Published in Cytokine Growth Factor Rev on August 01, 2004
Role of platelet-derived growth factors in physiology and medicine. Genes Dev (2008) 8.89
PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR. J Clin Invest (2007) 3.54
The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors. J Biol Chem (2009) 2.05
Macrophage infiltration into adipose tissue may promote angiogenesis for adipose tissue remodeling in obesity. Am J Physiol Endocrinol Metab (2008) 1.84
Ion channels in cell proliferation and apoptotic cell death. J Membr Biol (2005) 1.69
MicroRNA-663 regulates human vascular smooth muscle cell phenotypic switch and vascular neointimal formation. Circ Res (2013) 1.67
PDGF signaling is required for epicardial function and blood vessel formation in regenerating zebrafish hearts. Proc Natl Acad Sci U S A (2010) 1.48
Overexpression of platelet-derived growth factor receptor alpha in breast cancer is associated with tumour progression. Breast Cancer Res (2005) 1.47
An MT1-MMP-PDGF receptor-beta axis regulates mural cell investment of the microvasculature. Genes Dev (2005) 1.47
Micromanaging vascular smooth muscle cell differentiation and phenotypic modulation. Arterioscler Thromb Vasc Biol (2011) 1.37
Mesenchymal stem cell migration is regulated by fibronectin through α5β1-integrin-mediated activation of PDGFR-β and potentiation of growth factor signals. J Cell Sci (2011) 1.33
Requirement of Nck adaptors for actin dynamics and cell migration stimulated by platelet-derived growth factor B. Proc Natl Acad Sci U S A (2006) 1.27
Structural basis for stem cell factor-KIT signaling and activation of class III receptor tyrosine kinases. EMBO J (2007) 1.22
Functions and mechanisms of receptor tyrosine kinase Torso signaling: lessons from Drosophila embryonic terminal development. Dev Dyn (2005) 1.21
Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans. J Clin Invest (2011) 1.20
Recent developments in our understanding of how platelet-derived growth factor (PDGF) and its receptors contribute to proliferative vitreoretinopathy. Exp Eye Res (2009) 1.19
Dynamin 2 mediates PDGFRα-SHP-2-promoted glioblastoma growth and invasion. Oncogene (2011) 1.18
PDGF, bFGF and IGF-I stimulate the proliferation of intervertebral disc cells in vitro via the activation of the ERK and Akt signaling pathways. Eur Spine J (2007) 1.16
SHP-2/PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans. J Clin Invest (2011) 1.16
Candidate pathways for promoting differentiation or quiescence of oligodendrocyte progenitor-like cells in glioma. Cancer Res (2012) 1.15
Pdgfra protects against ethanol-induced craniofacial defects in a zebrafish model of FASD. Development (2013) 1.12
Signal transduction induced in endothelial cells by growth factor receptors involved in angiogenesis. Thromb Haemost (2007) 1.10
LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation. PLoS One (2009) 1.09
Distribution and possible role of PDGF-AA and PDGFR-alpha in the gastrointestinal tract of adult guinea pigs. Virchows Arch (2010) 1.06
Targeting angiogenesis with multitargeted tyrosine kinase inhibitors in the treatment of non-small cell lung cancer. Oncologist (2010) 1.04
Regulation of platelet-derived growth factor receptor function by integrin-associated cell surface transglutaminase. J Biol Chem (2009) 1.03
MicroRNA regulation of smooth muscle gene expression and phenotype. Curr Opin Hematol (2012) 1.02
Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification. PLoS One (2015) 1.02
Imatinib mesylate inhibits fibrogenesis in asbestos-induced interstitial pneumonia. Exp Lung Res (2007) 1.02
