Published in Front Endocrinol (Lausanne) on June 25, 2013
The Ratio of Regulatory (FOXP3+) to Total (CD3+) T Cells Determined by Epigenetic Cell Counting and Cardiovascular Disease Risk: A Prospective Case-cohort Study in Non-diabetics. EBioMedicine (2016) 0.81
Generation and identification of tumor-evoked regulatory B cells. Methods Mol Biol (2014) 0.81
Influence of host immunoregulatory genes, ER stress and gut microbiota on the shared pathogenesis of inflammatory bowel disease and Type 1 diabetes. Immunotherapy (2013) 0.78
Tregs and kidney: From diabetic nephropathy to renal transplantation. World J Transplant (2016) 0.77
Role of alteration in Treg/Th17 cells' balance in nephropathic patients with Type 2 diabetes mellitus. Electron Physician (2015) 0.77
The role of the immune system in the pathogenesis of diabetic complications. Front Endocrinol (Lausanne) (2014) 0.75
Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest (2003) 41.22
Control of regulatory T cell development by the transcription factor Foxp3. Science (2003) 40.32
Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest (2007) 20.19
Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature (2004) 16.56
B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity (2000) 15.44
IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med (2005) 12.07
A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol (2005) 11.48
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med (2009) 11.28
Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes. N Engl J Med (2005) 10.16
Elevated C-reactive protein levels in overweight and obese adults. JAMA (1999) 9.94
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med (2009) 9.71
Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity (2009) 9.28
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N Engl J Med (2002) 8.84
Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat Immunol (2009) 8.65
Normalization of obesity-associated insulin resistance through immunotherapy. Nat Med (2009) 8.15
Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature (2010) 6.85
The NOD mouse: a model of immune dysregulation. Annu Rev Immunol (2005) 6.71
Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity (2008) 6.08
GAD treatment and insulin secretion in recent-onset type 1 diabetes. N Engl J Med (2008) 5.74
Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial--Type 1. Diabetes Care (2005) 5.04
Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. Annu Rev Immunol (2001) 4.99
Recovery from diabetes in mice by beta cell regeneration. J Clin Invest (2007) 4.32
PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature (2012) 4.31
Phenotypical and functional specialization of FOXP3+ regulatory T cells. Nat Rev Immunol (2011) 4.29
Natural regulatory T cells control the development of atherosclerosis in mice. Nat Med (2006) 4.28
Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice. Proc Natl Acad Sci U S A (1994) 3.77
Regulatory T cells: how do they suppress immune responses? Int Immunol (2009) 3.58
The NOD mouse model of type 1 diabetes: as good as it gets? Nat Med (1999) 3.37
Environmental triggers and determinants of type 1 diabetes. Diabetes (2005) 2.93
Human adipose tissue macrophages are of an anti-inflammatory phenotype but capable of excessive pro-inflammatory mediator production. Int J Obes (Lond) (2007) 2.92
Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1. Diabetes Care (2009) 2.91
Effects of autoimmunity and immune therapy on beta-cell turnover in type 1 diabetes. Diabetes (2006) 2.52
Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes. J Immunol (2011) 2.39
Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years. Clin Immunol (2009) 2.30
Functional waning of naturally occurring CD4+ regulatory T-cells contributes to the onset of autoimmune diabetes. Diabetes (2007) 2.27
IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells. J Exp Med (2010) 2.21
Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes. J Mol Med (Berl) (2003) 2.10
Adaptive TGF-beta-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment. Proc Natl Acad Sci U S A (2007) 1.90
Leukocyte recruitment and vascular injury in diabetic nephropathy. J Am Soc Nephrol (2006) 1.89
Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects. Diabetes (2009) 1.88
Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP. J Clin Invest (2006) 1.88
Pancreatic β-cell neogenesis by direct conversion from mature α-cells. Stem Cells (2010) 1.80
Regeneration of pancreatic beta cells from intra-islet precursor cells in an experimental model of diabetes. Endocrinology (2001) 1.78
Tolerance to islet autoantigens in type 1 diabetes. Annu Rev Immunol (2001) 1.70
Beta-cell mass and type 1 diabetes: going, going, gone? Diabetes (2008) 1.69
Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus. J Clin Invest (1992) 1.67
Induction of a regulatory T cell type 1 response reduces the development of atherosclerosis in apolipoprotein E-knockout mice. Circulation (2003) 1.59
Influence of microbial environment on autoimmunity. Nat Immunol (2009) 1.59
'The honeymoon phase' in children with type 1 diabetes mellitus: frequency, duration, and influential factors. Pediatr Diabetes (2006) 1.56
