and within human cells reveals the impact of nitrogen dioxide vs. peroxynitrite mechanisms. Proc Natl Acad Sci U S A (2002) 1.15
Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm. Am J Physiol Heart Circ Physiol (2003) 1.15
Molecular mechanisms for discrete nitric oxide levels in cancer. Nitric Oxide (2008) 1.14
Caveolin-1-eNOS signaling promotes p190RhoGAP-A nitration and endothelial permeability. J Cell Biol (2011) 1.10
Mitochondria oxidative stress, connexin43 remodeling, and sudden arrhythmic death. Circ Arrhythm Electrophysiol (2013) 1.10
Immuno-spin trapping of a post-translational carboxypeptidase B1 radical formed by a dual role of xanthine oxidase and endothelial nitric oxide synthase in acute septic mice. Free Radic Biol Med (2008) 1.08
Electron transfer between a tyrosyl radical and a cysteine residue in hemoproteins: spin trapping analysis. J Am Chem Soc (2007) 1.08
Peroxynitrite and myocardial contractility: in vivo versus in vitro effects. Free Radic Biol Med (2006) 1.08
Ingress and reactive chemistry of nitroxyl-derived species within human cells. Free Radic Biol Med (2002) 1.07
Dinitrosyliron complexes are the most abundant nitric oxide-derived cellular adduct: biological parameters of assembly and disappearance. Free Radic Biol Med (2011) 1.06
Nitric oxide cell signaling: S-nitrosation of Ras superfamily GTPases. Cardiovasc Res (2007) 1.06
Nitric oxide and cancer therapy: the emperor has NO clothes. Curr Pharm Des (2010) 1.05
A chemical perspective on the interplay between NO, reactive oxygen species, and reactive nitrogen oxide species. Ann N Y Acad Sci (2002) 1.04
Oxidative stress induces protein and DNA radical formation in follicular dendritic cells of the germinal center and modulates its cell death patterns in late sepsis. Free Radic Biol Med (2011) 1.04
A mutant telomerase defective in nuclear-cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction. Aging Cell (2010) 1.04
Discriminating formation of HNO from other reactive nitrogen oxide species. Free Radic Biol Med (2005) 1.03
Involvement of inducible nitric oxide synthase in hydroxyl radical-mediated lipid peroxidation in streptozotocin-induced diabetes. Free Radic Biol Med (2008) 1.03
Direct evidence of iNOS-mediated in vivo free radical production and protein oxidation in acetone-induced ketosis. Am J Physiol Endocrinol Metab (2008) 1.02
P-glycoprotein mediates drug resistance via a novel mechanism involving lysosomal sequestration. J Biol Chem (2013) 1.01
Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins. A chemical discussion of the differential biological effects of these redox related products of NOS. J Inorg Biochem (2003) 1.00
Further evidence for distinct reactive intermediates from nitroxyl and peroxynitrite: effects of buffer composition on the chemistry of Angeli's salt and synthetic peroxynitrite. Arch Biochem Biophys (2002) 0.98
Molecular mechanisms of the crosstalk between mitochondria and NADPH oxidase through reactive oxygen species-studies in white blood cells and in animal models. Antioxid Redox Signal (2013) 0.98
Evidence of a common mechanism of disassembly of adherens junctions through Gα13 targeting of VE-cadherin. J Exp Med (2014) 0.94
Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors. Carcinogenesis (2013) 0.93
Procainamide, but not N-acetylprocainamide, induces protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis. Chem Res Toxicol (2008) 0.92
Is S-nitrosocysteine a true surrogate for nitric oxide? Antioxid Redox Signal (2012) 0.91
Site-specific carboxypeptidase B1 tyrosine nitration and pathophysiological implications following its physical association with nitric oxide synthase-3 in experimental sepsis. J Immunol (2009) 0.91
Cooperative interaction of trp melastatin channel transient receptor potential (TRPM2) with its splice variant TRPM2 short variant is essential for endothelial cell apoptosis. Circ Res (2013) 0.91
The role of NDRG1 in the pathology and potential treatment of human cancers. J Clin Pathol (2013) 0.90
Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis. Chem Res Toxicol (2007) 0.90
CD40L contributes to angiotensin II-induced pro-thrombotic state, vascular inflammation, oxidative stress and endothelial dysfunction. Basic Res Cardiol (2013) 0.90
