Published in Science on January 07, 1994
A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase. Mol Cell (2006) 2.27
Epac and PKA: a tale of two intracellular cAMP receptors. Acta Biochim Biophys Sin (Shanghai) (2008) 2.04
Positive and negative regulation of T-cell activation through kinases and phosphatases. Biochem J (2003) 1.84
Mutations and polymorphisms in the gene encoding regulatory subunit type 1-alpha of protein kinase A (PRKAR1A): an update. Hum Mutat (2010) 1.81
D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain. Proc Natl Acad Sci U S A (1997) 1.79
Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor. J Exp Med (2001) 1.79
Assembly of allosteric macromolecular switches: lessons from PKA. Nat Rev Mol Cell Biol (2012) 1.78
Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450. EMBO J (1999) 1.75
Designing isoform-specific peptide disruptors of protein kinase A localization. Proc Natl Acad Sci U S A (2003) 1.61
Creating order from chaos: cellular regulation by kinase anchoring. Annu Rev Pharmacol Toxicol (2012) 1.44
Hippocampal long-term depression and depotentiation are defective in mice carrying a targeted disruption of the gene encoding the RI beta subunit of cAMP-dependent protein kinase. Proc Natl Acad Sci U S A (1995) 1.39
Structure of D-AKAP2:PKA RI complex: insights into AKAP specificity and selectivity. Structure (2010) 1.36
Type II regulatory subunits are not required for the anchoring-dependent modulation of Ca2+ channel activity by cAMP-dependent protein kinase. Proc Natl Acad Sci U S A (1997) 1.28
A-kinase anchoring protein 100 (AKAP100) is localized in multiple subcellular compartments in the adult rat heart. J Cell Biol (1998) 1.27
cAMP signal transduction in the heart: understanding spatial control for the development of novel therapeutic strategies. Br J Pharmacol (2009) 1.25
Altered intracellular and extracellular signaling leads to impaired T-cell functions in ADA-SCID patients. Blood (2008) 1.19
Protein kinase A-dependent and -independent signaling pathways contribute to cyclic AMP-stimulated proliferation. Mol Cell Biol (1999) 1.19
A-kinase anchoring proteins as potential drug targets. Br J Pharmacol (2012) 1.07
The Ca(2+)-activated K(+) channel KCa3.1 compartmentalizes in the immunological synapse of human T lymphocytes. Am J Physiol Cell Physiol (2006) 1.06
Disruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase-anchoring peptide reduces cardiac function. J Biol Chem (2010) 1.04
Novel isoform-specific interfaces revealed by PKA RIIbeta holoenzyme structures. J Mol Biol (2009) 1.03
Reprogrammed gene expression in a somatic cell-free extract. EMBO Rep (2002) 1.03
Characterization of an A-kinase anchoring protein in human ciliary axonemes. Mol Biol Cell (2002) 1.02
Localization and quaternary structure of the PKA RIβ holoenzyme. Proc Natl Acad Sci U S A (2012) 1.02
Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex. Mol Cell Biol (2010) 1.01
Dual specificity A-kinase anchoring proteins (AKAPs) contain an additional binding region that enhances targeting of protein kinase A type I. J Biol Chem (2008) 0.99
Molecular mechanisms underlying β-adrenergic receptor-mediated cross-talk between sympathetic neurons and immune cells. Int J Mol Sci (2015) 0.90
Adenosine regulates CD8 T-cell priming by inhibition of membrane-proximal T-cell receptor signalling. Immunology (2009) 0.90
Muscle-regulated expression and determinants for neuromuscular junctional localization of the mouse RIalpha regulatory subunit of cAMP-dependent protein kinase. Proc Natl Acad Sci U S A (2001) 0.89
Trafficking of intermediate (KCa3.1) and small (KCa2.x) conductance, Ca(2+)-activated K(+) channels: a novel target for medicinal chemistry efforts? ChemMedChem (2012) 0.86
Modulation of T cell immune functions by the prostaglandin E(2) - cAMP pathway in chronic inflammatory states. Br J Pharmacol (2012) 0.85
