Published in J Biol Chem on October 26, 2011
Crystal structure of α5β1 integrin ectodomain: atomic details of the fibronectin receptor. J Cell Biol (2012) 1.52
Dynamic structural changes are observed upon collagen and metal ion binding to the integrin α1 I domain. J Biol Chem (2012) 0.87
Enhancing integrin α1 inserted (I) domain affinity to ligand potentiates integrin α1β1-mediated down-regulation of collagen synthesis. J Biol Chem (2012) 0.85
Mapping of potent and specific binding motifs, GLOGEN and GVOGEA, for integrin α1β1 using collagen toolkits II and III. J Biol Chem (2012) 0.84
The structure of integrin α1I domain in complex with a collagen-mimetic peptide. J Biol Chem (2013) 0.79
An activating mutation reveals a second binding mode of the integrin α2 I domain to the GFOGER motif in collagens. PLoS One (2013) 0.79
Early chordate origin of the vertebrate integrin αI domains. PLoS One (2014) 0.76
Intrinsic local destabilization of the C-terminus predisposes integrin α1 I domain to a conformational switch induced by collagen binding. Protein Sci (2016) 0.75
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88
Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D Biol Crystallogr (1997) 137.43
XDS. Acta Crystallogr D Biol Crystallogr (2010) 67.46
MolProbity: all-atom structure validation for macromolecular crystallography. Acta Crystallogr D Biol Crystallogr (2009) 53.36
Integrins: bidirectional, allosteric signaling machines. Cell (2002) 36.25
Automated protein model building combined with iterative structure refinement. Nat Struct Biol (1999) 27.52
Structural basis of integrin regulation and signaling. Annu Rev Immunol (2007) 8.60
Structural basis of collagen recognition by integrin alpha2beta1. Cell (2000) 4.84
Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18). Cell (1995) 4.73
The tail of integrins, talin, and kindlins. Science (2009) 4.51
Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation. Cell (2003) 4.19
Regulation of cell signalling by uPAR. Nat Rev Mol Cell Biol (2010) 3.77
Conformational regulation of integrin structure and function. Annu Rev Biophys Biomol Struct (2001) 3.74
Integrin structure, allostery, and bidirectional signaling. Annu Rev Cell Dev Biol (2005) 3.54
Synergistic control of cell adhesion by integrins and syndecans. Nat Rev Mol Cell Biol (2007) 3.21
Two conformations of the integrin A-domain (I-domain): a pathway for activation? Structure (1995) 3.15
Computational design of an integrin I domain stabilized in the open high affinity conformation. Nat Struct Biol (2000) 2.45
Conversion between three conformational states of integrin I domains with a C-terminal pull spring studied with molecular dynamics. Structure (2004) 2.35
The collagen binding alpha1beta1 integrin VLA-1 regulates CD8 T cell-mediated immune protection against heterologous influenza infection. Immunity (2004) 2.13
Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin. Proc Natl Acad Sci U S A (1995) 2.12
Integrins in immunity. J Cell Sci (2009) 2.02
Rolling cell adhesion. Annu Rev Cell Dev Biol (2010) 1.97
Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin. Nature (2007) 1.87
An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11b A-domain. J Biol Chem (2000) 1.84
Structure of an integrin with an alphaI domain, complement receptor type 4. EMBO J (2009) 1.70
Crystal structure of the I domain from integrin alpha2beta1. J Biol Chem (1997) 1.69
Does the integrin alphaA domain act as a ligand for its betaA domain? Curr Biol (2002) 1.69
Two functional states of the CD11b A-domain: correlations with key features of two Mn2+-complexed crystal structures. J Cell Biol (1998) 1.67
Integrin alpha1beta1 mediates a unique collagen-dependent proliferation pathway in vivo. J Cell Biol (1998) 1.54
Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring. Proc Natl Acad Sci U S A (2004) 1.49
The collagen family members as cell adhesion proteins. Bioessays (2007) 1.45
Selective binding of collagen subtypes by integrin alpha 1I, alpha 2I, and alpha 10I domains. J Biol Chem (2001) 1.44
Absence of integrin alpha1beta1 in the mouse causes loss of feedback regulation of collagen synthesis in normal and wounded dermis. J Cell Sci (1999) 1.43
