Published in Cell on July 09, 2010
Fueling immunity: insights into metabolism and lymphocyte function. Science (2013) 3.62
Regulation of cellular iron metabolism. Biochem J (2011) 3.03
Hepcidin and iron homeostasis. Biochim Biophys Acta (2012) 2.96
Intra-graft expression of genes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantation. J Clin Invest (2011) 2.36
The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice. J Clin Invest (2011) 2.30
17β-Estradiol inhibits iron hormone hepcidin through an estrogen responsive element half-site. Endocrinology (2012) 1.79
Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats. Blood (2011) 1.63
The second transferrin receptor regulates red blood cell production in mice. Blood (2014) 1.57
Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation. Am J Hematol (2012) 1.52
Mechanisms of mammalian iron homeostasis. Biochemistry (2012) 1.51
Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling. Blood (2014) 1.50
Iron metabolism in the CNS: implications for neurodegenerative diseases. Nat Rev Neurosci (2013) 1.46
Diet in the pathogenesis and treatment of inflammatory bowel diseases. Gastroenterology (2015) 1.40
Myelodysplastic Syndromes and Iron Chelation Therapy. Mediterr J Hematol Infect Dis (2017) 1.37
Iron and diabetes risk. Cell Metab (2013) 1.36
The long history of iron in the Universe and in health and disease. Biochim Biophys Acta (2011) 1.33
Anaemia in inflammatory rheumatic diseases. Nat Rev Rheumatol (2012) 1.33
Iron at the interface of immunity and infection. Front Pharmacol (2014) 1.31
The liver: conductor of systemic iron balance. Blood (2013) 1.30
Ironing out cancer. Cancer Res (2011) 1.25
Deletion of TMPRSS6 attenuates the phenotype in a mouse model of β-thalassemia. Blood (2012) 1.25
Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes. Front Pharmacol (2014) 1.20
The pharmacokinetics and pharmacodynamics of iron preparations. Pharmaceutics (2011) 1.18
Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels. Hum Mol Genet (2010) 1.18
Normal and disordered reticulocyte maturation. Curr Opin Hematol (2011) 1.16
Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives. Eur Heart J (2012) 1.16
Distinct mechanisms of ferritin delivery to lysosomes in iron-depleted and iron-replete cells. Mol Cell Biol (2011) 1.14
The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption. Cell Metab (2013) 1.14
Iron refractory iron deficiency anemia. Haematologica (2013) 1.13
Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Biochim Biophys Acta (2014) 1.12
How the binding of human transferrin primes the transferrin receptor potentiating iron release at endosomal pH. Proc Natl Acad Sci U S A (2011) 1.12
HJV and HFE Play Distinct Roles in Regulating Hepcidin. Antioxid Redox Signal (2015) 1.10
Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5). J Biol Chem (2012) 1.10
HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis. Cell Metab (2013) 1.09
Coupling heme and iron metabolism via ferritin H chain. Antioxid Redox Signal (2013) 1.08
Hepcidin levels and their determinants in different types of myelodysplastic syndromes. PLoS One (2011) 1.08
The RNA-binding proteomes from yeast to man harbour conserved enigmRBPs. Nat Commun (2015) 1.08
Ferritin protein nanocage ion channels: gating by N-terminal extensions. J Biol Chem (2012) 1.08
HSPB1 as a novel regulator of ferroptotic cancer cell death. Oncogene (2015) 1.07
Associations of iron metabolism genes with blood manganese levels: a population-based study with validation data from animal models. Environ Health (2011) 1.06
The bone morphogenetic protein-hepcidin axis as a therapeutic target in inflammatory bowel disease. Inflamm Bowel Dis (2011) 1.05
Nitric oxide suppresses tumor cell migration through N-Myc downstream-regulated gene-1 (NDRG1) expression: role of chelatable iron. J Biol Chem (2011) 1.05
Increased serum hepcidin levels in subjects with the metabolic syndrome: a population study. PLoS One (2012) 1.05
Hepcidin antagonists for potential treatments of disorders with hepcidin excess. Front Pharmacol (2014) 1.04