An EP receptor with a novel pharmacological profile in the T-cell line Jurkat. Br J Pharmacol (1995) 0.83
Structural characterization of the membrane-associated regulatory subunit of type I cAMP-dependent protein kinase by mass spectrometry: identification of Ser81 as the in vivo phosphorylation site of RIalpha. Protein Sci (1999) 0.82
Identification, cloning and characterization of a novel 47 kDa murine PKA C subunit homologous to human and bovine Cbeta2. BMC Biochem (2006) 0.82
Role of soluble adenylyl cyclase in mitochondria. Biochim Biophys Acta (2014) 0.81
T cell receptor induced intracellular redistribution of type I protein kinase A. Immunology (2004) 0.80
CD2 signalling induces phosphorylation of CREB in primary lymphocytes. Immunology (1998) 0.80
Regulation of T cells in airway disease by beta-agonist. Front Biosci (Schol Ed) (2010) 0.79
Molecular Mechanisms for cAMP-Mediated Immunoregulation in T cells - Role of Anchored Protein Kinase A Signaling Units. Front Immunol (2016) 0.77
FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance. Cell (2001) 5.22
Quantification of the terminal complement complex in human plasma by an enzyme-linked immunosorbent assay based on monoclonal antibodies against a neoantigen of the complex. Scand J Immunol (1985) 2.06
Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor. J Exp Med (2001) 1.79
Phosphodiesterase 4D and protein kinase a type II constitute a signaling unit in the centrosomal area. J Biol Chem (2001) 1.78
Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450. EMBO J (1999) 1.75
Monoclonal antibodies recognizing a neoantigen of poly(C9) detect the human terminal complement complex in tissue and plasma. Scand J Immunol (1985) 1.72
HLA class I and II typing using cells positively selected from blood by immunomagnetic isolation--a fast and reliable technique. Tissue Antigens (1986) 1.67
Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase. Nat Cell Biol (1999) 1.62
The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis. J Cell Biol (1999) 1.57
Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase. Mol Endocrinol (1990) 1.56
Magnetic monosized polymer particles for fast and specific fractionation of human mononuclear cells. Scand J Immunol (1985) 1.51
Growth of colorectal polyps: redetection and evaluation of unresected polyps for a period of three years. Gut (1996) 1.50
Molecular cloning and predicted full-length amino acid sequence of the type I beta isozyme of cGMP-dependent protein kinase from human placenta. Tissue distribution and developmental changes in rat. FEBS Lett (1989) 1.39
Cyclic AMP-dependent protein kinase type I mediates the inhibitory effects of 3',5'-cyclic adenosine monophosphate on cell replication in human T lymphocytes. J Biol Chem (1992) 1.37
Structure, function, and regulation of human cAMP-dependent protein kinases. Adv Second Messenger Phosphoprotein Res (1997) 1.34
Release from tonic inhibition of T cell activation through transient displacement of C-terminal Src kinase (Csk) from lipid rafts. J Biol Chem (2001) 1.29
Various keratin antibodies produce immunohistochemical staining of human myocardium and myometrium. Histochemistry (1985) 1.27
Characterization of the human gene encoding the type I alpha and type I beta cGMP-dependent protein kinase (PRKG1). Genomics (1997) 1.27
Spatiotemporal control of cAMP signalling processes by anchored signalling complexes. Biochem Soc Trans (2007) 1.27
Relation between T cell number and epithelial HLA class II expression quantified by image analysis in normal and inflamed human gastric mucosa. Gut (1990) 1.26
Molecular cloning, chromosomal localization, and cell cycle-dependent subcellular distribution of the A-kinase anchoring protein, AKAP95. Exp Cell Res (1998) 1.25
Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis. Dev Biol (2000) 1.22
In situ measurement of colorectal polyps to compare video and fiberoptic endoscopes. Endoscopy (1994) 1.21
Complement activation in rheumatoid arthritis evaluated by C3dg and the terminal complement complex. Arthritis Rheum (1986) 1.20
Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells. J Exp Med (1998) 1.20
In situ characterization of mononuclear cells in rheumatoid tissues, using monoclonal antibodies. No reduction of T8-positive cells or augmentation in T4-positive cells. Scand J Immunol (1982) 1.17
Molecular cloning, cDNA structure, and regulation of the regulatory subunit of type II cAMP-dependent protein kinase from rat ovarian granulosa cells. J Biol Chem (1986) 1.17
Shared idiotypes of human peripheral blood B and T lymphocytes. J Immunol (1979) 1.16
Quantification in enzyme-linked immunosorbent assay of a C3 neoepitope expressed on activated human complement factor C3. Scand J Immunol (1988) 1.15
Complement activation in septic baboons detected by neoepitope-specific assays for C3b/iC3b/C3c, C5a and the terminal C5b-9 complement complex (TCC). Clin Exp Immunol (1993) 1.15
Binucleation and polyploidization patterns in developmental and regenerative rat liver growth. Cell Prolif (1993) 1.14
Specificity in the cAMP/PKA signaling pathway. differential expression, regulation, and subcellular localization of subunits of PKA. Front Biosci (1997) 1.12
Recruitment of protein phosphatase 1 to the nuclear envelope by A-kinase anchoring protein AKAP149 is a prerequisite for nuclear lamina assembly. J Cell Biol (2000) 1.12
Characterization of human mononuclear cells after positive selection with immunomagnetic particles. Scand J Immunol (1986) 1.11
Molecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sites. J Biol Chem (1998) 1.11
Protein kinase A type I antagonist restores immune responses of T cells from HIV-infected patients. FASEB J (1998) 1.07
Increased activation of protein kinase A type I contributes to the T cell deficiency in common variable immunodeficiency. J Immunol (1999) 1.05
HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics. J Cell Sci (2000) 1.04
T cell-specific adapter protein inhibits T cell activation by modulating Lck activity. J Immunol (2000) 1.03
Immunocytochemical localization of Shc and activated EGF receptor in early endosomes after EGF stimulation of HeLa cells. J Histochem Cytochem (2000) 1.03
Fast and slow cyclic nucleotide-dissociation sites in cAMP-dependent protein kinase are transposed in type Ibeta cGMP-dependent protein kinase. J Biol Chem (1996) 1.03
Selective modulation of protein kinase isozymes by the site-selective analog 8-chloroadenosine 3',5'-cyclic monophosphate provides a biological means for control of human colon cancer cell growth. Proc Natl Acad Sci U S A (1988) 1.02
Effect of nephritic factor on C3 and on the terminal pathway of complement in vivo and in vitro. Clin Exp Immunol (1986) 1.01
Steroid binding in polyacrylamide gels. Quantitation at steady state conditions. J Biol Chem (1974) 1.01
Epithelial expression of HLA, secretory component (poly-Ig receptor), and adhesion molecules in the human alimentary tract. Ann N Y Acad Sci (1992) 0.99
Quantitation of cells secreting rheumatoid factor of IgG, IgA, and IgM class after elution from rheumatoid synovial tissue. Arthritis Rheum (1982) 0.99
Androgen transport and receptor mechanisms in testis and epididymis. Nature (1974) 0.99
Re-localization of activated EGF receptor and its signal transducers to multivesicular compartments downstream of early endosomes in response to EGF. Eur J Cell Biol (2001) 0.99
Identification of novel splice variants of the human catalytic subunit Cbeta of cAMP-dependent protein kinase. Eur J Biochem (2001) 0.98
Characterization of a monoclonal antibody MoAb bH6 reacting with a neoepitope of human C3 expressed on C3b, iC3b, and C3c. Scand J Immunol (1988) 0.98