Interaction of a specific population of human embryonic stem cell-derived progenitor cells with CD11b+ cells ameliorates sepsis-induced lung inflammatory injury. Am J Pathol (2010) 0.89
Spatial distribution of protein damage by singlet oxygen in keratinocytes. Photochem Photobiol (2008) 0.89
(Bi)sulfite oxidation by copper, zinc-superoxide dismutase: Sulfite-derived, radical-initiated protein radical formation. Environ Health Perspect (2010) 0.89
Nitroglycerin drives endothelial nitric oxide synthase activation via the phosphatidylinositol 3-kinase/protein kinase B pathway. Free Radic Biol Med (2011) 0.88
The chemical dynamics of NO and reactive nitrogen oxides: a practical guide. Curr Mol Med (2004) 0.87
Glutathiolated Ras: characterization and implications for Ras activation. Free Radic Biol Med (2012) 0.86
In vivo imaging of immuno-spin trapped radicals with molecular magnetic resonance imaging in a diabetic mouse model. Diabetes (2012) 0.86
Endothelial barrier protection by local anesthetics: ropivacaine and lidocaine block tumor necrosis factor-α-induced endothelial cell Src activation. Anesthesiology (2014) 0.85
Comparing the chemical biology of NO and HNO. Arch Pharm Res (2009) 0.85
Simultaneous detection of seven sexually transmitted agents in human immunodeficiency virus-infected Brazilian women by multiplex polymerase chain reaction. Am J Trop Med Hyg (2013) 0.84
Redox regulation of NF-κB p50 and M1 polarization in microglia. Glia (2014) 0.83
Conditional deletion of FAK in mice endothelium disrupts lung vascular barrier function due to destabilization of RhoA and Rac1 activities. Am J Physiol Lung Cell Mol Physiol (2013) 0.83
Nitric oxide modifies global histone methylation by inhibiting Jumonji C domain-containing demethylases. J Biol Chem (2013) 0.83
The activation of metabolites of nitric oxide synthase by metals is both redox and oxygen dependent: a new feature of nitrogen oxide signaling. Antioxid Redox Signal (2006) 0.83
Partial colocalization of oxidized, N-formylkynurenine-containing proteins in mitochondria and Golgi of keratinocytes. Photochem Photobiol (2010) 0.82
Guanylyl cyclase-dependent chemotaxis of endothelial cells in response to nitric oxide gradients. Free Radic Biol Med (2005) 0.82
The compromise of macrophage functions by hyperoxia is attenuated by ethacrynic acid via inhibition of NF-κB-mediated release of high-mobility group box-1. Am J Respir Cell Mol Biol (2015) 0.82
Gliptin and GLP-1 analog treatment improves survival and vascular inflammation/dysfunction in animals with lipopolysaccharide-induced endotoxemia. Basic Res Cardiol (2015) 0.82
In vivo detection of free radicals using molecular MRI and immuno-spin trapping in a mouse model for amyotrophic lateral sclerosis. Free Radic Biol Med (2013) 0.81
Oxygen dependence of nitric oxide-mediated signaling. Redox Biol (2013) 0.81
Spin trapping of glutathiyl and protein radicals produced from nitric oxide-derived oxidants. Free Radic Biol Med (2004) 0.80
Making a case for albumin – a highly promising drug-delivery system. Future Med Chem (2015) 0.80
Detection of Ras GTPase protein radicals through immuno-spin trapping. Free Radic Biol Med (2012) 0.80
Cellular uptake of the antitumor agent Dp44mT occurs via a carrier/receptor-mediated mechanism. Mol Pharmacol (2013) 0.80
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NOS-1-derived NO is an essential triggering signal for the development of systemic inflammatory responses. Eur J Pharmacol (2011) 0.78
Kinetics of the oxidation of reduced Cu,Zn-superoxide dismutase by peroxymonocarbonate. Free Radic Biol Med (2012) 0.78
Differences in the mutation of the p53 gene in exons 6 and 7 in cervical samples from HIV- and HPV-infected women. Infect Agent Cancer (2013) 0.75
Two hypotheses for the oxidation of SOD1-Cu(I). Free Radic Biol Med (2012) 0.75
Effective antioxidant therapy for the management of arrhythmia. Expert Rev Cardiovasc Ther (2011) 0.75
Microglial activation decreases retention of the protease inhibitor saquinavir: implications for HIV treatment. J Neuroinflammation (2013) 0.75
Copper and conquer: copper complexes of di-2-pyridylketone thiosemicarbazones as novel anti-cancer therapeutics. Metallomics (2016) 0.75