Interaction of type IV collagen with the isolated integrins alpha 1 beta 1 and alpha 2 beta 1. Eur J Biochem (1993) 1.41
Lack of integrin alpha1beta1 leads to severe glomerulosclerosis after glomerular injury. Am J Pathol (2004) 1.33
Integrin activation state determines selectivity for novel recognition sites in fibrillar collagens. J Biol Chem (2004) 1.33
Requirement of open headpiece conformation for activation of leukocyte integrin alphaXbeta2. Proc Natl Acad Sci U S A (2010) 1.32
Direct binding of collagen to the I domain of integrin alpha 2 beta 1 (VLA-2, CD49b/CD29) in a divalent cation-independent manner. J Biol Chem (1994) 1.27
Importance of innate immunity and collagen binding integrin alpha1beta1 in TNBS-induced colitis. Immunity (2002) 1.25
Trench-shaped binding sites promote multiple classes of interactions between collagen and the adherence receptors, alpha(1)beta(1) integrin and Staphylococcus aureus cna MSCRAMM. J Biol Chem (1999) 1.19
Distinct recognition of collagen subtypes by alpha(1)beta(1) and alpha(2)beta(1) integrins. Alpha(1)beta(1) mediates cell adhesion to type XIII collagen. J Biol Chem (2000) 1.19
Structure and allosteric regulation of the alpha X beta 2 integrin I domain. Proc Natl Acad Sci U S A (2003) 1.18
Engineered allosteric mutants of the integrin alphaMbeta2 I domain: structural and functional studies. Biochem J (2003) 1.14
Diminished callus size and cartilage synthesis in alpha 1 beta 1 integrin-deficient mice during bone fracture healing. Am J Pathol (2002) 1.05
An unusual allosteric mobility of the C-terminal helix of a high-affinity alphaL integrin I domain variant bound to ICAM-5. Mol Cell (2008) 1.01
Integrin alpha(2)I domain recognizes type I and type IV collagens by different mechanisms. J Biol Chem (2000) 0.95
Effects of conformational activation of integrin alpha 1I and alpha 2I domains on selective recognition of laminin and collagen subtypes. Exp Cell Res (2008) 0.94
Two synergistic activation mechanisms of alpha2beta1 integrin-mediated collagen binding. J Biol Chem (2007) 0.93
Jararhagin-derived RKKH peptides induce structural changes in alpha1I domain of human integrin alpha1beta1. J Biol Chem (2003) 0.93
Molecular mechanism of alpha2beta1 integrin interaction with human echovirus 1. EMBO J (2009) 0.92
A novel gain-of-function mutation of the integrin alpha2 VWFA domain. Eur J Biochem (2002) 0.92
The fibril-associated collagen IX provides a novel mechanism for cell adhesion to cartilaginous matrix. J Biol Chem (2004) 0.91
Distribution and quantification of alpha 1-integrin subunit in rat organs. Histochem J (1995) 0.89
Crystal structure of the alpha1beta1 integrin I-domain: insights into integrin I-domain function. FEBS Lett (1999) 0.84
Production, crystallization and preliminary X-ray analysis of the human integrin alpha1 I domain. Acta Crystallogr D Biol Crystallogr (1999) 0.77
BioImageXD: an open, general-purpose and high-throughput image-processing platform. Nat Methods (2012) 2.22
Internalization of echovirus 1 in caveolae. J Virol (2002) 1.87
Integrin-mediated cell adhesion to type I collagen fibrils. J Biol Chem (2004) 1.75
Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta. Mol Cell Biol (2002) 1.67
Clustering induces a lateral redistribution of alpha 2 beta 1 integrin from membrane rafts to caveolae and subsequent protein kinase C-dependent internalization. Mol Biol Cell (2003) 1.59
Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells--implications for age-related macular degeneration (AMD). Immunol Lett (2012) 1.46
Cooperation between integrins and growth factor receptors in signaling and endocytosis. Annu Rev Cell Dev Biol (2011) 1.40
Differential expression of collagen- and laminin-binding integrins mediates ureteric bud and inner medullary collecting duct cell tubulogenesis. Am J Physiol Renal Physiol (2004) 1.34
Operon flv4-flv2 provides cyanobacterial photosystem II with flexibility of electron transfer. Plant Cell (2012) 1.29
Increased expression of beta6-integrin in skin leads to spontaneous development of chronic wounds. Am J Pathol (2004) 1.24
