Published in MAbs on September 03, 2016
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcgammaRIIIa gene. Blood (2002) 8.76
Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote. PLoS Biol (2006) 5.44
Characterization of glycoproteins and their associated oligosaccharides through the use of endoglycosidases. Anal Biochem (1989) 3.99
Structural analysis of human IgG-Fc glycoforms reveals a correlation between glycosylation and structural integrity. J Mol Biol (2003) 3.25
Germline and somatic transformation of mating Tetrahymena thermophila by particle bombardment. Genetics (1997) 3.04
Proposal for a standard system for drawing structural diagrams of N- and O-linked carbohydrates and related compounds. Proteomics (2009) 2.93
Optimal and consistent protein glycosylation in mammalian cell culture. Glycobiology (2009) 2.87
Applications of a travelling wave-based radio-frequency-only stacked ring ion guide. Rapid Commun Mass Spectrom (2004) 2.80
Rituximab (monoclonal anti-CD20 antibody): mechanisms of action and resistance. Oncogene (2003) 2.80
High concentrations of therapeutic IgG1 antibodies are needed to compensate for inhibition of antibody-dependent cellular cytotoxicity by excess endogenous immunoglobulin G. Mol Immunol (2005) 2.54
Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity. Nat Biotechnol (1999) 2.44
Glycosylation: heterogeneity and the 3D structure of proteins. Crit Rev Biochem Mol Biol (1997) 2.36
Efficient mass transformation of Tetrahymena thermophila by electroporation of conjugants. Proc Natl Acad Sci U S A (1992) 2.33
Establishment of FUT8 knockout Chinese hamster ovary cells: an ideal host cell line for producing completely defucosylated antibodies with enhanced antibody-dependent cellular cytotoxicity. Biotechnol Bioeng (2004) 2.22
Glycosylation of recombinant antibody therapeutics. Biotechnol Prog (2005) 2.09
Emerging principles for the therapeutic exploitation of glycosylation. Science (2014) 1.83
Fc receptors. Curr Opin Immunol (1997) 1.74
Comparison of biological activity among nonfucosylated therapeutic IgG1 antibodies with three different N-linked Fc oligosaccharides: the high-mannose, hybrid, and complex types. Glycobiology (2006) 1.69
High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans. Glycobiology (2011) 1.68
The therapeutic monoclonal antibody market. MAbs (2015) 1.66
The influence of glycosylation on the thermal stability and effector function expression of human IgG1-Fc: properties of a series of truncated glycoforms. Mol Immunol (2001) 1.51
Structural and quantitative analysis of N-linked glycans by matrix-assisted laser desorption ionization and negative ion nanospray mass spectrometry. Anal Biochem (2008) 1.49
Tetrahymena Genome Database (TGD): a new genomic resource for Tetrahymena thermophila research. Nucleic Acids Res (2006) 1.40
Impact of immune complex size and glycosylation on IgG binding to human FcγRs. J Immunol (2013) 1.36
Fragmentation of negative ions from carbohydrates: part 2. Fragmentation of high-mannose N-linked glycans. J Am Soc Mass Spectrom (2005) 1.35
Marketing approval of mogamulizumab: a triumph for glyco-engineering. MAbs (2012) 1.29
Tetrahymena thermophila. Curr Biol (2005) 1.25
Transient and stable DNA transformation of Tetrahymena thermophila by electroporation. Methods Cell Biol (2000) 1.19
Improving effector functions of antibodies for cancer treatment: Enhancing ADCC and CDC. Drug Des Devel Ther (2009) 1.17
Crystal structure of sialylated IgG Fc: implications for the mechanism of intravenous immunoglobulin therapy. Proc Natl Acad Sci U S A (2013) 1.17
The solution NMR structure of glucosylated N-glycans involved in the early stages of glycoprotein biosynthesis and folding. EMBO J (1997) 1.16
Chemoenzymatic synthesis and Fcγ receptor binding of homogeneous glycoforms of antibody Fc domain. Presence of a bisecting sugar moiety enhances the affinity of Fc to FcγIIIa receptor. J Am Chem Soc (2011) 1.14
Chemical and structural analysis of an antibody folding intermediate trapped during glycan biosynthesis. J Am Chem Soc (2012) 1.12
Glycoengineered Pichia produced anti-HER2 is comparable to trastuzumab in preclinical study. MAbs (2011) 1.08
Expression of recombinant antibodies. Front Immunol (2013) 1.06
