Published in Clin Cancer Res on November 08, 2011
Systemic delivery of Salmonella typhimurium transformed with IDO shRNA enhances intratumoral vector colonization and suppresses tumor growth. Cancer Res (2012) 1.84
EBV-positive large B-cell lymphomas in young patients: a nodal lymphoma with evidence for a tolerogenic immune environment. Blood (2015) 1.68
The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment. Cancer Microenviron (2014) 1.24
Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev (2016) 1.13
Distinct tryptophan catabolism and Th17/Treg balance in HIV progressors and elite controllers. PLoS One (2013) 1.08
Breast cancer immunobiology driving immunotherapy: vaccines and immune checkpoint blockade. Expert Rev Anticancer Ther (2012) 1.03
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Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein e7. J Invest Dermatol (2013) 0.92
Soluble CD40-ligand (sCD40L, sCD154) plays an immunosuppressive role via regulatory T cell expansion in HIV infection. Clin Exp Immunol (2014) 0.91
Indoleamine 2,3-dioxygenase (IDO) is frequently expressed in stromal cells of Hodgkin lymphoma and is associated with adverse clinical features: a retrospective cohort study. BMC Cancer (2014) 0.90
Indoleamine 2,3-dioxygenase promotes peritoneal metastasis of ovarian cancer by inducing an immunosuppressive environment. Cancer Sci (2014) 0.90
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Reprogramming the tumor microenvironment: tumor-induced immunosuppressive factors paralyze T cells. Oncoimmunology (2015) 0.88
Shaping of NK cell responses by the tumor microenvironment. Cancer Microenviron (2012) 0.87
In vivo metabolism of tryptophan in meningiomas is mediated by indoleamine 2,3-dioxygenase 1. Cancer Biol Ther (2013) 0.85
Tryptophan-degrading enzymes in tumoral immune resistance. Front Immunol (2015) 0.84
Immune Suppression by Myeloid Cells in HIV Infection: New Targets for Immunotherapy. Open AIDS J (2014) 0.83
Crystal Structures and Structure-Activity Relationships of Imidazothiazole Derivatives as IDO1 Inhibitors. ACS Med Chem Lett (2014) 0.83
The dark side of dendritic cells: development and exploitation of tolerogenic activity that favor tumor outgrowth and immune escape. Front Immunol (2013) 0.83
Fludarabine downregulates indoleamine 2,3-dioxygenase in tumors via a proteasome-mediated degradation mechanism. PLoS One (2014) 0.83
Immunological and nonimmunological effects of indoleamine 2,3-dioxygenase on breast tumor growth and spontaneous metastasis formation. Clin Dev Immunol (2012) 0.82
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Early Carcinogenesis Involves the Establishment of Immune Privilege via Intrinsic and Extrinsic Regulation of Indoleamine 2,3-dioxygenase-1: Translational Implications in Cancer Immunotherapy. Front Immunol (2014) 0.80
An Autocrine Cytokine/JAK/STAT-Signaling Induces Kynurenine Synthesis in Multidrug Resistant Human Cancer Cells. PLoS One (2015) 0.80
Accumulation of an endogenous tryptophan-derived metabolite in colorectal and breast cancers. PLoS One (2015) 0.79
Tumoral indoleamine 2,3-dioxygenase expression predicts poor outcome in laryngeal squamous cell carcinoma. Virchows Arch (2012) 0.79
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Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase. Sci Rep (2016) 0.78
A Pt(IV) Pro-drug Preferentially Targets Indoleamine-2,3-dioxygenase, Providing Enhanced Ovarian Cancer Immuno-Chemotherapy. J Am Chem Soc (2015) 0.78
Metabolic phenotyping for monitoring ovarian cancer patients. Sci Rep (2016) 0.77
Molecular characterization of subcutaneous panniculitis-like T-cell lymphoma reveals upregulation of immunosuppression- and autoimmunity-associated genes. Orphanet J Rare Dis (2014) 0.77