Understanding the genetic and molecular pathogenesis of Friedreich's ataxia through animal and cellular models. Dis Model Mech (2012) 1.04
Host iron withholding demands siderophore utilization for Candida glabrata to survive macrophage killing. PLoS Pathog (2011) 1.03
Iron-induced dissociation of the Aft1p transcriptional regulator from target gene promoters is an initial event in iron-dependent gene suppression. Mol Cell Biol (2012) 1.03
Glycol-split nonanticoagulant heparins are inhibitors of hepcidin expression in vitro and in vivo. Blood (2014) 1.03
Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels. Hum Mol Genet (2010) 1.03
Shared and distinct mechanisms of iron acquisition by bacterial and fungal pathogens of humans. Front Cell Infect Microbiol (2013) 1.03
Targeting iron acquisition blocks infection with the fungal pathogens Aspergillus fumigatus and Fusarium oxysporum. PLoS Pathog (2013) 1.03
Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2α. Cell Metab (2013) 1.02
Iron deficiency in critically ill patients: highlighting the role of hepcidin. Crit Care (2011) 1.02
Grx4 monothiol glutaredoxin is required for iron limitation-dependent inhibition of Fep1. Eukaryot Cell (2011) 1.00
Mammalian siderophores, siderophore-binding lipocalins, and the labile iron pool. J Biol Chem (2012) 1.00
The pleiotropic effects of erythropoietin in infection and inflammation. Microbes Infect (2011) 0.99
Iron status in patients with chronic heart failure. Eur Heart J (2012) 0.99
Pathways for the regulation of hepcidin expression in anemia of chronic disease and iron deficiency anemia in vivo. Haematologica (2011) 0.99
From cis-regulatory elements to complex RNPs and back. Cold Spring Harb Perspect Biol (2012) 0.98
Iron metabolism in the pathogenesis of iron-induced kidney injury. Nat Rev Nephrol (2013) 0.98
Control of systemic iron homeostasis by the hemojuvelin-hepcidin axis. Adv Nutr (2010) 0.98
Ferritin upregulates hepatic expression of bone morphogenetic protein 6 and hepcidin in mice. Am J Physiol Gastrointest Liver Physiol (2012) 0.97
Mycobacteria, metals, and the macrophage. Immunol Rev (2015) 0.97
Identification of nonferritin mitochondrial iron deposits in a mouse model of Friedreich ataxia. Proc Natl Acad Sci U S A (2012) 0.97
The European Hematology Association Roadmap for European Hematology Research: a consensus document. Haematologica (2016) 0.97
Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease. Prog Neurobiol (2015) 0.97
The role of the Yap5 transcription factor in remodeling gene expression in response to Fe bioavailability. PLoS One (2012) 0.96
The gut in iron homeostasis: role of HIF-2 under normal and pathological conditions. Blood (2013) 0.96
Dysregulation of iron and copper homeostasis in nonalcoholic fatty liver. World J Hepatol (2015) 0.95
Increased iron loading induces Bmp6 expression in the non-parenchymal cells of the liver independent of the BMP-signaling pathway. PLoS One (2013) 0.95
mTOR regulates cellular iron homeostasis through tristetraprolin. Cell Metab (2012) 0.95
Negative feedback regulation of the yeast CTH1 and CTH2 mRNA binding proteins is required for adaptation to iron deficiency and iron supplementation. Mol Cell Biol (2013) 0.95
Obesity as an emerging risk factor for iron deficiency. Nutrients (2014) 0.95
Brain iron homeostasis: from molecular mechanisms to clinical significance and therapeutic opportunities. Antioxid Redox Signal (2013) 0.94
Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression. Blood (2011) 0.94
Neuroferritinopathy: From ferritin structure modification to pathogenetic mechanism. Neurobiol Dis (2015) 0.94
Iron status and systemic inflammation, but not gut inflammation, strongly predict gender-specific concentrations of serum hepcidin in infants in rural Kenya. PLoS One (2013) 0.94
Hepcidin in the diagnosis of iron disorders. Blood (2016) 0.93
Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice. Nat Med (2016) 0.93
Ferroportin and hepcidin: a new hope in diagnosis, prognosis, and therapy for breast cancer. Breast Cancer Res (2010) 0.93
Out of balance--systemic iron homeostasis in iron-related disorders. Nutrients (2013) 0.92