C-terminal lysine variants in fully human monoclonal antibodies: investigation of test methods and possible causes. Biotechnol Bioeng (2008) 1.05
Carbohydrate and domain architecture of an immature antibody glycoform exhibiting enhanced effector functions. J Mol Biol (2009) 1.05
Controlled tetra-Fc sialylation of IVIg results in a drug candidate with consistent enhanced anti-inflammatory activity. Proc Natl Acad Sci U S A (2015) 1.03
Analysis of genomic G + C content, codon usage, initiator codon context and translation termination sites in Tetrahymena thermophila. J Eukaryot Microbiol (1999) 0.99
Tetrahymena Gene Expression Database (TGED): a resource of microarray data and co-expression analyses for Tetrahymena. Sci China Life Sci (2011) 0.99
Development and validation of an antibody-dependent cell-mediated cytotoxicity-reporter gene assay. MAbs (2012) 0.97
Selective deactivation of serum IgG: a general strategy for the enhancement of monoclonal antibody receptor interactions. J Mol Biol (2012) 0.96
Production, characterization, and pharmacokinetic properties of antibodies with N-linked mannose-5 glycans. MAbs (2012) 0.95
Tetrahymena: a model for growth, cell cycle and nutritional studies, with biotechnological potential. Bioessays (1994) 0.94
Development of a single column method for the separation of lipid- and protein-derived oligosaccharides. J Proteome Res (2009) 0.94
Isolation and characterization of IgG1 with asymmetrical Fc glycosylation. Glycobiology (2011) 0.93
Separation of post-translational modifications in monoclonal antibodies by exploiting subtle conformational changes under mildly acidic conditions. J Chromatogr A (2010) 0.87
Secretion of functional human enzymes by Tetrahymena thermophila. BMC Biotechnol (2006) 0.86
Carbohydrates of lysosomal enzymes secreted by Tetrahymena pyriformis. J Biol Chem (1985) 0.85
Endoplasmic reticulum retention signal-dependent glycylation of the Hsp70/Grp170-related Pgp1p in Tetrahymena. Eukaryot Cell (2006) 0.85
The Golgi apparatus of Tetrahymena thermophila. J Eukaryot Microbiol (1993) 0.84
Lepidopteran cells, an alternative for the production of recombinant antibodies? MAbs (2012) 0.83
Cloning and characterization of the gene encoding the highly expressed ribosomal protein l3 of the ciliated protozoan Tetrahymena thermophila. Evidence for differential codon usage in highly expressed genes. Cell Biol Int (1999) 0.83
New downstream processing strategy for the purification of monoclonal antibodies from transgenic tobacco plants. J Chromatogr A (2008) 0.83
Towards the development of a surface plasmon resonance assay to evaluate the glycosylation pattern of monoclonal antibodies using the extracellular domains of CD16a and CD64. J Immunol Methods (2014) 0.81
Biochemical and biophysical characterization of humanized IgG1 produced in Pichia pastoris. MAbs (2011) 0.81
Secretion heterogeneity of lysosomal enzymes in Tetrahymena pyriformis. Exp Cell Res (1987) 0.81
A recombinase system facilitates cloning of expression cassettes in the ciliate Tetrahymena thermophila. BMC Microbiol (2007) 0.81
The bifunctional dihydrofolate reductase thymidylate synthase of Tetrahymena thermophila provides a tool for molecular and biotechnology applications. BMC Biotechnol (2006) 0.81
Applications of CE SDS gel in development of biopharmaceutical antibody-based products. Electrophoresis (2008) 0.80
Lysosomal hydrolase secretion by Tetrahymena: a comparison of several intralysosomal enzymes with the isoenzymes released into the medium. J Cell Physiol (1976) 0.79
A high-throughput media design approach for high performance mammalian fed-batch cultures. MAbs (2013) 0.79
Effect of high mannose glycan pairing on IgG antibody clearance. Biologicals (2016) 0.78
Expression, secretion and surface display of a human alkaline phosphatase by the ciliate Tetrahymena thermophila. BMC Biotechnol (2011) 0.78
A novel malaria vaccine candidate antigen expressed in Tetrahymena thermophila. PLoS One (2014) 0.77
Use of the α-mannosidase I inhibitor kifunensine allows the crystallization of apo CTLA-4 homodimer produced in long-term cultures of Chinese hamster ovary cells. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.76
Characterization of anti-CD20 monoclonal antibody produced by transgenic silkworms (Bombyx mori). MAbs (2015) 0.76