Published in Oncogene on September 26, 2011
MiR-34a/c-Dependent PDGFR-α/β Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer. PLoS One (2013) 1.82
Spatial regulation of receptor tyrosine kinases in development and cancer. Nat Rev Cancer (2012) 1.44
PDGF receptor-α does not promote HCMV entry into epithelial and endothelial cells but increased quantities stimulate entry by an abnormal pathway. PLoS Pathog (2012) 1.10
Implications of Rho GTPase Signaling in Glioma Cell Invasion and Tumor Progression. Front Oncol (2013) 1.05
MicroRNA-34A inhibits the growth, invasion and metastasis of gastric cancer by targeting PDGFR and MET expression. Biosci Rep (2014) 1.02
Dynamin 2 potentiates invasive migration of pancreatic tumor cells through stabilization of the Rac1 GEF Vav1. Dev Cell (2013) 0.98
miR-638 promotes melanoma metastasis and protects melanoma cells from apoptosis and autophagy. Oncotarget (2015) 0.93
Protein tyrosine phosphatase expression profile of rheumatoid arthritis fibroblast-like synoviocytes: a novel role of SH2 domain-containing phosphatase 2 as a modulator of invasion and survival. Arthritis Rheum (2013) 0.92
A critical role for PDGFRα signaling in medial nasal process development. PLoS Genet (2013) 0.89
PDGF receptor alpha inhibition induces apoptosis in glioblastoma cancer stem cells refractory to anti-Notch and anti-EGFR treatment. Mol Cancer (2014) 0.87
Dynamin inhibitors impair endocytosis and mitogenic signaling of PDGF. Traffic (2013) 0.86
Increased expression of tyrosine phosphatase SHP-2 in Helicobacter pylori-infected gastric cancer. World J Gastroenterol (2013) 0.86
Characterization of dual PTEN and p53-targeting microRNAs identifies microRNA-638/Dnm2 as a two-hit oncogenic locus. Cell Rep (2014) 0.85
Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis. Nat Commun (2015) 0.85
New approaches to prevent LEOPARD syndrome-associated cardiac hypertrophy by specifically targeting Shp2-dependent signaling. J Biol Chem (2013) 0.81
Tanshinone-1 induces tumor cell killing, enhanced by inhibition of secondary activation of signaling networks. Cell Death Dis (2013) 0.81
SHP-2-upregulated ZEB1 is important for PDGFRα-driven glioma epithelial-mesenchymal transition and invasion in mice and humans. Oncogene (2016) 0.80
PCSK9 regulates apoptosis in human neuroglioma u251 cells via mitochondrial signaling pathways. Int J Clin Exp Pathol (2015) 0.79
Migration Phenotype of Brain-Cancer Cells Predicts Patient Outcomes. Cell Rep (2016) 0.77
Protein kinase A-dependent phosphorylation of Dock180 at serine residue 1250 is important for glioma growth and invasion stimulated by platelet derived-growth factor receptor α. Neuro Oncol (2014) 0.77
Dynamin2 downregulation delays EGFR endocytic trafficking and promotes EGFR signaling and invasion in hepatocellular carcinoma. Am J Cancer Res (2015) 0.77
Overexpression of DCF1 inhibits glioma through destruction of mitochondria and activation of apoptosis pathway. Sci Rep (2014) 0.77
Cyclin G2 promotes hypoxia-driven local invasion of glioblastoma by orchestrating cytoskeletal dynamics. Neoplasia (2013) 0.77
Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation. JCI Insight (2016) 0.77
Actin bundling by dynamin 2 and cortactin is implicated in cell migration by stabilizing filopodia in human non-small cell lung carcinoma cells. Int J Oncol (2016) 0.76
Targeting High Dynamin-2 (DNM2) Expression by Restoring Ikaros Function in Acute Lymphoblastic Leukemia. Sci Rep (2016) 0.75
Shp2 Inhibits Proliferation of Esophageal Squamous Cell Cancer via Dephosphorylation of Stat3. Int J Mol Sci (2017) 0.75
Cancer statistics, 2010. CA Cancer J Clin (2010) 103.28
Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature (2008) 75.40
