Desmoglein-1/Erbin interaction suppresses ERK activation to support epidermal differentiation.

PubWeight™: 1.11‹?› | Rank: Top 10%

🔗 View Article (PMC 3613912)

Published in J Clin Invest on March 25, 2013

Authors

Robert M Harmon1, Cory L Simpson, Jodi L Johnson, Jennifer L Koetsier, Adi D Dubash, Nicole A Najor, Ofer Sarig, Eli Sprecher, Kathleen J Green

Author Affiliations

1: Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

Articles citing this

The desmosomal protein desmoglein 1 aids recovery of epidermal differentiation after acute UV light exposure. J Invest Dermatol (2014) 1.43

Desmoglein-1 regulates esophageal epithelial barrier function and immune responses in eosinophilic esophagitis. Mucosal Immunol (2013) 1.30

Immature truncated O-glycophenotype of cancer directly induces oncogenic features. Proc Natl Acad Sci U S A (2014) 1.19

Disease mutations in desmoplakin inhibit Cx43 membrane targeting mediated by desmoplakin-EB1 interactions. J Cell Biol (2014) 1.02

Desmosome assembly and dynamics. Trends Cell Biol (2013) 0.96

Desmosomes: regulators of cellular signaling and adhesion in epidermal health and disease. Cold Spring Harb Perspect Med (2014) 0.84

Desmosome regulation and signaling in disease. Cell Tissue Res (2015) 0.84

In vitro assessment of IL-4- or IL-13-mediated changes in the structural components of keratinocytes in mice and humans. J Invest Dermatol (2013) 0.84

Deficiency of Erbin induces resistance of cervical cancer cells to anoikis in a STAT3-dependent manner. Oncogenesis (2013) 0.82

Severe dermatitis, multiple allergies, and metabolic wasting syndrome caused by a novel mutation in the N-terminal plakin domain of desmoplakin. J Allergy Clin Immunol (2015) 0.82

Desmoglein-1, differentiation, and disease. J Clin Invest (2013) 0.81

Dominant de novo DSP mutations cause erythrokeratodermia-cardiomyopathy syndrome. Hum Mol Genet (2015) 0.79

In Vitro Model of the Epidermis: Connecting Protein Function to 3D Structure. Methods Enzymol (2015) 0.79

Keratinocyte detachment-differentiation connection revisited, or anoikis-pityriasi nexus redux. PLoS One (2014) 0.78

Different roles of cadherins in the assembly and structural integrity of the desmosome complex. J Cell Sci (2014) 0.78

Cell adhesion in epidermal development and barrier formation. Curr Top Dev Biol (2015) 0.77

GSK3- and PRMT-1-dependent modifications of desmoplakin control desmoplakin-cytoskeleton dynamics. J Cell Biol (2015) 0.77

Mechanisms of Autoantibody-Induced Pathology. Front Immunol (2017) 0.76

Epidermal Desmoglein 1 Expression Is Reduced in Kidney Transplant Recipients Compared with Immunocompetent Patients. J Invest Dermatol (2016) 0.75

Shoc2/Sur8 protein regulates neurite outgrowth. PLoS One (2014) 0.75

ΔNp63 intronic miR-944 is implicated in the ΔNp63-mediated induction of epidermal differentiation. Nucleic Acids Res (2015) 0.75

The function of Shoc2: A scaffold and beyond. Commun Integr Biol (2016) 0.75

Effect of purified fractions from cell culture supernate of high-density pre-B acute lymphoblastic leukemia cells (ALL3) on the growth of ALL3 cells at low density. Electrophoresis (2016) 0.75

SVEP1 plays a crucial role in epidermal differentiation. Exp Dermatol (2016) 0.75

Phosphorylation of Pkp1 by RIPK4 regulates epidermal differentiation and skin tumorigenesis. EMBO J (2017) 0.75

Articles cited by this

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell (2006) 20.92

A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A (2008) 10.07

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. Nat Biotechnol (2004) 7.69

Ras signalling on the endoplasmic reticulum and the Golgi. Nat Cell Biol (2002) 4.91

Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks. Proc Natl Acad Sci U S A (2007) 4.80

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal (2009) 2.92

ERBIN: a basolateral PDZ protein that interacts with the mammalian ERBB2/HER2 receptor. Nat Cell Biol (2000) 2.90

Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. Nat Methods (2005) 2.87

Mutation of SHOC2 promotes aberrant protein N-myristoylation and causes Noonan-like syndrome with loose anagen hair. Nat Genet (2009) 2.57

Molecular pathogenesis of chronic wounds: the role of beta-catenin and c-myc in the inhibition of epithelialization and wound healing. Am J Pathol (2005) 2.21

Signaling via beta1 integrins and mitogen-activated protein kinase determines human epidermal stem cell fate in vitro. Proc Natl Acad Sci U S A (1999) 2.06

Molecular markers in patients with chronic wounds to guide surgical debridement. Mol Med (2007) 2.06

EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer. Nat Cell Biol (2008) 1.88

Desmoglein 1-dependent suppression of EGFR signaling promotes epidermal differentiation and morphogenesis. J Cell Biol (2009) 1.73

Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. Anal Chem (2004) 1.72

Proximity ligation assays: a recent addition to the proteomics toolbox. Expert Rev Proteomics (2010) 1.70