Gastrin stimulates beta-cell neogenesis and increases islet mass from transdifferentiated but not from normal exocrine pancreas tissue. Diabetes (2002) 1.54
Potential role of regulatory T cells in reversing obesity-linked insulin resistance and diabetic nephropathy. Diabetes (2011) 1.52
Low numbers of FOXP3 positive regulatory T cells are present in all developmental stages of human atherosclerotic lesions. PLoS One (2007) 1.51
Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance. Mol Cell Biol (2010) 1.42
Ontogeny of regeneration of beta-cells in the neonatal rat after treatment with streptozotocin. Endocrinology (2006) 1.42
Induction of oral tolerance to oxidized low-density lipoprotein ameliorates atherosclerosis. Circulation (2006) 1.41
Human in vivo antigenic modulation induced by the anti-T cell OKT3 monoclonal antibody. Eur J Immunol (1982) 1.37
Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping. Genome Res (2000) 1.34
Intranasal immunization with an apolipoprotein B-100 fusion protein induces antigen-specific regulatory T cells and reduces atherosclerosis. Arterioscler Thromb Vasc Biol (2010) 1.31
Short-term treatment with anti-CD3 antibody reduces the development and progression of atherosclerosis in mice. Circulation (2006) 1.31
Differentiation of new insulin-producing cells is induced by injury in adult pancreatic islets. Endocrinology (1997) 1.28
Association between measures of insulin sensitivity and circulating levels of interleukin-8, interleukin-6 and tumor necrosis factor-alpha. Effect of weight loss in obese men. Eur J Endocrinol (2003) 1.26
Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells. J Immunol (2011) 1.25
Inflammation correlates with markers of T-cell subsets including regulatory T cells in adipose tissue from obese patients. Obesity (Silver Spring) (2010) 1.20
Impact of protective IL-2 allelic variants on CD4+ Foxp3+ regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice. J Immunol (2008) 1.20
Partial remission phase of diabetes in children younger than age 10 years. Arch Dis Child (1999) 1.16
The immunogenetics of immune dysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome. J Med Genet (2012) 1.16
The influence of the microbiota on type-1 diabetes: on the threshold of a leap forward in our understanding. Immunol Rev (2012) 1.13
Systemic transforming growth factor-beta1 gene therapy induces Foxp3+ regulatory cells, restores self-tolerance, and facilitates regeneration of beta cell function in overtly diabetic nonobese diabetic mice. Transplantation (2005) 1.13
Autoimmunity and beta cell regeneration in mouse and human type 1 diabetes: the peace is not enough. Ann N Y Acad Sci (2007) 1.08
Control of type 1 autoimmune diabetes by naturally occurring CD4+CD25+ regulatory T lymphocytes in neonatal NOD mice. Ann N Y Acad Sci (2005) 1.08
Diabetes-associated autoantibodies in relation to clinical characteristics and natural course in children with newly diagnosed type 1 diabetes. The Childhood Diabetes In Finland Study Group. J Clin Endocrinol Metab (1999) 1.05
ICOS-dependent homeostasis and function of Foxp3+ regulatory T cells in islets of nonobese diabetic mice. J Immunol (2012) 1.04
Aberrant recruitment and activation of T cells in diabetic nephropathy. Am J Nephrol (2012) 1.02
Transcriptional regulation of Foxp3 in regulatory T cells. Immunobiology (2010) 0.89
Differential expression patterns of proinflammatory and antiinflammatory mediators during atherogenesis in mice. Arterioscler Thromb Vasc Biol (2004) 0.88
Induction of the chemokine interferon-gamma-inducible protein-10 in human pancreatic islets during enterovirus infection. Diabetologia (2006) 0.84
Transcriptional regulation of Foxp3 gene: multiple signal pathways on the road. Med Res Rev (2009) 0.84
Diabetes forum: Extreme makeover of pancreatic alpha-cells. Nature (2010) 0.79
Role of tumor necrosis factor-alpha and interferon-gamma as growth factors to the human fetal beta-cell. J Clin Endocrinol Metab (1991) 0.76
CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature (2002) 11.79
CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity (2002) 8.28
CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells. J Immunol (2005) 6.95
Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity (2008) 6.08
Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function. J Immunol (2004) 4.62
Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens. J Exp Med (2006) 3.22
Activation requirements for the induction of CD4+CD25+ T cell suppressor function. Eur J Immunol (2004) 2.99
The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells. J Immunol (2004) 2.50
Functional waning of naturally occurring CD4+ regulatory T-cells contributes to the onset of autoimmune diabetes. Diabetes (2007) 2.27
Intravenous immunoglobulin attenuates airway inflammation through induction of forkhead box protein 3-positive regulatory T cells. J Allergy Clin Immunol (2012) 2.12
CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence. J Exp Med (2006) 1.88
TGF-beta1 production by CD4+ CD25+ regulatory T cells is not essential for suppression of intestinal inflammation. Eur J Immunol (2005) 1.46