Malignant gliomas in adults. N Engl J Med (2008) 20.54
Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev (2007) 17.20
Induction of mutant dynamin specifically blocks endocytic coated vesicle formation. J Cell Biol (1994) 11.55
Mutations in human dynamin block an intermediate stage in coated vesicle formation. J Cell Biol (1993) 7.37
The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling. Trends Biochem Sci (2003) 6.24
Cost of migration: invasion of malignant gliomas and implications for treatment. J Clin Oncol (2003) 5.28
The GTPase dynamin binds to and is activated by a subset of SH3 domains. Cell (1993) 4.84
Identification and characterization of a novel cytoskeleton-associated pp60src substrate. Mol Cell Biol (1991) 3.83
Automated network analysis identifies core pathways in glioblastoma. PLoS One (2010) 3.64
Differential distribution of dynamin isoforms in mammalian cells. Mol Biol Cell (1998) 3.42
Regulated interactions between dynamin and the actin-binding protein cortactin modulate cell shape. J Cell Biol (2000) 3.30
A functional link between dynamin and the actin cytoskeleton at podosomes. J Cell Biol (2000) 3.12
Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment. Mol Cell (2004) 2.82
The dynamin family of mechanoenzymes: pinching in new places. Trends Biochem Sci (2000) 2.75
The tyrosine phosphatase Shp2 (PTPN11) in cancer. Cancer Metastasis Rev (2008) 2.74
PDGF signaling in cells and mice. Cytokine Growth Factor Rev (2004) 2.57
Dynamin at actin tails. Proc Natl Acad Sci U S A (2002) 2.31
Dynamin 2 is required for phagocytosis in macrophages. J Exp Med (1999) 2.22
Dynamin participates in focal extracellular matrix degradation by invasive cells. Mol Biol Cell (2003) 2.19
Dynamin at the actin-membrane interface. Curr Opin Cell Biol (2003) 1.88
A dynamin-cortactin-Arp2/3 complex mediates actin reorganization in growth factor-stimulated cells. Mol Biol Cell (2003) 1.80
Modulation of Rac localization and function by dynamin. Mol Biol Cell (2003) 1.75
A critical role for cortactin phosphorylation by Abl-family kinases in PDGF-induced dorsal-wave formation. Curr Biol (2007) 1.69
Angiopoietin-2 stimulates breast cancer metastasis through the alpha(5)beta(1) integrin-mediated pathway. Cancer Res (2007) 1.68
Dynamin as a mover and pincher during cell migration and invasion. J Cell Sci (2006) 1.61
Cortactin regulates cell migration through activation of N-WASP. J Cell Sci (2004) 1.61
Growth factor-induced binding of dynamin to signal transduction proteins involves sorting to distinct and separate proline-rich dynamin sequences. EMBO J (1994) 1.46
Poliovirus entry into human brain microvascular cells requires receptor-induced activation of SHP-2. EMBO J (2007) 1.44
SRC-mediated phosphorylation of dynamin and cortactin regulates the "constitutive" endocytosis of transferrin. Mol Cell Biol (2009) 1.39
Protein tyrosine phosphatase SHP-2: a proto-oncogene product that promotes Ras activation. Cancer Sci (2009) 1.32
Src kinase regulates the integrity and function of the Golgi apparatus via activation of dynamin 2. Proc Natl Acad Sci U S A (2010) 1.19
SHP-2/PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans. J Clin Invest (2011) 1.16
Recent insights into PDGF-induced gliomagenesis. Brain Pathol (2009) 1.15
Cell migration is regulated by platelet-derived growth factor receptor endocytosis. Mol Cell Biol (2009) 1.15
Immunohistochemical analysis of platelet-derived growth factor receptor-alpha, -beta, c-kit, c-abl, and arg proteins in glioblastoma: possible implications for patient selection for imatinib mesylate therapy. J Neurooncol (2006) 1.14
c-Src is involved in regulating signal transmission from PDGFbeta receptor-GPCR(s) complexes in mammalian cells. Cell Signal (2005) 1.10