Selective activation of cAMP-dependent protein kinase type I inhibits rat natural killer cell cytotoxicity. J Biol Chem (1997) 0.97
Cyclic AMP-dependent protein kinase (cAK) in human B cells: co-localization of type I cAK (RI alpha 2 C2) with the antigen receptor during anti-immunoglobulin-induced B cell activation. Eur J Immunol (1996) 0.96
Endocytosed epidermal growth factor (EGF) receptors contribute to the EGF-mediated growth arrest in A431 cells by inducing a sustained increase in p21/CIP1. Exp Cell Res (1998) 0.96
Correlation analysis of p53 protein isoforms with NPM1/FLT3 mutations and therapy response in acute myeloid leukemia. Oncogene (2011) 0.96
Molecular cloning and exon-intron mapping of the gene encoding human transmembrane secretory component (the poly-Ig receptor) Eur J Immunol (1992) 0.95
Activated protein kinase A is required for differentiation-dependent transcription of the decidual prolactin gene in human endometrial stromal cells. Endocrinology (1997) 0.95
Exogenous pyruvate accelerates glycolysis and promotes capacitation in human spermatozoa. Hum Reprod (2011) 0.95
Molecular cloning of the human transmembrane secretory component (poly-Ig receptor) and its mRNA expression in human tissues. Biochem Biophys Res Commun (1989) 0.95
cAMP-dependent protein kinase (PKA) inhibits T cell activation by phosphorylating ser-43 of raf-1 in the MAPK/ERK pathway. Cell Signal (2000) 0.94
Ovarian follicular development: from physiology to molecular biology. Recent Prog Horm Res (1987) 0.94
Molecular characterization of choline acetyltransferase from bovine brain caudate nucleus and some immunological properties of the highly purified enzyme. J Neurochem (1978) 0.94
Androgens and androgen-binding protein in the rat epididymis. J Reprod Fertil (1978) 0.93
Cellular localization of the Mn2+-dependent adenylyl cyclase (AC) in rat testis. Int J Androl (1981) 0.92
The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon. Genomics (1998) 0.92
The two mRNA forms for the type I alpha regulatory subunit of cAMP-dependent protein kinase from human testis are due to the use of different polyadenylation site signals. Biochem Biophys Res Commun (1990) 0.92
Non-reactive tuberculosis and malignant blood disorders. J Oslo City Hosp (1972) 0.92
Review: Spatiotemporal dynamics of hCG/cAMP signaling and regulation of placental function. Placenta (2011) 0.91
Mitosis-specific phosphorylation and subcellular redistribution of the RIIalpha regulatory subunit of cAMP-dependent protein kinase. J Biol Chem (1998) 0.91
Androgen receptors in the anterior pituitary and central nervous system of the androgen "insensitive" (Tfm) rat: correlation between receptor binding and effects of androgens on gonadotropin secretion. Endocrinology (1976) 0.91
Molecular cloning, cDNA structure, and chromosomal localization of the human type II cGMP-dependent protein kinase. Biochem Biophys Res Commun (1996) 0.91
T-cell immunoregulatory functions in rheumatoid arthritis patients. Scand J Immunol (1983) 0.91
Lithium carbonate in the management of cannabis withdrawal in humans: an open-label study. J Psychopharmacol (2008) 0.91
Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes. J Biol Chem (1993) 0.90
Detection and quantification of the terminal C5b-9 complex of human complement by a sensitive enzyme-linked immunosorbent assay. Scand J Immunol (1984) 0.90
Identification, cloning and characterization of a novel nuclear protein, HA95, homologous to A-kinase anchoring protein 95. Biol Cell (2000) 0.90
Molecular cloning, complementary deoxyribonucleic acid structure and predicted full-length amino acid sequence of the hormone-inducible regulatory subunit of 3'-5'-cyclic adenosine monophosphate-dependent protein kinase from human testis. Mol Endocrinol (1988) 0.90