Influence of host iron status on Plasmodium falciparum infection. Front Pharmacol (2014) 0.91
Dysregulation of cellular iron metabolism in Friedreich ataxia: from primary iron-sulfur cluster deficit to mitochondrial iron accumulation. Front Pharmacol (2014) 0.91
Iron and thiols as two major players in carcinogenesis: friends or foes? Front Pharmacol (2014) 0.91
Crucial function of vertebrate glutaredoxin 3 (PICOT) in iron homeostasis and hemoglobin maturation. Mol Biol Cell (2013) 0.91
Ferritin levels and risk of metabolic syndrome: meta-analysis of observational studies. BMC Public Health (2014) 0.90
Protein degradation and iron homeostasis. Biochim Biophys Acta (2012) 0.90
Translational repression of the disintegrin and metalloprotease ADAM10 by a stable G-quadruplex secondary structure in its 5'-untranslated region. J Biol Chem (2011) 0.90
Iron homeostasis regulates the activity of the microRNA pathway through poly(C)-binding protein 2. Cell Metab (2012) 0.90
TGF-β and iron differently alter HBV replication in human hepatocytes through TGF-β/BMP signaling and cellular microRNA expression. PLoS One (2012) 0.90
The role of iron in the immune response to bacterial infection. Immunol Res (2011) 0.90
Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease. Blood (2015) 0.90
Low hepcidin levels in severely anemic malawian children with high incidence of infectious diseases and bone marrow iron deficiency. PLoS One (2013) 0.90
Fe2+ binds iron responsive element-RNA, selectively changing protein-binding affinities and regulating mRNA repression and activation. Proc Natl Acad Sci U S A (2012) 0.90
Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice. Proc Natl Acad Sci U S A (2016) 0.89
Effect of iron overload and iron deficiency on liver hemojuvelin protein. PLoS One (2012) 0.89
Exploiting endocytosis for nanomedicines. Cold Spring Harb Perspect Biol (2013) 0.89
Macrophages and iron trafficking at the birth and death of red cells. Blood (2015) 0.89
Metabolic Enzymes Enjoying New Partnerships as RNA-Binding Proteins. Trends Endocrinol Metab (2015) 0.88
On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver. Nat Med (2016) 0.88
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature (2008) 10.73
Balancing acts: molecular control of mammalian iron metabolism. Cell (2004) 7.82
Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet (2002) 4.19
Iron-deficiency anemia. N Engl J Med (2015) 3.94
The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin. Cell Metab (2008) 3.78
A sensitive array for microRNA expression profiling (miChip) based on locked nucleic acids (LNA). RNA (2006) 3.71
Hepcidin is decreased in TFR2 hemochromatosis. Blood (2004) 3.46
STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood (2006) 3.38
Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network. Annu Rev Nutr (2008) 2.98
Gain-of-function mutations in interleukin-7 receptor-α (IL7R) in childhood acute lymphoblastic leukemias. J Exp Med (2011) 2.59
Expression of the miR-17-92 polycistron in chronic myeloid leukemia (CML) CD34+ cells. Blood (2007) 2.46
The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice. J Clin Invest (2011) 2.30
Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD. J Mol Med (Berl) (2009) 2.15
Pegylated interferon-α induced hypoferremia is associated with the immediate response to treatment in hepatitis C. Hepatology (2012) 2.12
Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia. Blood (2006) 2.10
Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis. Blood (2007) 2.09
Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway. Blood (2010) 2.02
Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency. Nat Struct Mol Biol (2007) 1.96
Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis. Blood (2007) 1.78
Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1. Nat Med (2007) 1.73
A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells. J Mol Med (Berl) (2008) 1.71
An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice. Nat Genet (2004) 1.68
Spectrum of hemojuvelin gene mutations in 1q-linked juvenile hemochromatosis. Blood (2004) 1.59