Type I collagen limits VEGFR-2 signaling by a SHP2 protein-tyrosine phosphatase-dependent mechanism 1. Circ Res (2005) 1.07
The dynamin inhibitors MiTMAB and OcTMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells. Mol Cancer Ther (2010) 1.01
Protein tyrosine phosphatases in glioma biology. Acta Neuropathol (2009) 0.92
Prolactin enhances insulin-like growth factor I receptor phosphorylation by decreasing its association with the tyrosine phosphatase SHP-2 in MCF-7 breast cancer cells. J Biol Chem (2010) 0.86
A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. N Engl J Med (2005) 17.06
Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell (1995) 12.39
Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J Exp Med (2001) 12.38
p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells. Science (1995) 6.01
Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene (2009) 5.81
Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice. Proc Natl Acad Sci U S A (1997) 5.44
Dynamin-mediated internalization of caveolae. J Cell Biol (1998) 5.26
Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase. Science (1999) 5.15
p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. Genes Dev (1995) 4.87
Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia. Nat Genet (2001) 4.79
Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood (1997) 4.78
Caveolins, liquid-ordered domains, and signal transduction. Mol Cell Biol (1999) 4.70
Interleukin-17 and lung host defense against Klebsiella pneumoniae infection. Am J Respir Cell Mol Biol (2001) 4.56
Inhibition of cyclin-dependent kinases by p21. Mol Biol Cell (1995) 4.48
Activation of Arp2/3 complex-mediated actin polymerization by cortactin. Nat Cell Biol (2001) 4.38
Reversibility of acute B-cell leukaemia induced by BCR-ABL1. Nat Genet (2000) 3.67
The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development. Cell (1997) 3.61
Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells. Blood (1997) 3.56
Differential distribution of dynamin isoforms in mammalian cells. Mol Biol Cell (1998) 3.42
Elements of a paracrine tubular renin-angiotensin system along the entire nephron. Hypertension (1999) 3.33
The impact of clean indoor-air laws and cigarette smuggling on demand for cigarettes: an empirical model. Health Econ (2000) 3.31
CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors. Mol Cell Biol (1998) 3.19
Resting and activated subsets of mouse multipotent hematopoietic stem cells. Proc Natl Acad Sci U S A (1990) 3.19
Dynamin and its partners: a progress report. Curr Opin Cell Biol (1998) 3.15
Prevalence and associations of abdominal aortic aneurysm detected through screening. Aneurysm Detection and Management (ADAM) Veterans Affairs Cooperative Study Group. Ann Intern Med (1997) 3.08
Mammalian dynamin-like protein DLP1 tubulates membranes. Mol Biol Cell (2001) 3.08
The dynamins: redundant or distinct functions for an expanding family of related GTPases? Proc Natl Acad Sci U S A (1997) 2.98
Purification of a factor inducing differentiation in murine myelomonocytic leukemia cells. Identification as granulocyte colony-stimulating factor. J Biol Chem (1983) 2.97
Evaluation of protein multiple alignments by SAM-T99 using the BAliBASE multiple alignment test set. Bioinformatics (2001) 2.92
The aneurysm detection and management study screening program: validation cohort and final results. Aneurysm Detection and Management Veterans Affairs Cooperative Study Investigators. Arch Intern Med (2000) 2.78
Cryptosporidium parvum is cytopathic for cultured human biliary epithelia via an apoptotic mechanism. Hepatology (1998) 2.75
Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia. Blood (2001) 2.73
Role of dynamin in the formation of transport vesicles from the trans-Golgi network. Science (1998) 2.71
