Published in Br J Pharmacol on May 01, 2012
Small-molecule screening identifies modulators of aquaporin-2 trafficking. J Am Soc Nephrol (2013) 1.41
cAMP signaling in subcellular compartments. Pharmacol Ther (2014) 1.02
Isoform-selective disruption of AKAP-localized PKA using hydrocarbon stapled peptides. ACS Chem Biol (2014) 1.00
Biophysical techniques for detection of cAMP and cGMP in living cells. Int J Mol Sci (2013) 0.88
Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions. Angew Chem Int Ed Engl (2013) 0.88
Local cAMP signaling in disease at a glance. J Cell Sci (2013) 0.87
Therapeutic strategies for anchored kinases and phosphatases: exploiting short linear motifs and intrinsic disorder. Front Pharmacol (2015) 0.83
Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung. Pharmaceuticals (Basel) (2012) 0.82
Molecular evolution of A-kinase anchoring protein (AKAP)-7: implications in comparative PKA compartmentalization. BMC Evol Biol (2012) 0.81
A-kinase anchoring proteins: cAMP compartmentalization in neurodegenerative and obstructive pulmonary diseases. Br J Pharmacol (2014) 0.81
Regulating the ubiquitin/proteasome pathway via cAMP-signaling: neuroprotective potential. Cell Biochem Biophys (2013) 0.81
Targeting protein kinase A in cancer therapy: an update. EXCLI J (2014) 0.80
Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains. Cell Signal (2014) 0.80
The Trafficking of the Water Channel Aquaporin-2 in Renal Principal Cells-a Potential Target for Pharmacological Intervention in Cardiovascular Diseases. Front Pharmacol (2016) 0.78
A-kinase-anchoring proteins coordinate inflammatory responses to cigarette smoke in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol (2015) 0.78
HIF-dependent regulation of AKAP12 (gravin) in the control of human vascular endothelial function. FASEB J (2013) 0.78
Targeting protein-protein interactions in complexes organized by A kinase anchoring proteins. Front Pharmacol (2015) 0.77
PDE8A runs interference to limit PKA inhibition of Raf-1. Proc Natl Acad Sci U S A (2013) 0.76
Protein kinase A regulates C-terminally truncated CaV 1.2 in Xenopus oocytes: roles of N- and C-termini of the α1C subunit. J Physiol (2017) 0.75
Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners. Biochem J (2016) 0.75
The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3β Interaction Protein (GSKIP) Regulates β-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3β. J Biol Chem (2016) 0.75
AKAP3 correlates with triple negative status and disease free survival in breast cancer. BMC Cancer (2015) 0.75
Targeting kinase signaling pathways with constrained peptide scaffolds. Pharmacol Ther (2017) 0.75
AKAP18:PKA-RIIα structure reveals crucial anchor points for recognition of regulatory subunits of PKA. Biochem J (2016) 0.75
Regulation of Active ICAM-4 on Normal and Sickle Cell Disease RBCs via AKAPs Is Revealed by AFM. Biophys J (2017) 0.75
Scaffolding during the cell cycle by A-kinase anchoring proteins. Pflugers Arch (2015) 0.75
Molecular portraits of human breast tumours. Nature (2000) 94.14
Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol (2007) 11.04
PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell (2000) 10.25
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature (2007) 9.12
AKAP signalling complexes: focal points in space and time. Nat Rev Mol Cell Biol (2004) 6.97
Effects of oral tolvaptan in patients hospitalized for worsening heart failure: the EVEREST Outcome Trial. JAMA (2007) 6.25
Analysis of gene expression profiles in normal and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer. Proc Natl Acad Sci U S A (2001) 5.57
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Short-term clinical effects of tolvaptan, an oral vasopressin antagonist, in patients hospitalized for heart failure: the EVEREST Clinical Status Trials. JAMA (2007) 4.30
Mutations in the pericentrin (PCNT) gene cause primordial dwarfism. Science (2008) 4.04
From structure to disease: the evolving tale of aquaporin biology. Nat Rev Mol Cell Biol (2004) 4.01
The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways. Nature (2005) 3.82
Localized effects of cAMP mediated by distinct routes of protein kinase A. Physiol Rev (2004) 3.65
The PACT domain, a conserved centrosomal targeting motif in the coiled-coil proteins AKAP450 and pericentrin. EMBO Rep (2000) 3.31
Mutation of an A-kinase-anchoring protein causes long-QT syndrome. Proc Natl Acad Sci U S A (2007) 2.49
Continental differences in clinical characteristics, management, and outcomes in patients hospitalized with worsening heart failure results from the EVEREST (Efficacy of Vasopressin Antagonism in Heart Failure: Outcome Study with Tolvaptan) program. J Am Coll Cardiol (2008) 2.35