Variation of hemoglobin levels in normal Italian populations from genetic isolates. Haematologica (2008) 1.57
Hfe acts in hepatocytes to prevent hemochromatosis. Cell Metab (2008) 1.55
Italian Society of Hematology practice guidelines for the management of iron overload in thalassemia major and related disorders. Haematologica (2008) 1.54
Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling. Blood (2014) 1.50
Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position -7007 of the FPN1 promoter. Haematologica (2010) 1.47
Iron toxicity in diseases of aging: Alzheimer's disease, Parkinson's disease and atherosclerosis. J Alzheimers Dis (2009) 1.43
miChip: an array-based method for microRNA expression profiling using locked nucleic acid capture probes. Nat Protoc (2008) 1.43
TMPRSS6 rs855791 modulates hepcidin transcription in vitro and serum hepcidin levels in normal individuals. Blood (2011) 1.39
Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity. Mol Cell Biol (2004) 1.37
Polarization dictates iron handling by inflammatory and alternatively activated macrophages. Haematologica (2010) 1.36
Defective targeting of hemojuvelin to plasma membrane is a common pathogenetic mechanism in juvenile hemochromatosis. Blood (2007) 1.36
Enhancement of IRES-mediated translation of the c-myc and BiP mRNAs by the poly(A) tail is independent of intact eIF4G and PABP. Mol Cell (2004) 1.36
Liver expression of hepcidin and other iron genes in two mouse models of beta-thalassemia. Haematologica (2006) 1.34
SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression. Blood (2009) 1.33
Towards explaining "unexplained hyperferritinemia". Haematologica (2009) 1.33
Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts. J Clin Invest (2010) 1.32
Low hepcidin accounts for the proinflammatory status associated with iron deficiency. Blood (2011) 1.31
A valine deletion of ferroportin 1: a common mutation in hemochromastosis type 4. Blood (2002) 1.31
Association of HFE and TMPRSS6 genetic variants with iron and erythrocyte parameters is only in part dependent on serum hepcidin concentrations. J Med Genet (2011) 1.28
The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation. J Hepatol (2012) 1.28
RNA degradation compromises the reliability of microRNA expression profiling. BMC Biotechnol (2009) 1.27
Iron regulation and the cell cycle: identification of an iron-responsive element in the 3'-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy. J Biol Chem (2006) 1.25
Hyperferritinaemia-cataract syndrome: worldwide mutations and phenotype of an increasingly diagnosed genetic disorder. Hum Genomics (2010) 1.25
Deletion of TMPRSS6 attenuates the phenotype in a mouse model of β-thalassemia. Blood (2012) 1.25
Transferrin receptor 2 is a component of the erythropoietin receptor complex and is required for efficient erythropoiesis. Blood (2010) 1.23
Nitric oxide-mediated regulation of ferroportin-1 controls macrophage iron homeostasis and immune function in Salmonella infection. J Exp Med (2013) 1.22
Novel genomic amplification targeting the microRNA cluster at 19q13.42 in a pediatric embryonal tumor with abundant neuropil and true rosettes. Acta Neuropathol (2008) 1.20
Measurement of urinary hepcidin levels by SELDI-TOF-MS in HFE-hemochromatosis. Blood Cells Mol Dis (2007) 1.20
Microcytic anemia and hepatic iron overload in a child with compound heterozygous mutations in DMT1 (SCL11A2). Blood (2005) 1.17
The REM phase of gene regulation. Trends Biochem Sci (2010) 1.15
The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption. Cell Metab (2013) 1.14
Signal transducer and activator of transcription 3-mediated regulation of miR-199a-5p links cardiomyocyte and endothelial cell function in the heart: a key role for ubiquitin-conjugating enzymes. Eur Heart J (2010) 1.14
Iron refractory iron deficiency anemia. Haematologica (2013) 1.13
A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. PLoS Genet (2013) 1.12
Heritability and demographic analyses in the large isolated population of Val Borbera suggest advantages in mapping complex traits genes. PLoS One (2009) 1.11
