Chemoenzymatic synthesis and Fcγ receptor binding of homogeneous glycoforms of antibody Fc domain. Presence of a bisecting sugar moiety enhances the affinity of Fc to FcγIIIa receptor.

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Published in J Am Chem Soc on November 01, 2011

Authors

Guozhang Zou1, Hirofumi Ochiai, Wei Huang, Qiang Yang, Cishan Li, Lai-Xi Wang

Author Affiliations

1: Institute of Human Virology and Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.

Associated clinical trials:

Serum Concentration of lgG in Patient With Acute Coronary Syndrome | NCT03394092

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