Indoleamine 2,3-dioxygenase expression in human cancers: clinical and immunologic perspectives. Clin Cancer Res (2011) 1.39
Inflammation-driven reprogramming of CD4+ Foxp3+ regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo. PLoS One (2012) 1.26
Foxp3+CD4+CD25+ T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis C. Blood (2006) 1.25
The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease. Immunology (2008) 1.23
Cell line-dependent internalization pathways and intracellular trafficking determine transfection efficiency of nanoparticle vectors. Eur J Pharm Biopharm (2007) 1.20
Impact of protective IL-2 allelic variants on CD4+ Foxp3+ regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice. J Immunol (2008) 1.20
Cardiolipin binds to CD1d and stimulates CD1d-restricted γδ T cells in the normal murine repertoire. J Immunol (2011) 1.19
The immunogenetics of immune dysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome. J Med Genet (2012) 1.16
Control of type 1 diabetes by CD4+Foxp3+ regulatory T cells: lessons from mouse models and implications for human disease. Diabetes Metab Res Rev (2009) 1.12
Single-cell analysis of the human T regulatory population uncovers functional heterogeneity and instability within FOXP3+ cells. J Immunol (2011) 1.12
FOXP3 forkhead domain mutation and regulatory T cells in the IPEX syndrome. N Engl J Med (2009) 1.09
ICOS-dependent homeostasis and function of Foxp3+ regulatory T cells in islets of nonobese diabetic mice. J Immunol (2012) 1.04
Control of T cell activation by CD4+CD25+ suppressor T cells. Novartis Found Symp (2003) 1.00
Functional crosstalk between dendritic cells and Foxp3(+) regulatory T cells in the maintenance of immune tolerance. Front Immunol (2012) 0.99
Development and function of naturally occurring CD4+CD25+ regulatory T cells. J Leukoc Biol (2006) 0.97
T regulatory cells control numbers of NK cells and CD8alpha+ immature dendritic cells in the lymph node paracortex. J Immunol (2007) 0.97
Functional dynamics of naturally occurring regulatory T cells in health and autoimmunity. Adv Immunol (2006) 0.93
IL-2 contributes to maintaining a balance between CD4+Foxp3+ regulatory T cells and effector CD4+ T cells required for immune control of blood-stage malaria infection. J Immunol (2011) 0.93
Phenotypic characterization and functional analysis of human tumor immune infiltration after mechanical and enzymatic disaggregation. J Immunol Methods (2011) 0.91
Functional stability of Foxp3+ regulatory T cells. Trends Mol Med (2012) 0.90
Effects of alginate inclusion on the vector properties of chitosan-based nanoparticles. J Control Release (2006) 0.89
Receptor tyrosine kinase signaling favors a protumorigenic state in breast cancer cells by inhibiting the adaptive immune response. Cancer Res (2010) 0.89
IL-2 production by dendritic cells promotes Foxp3(+) regulatory T-cell expansion in autoimmune-resistant NOD congenic mice. Autoimmunity (2011) 0.87
Critical co-stimulatory pathways in the stability of Foxp3+ Treg cell homeostasis in Type I diabetes. Autoimmun Rev (2011) 0.86
CD4+ Foxp3+ regulatory T cells suppress γδ T-cell effector functions in a model of T-cell-induced mucosal inflammation. Eur J Immunol (2011) 0.86
Analysis of human FOXP3+ Treg cells phenotype and function. Methods Mol Biol (2011) 0.84
Distinct translational control in CD4+ T cell subsets. PLoS Genet (2013) 0.84
Mesenchymal stromal cells improve salivary function and reduce lymphocytic infiltrates in mice with Sjögren's-like disease. PLoS One (2012) 0.84
The TGF-beta1/Foxp3 regulatory axis in immune self-tolerance: implications for health and disease. Inflamm Allergy Drug Targets (2006) 0.83
Toll-like receptor 5 deficiency protects from wasting disease in a T cell transfer colitis model in T cell receptor-β-deficient mice. Inflamm Bowel Dis (2011) 0.82
Functional dynamics of Foxp3⁺ regulatory T cells in mice and humans. Immunol Rev (2014) 0.82
Phosphatidylinositol 3-kinase-independent signaling pathways contribute to ICOS-mediated T cell costimulation in acute graft-versus-host disease in mice. J Immunol (2013) 0.80
Ubiquitous expression of mRFP-1 in vivo by site-directed transgenesis. Transgenic Res (2006) 0.80
Developmental plasticity of murine and human Foxp3(+) regulatory T cells. Adv Immunol (2013) 0.80
Altered T helper 17 responses in children with food allergy. Int Arch Allergy Immunol (2013) 0.79
Pancreatic islet cell phenotype and endocrine function throughout diabetes development in non-obese diabetic mice. Autoimmunity (2013) 0.79
The immunological and genetic basis of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. Curr Opin Allergy Clin Immunol (2015) 0.79
Functional plasticity in human FOXP3(+) regulatory T cells: implications for cell-based immunotherapy. Hum Vaccin Immunother (2012) 0.77
IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease. J Transl Med (2010) 0.75
Tolerance, immune regulation, and autoimmunity: cells and cytokines that make a difference. Curr Opin Immunol (2008) 0.75
Acquired Omenn-like syndrome, a novel posttransplant autoaggression syndrome reversed by rapamycin. Clin Vaccine Immunol (2011) 0.75