Regulation in the rpoS regulon of Escherichia coli. Can J Microbiol (1998) 2.68
Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation. J Biol Chem (2001) 2.65
The dynamin-like protein DLP1 is essential for normal distribution and morphology of the endoplasmic reticulum and mitochondria in mammalian cells. Mol Biol Cell (1999) 2.64
Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene. Nat Genet (1997) 2.64
An evidence ontology for use in pathway/genome databases. Pac Symp Biocomput (2004) 2.63
Modular nature of abscisic acid (ABA) response complexes: composite promoter units that are necessary and sufficient for ABA induction of gene expression in barley. Plant Cell (1996) 2.56
Pure and mixed erythroid colony formation in vitro stimulated by spleen conditioned medium with no detectable erythropoietin. Proc Natl Acad Sci U S A (1977) 2.55
Rapid endocytosis coupled to exocytosis in adrenal chromaffin cells involves Ca2+, GTP, and dynamin but not clathrin. Proc Natl Acad Sci U S A (1995) 2.51
Biologic properties in vitro of a recombinant human granulocyte-macrophage colony-stimulating factor. Blood (1986) 2.45
The three-dimensional structure of a glutathione S-transferase from the mu gene class. Structural analysis of the binary complex of isoenzyme 3-3 and glutathione at 2.2-A resolution. Biochemistry (1992) 2.43
Conjugation of biomolecules with luminophore-doped silica nanoparticles for photostable biomarkers. Anal Chem (2001) 2.42
A universal nucleoside for use at ambiguous sites in DNA primers. Nature (1994) 2.38
A novel dynamin-like protein associates with cytoplasmic vesicles and tubules of the endoplasmic reticulum in mammalian cells. J Cell Biol (1998) 2.37
Identification of dynamin 2, an isoform ubiquitously expressed in rat tissues. Proc Natl Acad Sci U S A (1994) 2.36
Epidemiological link between exposure to poultry and all influenza A(H7N9) confirmed cases in Huzhou city, China, March to May 2013. Euro Surveill (2013) 2.34
Cerebral hemispherectomy: hospital course, seizure, developmental, language, and motor outcomes. Neurology (2004) 2.30
Effects of purified bacterially synthesized murine multi-CSF (IL-3) on hematopoiesis in normal adult mice. Blood (1986) 2.26
Transgastric endoscopic splenectomy: is it possible? Surg Endosc (2006) 2.26
Varicella-zoster virus-specific immune responses in elderly recipients of a herpes zoster vaccine. J Infect Dis (2008) 2.25
A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro. J Clin Invest (1997) 2.23
Dynamin 2 is required for phagocytosis in macrophages. J Exp Med (1999) 2.22
Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells. Genes Dev (2000) 2.21
Results from the ARTEMIS DISK Global Antifungal Surveillance Study: a 6.5-year analysis of susceptibilities of Candida and other yeast species to fluconazole and voriconazole by standardized disk diffusion testing. J Clin Microbiol (2005) 2.18
An international phase II trial of single-agent lenalidomide for relapsed or refractory aggressive B-cell non-Hodgkin's lymphoma. Ann Oncol (2011) 2.12
Association of a dynamin-like protein with the Golgi apparatus in mammalian cells. J Cell Biol (1996) 2.09
A defined system for in vitro packaging of DNA-gp3 of the Bacillus subtilis bacteriophage phi 29. Proc Natl Acad Sci U S A (1986) 2.07
Simultaneous near-infrared diffusive light and ultrasound imaging. Appl Opt (2001) 2.07
Separation of functionally distinct human granulocyte-macrophage colony-stimulating factors. Blood (1979) 2.05
Colony formation by human T lymphocytes in agar medium. Clin Exp Immunol (1977) 2.03
A review of the properties and limitations of the Ashworth and modified Ashworth Scales as measures of spasticity. Clin Rehabil (1999) 1.99