miChip: a microarray platform for expression profiling of microRNAs based on locked nucleic acid (LNA) oligonucleotide capture probes. Methods (2007) 1.10
Molecular mechanisms of the defective hepcidin inhibition in TMPRSS6 mutations associated with iron-refractory iron deficiency anemia. Blood (2009) 1.10
Hemojuvelin N-terminal mutants reach the plasma membrane but do not activate the hepcidin response. Haematologica (2008) 1.08
Reactive thrombocytosis might contribute to chemotherapy-related thrombophilia in patients with lung cancer. Clin Lung Cancer (2007) 1.08
The murine growth differentiation factor 15 is not essential for systemic iron homeostasis in phlebotomized mice. Haematologica (2012) 1.08
Testosterone administration inhibits hepcidin transcription and is associated with increased iron incorporation into red blood cells. Aging Cell (2013) 1.07
Natural history of juvenile haemochromatosis. Br J Haematol (2002) 1.07
Hepcidin: iron-hormone and anti-microbial peptide. Gene (2005) 1.07
Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse. Nat Genet (2006) 1.07
Genetic and clinical heterogeneity of ferroportin disease. Br J Haematol (2005) 1.07
A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis. Haematologica (2010) 1.07
NOTCH1 activation clinically antagonizes the unfavorable effect of PTEN inactivation in BFM-treated children with precursor T-cell acute lymphoblastic leukemia. Haematologica (2013) 1.06
Increased serum hepcidin levels in subjects with the metabolic syndrome: a population study. PLoS One (2012) 1.05
Physiologic systemic iron metabolism in mice deficient for duodenal Hfe. Blood (2007) 1.03
Lack of haptoglobin affects iron transport across duodenum by modulating ferroportin expression. Gastroenterology (2007) 1.03
Hepatic expression of hemochromatosis genes in two mouse strains after phlebotomy and iron overload. Haematologica (2005) 1.02
Novel TMPRSS6 mutations associated with iron-refractory iron deficiency anemia (IRIDA). Hum Mutat (2010) 0.98
2-Oxoglutarate-dependent oxygenases control hepcidin gene expression. J Hepatol (2008) 0.98
MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma. Nucleic Acids Res (2013) 0.98
Clinical and pathologic findings in hemochromatosis type 3 due to a novel mutation in transferrin receptor 2 gene. Gastroenterology (2002) 0.98
Microelectronic DNA chip for hereditary hyperferritinemia cataract syndrome, a model for large-scale analysis of disorders of iron metabolism. Hum Mutat (2006) 0.97
Hyperhomocysteinemia in patients with Cushing's syndrome. J Clin Endocrinol Metab (2004) 0.97
Comparison of 3 Tfr2-deficient murine models suggests distinct functions for Tfr2-alpha and Tfr2-beta isoforms in different tissues. Blood (2010) 0.96
Identification of new mutations of hepcidin and hemojuvelin in patients with HFE C282Y allele. Blood Cells Mol Dis (2004) 0.96
Iron regulatory protein-1 and -2: transcriptome-wide definition of binding mRNAs and shaping of the cellular proteome by iron regulatory proteins. Blood (2011) 0.96
A novel TMPRSS6 mutation that prevents protease auto-activation causes IRIDA. Biochem J (2010) 0.96
Growth differentiation factor 15 in patients with congenital dyserythropoietic anaemia (CDA) type II. J Mol Med (Berl) (2011) 0.95
Increased susceptibility to iron deficiency of Tmprss6-haploinsufficient mice. Blood (2010) 0.95
New insights into iron homeostasis through the study of non-HFE hereditary haemochromatosis. Best Pract Res Clin Haematol (2005) 0.94
Anemia and iron overload due to compound heterozygosity for novel ceruloplasmin mutations. Blood (2002) 0.93
New and old players in the hepcidin pathway. Haematologica (2008) 0.93
Cell-autonomous and systemic context-dependent functions of iron regulatory protein 2 in mammalian iron metabolism. Blood (2008) 0.93
How I treat unexplained refractory iron deficiency anemia. Blood (2013) 0.92
Mycobacteria-induced anaemia revisited: a molecular approach reveals the involvement of NRAMP1 and lipocalin-2, but not of hepcidin. Immunobiology (2011) 0.92
Out of balance--systemic iron homeostasis in iron-related disorders. Nutrients (2013) 0.92