Molecular basis of AKAP specificity for PKA regulatory subunits. Mol Cell (2006) 2.33
New life in an old idea: the synaptic plasticity and memory hypothesis revisited. Hippocampus (2002) 2.28
A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase. Mol Cell (2006) 2.27
Phosphorylation-dependent regulation of ryanodine receptors: a novel role for leucine/isoleucine zippers. J Cell Biol (2001) 2.16
Anchoring of protein kinase A is required for modulation of AMPA/kainate receptors on hippocampal neurons. Nature (1994) 2.09
A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events. EMBO J (1998) 2.05
Membrane-targeting sequences on AKAP79 bind phosphatidylinositol-4, 5-bisphosphate. EMBO J (1998) 2.01
AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation. J Biol Chem (2001) 1.96
Loss of AKAP150 perturbs distinct neuronal processes in mice. Proc Natl Acad Sci U S A (2008) 1.96
A-kinase anchoring proteins: from protein complexes to physiology and disease. IUBMB Life (2009) 1.89
Age-dependent requirement of AKAP150-anchored PKA and GluR2-lacking AMPA receptors in LTP. EMBO J (2007) 1.88
Postsynaptic protein phosphorylation and LTP. Trends Neurosci (2000) 1.87
Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice. Proc Natl Acad Sci U S A (2003) 1.86
Targeted disruption of the Akap4 gene causes defects in sperm flagellum and motility. Dev Biol (2002) 1.86
Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring. Proc Natl Acad Sci U S A (2003) 1.80
Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor. J Exp Med (2001) 1.79
mAKAP: an A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes. J Cell Sci (1999) 1.78
A novel mechanism of PKA anchoring revealed by solution structures of anchoring complexes. EMBO J (2001) 1.75
The molecular basis for protein kinase A anchoring revealed by solution NMR. Nat Struct Biol (1999) 1.74
AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum. EMBO Rep (2007) 1.72
AKAP150 is required for stuttering persistent Ca2+ sparklets and angiotensin II-induced hypertension. Circ Res (2008) 1.72
Networking with AKAPs: context-dependent regulation of anchored enzymes. Mol Interv (2010) 1.69
AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade. Nat Cell Biol (2010) 1.64
Pericentrin anchors protein kinase A at the centrosome through a newly identified RII-binding domain. Curr Biol (2000) 1.64
Regulation of actin dynamics by WASP family proteins. J Biochem (2003) 1.63
Designing isoform-specific peptide disruptors of protein kinase A localization. Proc Natl Acad Sci U S A (2003) 1.61
The syndrome of inappropriate antidiuresis: pathophysiology, clinical management and new therapeutic options. Nephron Clin Pract (2011) 1.61
Location of cAMP-dependent protein kinase type I with the TCR-CD3 complex. Science (1994) 1.59
Sympathetic stimulation of adult cardiomyocytes requires association of AKAP5 with a subpopulation of L-type calcium channels. Circ Res (2010) 1.59
AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway. Mol Cell (2008) 1.57
A novel leucine zipper targets AKAP15 and cyclic AMP-dependent protein kinase to the C terminus of the skeletal muscle Ca2+ channel and modulates its function. J Biol Chem (2001) 1.57
Protein kinase A-anchoring inhibitor peptides arrest mammalian sperm motility. J Biol Chem (1997) 1.56
mAKAP and the ryanodine receptor are part of a multi-component signaling complex on the cardiomyocyte nuclear envelope. J Cell Sci (2001) 1.54
Specificity and spatial dynamics of protein kinase A signaling organized by A-kinase-anchoring proteins. J Mol Endocrinol (2010) 1.52
Mechanisms of protein kinase A anchoring. Int Rev Cell Mol Biol (2010) 1.52
Rho GTPases and their role in organizing the actin cytoskeleton. J Cell Sci (2011) 1.50
Anchoring of protein kinase A facilitates hormone-mediated insulin secretion. Proc Natl Acad Sci U S A (1997) 1.50
Delineation of type I protein kinase A-selective signaling events using an RI anchoring disruptor. J Biol Chem (2006) 1.48
The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signaling. J Cell Sci (2005) 1.47
NH2-Terminal targeting motifs direct dual specificity A-kinase-anchoring protein 1 (D-AKAP1) to either mitochondria or endoplasmic reticulum. J Cell Biol (1999) 1.46
Cyclic AMP-mediated immune regulation--overview of mechanisms of action in T cells. Cell Signal (2010) 1.46
Protein kinase A anchoring proteins are required for vasopressin-mediated translocation of aquaporin-2 into cell membranes of renal principal cells. J Biol Chem (1999) 1.45
Regulation of aquaporin-2 trafficking. Handb Exp Pharmacol (2009) 1.45
