Published in J Immunol on November 01, 2011
Interleukin 17 is a chief orchestrator of immunity. Nat Immunol (2017) 0.77
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol (2005) 30.22
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol (2005) 27.17
IL-17 and Th17 Cells. Annu Rev Immunol (2009) 23.02
Interleukin-17 family members and inflammation. Immunity (2004) 16.16
Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J Exp Med (2001) 12.38
STAT3 mutations in the hyper-IgE syndrome. N Engl J Med (2007) 8.99
A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage. Nat Med (2007) 8.97
Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. J Gen Virol (2008) 8.85
Innate IL-17-producing cells: the sentinels of the immune system. Nat Rev Immunol (2010) 6.88
Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. Nat Immunol (2007) 6.67
Human IL-17: a novel cytokine derived from T cells. J Immunol (1995) 6.65
Structure and signalling in the IL-17 receptor family. Nat Rev Immunol (2009) 6.38
Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. Science (2011) 6.19
Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity (1995) 5.96
Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev (2003) 5.57
Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. J Exp Med (2009) 5.55
Functional specialization of interleukin-17 family members. Immunity (2011) 5.36
The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease. Nat Immunol (2007) 5.33
Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis. Sci Transl Med (2010) 4.95
Cutting edge: interleukin 17 signals through a heteromeric receptor complex. J Immunol (2006) 4.60
IL-17: prototype member of an emerging cytokine family. J Leukoc Biol (2002) 4.39
Viral evasion and subversion of pattern-recognition receptor signalling. Nat Rev Immunol (2008) 4.16
Retracted Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus. Nat Immunol (2009) 3.84
CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. J Immunol (1993) 3.74
IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J Clin Invest (2010) 3.40
Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor. J Biol Chem (2006) 3.16
LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: A phase I randomized, double-blind, placebo-controlled, proof-of-concept study. Arthritis Rheum (2010) 2.99
IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding. EMBO J (2001) 2.84
Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities. J Immunol (2008) 2.29
The STIR-domain superfamily in signal transduction, development and immunity. Trends Biochem Sci (2003) 2.24
Act1, a U-box E3 ubiquitin ligase for IL-17 signaling. Sci Signal (2009) 2.05
Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression. Proc Natl Acad Sci U S A (2007) 1.85
IL-23 and IL-17A, but not IL-12 and IL-22, are required for optimal skin host defense against Candida albicans. J Immunol (2010) 1.83
Identification of Sef, a novel modulator of FGF signalling. Nat Cell Biol (2002) 1.75
IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail. J Immunol (2010) 1.69
Inborn errors of mucocutaneous immunity to Candida albicans in humans: a role for IL-17 cytokines? Curr Opin Immunol (2010) 1.66
Act1, a negative regulator in CD40- and BAFF-mediated B cell survival. Immunity (2004) 1.65
IL-17RC is required for IL-17A- and IL-17F-dependent signaling and the pathogenesis of experimental autoimmune encephalomyelitis. J Immunol (2010) 1.65
Precarious balance: Th17 cells in host defense. Infect Immun (2009) 1.60
Structural basis of receptor sharing by interleukin 17 cytokines. Nat Immunol (2009) 1.60
Interleukin-17: a novel inflammatory cytokine that bridges innate and adaptive immunity. Front Biosci (2008) 1.60
Prototypic T cell receptor and CD4-like coreceptor are expressed by lymphocytes in the agnathan sea lamprey. Proc Natl Acad Sci U S A (2004) 1.40
Interleukin 17: an example for gene therapy as a tool to study cytokine mediated regulation of hematopoiesis. J Cell Biochem Suppl (2002) 1.09
Rapid accumulation of an interleukin 17 homolog transcript in Crassostrea gigas hemocytes following bacterial exposure. Dev Comp Immunol (2008) 1.06
SEF/IL-17R (SEFIR) is not enough: an extended SEFIR domain is required for il-17RA-mediated signal transduction. J Biol Chem (2010) 1.02
Lamprey (Lethenteron japonicum) IL-17 upregulated by LPS-stimulation in the skin cells. Immunogenetics (2007) 1.01
The interleukin-17 gene of herpesvirus saimiri. J Virol (1998) 0.92
Evolution of vertebrate immunity: sequence and functional analysis of the SEFIR domain family member Act1. J Mol Evol (2011) 0.88
Herpesvirus saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. J Immunol (2011) 0.81
Viral TNF inhibitors as potential therapeutics. Adv Exp Med Biol (2009) 0.78