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Nutritional Stress Induced by Tryptophan-Degrading Enzymes Results in ATF4-Dependent Reprogramming of the Amino Acid Transporter Profile in Tumor Cells. Cancer Res (2016) 0.75
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Biological and clinical significance of tryptophan-catabolizing enzymes in cutaneous T-cell lymphomas. Oncoimmunology (2017) 0.75
Targeting immune checkpoints in malignant glioma. Oncotarget (2016) 0.75
The prognostic role of immune checkpoint markers programmed cell death protein 1 (PD-1) and programmed death ligand 1 (PD-L1) in a large, multicenter prostate cancer cohort. Oncotarget (2017) 0.75
PD-L1, Galectin-9 and CD8(+) tumor-infiltrating lymphocytes are associated with survival in hepatocellular carcinoma. Oncoimmunology (2017) 0.75
Interleukin-17 and type 17 helper T cells in cancer management and research. Immunotargets Ther (2014) 0.75
Improved Radiosynthesis and Biological Evaluations of L- and D-1-[(18)F]Fluoroethyl-Tryptophan for PET Imaging of IDO-Mediated Kynurenine Pathway of Tryptophan Metabolism. Mol Imaging Biol (2016) 0.75
CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature (2002) 11.79
CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity (2002) 8.28
CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells. J Immunol (2005) 6.95
Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity (2008) 6.08
Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function. J Immunol (2004) 4.62
Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens. J Exp Med (2006) 3.22
Activation requirements for the induction of CD4+CD25+ T cell suppressor function. Eur J Immunol (2004) 2.99
Cancer classification using the Immunoscore: a worldwide task force. J Transl Med (2012) 2.88
The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells. J Immunol (2004) 2.50
Functional waning of naturally occurring CD4+ regulatory T-cells contributes to the onset of autoimmune diabetes. Diabetes (2007) 2.27
Intravenous immunoglobulin attenuates airway inflammation through induction of forkhead box protein 3-positive regulatory T cells. J Allergy Clin Immunol (2012) 2.12
CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence. J Exp Med (2006) 1.88
CD19 CAR-T cells of defined CD4+:CD8+ composition in adult B cell ALL patients. J Clin Invest (2016) 1.75
Characterization of the intra-prostatic immune cell infiltration in androgen-deprived prostate cancer patients. J Immunol Methods (2009) 1.48
TGF-beta1 production by CD4+ CD25+ regulatory T cells is not essential for suppression of intestinal inflammation. Eur J Immunol (2005) 1.46
Inflammation-driven reprogramming of CD4+ Foxp3+ regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo. PLoS One (2012) 1.26
Foxp3+CD4+CD25+ T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis C. Blood (2006) 1.25
The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease. Immunology (2008) 1.23
Immunogenicity of papaya mosaic virus-like particles fused to a hepatitis C virus epitope: evidence for the critical function of multimerization. Virology (2007) 1.22
Cell line-dependent internalization pathways and intracellular trafficking determine transfection efficiency of nanoparticle vectors. Eur J Pharm Biopharm (2007) 1.20
Impact of protective IL-2 allelic variants on CD4+ Foxp3+ regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice. J Immunol (2008) 1.20
Cardiolipin binds to CD1d and stimulates CD1d-restricted γδ T cells in the normal murine repertoire. J Immunol (2011) 1.19
The immunogenetics of immune dysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome. J Med Genet (2012) 1.16
Control of type 1 diabetes by CD4+Foxp3+ regulatory T cells: lessons from mouse models and implications for human disease. Diabetes Metab Res Rev (2009) 1.12