Divergent roles of c-Src in controlling platelet-derived growth factor-dependent signaling in fibroblasts. Mol Biol Cell (2005) 1.00
Functions and regulation of circular dorsal ruffles. Mol Cell Biol (2012) 1.00
Neuraminidase-1, a subunit of the cell surface elastin receptor, desialylates and functionally inactivates adjacent receptors interacting with the mitogenic growth factors PDGF-BB and IGF-2. Am J Pathol (2008) 0.99
The absence of platelet-derived growth factor-B in circulating cells promotes immune and inflammatory responses in atherosclerosis-prone ApoE-/- mice. Am J Pathol (2005) 0.99
PDGFR-β as a positive regulator of tissue repair in a mouse model of focal cerebral ischemia. J Cereb Blood Flow Metab (2011) 0.98
Nck adapters are involved in the formation of dorsal ruffles, cell migration, and Rho signaling downstream of the platelet-derived growth factor beta receptor. J Biol Chem (2008) 0.97
The PDGF family in renal fibrosis. Pediatr Nephrol (2011) 0.94
Intrinsic regulation of hemangioma involution by platelet-derived growth factor. Cell Death Dis (2012) 0.92
Where catabolism meets signalling: neuraminidase 1 as a modulator of cell receptors. Glycoconj J (2011) 0.92
Over-expression of PDGFR-β promotes PDGF-induced proliferation, migration, and angiogenesis of EPCs through PI3K/Akt signaling pathway. PLoS One (2012) 0.92
Piperlongumine inhibits atherosclerotic plaque formation and vascular smooth muscle cell proliferation by suppressing PDGF receptor signaling. Biochem Biophys Res Commun (2012) 0.92
Resveratrol inhibits PDGF receptor mitogenic signaling in mesangial cells: role of PTP1B. FASEB J (2008) 0.91
Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis. Proc Natl Acad Sci U S A (2013) 0.91
Platelet-derived growth factors and their receptors: structural and functional perspectives. Biochim Biophys Acta (2012) 0.91
Role of receptor tyrosine kinases and their ligands in glioblastoma. Cells (2014) 0.91
PDGF signaling is required for primitive endoderm cell survival in the inner cell mass of the mouse blastocyst. Stem Cells (2013) 0.90
Profilin-1 is expressed in human atherosclerotic plaques and induces atherogenic effects on vascular smooth muscle cells. PLoS One (2010) 0.89
Platelet-derived growth factor receptor alpha in glioma: a bad seed. Chin J Cancer (2011) 0.89
A critical role for PDGFRα signaling in medial nasal process development. PLoS Genet (2013) 0.89
Activation of Src mediates PDGF-induced Smad1 phosphorylation and contributes to the progression of glomerulosclerosis in glomerulonephritis. PLoS One (2011) 0.89
Role of bone marrow-derived cells in angiogenesis: focus on macrophages and pericytes. Cancer Microenviron (2012) 0.88
Systems biology approaches in cell signaling research. Genome Biol (2005) 0.88
Cytokine profiling of pancreatic fluid using the ePFT collection method in tandem with a multiplexed microarray assay. J Immunol Methods (2011) 0.88
Control of PDGF-induced reactive oxygen species (ROS) generation and signal transduction in human lens epithelial cells. Mol Vis (2007) 0.88
Interdependence of platelet-derived growth factor and estrogen-signaling pathways in inducing neonatal rat testicular gonocytes proliferation. Biol Reprod (2010) 0.88
The VEGF- and PDGF-family of angiogenic markers have prognostic impact in soft tissue sarcomas arising in the extremities and trunk. BMC Clin Pathol (2014) 0.87
Small-molecule protein tyrosine kinase inhibitors for the treatment of metastatic prostate cancer. Future Med Chem (2012) 0.87
Human endometrial stem cells confer enhanced myocardial salvage and regeneration by paracrine mechanisms. J Cell Mol Med (2013) 0.87
