Published in Nat Protoc on December 01, 2011
The Role of Ect2 Nuclear RhoGEF Activity in Ovarian Cancer Cell Transformation. Genes Cancer (2013) 0.85
Vimentin intermediate filaments control actin stress fiber assembly through GEF-H1 and RhoA. J Cell Sci (2017) 0.85
Smooth muscle specific Rac1 deficiency induces hypertension by preventing p116RIP3-dependent RhoA inhibition. J Am Heart Assoc (2014) 0.83
Valvular dystrophy associated filamin A mutations reveal a new role of its first repeats in small-GTPase regulation. Biochim Biophys Acta (2013) 0.82
Nuclear RhoA signaling regulates MRTF-dependent SMC-specific transcription. Am J Physiol Heart Circ Physiol (2014) 0.81
Prostaglandins regulate nuclear localization of Fascin and its function in nucleolar architecture. Mol Biol Cell (2015) 0.81
Affinity precipitation of active Rho-GEFs using a GST-tagged mutant Rho protein (GST-RhoA(G17A)) from epithelial cell lysates. J Vis Exp (2012) 0.79
SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide. Mol Cancer Res (2016) 0.79
Generation of a single chain antibody variable fragment (scFv) to sense selectively RhoB activation. PLoS One (2014) 0.77
Endothelial Mechanosignaling: Does One Sensor Fit All? Antioxid Redox Signal (2016) 0.77
Fascin regulates nuclear actin during Drosophila oogenesis. Mol Biol Cell (2016) 0.77
Tension on JAM-A activates RhoA via GEF-H1 and p115 RhoGEF. Mol Biol Cell (2016) 0.77
Bilobol inhibits the lipopolysaccharide-induced expression and distribution of RhoA in HepG2 human hepatocellular carcinoma cells. Oncol Lett (2015) 0.77
piggyBac insertional mutagenesis screen identifies a role for nuclear RHOA in human ES cell differentiation. Stem Cell Reports (2015) 0.76
Protein Kinase A (PKA) Type I Interacts with P-Rex1, a Rac Guanine Nucleotide Exchange Factor: EFFECT ON PKA LOCALIZATION AND P-Rex1 SIGNALING. J Biol Chem (2016) 0.76
Guanine nucleotide exchange factor Dock7 mediates HGF-induced glioblastoma cell invasion via Rac activation. Br J Cancer (2014) 0.76
MVP-Associated Filamin A Mutations Affect FlnA-PTPN12 (PTP-PEST) Interactions. J Cardiovasc Dev Dis (2015) 0.75
Nucleolar localization of Small G protein RhoA is associated with active RNA synthesis in human carcinoma HEp-2 cells. Oncol Lett (2016) 0.75
Detection and Quantification of ADP-Ribosylated RhoA/B by Monoclonal Antibody. Toxins (Basel) (2016) 0.75
Benefit of Mineralocorticoid Receptor Antagonism in AKI: Role of Vascular Smooth Muscle Rac1. J Am Soc Nephrol (2017) 0.75
RNase L Suppresses Androgen Receptor Signaling, Cell Migration and Matrix Metalloproteinase Activity in Prostate Cancer Cells. Int J Mol Sci (2017) 0.75
Mechanochemical feedback underlies coexistence of qualitatively distinct cell polarity patterns within diverse cell populations. Proc Natl Acad Sci U S A (2017) 0.75
The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell (1992) 30.02
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell (1992) 28.36
ras genes. Annu Rev Biochem (1987) 22.59
Rho GTPases and signaling networks. Genes Dev (1997) 11.70
Rho and Rac take center stage. Cell (2004) 10.64
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat Rev Mol Cell Biol (2005) 10.44
Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO J (1999) 9.76
A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants. Science (1987) 7.69
Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases. J Biol Chem (1999) 5.80
Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton. Nat Cell Biol (2002) 4.49
Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases. Nat Cell Biol (1999) 3.18
Fibroblast contractility and actin organization are stimulated by microtubule inhibitors. J Cell Sci (1989) 2.82
GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila. Biochim Biophys Acta (2003) 2.71
Analysis of activated GAPs and GEFs in cell lysates. Methods Enzymol (2006) 2.45
GEFs: structural basis for their activation of small GTP-binding proteins. Trends Biochem Sci (1999) 2.29
Identification of distinct cytoplasmic targets for ras/R-ras and rho regulatory proteins. J Biol Chem (1989) 2.15
Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division. J Cell Biol (2008) 2.08
A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin. J Cell Sci (2007) 1.63
The small GTPase RhoA localizes to the nucleus and is activated by Net1 and DNA damage signals. PLoS One (2011) 1.43
SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis. Mol Biol Cell (2004) 1.42
Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA. J Biol Chem (2001) 1.39
The preparation of subcellular organelles from mouse liver in self-generated gradients of iodixanol. Anal Biochem (1994) 1.37
Distinct signals via Rho GTPases and Src drive shape changes by thrombin and sphingosine-1-phosphate in endothelial cells. J Cell Sci (2002) 1.24
Ras-15A protein shares highly similar dominant-negative biological properties with Ras-17N and forms a stable, guanine-nucleotide resistant complex with CDC25 exchange factor. Oncogene (1994) 1.22
The Rho exchange factor Net1 is regulated by nuclear sequestration. J Biol Chem (2002) 1.22
DLC1 interacts with 14-3-3 proteins to inhibit RhoGAP activity and block nucleocytoplasmic shuttling. J Cell Sci (2008) 1.17
The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity. Mol Cell Biol (2007) 1.07
A bacterial cytotoxin identifies the RhoA exchange factor Net1 as a key effector in the response to DNA damage. PLoS One (2008) 1.00
Disruption of oligomerization induces nucleocytoplasmic shuttling of leukemia-associated rho Guanine-nucleotide exchange factor. Mol Pharmacol (2007) 0.97
Regulated shuttling of Slit-Robo-GTPase activating proteins between nucleus and cytoplasm during brain development. Cell Mol Neurobiol (2007) 0.93
Ultrastructural localization of actin and actin-binding proteins in the nucleus. Histochem Cell Biol (2008) 0.93
Isolation of nuclei and nuclear membranes from animal tissues. Curr Protoc Cell Biol (2001) 0.85
The isolation of nuclei and nuclear membranes from rat liver. Methods Mol Biol (1993) 0.78
RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration. J Cell Biol (2007) 1.71
A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin. J Cell Sci (2007) 1.63
The UDP-sugar-sensing P2Y(14) receptor promotes Rho-mediated signaling and chemotaxis in human neutrophils. Am J Physiol Cell Physiol (2012) 1.57
The small GTPase RhoA localizes to the nucleus and is activated by Net1 and DNA damage signals. PLoS One (2011) 1.43
Chapter 1. Focal adhesions: new angles on an old structure. Int Rev Cell Mol Biol (2009) 1.24
Desmoglein-1/Erbin interaction suppresses ERK activation to support epidermal differentiation. J Clin Invest (2013) 1.11
Plakoglobin regulates cell motility through Rho- and fibronectin-dependent Src signaling. J Cell Sci (2010) 1.08
The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity. Mol Cell Biol (2007) 1.07
Plakophilin 2 couples actomyosin remodeling to desmosomal plaque assembly via RhoA. Mol Biol Cell (2010) 1.04
Inhibition of proteasomes induces accumulation, phosphorylation, and recruitment of HSP27 and alphaB-crystallin to aggresomes. J Biochem (2002) 1.00
Sphingosine 1-phosphate receptor 2 signals through leukemia-associated RhoGEF (LARG), to promote smooth muscle cell differentiation. Arterioscler Thromb Vasc Biol (2010) 0.96