Novel plant virus-based vaccine induces protective cytotoxic T-lymphocyte-mediated antiviral immunity through dendritic cell maturation. J Virol (2007) 1.12
Single-cell analysis of the human T regulatory population uncovers functional heterogeneity and instability within FOXP3+ cells. J Immunol (2011) 1.12
FOXP3 forkhead domain mutation and regulatory T cells in the IPEX syndrome. N Engl J Med (2009) 1.09
Distinct tryptophan catabolism and Th17/Treg balance in HIV progressors and elite controllers. PLoS One (2013) 1.08
ICOS-dependent homeostasis and function of Foxp3+ regulatory T cells in islets of nonobese diabetic mice. J Immunol (2012) 1.04
A comprehensive characterization of membrane vesicles released by autophagic human endothelial cells. Proteomics (2013) 1.04
Proteasome-independent major histocompatibility complex class I cross-presentation mediated by papaya mosaic virus-like particles leads to expansion of specific human T cells. J Virol (2006) 1.04
Control of T cell activation by CD4+CD25+ suppressor T cells. Novartis Found Symp (2003) 1.00
Functional crosstalk between dendritic cells and Foxp3(+) regulatory T cells in the maintenance of immune tolerance. Front Immunol (2012) 0.99
Targeting the MHC Class II antigen presentation pathway in cancer immunotherapy. Oncoimmunology (2012) 0.97
Melanosomal targeting sequences from gp100 are essential for MHC class II-restricted endogenous epitope presentation and mobilization to endosomal compartments. Cancer Res (2006) 0.97
Development and function of naturally occurring CD4+CD25+ regulatory T cells. J Leukoc Biol (2006) 0.97
T regulatory cells control numbers of NK cells and CD8alpha+ immature dendritic cells in the lymph node paracortex. J Immunol (2007) 0.97
Immune Regulation in T1D and T2D: Prospective Role of Foxp3+ Treg Cells in Disease Pathogenesis and Treatment. Front Endocrinol (Lausanne) (2013) 0.93
IL-2 contributes to maintaining a balance between CD4+Foxp3+ regulatory T cells and effector CD4+ T cells required for immune control of blood-stage malaria infection. J Immunol (2011) 0.93
Functional dynamics of naturally occurring regulatory T cells in health and autoimmunity. Adv Immunol (2006) 0.93
Human activated T lymphocytes modulate IDO expression in tumors through Th1/Th2 balance. J Immunol (2009) 0.93
Prostate-derived Ets transcription factor overexpression is associated with nodal metastasis and hormone receptor positivity in invasive breast cancer. Neoplasia (2007) 0.91
Phenotypic characterization and functional analysis of human tumor immune infiltration after mechanical and enzymatic disaggregation. J Immunol Methods (2011) 0.91
Improvement of the PapMV nanoparticle adjuvant property through an increased of its avidity for the antigen [influenza NP]. Vaccine (2012) 0.90
Functional stability of Foxp3+ regulatory T cells. Trends Mol Med (2012) 0.90
MARCH1 down-regulation in IL-10-activated B cells increases MHC class II expression. Cytokine (2012) 0.89
Effects of alginate inclusion on the vector properties of chitosan-based nanoparticles. J Control Release (2006) 0.89
Receptor tyrosine kinase signaling favors a protumorigenic state in breast cancer cells by inhibiting the adaptive immune response. Cancer Res (2010) 0.89
IL-2 production by dendritic cells promotes Foxp3(+) regulatory T-cell expansion in autoimmune-resistant NOD congenic mice. Autoimmunity (2011) 0.87
Critical co-stimulatory pathways in the stability of Foxp3+ Treg cell homeostasis in Type I diabetes. Autoimmun Rev (2011) 0.86
CD4+ Foxp3+ regulatory T cells suppress γδ T-cell effector functions in a model of T-cell-induced mucosal inflammation. Eur J Immunol (2011) 0.86
Presence of prostate cancer metastasis correlates with lower lymph node reactivity. Prostate (2006) 0.85