PPARgamma as a potential therapeutic target in pulmonary hypertension. Ther Adv Respir Dis (2010) 0.87
Pulmonary artery smooth muscle cell proliferation and migration in fetal lambs acclimatized to high-altitude long-term hypoxia: role of histone acetylation. Am J Physiol Lung Cell Mol Physiol (2012) 0.87
Constitutive activation of oncogenic PDGFRα-mutant proteins occurring in GIST patients induces receptor mislocalisation and alters PDGFRα signalling characteristics. Cell Commun Signal (2015) 0.86
Platelet-derived growth factor-B gene delivery sustains gingival fibroblast signal transduction. J Periodontal Res (2008) 0.86
Platelet rich plasma clot releasate preconditioning induced PI3K/AKT/NFκB signaling enhances survival and regenerative function of rat bone marrow mesenchymal stem cells in hostile microenvironments. Stem Cells Dev (2013) 0.86
Serotonin transporter interacts with the PDGFβ receptor in PDGF-BB-induced signaling and mitogenesis in pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2010) 0.86
Dynamin inhibitors impair endocytosis and mitogenic signaling of PDGF. Traffic (2013) 0.86
12/15-lipoxygenase contributes to platelet-derived growth factor-induced activation of signal transducer and activator of transcription 3. J Biol Chem (2013) 0.85
Reciprocal control of cell proliferation and migration. Cell Commun Signal (2010) 0.85
Sunitinib in combination with paclitaxel plus carboplatin in patients with advanced solid tumors: phase I study results. Cancer Chemother Pharmacol (2010) 0.85
Kv1.3 channels modulate human vascular smooth muscle cells proliferation independently of mTOR signaling pathway. Pflugers Arch (2014) 0.85
Beta-adrenergic receptor mediated protection against doxorubicin-induced apoptosis in cardiomyocytes: the impact of high ambient glucose. Endocrinology (2008) 0.84
Lycopene binding compromised PDGF-AA/-AB signaling and migration in smooth muscle cells and fibroblasts: prediction of the possible lycopene binding site within PDGF. Naunyn Schmiedebergs Arch Pharmacol (2010) 0.84
Ovarian wedge resection restores fertility in estrogen receptor beta knockout (ERbeta-/-) mice. Proc Natl Acad Sci U S A (2006) 0.84
Integrative analysis of cancer-related signaling pathways. Front Physiol (2013) 0.83
PDGF-dependent regulation of regulator of G protein signaling-5 expression and vascular smooth muscle cell functionality. Am J Physiol Cell Physiol (2011) 0.83
Platelet-derived growth factors (PDGFs) in glomerular and tubulointerstitial fibrosis. Kidney Int Suppl (2011) (2014) 0.82
Signal transduction in podocytes--spotlight on receptor tyrosine kinases. Nat Rev Nephrol (2014) 0.82
Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling. Dev Cell (2012) 0.82
History of discovery: platelet-derived growth factor. Arterioscler Thromb Vasc Biol (2011) 0.82
A positive feedback loop involving Erk5 and Akt turns on mesangial cell proliferation in response to PDGF. Am J Physiol Cell Physiol (2014) 0.82
Regulation of signaling interactions and receptor endocytosis in growing blood vessels. Cell Adh Migr (2014) 0.82
A naturally occurring carotenoid, lutein, reduces PDGF and H₂O₂ signaling and compromised migration in cultured vascular smooth muscle cells. J Biomed Sci (2012) 0.81
Mesenchymal stromal cells: inhibiting PDGF receptors or depleting fibronectin induces mesodermal progenitors with endothelial potential. Stem Cells (2014) 0.81
RasGAP Promotes Autophagy and Thereby Suppresses Platelet-Derived Growth Factor Receptor-Mediated Signaling Events, Cellular Responses, and Pathology. Mol Cell Biol (2015) 0.81
p90 Ribosomal S6 kinase 2, a novel GPCR kinase, is required for growth factor-mediated attenuation of GPCR signaling. Biochemistry (2010) 0.81