A novel src- and ras-suppressed protein kinase C substrate associated with cytoskeletal architecture. J Biol Chem (1996) 1.45
Identification of a novel A-kinase anchoring protein 18 isoform and evidence for its role in the vasopressin-induced aquaporin-2 shuttle in renal principal cells. J Biol Chem (2004) 1.39
Molecular analysis of pericentrin gene (PCNT) in a series of 24 Seckel/microcephalic osteodysplastic primordial dwarfism type II (MOPD II) families. J Med Genet (2009) 1.38
Association of a common AKAP9 variant with breast cancer risk: a collaborative analysis. J Natl Cancer Inst (2008) 1.36
Nesprin-1alpha contributes to the targeting of mAKAP to the cardiac myocyte nuclear envelope. Exp Cell Res (2005) 1.34
The A-kinase anchoring protein (AKAP)-Lbc-signaling complex mediates alpha1 adrenergic receptor-induced cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A (2007) 1.34
Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism. Proc Natl Acad Sci U S A (2003) 1.33
Disruption of protein kinase A interaction with A-kinase-anchoring proteins in the heart in vivo: effects on cardiac contractility, protein kinase A phosphorylation, and troponin I proteolysis. J Biol Chem (2008) 1.29
Isolation and molecular characterization of AKAP110, a novel, sperm-specific protein kinase A-anchoring protein. Mol Endocrinol (1999) 1.28
Sodium/calcium exchanger (NCX1) macromolecular complex. J Biol Chem (2003) 1.28
The Src-suppressed C kinase substrate, SSeCKS, is a potential metastasis inhibitor in prostate cancer. Cancer Res (2001) 1.27
Regulatory actions of the A-kinase anchoring protein Yotiao on a heart potassium channel downstream of PKA phosphorylation. Proc Natl Acad Sci U S A (2004) 1.26
Mutations in AKAP5 disrupt dendritic signaling complexes and lead to electrophysiological and behavioral phenotypes in mice. PLoS One (2010) 1.21
The role of SSeCKS/gravin/AKAP12 scaffolding proteins in the spaciotemporal control of signaling pathways in oncogenesis and development . Front Biosci (2002) 1.21
Dynamic anchoring of PKA is essential during oocyte maturation. Curr Biol (2006) 1.20
AKAP-scaffolding proteins and regulation of cardiac physiology. Physiology (Bethesda) (2009) 1.20
A-kinase anchoring proteins: scaffolding proteins in the heart. Am J Physiol Heart Circ Physiol (2011) 1.19
Inhibition of T cell activation by cyclic adenosine 5'-monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin. J Immunol (2007) 1.19
SSeCKS/Gravin/AKAP12 inhibits cancer cell invasiveness and chemotaxis by suppressing a protein kinase C- Raf/MEK/ERK pathway. J Biol Chem (2009) 1.19
The neurobeachin gene is disrupted by a translocation in a patient with idiopathic autism. J Med Genet (2003) 1.19
Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes. J Biol Chem (2010) 1.18
A calcineurin/AKAP complex is required for NMDA receptor-dependent long-term depression. Nat Neurosci (2010) 1.17
Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses. J Physiol (2009) 1.14
The major fibrous sheath polypeptide of mouse sperm: structural and functional similarities to the A-kinase anchoring proteins. Dev Biol (1994) 1.14
Alternative splicing regulates the subcellular localization of A-kinase anchoring protein 18 isoforms. J Cell Biol (1999) 1.13
Regulation of AKAP-membrane interactions by calcium. J Biol Chem (2006) 1.12
Identification of AKAP-4 as a new cancer/testis antigen for detection and immunotherapy of prostate cancer. Prostate (2011) 1.11
AKAP-4: a novel cancer testis antigen for multiple myeloma. Br J Haematol (2008) 1.11
Sphingosine kinase interacting protein is an A-kinase anchoring protein specific for type I cAMP-dependent protein kinase. Chembiochem (2010) 1.11
Loss of the SSeCKS/Gravin/AKAP12 gene results in prostatic hyperplasia. Cancer Res (2008) 1.11
Reorganized PKA-AKAP associations in the failing human heart. J Mol Cell Cardiol (2011) 1.10
Compartmentalized cAMP signalling in regulated exocytic processes in non-neuronal cells. Cell Signal (2007) 1.10
Targeted protein kinase A and PP-2B regulate insulin secretion through reversible phosphorylation. Endocrinology (2001) 1.10
Protein kinase A type I antagonist restores immune responses of T cells from HIV-infected patients. FASEB J (1998) 1.07
Reexpression of the major protein kinase C substrate, SSeCKS, suppresses v-src-induced morphological transformation and tumorigenesis. Cancer Res (1997) 1.07
A molecular switch for targeting between endoplasmic reticulum (ER) and mitochondria: conversion of a mitochondria-targeting element into an ER-targeting signal in DAKAP1. J Biol Chem (2008) 1.05