Heterotrimerization of heat-shock factors 1 and 2 provides a transcriptional switch in response to distinct stimuli. Mol Biol Cell (2009) 1.23
A Raft-derived, Pak1-regulated entry participates in alpha2beta1 integrin-dependent sorting to caveosomes. Mol Biol Cell (2008) 1.23
Crystal structure of the human vascular adhesion protein-1: unique structural features with functional implications. Protein Sci (2005) 1.18
The collagen receptor subfamily of the integrins. Int J Biochem Cell Biol (2004) 1.15
Structural evidence for adaptive ligand binding of glycolipid transfer protein. J Mol Biol (2005) 1.14
Evolution of collagen-based adhesion systems. Int J Biochem Cell Biol (2008) 1.14
Integrin evolution: insights from ascidian and teleost fish genomes. Matrix Biol (2005) 1.13
Human Siglec-10 can bind to vascular adhesion protein-1 and serves as its substrate. Blood (2009) 1.10
Structural and functional analysis of integrin alpha2I domain interaction with echovirus 1. J Biol Chem (2003) 1.10
Endothelial cell-matrix interactions. Microsc Res Tech (2003) 1.09
Structural and functional characterization of ferredoxin-NADP+-oxidoreductase using knock-out mutants of Arabidopsis. Plant J (2007) 1.09
Integrins during evolution: evolutionary trees and model organisms. Biochim Biophys Acta (2009) 1.08
Viral entry, lipid rafts and caveosomes. Ann Med (2005) 1.07
Interplay between cell adhesion and growth factor receptors: from the plasma membrane to the endosomes. Cell Tissue Res (2009) 1.05
Integrin chains beta1 and alphav as prognostic factors in human metastatic melanoma. Melanoma Res (2004) 1.05
Diminished callus size and cartilage synthesis in alpha 1 beta 1 integrin-deficient mice during bone fracture healing. Am J Pathol (2002) 1.05
Efficient production of active chicken avidin using a bacterial signal peptide in Escherichia coli. Biochem J (2004) 1.05
alpha 11beta 1 integrin recognizes the GFOGER sequence in interstitial collagens. J Biol Chem (2002) 1.04
Evolutionary history of the non-specific lipid transfer proteins. Mol Plant (2011) 1.00
Cellular receptors of extracellular matrix molecules. Curr Pharm Des (2009) 0.98
Exploring scarless healing of oral soft tissues. J Can Dent Assoc (2011) 0.97
Lumican inhibits cell migration through α2β1 integrin. Exp Cell Res (2010) 0.96
Cross-talk between integrins alpha1beta1 and alpha2beta1 in renal epithelial cells. Exp Cell Res (2008) 0.96
Calpain 1 and 2 are required for RNA replication of echovirus 1. J Virol (2007) 0.96
Critical role for αvβ6 integrin in enamel biomineralization. J Cell Sci (2012) 0.95
Must we press on until a young mother dies? Remifentanil patient controlled analgesia in labour may not be suited as a "poor man's epidural". BMC Pregnancy Childbirth (2013) 0.95
Effects of conformational activation of integrin alpha 1I and alpha 2I domains on selective recognition of laminin and collagen subtypes. Exp Cell Res (2008) 0.94
Two synergistic activation mechanisms of alpha2beta1 integrin-mediated collagen binding. J Biol Chem (2007) 0.93
Syndecan-1 supports integrin alpha2beta1-mediated adhesion to collagen. Exp Cell Res (2008) 0.93
Jararhagin-derived RKKH peptides induce structural changes in alpha1I domain of human integrin alpha1beta1. J Biol Chem (2003) 0.93
Increased gene expression levels of collagen receptor integrins are associated with decreased survival parameters in patients with advanced melanoma. Melanoma Res (2007) 0.93
The selective regulation of alpha Vbeta 1 integrin expression is based on the hierarchical formation of alpha V-containing heterodimers. J Biol Chem (2002) 0.92
Avidin related protein 2 shows unique structural and functional features among the avidin protein family. BMC Biotechnol (2005) 0.92
Molecular mechanism of alpha2beta1 integrin interaction with human echovirus 1. EMBO J (2009) 0.92
Continuous intravenous perioperative lidocaine infusion for postoperative pain and recovery. Cochrane Database Syst Rev (2015) 0.92
c-Jun supports ribosomal RNA processing and nucleolar localization of RNA helicase DDX21. J Biol Chem (2008) 0.91
The fibril-associated collagen IX provides a novel mechanism for cell adhesion to cartilaginous matrix. J Biol Chem (2004) 0.91