Effect of serum replacement with plysate on cell growth and metabolismin primary cultures of human skeletal muscle. Cytotechnology (2005) 0.79
Role of Receptor Tyrosine Kinase Signaling in Renal Fibrosis. Int J Mol Sci (2016) 0.79
Platelet-Derived Growth Factors in Non-GIST Soft-Tissue Sarcomas Identify a Subgroup of Patients with Wide Resection Margins and Poor Disease-Specific Survival. Sarcoma (2011) 0.79
MicroRNA-26a targets MAPK6 to inhibit smooth muscle cell proliferation and vein graft neointimal hyperplasia. Sci Rep (2017) 0.78
In silico pharmacokinetic and molecular docking studies of small molecules derived from Indigofera aspalathoides Vahl targeting receptor tyrosine kinases. Bioinformation (2015) 0.78
Platelet-derived growth factor/vascular endothelial growth factor receptor inactivation by sunitinib results in Tsc1/Tsc2-dependent inhibition of TORC1. Mol Cell Biol (2013) 0.78
Retracted Injury-induced platelet-derived growth factor receptor-alpha expression mediated by interleukin-1beta (IL-1beta) release and cooperative transactivation by NF-kappaB and ATF-4: IL-1beta facilitates HDAC-1/2 dissociation from promoter. J Biol Chem (2009) 0.78
PDGFRα in liver pathophysiology: emerging roles in development, regeneration, fibrosis, and cancer. Gene Expr (2015) 0.78
The receptor tyrosine kinase Pvr promotes tissue closure by coordinating corpse removal and epidermal zippering. Development (2015) 0.78
rhPDGF-BB promotes early healing in a rat rotator cuff repair model. Clin Orthop Relat Res (2015) 0.77
Mechanisms for PDGF, a serum cytokine, stimulating loss of corneal keratocyte crystallins. Cornea (2013) 0.77
PDGF suppresses oxidative stress induced Ca2+ overload and calpain activation in neurons. Oxid Med Cell Longev (2013) 0.77
New diagnostic markers in salivary gland tumors. Eur Arch Otorhinolaryngol (2013) 0.77
Characterization of Endoneurial Fibroblast-like Cells from Human and Rat Peripheral Nerves. J Histochem Cytochem (2014) 0.77
Multiple biomarker tissue arrays: A computational approach to identifying protein-protein interactions in the EGFR/ERK signalling pathway. J Mol Signal (2012) 0.77
Pdgfra and Pdgfrb genetically interact during craniofacial development. Dev Dyn (2016) 0.77
Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis. N Engl J Med (2006) 4.46
Attenuated expression of profilin-1 confers protection from atherosclerosis in the LDL receptor null mouse. Circ Res (2007) 1.64
A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1. Nat Cell Biol (2003) 1.53
Platelet-derived growth factor receptor-mediated signal transduction from endosomes. J Biol Chem (2003) 1.49
Platelet-derived growth factor receptor beta-mediated phosphorylation of MUC1 enhances invasiveness in pancreatic adenocarcinoma cells. Cancer Res (2007) 1.49
A potential role for PDGF-C in experimental and clinical proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci (2007) 1.41
Axl is essential for VEGF-A-dependent activation of PI3K/Akt. EMBO J (2012) 1.38
Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cells. Mol Biol Cell (2005) 1.35
Growth factors outside of the platelet-derived growth factor (PDGF) family employ reactive oxygen species/Src family kinases to activate PDGF receptor alpha and thereby promote proliferation and survival of cells. J Biol Chem (2009) 1.31
A NHERF binding site links the betaPDGFR to the cytoskeleton and regulates cell spreading and migration. J Cell Sci (2004) 1.30
Pericytes and ocular diseases. Exp Eye Res (2007) 1.21
Recent developments in our understanding of how platelet-derived growth factor (PDGF) and its receptors contribute to proliferative vitreoretinopathy. Exp Eye Res (2009) 1.19