The mAKAPbeta scaffold regulates cardiac myocyte hypertrophy via recruitment of activated calcineurin. J Mol Cell Cardiol (2009) 1.05
High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A-anchoring disruptor peptides. Biochem J (2006) 1.04
Disruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase-anchoring peptide reduces cardiac function. J Biol Chem (2010) 1.04
Molecular cloning and preliminary characterization of a novel cytoplasmic antigen recognized by myasthenia gravis sera. J Clin Invest (1992) 1.04
AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum. EMBO Rep (2007) 1.72
Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels. J Neurosci (2007) 1.64
A Role of myosin Vb and Rab11-FIP2 in the aquaporin-2 shuttle. Traffic (2006) 1.62
Mechanisms of protein kinase A anchoring. Int Rev Cell Mol Biol (2010) 1.52
Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells. J Am Soc Nephrol (2006) 1.50
Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5. Biochem J (2006) 1.46
Regulation of aquaporin-2 trafficking. Handb Exp Pharmacol (2009) 1.45
Small-molecule screening identifies modulators of aquaporin-2 trafficking. J Am Soc Nephrol (2013) 1.41
Identification of a novel A-kinase anchoring protein 18 isoform and evidence for its role in the vasopressin-induced aquaporin-2 shuttle in renal principal cells. J Biol Chem (2004) 1.39
p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway. J Cell Biol (2007) 1.30
cAMP-induced AQP2 translocation is associated with RhoA inhibition through RhoA phosphorylation and interaction with RhoGDI. J Cell Sci (2003) 1.18
Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes. J Biol Chem (2010) 1.18
Reciprocal regulation of aquaporin-2 abundance and degradation by protein kinase A and p38-MAP kinase. J Am Soc Nephrol (2010) 1.16
Actin remodeling requires ERM function to facilitate AQP2 apical targeting. J Cell Sci (2005) 1.10
Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of beta-arrestin using spot-immobilized peptide arrays. Biochem J (2007) 1.10
Compartmentalized cAMP signalling in regulated exocytic processes in non-neuronal cells. Cell Signal (2007) 1.10
Direct binding between Orai1 and AC8 mediates dynamic interplay between Ca2+ and cAMP signaling. Sci Signal (2012) 1.10
High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A-anchoring disruptor peptides. Biochem J (2006) 1.04
Renal expression of sodium transporters and aquaporin-2 in hypothyroid rats. Am J Physiol Renal Physiol (2003) 1.04
Microtubules are needed for the perinuclear positioning of aquaporin-2 after its endocytic retrieval in renal principal cells. Am J Physiol Cell Physiol (2007) 1.02
MEK1 binds directly to betaarrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization. J Biol Chem (2009) 1.02
The prostaglandin E2 analogue sulprostone antagonizes vasopressin-induced antidiuresis through activation of Rho. J Cell Sci (2003) 1.01
Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein. J Biol Chem (2009) 0.96
Spatial organisation of AKAP18 and PDE4 isoforms in renal collecting duct principal cells. Eur J Cell Biol (2006) 0.96
Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK. Biochem J (2010) 0.91
Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4). J Med Chem (2011) 0.90
PI3Kgamma controls oxidative bursts in neutrophils via interactions with PKCalpha and p47phox. Biochem J (2009) 0.90
Highly functionalized terpyridines as competitive inhibitors of AKAP-PKA interactions. Angew Chem Int Ed Engl (2013) 0.88
Mechanism for targeting the A-kinase anchoring protein AKAP18δ to the membrane. J Biol Chem (2012) 0.87
Vasopressin increases S261 phosphorylation in AQP2-P262L, a mutant in recessive nephrogenic diabetes insipidus. Nephrol Dial Transplant (2012) 0.83
Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function. J Cell Sci (2011) 0.82
Routes of epithelial water flow: aquaporins versus cotransporters. Biophys J (2010) 0.82
Proteomics in aortic aneurysm--what have we learnt so far? Proteomics Clin Appl (2013) 0.82
Spinophilin regulates central angiotensin II-mediated effect on blood pressure. J Mol Med (Berl) (2011) 0.81
Culturing primary rat inner medullary collecting duct cells. J Vis Exp (2013) 0.80
Screening for small molecule disruptors of AKAP-PKA interactions. Methods Mol Biol (2015) 0.77
A key phosphorylation site in AC8 mediates regulation of Ca(2+)-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex. J Cell Sci (2012) 0.77
Protein-protein interactions as new drug targets. Preface. Handb Exp Pharmacol (2008) 0.76
Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques. J Clin Invest (2017) 0.75
AKAPS act in a two-step mechanism of memory acquisition. J Neurosci (2013) 0.75