Androgen-regulated expression of arginase 1, arginase 2 and interleukin-8 in human prostate cancer. PLoS One (2010) 0.85
Requirement of oxidation-dependent CD40 homodimers for CD154/CD40 bidirectional signaling. J Biol Chem (2007) 0.85
Analysis of human FOXP3+ Treg cells phenotype and function. Methods Mol Biol (2011) 0.84
Distinct translational control in CD4+ T cell subsets. PLoS Genet (2013) 0.84
CD40-activated B cells can efficiently prime antigen-specific naïve CD8+ T cells to generate effector but not memory T cells. PLoS One (2012) 0.84
Mesenchymal stromal cells improve salivary function and reduce lymphocytic infiltrates in mice with Sjögren's-like disease. PLoS One (2012) 0.84
The TGF-beta1/Foxp3 regulatory axis in immune self-tolerance: implications for health and disease. Inflamm Allergy Drug Targets (2006) 0.83
Toll-like receptor 5 deficiency protects from wasting disease in a T cell transfer colitis model in T cell receptor-β-deficient mice. Inflamm Bowel Dis (2011) 0.82
Functional dynamics of Foxp3⁺ regulatory T cells in mice and humans. Immunol Rev (2014) 0.82
IDO expression by human B lymphocytes in response to T lymphocyte stimuli and TLR engagement is biologically inactive. Mol Immunol (2011) 0.82
Stimulation of Wnt/ß-catenin pathway in human CD8+ T lymphocytes from blood and lung tumors leads to a shared young/memory phenotype. PLoS One (2012) 0.81
A new clinically relevant approach to expand myelin specific T cells. J Immunol Methods (2006) 0.81
Developmental plasticity of murine and human Foxp3(+) regulatory T cells. Adv Immunol (2013) 0.80
Ubiquitous expression of mRFP-1 in vivo by site-directed transgenesis. Transgenic Res (2006) 0.80
Two distinct chimeric potexviruses share antigenic cross-presentation properties of MHC class I epitopes. Vaccine (2010) 0.80
Phosphatidylinositol 3-kinase-independent signaling pathways contribute to ICOS-mediated T cell costimulation in acute graft-versus-host disease in mice. J Immunol (2013) 0.80
Endogenously expressed matrix protein M1 and nucleoprotein of influenza A are efficiently presented by class I and class II major histocompatibility complexes. J Gen Virol (2011) 0.79
Altered T helper 17 responses in children with food allergy. Int Arch Allergy Immunol (2013) 0.79
Pancreatic islet cell phenotype and endocrine function throughout diabetes development in non-obese diabetic mice. Autoimmunity (2013) 0.79
The immunological and genetic basis of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. Curr Opin Allergy Clin Immunol (2015) 0.79
TGF-alpha as a candidate tumor antigen for renal cell carcinomas. Cancer Immunol Immunother (2008) 0.78
HLA-DO transduced in human monocyte-derived dendritic cells modulates MHC class II antigen processing. J Leukoc Biol (2005) 0.78
The WT hemochromatosis protein HFE inhibits CD8⁺ T-lymphocyte activation. Eur J Immunol (2014) 0.77
Functional plasticity in human FOXP3(+) regulatory T cells: implications for cell-based immunotherapy. Hum Vaccin Immunother (2012) 0.77
IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease. J Transl Med (2010) 0.75
Tolerance, immune regulation, and autoimmunity: cells and cytokines that make a difference. Curr Opin Immunol (2008) 0.75
Acquired Omenn-like syndrome, a novel posttransplant autoaggression syndrome reversed by rapamycin. Clin Vaccine Immunol (2011) 0.75
mRNA PCR-based epitope chase method. Methods Mol Biol (2013) 0.75
Phenotypic characterization of chronic inflammation in a rare case of endobronchial carcinoma. Cancer Immunol Immunother (2010) 0.75
Polyfunctionality of a DKK1 self-antigen-specific CD8(+) T lymphocyte clone in lung cancer. Cancer Immunol Immunother (2011) 0.75
Identification of T-cell epitopes by a novel mRNA PCR-based epitope chase technique. J Immunother (2011) 0.75