Protein kinase A-dependent translocation of Hsp90 alpha impairs endothelial nitric-oxide synthase activity in high glucose and diabetes. J Biol Chem (2007) 1.18
SHP-2/PTPN11 mediates gliomagenesis driven by PDGFRA and INK4A/ARF aberrations in mice and humans. J Clin Invest (2011) 1.16
Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor. Mol Cell Biol (2004) 1.14
Involvement of phospholipase D2 in lysophosphatidate-induced transactivation of platelet-derived growth factor receptor-beta in human bronchial epithelial cells. J Biol Chem (2003) 1.12
N-acetylcysteine suppresses retinal detachment in an experimental model of proliferative vitreoretinopathy. Am J Pathol (2010) 1.11
PDGF receptor-α does not promote HCMV entry into epithelial and endothelial cells but increased quantities stimulate entry by an abnormal pathway. PLoS Pathog (2012) 1.10
Plasmin is the major protease responsible for processing PDGF-C in the vitreous of patients with proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci (2008) 1.10
Heat shock protein 90alpha-dependent translocation of annexin II to the surface of endothelial cells modulates plasmin activity in the diabetic rat aorta. Circ Res (2004) 1.09
An in vivo gene therapy approach for experimental proliferative vitreoretinopathy using the truncated platelet-derived growth factor alpha receptor. Invest Ophthalmol Vis Sci (2002) 1.06
PDGF receptors are activated in human epiretinal membranes. Exp Eye Res (2008) 1.06
Pathological signaling via platelet-derived growth factor receptor {alpha} involves chronic activation of Akt and suppression of p53. Mol Cell Biol (2011) 1.06
Src family kinases promote vessel stability by antagonizing the Rho/ROCK pathway. J Biol Chem (2007) 1.04
Regulating angiogenesis at the level of PtdIns-4,5-P2. EMBO J (2006) 1.00
A novel strategy to develop therapeutic approaches to prevent proliferative vitreoretinopathy. Am J Pathol (2011) 0.99
Growth factors outside the PDGF family drive experimental PVR. Invest Ophthalmol Vis Sci (2009) 0.99
Lactate engages receptor tyrosine kinases Axl, Tie2, and vascular endothelial growth factor receptor 2 to activate phosphoinositide 3-kinase/Akt and promote angiogenesis. J Biol Chem (2013) 0.99
Ranibizumab is a potential prophylaxis for proliferative vitreoretinopathy, a nonangiogenic blinding disease. Am J Pathol (2013) 0.98
The role of cathepsins in ocular physiology and pathology. Exp Eye Res (2006) 0.97
Expression of PDGFRα is a determinant of the PVR potential of ARPE19 cells. Invest Ophthalmol Vis Sci (2011) 0.96
Phospholipase Cgamma activation drives increased production of autotaxin in endothelial cells and lysophosphatidic acid-dependent regression. Mol Cell Biol (2010) 0.96
TGFbeta1-dependent contraction of fibroblasts is mediated by the PDGFalpha receptor. Invest Ophthalmol Vis Sci (2002) 0.96
Vascular endothelial growth factor A competitively inhibits platelet-derived growth factor (PDGF)-dependent activation of PDGF receptor and subsequent signaling events and cellular responses. Mol Cell Biol (2012) 0.95
Effect of overexpression of constitutively active PKCalpha on rat lacrimal gland protein secretion. Invest Ophthalmol Vis Sci (2004) 0.94
New insights regarding vessel regression. Cell Cycle (2006) 0.91
Profilin-1 is expressed in human atherosclerotic plaques and induces atherogenic effects on vascular smooth muscle cells. PLoS One (2010) 0.89
Dual-modality fluorescence and full-field optical coherence microscopy for biomedical imaging applications. Biomed Opt Express (2012) 0.89
