Autocrine endothelin-3/endothelin receptor B signaling maintains cellular and molecular properties of glioblastoma stem cells.

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Published in Mol Cancer Res on October 19, 2011

Authors

Yue Liu1, Fei Ye, Kazunari Yamada, Jonathan L Tso, Yibei Zhang, David H Nguyen, Qinghua Dong, Horacio Soto, Jinny Choe, Anna Dembo, Hayley Wheeler, Ascia Eskin, Ingrid Schmid, William H Yong, Paul S Mischel, Timothy F Cloughesy, Harley I Kornblum, Stanley F Nelson, Linda M Liau, Cho-Lea Tso

Author Affiliations

1: Department of Surgery/Surgical Oncology, University of California Los Angeles, Los Angeles, California 90095, USA.

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Endothelins. N Engl J Med (1995) 2.52

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Cloning and functional expression of human endothelin-converting enzyme cDNA. Biochem Biophys Res Commun (1995) 1.09

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