Rhodamine123 reveals heterogeneity within murine Lin-, Sca-1+ hemopoietic stem cells. J Exp Med (1992) 1.98
Colony formation in agar by multipotential hemopoietic cells. J Cell Physiol (1979) 1.96
Disruption of Golgi structure and function in mammalian cells expressing a mutant dynamin. J Cell Sci (2000) 1.95
Monitoring mRNA expression by polymerase chain reaction: the "primer-dropping" method. Anal Biochem (1994) 1.93
Developmental potential of the earliest precursor cells from the adult mouse thymus. J Exp Med (1991) 1.88
Risk factors for acute hepatitis B and its progression to chronic hepatitis in Shanghai, China. Gut (2008) 1.86
Ejection fraction, peak exercise oxygen consumption, cardiothoracic ratio, ventricular arrhythmias, and plasma norepinephrine as determinants of prognosis in heart failure. The V-HeFT VA Cooperative Studies Group. Circulation (1993) 1.84
Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants. Mol Psychiatry (2012) 1.84
Lack of acrosome formation in Hrb-deficient mice. Science (2001) 1.84
Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK. J Neurochem (2001) 1.81
Absence of a holelike fermi surface for the iron-based K0.8F1.7Se2 superconductor revealed by angle-resolved photoemission spectroscopy. Phys Rev Lett (2011) 1.81
CXCR-4 desensitization is associated with tissue localization of hemopoietic progenitor cells. J Immunol (2001) 1.77
PU.1 (Spi-1) autoregulates its expression in myeloid cells. Oncogene (1995) 1.76
The proximate 5' and 3' ends of the 120-base viral RNA (pRNA) are crucial for the packaging of bacteriophage phi 29 DNA. Virology (1994) 1.76
Congenital muscular dystrophy with rigid spine syndrome: a clinical, pathological, radiological, and genetic study. Ann Neurol (2000) 1.75
Comparison of expression in hemopoietic cells by retroviral vectors carrying two genes. J Virol (1988) 1.75
Molecular basis for specific recognition of both RNA and DNA by a zinc finger protein. Science (1993) 1.75
Repeat polymorphisms within gene regions: phenotypic and evolutionary implications. Am J Hum Genet (2000) 1.75
Structure and regulation of amiloride-sensitive sodium channels. Annu Rev Physiol (2000) 1.74
A dimer as a building block in assembling RNA. A hexamer that gears bacterial virus phi29 DNA-translocating machinery. J Biol Chem (2000) 1.73
Neuropilin-1 promotes human glioma progression through potentiating the activity of the HGF/SF autocrine pathway. Oncogene (2007) 1.71
Downregulation of transcription factor SOX2 in cancer stem cells suppresses growth and metastasis of lung cancer. Br J Cancer (2011) 1.69
The proto-oncogene/translation factor eIF4E: a survey of its expression in breast carcinomas. Int J Cancer (1995) 1.68
Long-term effects of a randomised trial of a 6-year lifestyle intervention in impaired glucose tolerance on diabetes-related microvascular complications: the China Da Qing Diabetes Prevention Outcome Study. Diabetologia (2010) 1.68
Cloning and gene mapping of the chromosome 13q14 region deleted in chronic lymphocytic leukemia. Genomics (1997) 1.68
Injury-induced upregulation of bFGF and CNTF mRNAS in the rat retina. J Neurosci (1995) 1.67
Drugs in salmonid aquaculture--a review. J Vet Pharmacol Ther (1997) 1.65
Evaluation of a unique oral contraceptive in the treatment of premenstrual dysphoric disorder. J Womens Health Gend Based Med (2001) 1.65
1,25(OH)2 vitamin D3, and retinoic acid antagonize endothelin-stimulated hypertrophy of neonatal rat cardiac myocytes. J Clin Invest (1996) 1.65
Biochemically functionalized silica nanoparticles. Analyst (2001) 1.64
Wheat genetic diversity trends during domestication and breeding. Theor Appl Genet (2005) 1.63
Spasticity: clinical perceptions, neurological realities and meaningful measurement. Disabil Rehabil (2005) 1.63