An arthritogenic alphavirus uses the alpha1beta1 integrin collagen receptor. Virology (2005) 0.91
Functional classification of amino acid decarboxylases from the alanine racemase structural family by phylogenetic studies. Mol Biol Evol (2006) 0.90
Collagenase-3 (MMP-13) enhances remodeling of three-dimensional collagen and promotes survival of human skin fibroblasts. J Invest Dermatol (2006) 0.90
Novel vascular endothelial growth factor D variants with increased biological activity. J Biol Chem (2009) 0.89
TPA primes alpha2beta1 integrins for cell adhesion. FEBS Lett (2008) 0.88
Binding properties of HABA-type azo derivatives to avidin and avidin-related protein 4. Chem Biol (2006) 0.88
Plants express a lipid transfer protein with high similarity to mammalian sterol carrier protein-2. J Biol Chem (2004) 0.88
Expression of alpha7beta1 integrin splicing variants during skeletal muscle regeneration. Am J Pathol (2002) 0.87
Identification of late-stage glycosylation steps in the biosynthetic pathway of the anthracycline nogalamycin. Chembiochem (2011) 0.87
Small molecule designed to target metal binding site in the alpha2I domain inhibits integrin function. J Med Chem (2007) 0.86
Bacterial heat shock protein 60 may increase epithelial cell migration through activation of MAP kinases and inhibition of alpha6beta4 integrin expression. Biochem Biophys Res Commun (2004) 0.85
alphaV integrin promotes in vitro and in vivo survival of cells in metastatic melanoma. Int J Cancer (2004) 0.85
Identification of two imidazole binding sites and key residues for substrate specificity in human primary amine oxidase AOC3. Biochemistry (2011) 0.84
Identification of a glycosphingolipid transfer protein GLTP1 in Arabidopsis thaliana. FEBS J (2008) 0.83
Characterization of intrinsically disordered prostate associated gene (PAGE5) at single residue resolution by NMR spectroscopy. PLoS One (2011) 0.83
Collagen XXIII, novel ligand for integrin alpha2beta1 in the epidermis. J Biol Chem (2011) 0.83
Crystallization and preliminary X-ray analysis of the human vascular adhesion protein-1. Acta Crystallogr D Biol Crystallogr (2003) 0.82
Deciphering the acylation pattern of Yersinia enterocolitica lipid A. PLoS Pathog (2012) 0.82
Overexpression of chloroplast NADPH-dependent thioredoxin reductase in Arabidopsis enhances leaf growth and elucidates in vivo function of reductase and thioredoxin domains. Front Plant Sci (2013) 0.82
Characterization of SCP-2 from Euphorbia lagascae reveals that a single Leu/Met exchange enhances sterol transfer activity. FEBS J (2006) 0.82
Flavoprotein hydroxylase PgaE catalyzes two consecutive oxygen-dependent tailoring reactions in angucycline biosynthesis. Biochemistry (2011) 0.82
Detection of melanoma-derived cancer-testis antigen CT16 in patient sera by a novel immunoassay. Int J Cancer (2011) 0.82
Characterization of the six glycosyltransferases involved in the biosynthesis of Yersinia enterocolitica serotype O:3 lipopolysaccharide outer core. J Biol Chem (2010) 0.82
Analysis of an ascidian integrin provides new insight into early evolution of collagen recognition. FEBS Lett (2007) 0.81
Controlling quaternary structure assembly: subunit interface engineering and crystal structure of dual chain avidin. J Mol Biol (2006) 0.81
A duplexed microsphere-based cellular adhesion assay. Anal Biochem (2005) 0.80
Arabidopsis sterol carrier protein-2 is required for normal development of seeds and seedlings. J Exp Bot (2008) 0.80
Structure and characterization of a novel chicken biotin-binding protein A (BBP-A). BMC Struct Biol (2007) 0.80
Leukocyte integrins αLβ2, αMβ2 and αXβ2 as collagen receptors--receptor activation and recognition of GFOGER motif. Int J Biochem Cell Biol (2013) 0.79
Novel α2β1 integrin inhibitors reveal that integrin binding to collagen under shear stress conditions does not require receptor preactivation. J Biol Chem (2012) 0.79
Regulation of prostate cell collagen receptors by malignant transformation. Int J Cancer (2006) 0.79
Fluorescent small molecule probe to modulate and explore α2β1 integrin function. J Am Chem Soc (2011) 0.78