The role of c-Src in platelet-derived growth factor alpha receptor internalization. Exp Cell Res (2003) 0.88
A novel function of p53: a gatekeeper of retinal detachment. Am J Pathol (2012) 0.87
PI3K and PLCgamma play a central role in experimental PVR. Invest Ophthalmol Vis Sci (2002) 0.87
Phosphatidylinositol (3,4,5)-trisphosphate specifically interacts with the phox homology domain of phospholipase D1 and stimulates its activity. J Cell Sci (2005) 0.87
Corneal endothelial cells are protected from apoptosis by gene therapy. Hum Gene Ther (2011) 0.87
Distinct effectors of platelet-derived growth factor receptor-alpha signaling are required for cell survival during embryogenesis. Proc Natl Acad Sci U S A (2005) 0.86
Focus on molecules: platelet-derived growth factor C, PDGF-C. Exp Eye Res (2007) 0.86
Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1. J Biol Chem (2008) 0.85
Diabetes disrupts the response of retinal endothelial cells to the angiomodulator lysophosphatidic acid. Diabetes (2012) 0.85
Ex vivo adenovirus-mediated gene transfer to corneal graft endothelial cells in mice. Invest Ophthalmol Vis Sci (2004) 0.85
The alpha-receptor for platelet-derived growth factor confers bone-metastatic potential to prostate cancer cells by ligand- and dimerization-independent mechanisms. Cancer Res (2010) 0.84
Regulation of Ras signaling by the cell cycle. Curr Opin Genet Dev (2002) 0.84
Functional tyrosine kinase inhibitor profiling: a generally applicable method points to a novel role of platelet-derived growth factor receptor-beta in tuberous sclerosis. Am J Pathol (2002) 0.84
A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor α. Mol Cell Biol (2013) 0.84
Age-related macular degeneration-associated silent polymorphisms in HtrA1 impair its ability to antagonize insulin-like growth factor 1. Mol Cell Biol (2013) 0.83
PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by PDGF AA. Am J Physiol Renal Physiol (2008) 0.82
Profilin acts downstream of LDL to mediate diabetic endothelial cell dysfunction. FASEB J (2004) 0.82
Primary human endothelial cells secrete agents that reduce responsiveness to lysophosphatidic acid (LPA). Biosci Rep (2012) 0.82
Retinal Pigment Epithelium and Müller Progenitor Cell Interaction Increase Müller Progenitor Cell Expression of PDGFRα and Ability to Induce Proliferative Vitreoretinopathy in a Rabbit Model. Stem Cells Int (2012) 0.81
VE-cadherin increases the half-life of VEGF receptor 2. Exp Cell Res (2004) 0.81
VEGF-A engages at least three tyrosine kinases to activate PI3K/Akt. Cell Cycle (2012) 0.80
SU9518 inhibits proliferative vitreoretinopathy in fibroblast and genetically modified Müller cell-induced rabbit models. Invest Ophthalmol Vis Sci (2013) 0.79
Focus on molecules: Akt (PKB). Exp Eye Res (2010) 0.78
Keratocyte apoptosis and failure of corneal allografts. Transplantation (2006) 0.78
Cambogin is preferentially cytotoxic to cells expressing PDGFR. PLoS One (2011) 0.77
PtdIns-4,5-P2 as a potential therapeutic target for pathologic angiogenesis. Expert Opin Ther Targets (2007) 0.76
Focus on molecules: HtrA1 and neovascular AMD. Exp Eye Res (2010) 0.75
The timing and extent of activation of diacylglycerol-responsive protein kinase-cs determines their ability to inhibit or promote platelet-derived growth factor-dependent DNA synthesis. Exp Cell Res (2002) 0.75
Effect of overexpression of protein kinase C alpha on rat lacrimal gland protein secretion. Adv Exp Med Biol (2002) 0.75
Detection of H2O2-mediated phosphorylation of kinase-inactive PDGFRα. Methods Enzymol (2013) 0.75
A phage display-based approach to investigate abnormal neovessels of the retina. Invest Ophthalmol Vis Sci (2012) 0.75