A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity. Mol Cell (2006) 1.68

The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex. Dev Cell (2010) 1.67

Noonan, Costello and cardio-facio-cutaneous syndromes: dysregulation of the Ras-MAPK pathway. Expert Rev Mol Med (2008) 1.64

Molecular mechanisms of blister formation in bullous impetigo and staphylococcal scalded skin syndrome. J Clin Invest (2002) 1.64

Noonan syndrome: clinical aspects and molecular pathogenesis. Mol Syndromol (2010) 1.60

The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf. Genes Dev (2000) 1.60

The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF. J Biol Chem (2002) 1.59

Desmosomes: adhesive strength and signalling in health and disease. Biochem J (2010) 1.51

Compartmentalized signaling of Ras in fission yeast. Proc Natl Acad Sci U S A (2006) 1.51

Outside-in signaling through integrins and cadherins: a central mechanism to control epidermal growth and differentiation? J Invest Dermatol (2008) 1.50

Lipid rafts and the local density of ErbB proteins influence the biological role of homo- and heteroassociations of ErbB2. J Cell Sci (2002) 1.48

Fusion of docked membranes requires the armadillo repeat protein Vac8p. J Biol Chem (2001) 1.45

Phosphoinositide 3-kinase signaling to Akt promotes keratinocyte differentiation versus death. J Biol Chem (2005) 1.42

Impaired epidermal wound healing in vivo upon inhibition or deletion of Rac1. J Cell Sci (2007) 1.39

Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra. J Proteome Res (2007) 1.37

Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back. Am J Med Genet A (2010) 1.36

Identification of the plakoglobin-binding domain in desmoglein and its role in plaque assembly and intermediate filament anchorage. J Cell Biol (1994) 1.35

Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo. Oncogene (2010) 1.35

Discriminating roles of desmosomal cadherins: beyond desmosomal adhesion. J Dermatol Sci (2006) 1.32

A role for mitogen-activated protein kinase activation by integrins in the pathogenesis of psoriasis. J Clin Invest (2001) 1.31

A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes. J Cell Biol (2009) 1.30

Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex. J Biol Chem (2005) 1.28

Dermatological phenotype in Costello syndrome: consequences of Ras dysregulation in development. Br J Dermatol (2012) 1.25

Erbin suppresses the MAP kinase pathway. J Biol Chem (2002) 1.23

ADAM10-mediated E-cadherin release is regulated by proinflammatory cytokines and modulates keratinocyte cohesion in eczematous dermatitis. J Invest Dermatol (2008) 1.20

The differentiation-dependent desmosomal cadherin desmoglein 1 is a novel caspase-3 target that regulates apoptosis in keratinocytes. J Biol Chem (2005) 1.17

Coordinated expression of desmoglein 1 and desmocollin 1 regulates intercellular adhesion. Differentiation (2004) 1.17

Clinical manifestations of mutations in RAS and related intracellular signal transduction factors. Curr Opin Pediatr (2011) 1.13

Ras/Erk MAPK signaling in epidermal homeostasis and neoplasia. Cell Cycle (2007) 1.13

Extracellular regulated kinase and c-Jun N-terminal kinase are activated in psoriatic involved epidermis. J Dermatol Sci (2002) 1.12

Transcriptional profiling defines the roles of ERK and p38 kinases in epidermal keratinocytes. J Cell Physiol (2008) 1.11

RNA interference in keratinocytes and an organotypic model of human epidermis. Methods Mol Biol (2010) 1.10

Deregulation of keratinocyte differentiation and activation: a hallmark of venous ulcers. J Cell Mol Med (2008) 1.08

Cardio-facio-cutaneous syndrome: does genotype predict phenotype? Am J Med Genet C Semin Med Genet (2011) 1.08

An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells. J Proteome Res (2009) 1.07

Compartmentalized signalling: Ras proteins and signalling nanoclusters. FEBS J (2009) 1.06

Disruption of desmosome assembly by monovalent human pemphigus vulgaris monoclonal antibodies. J Invest Dermatol (2008) 1.05

Striate palmoplantar keratoderma arising from desmoplakin and desmoglein 1 mutations is associated with contrasting perturbations of desmosomes and the keratin filament network. Br J Dermatol (2004) 1.05

Specific protein kinase C isozymes mediate the induction of keratinocyte differentiation markers by calcium. Cell Growth Differ (1995) 1.04

Spectrum of dominant mutations in the desmosomal cadherin desmoglein 1, causing the skin disease striate palmoplantar keratoderma. Eur J Hum Genet (2001) 1.03

Desmosome disassembly in response to pemphigus vulgaris IgG occurs in distinct phases and can be reversed by expression of exogenous Dsg3. J Invest Dermatol (2010) 1.03

Erbin regulates mitogen-activated protein (MAP) kinase activation and MAP kinase-dependent interactions between Merlin and adherens junction protein complexes in Schwann cells. J Biol Chem (2005) 1.02

SHOC2 and CRAF mediate ERK1/2 reactivation in mutant NRAS-mediated resistance to RAF inhibitor. J Biol Chem (2012) 1.01

Nonconventional trafficking of Ras associated with Ras signal organization. Traffic (2006) 1.00

The scaffold protein Shoc2/SUR-8 accelerates the interaction of Ras and Raf. J Biol Chem (2010) 0.99

Broken hearts, woolly hair, and tattered skin: when desmosomal adhesion goes awry. Curr Opin Cell Biol (2007) 0.99

Molecular organization of the desmoglein-plakoglobin complex. J Cell Sci (1998) 0.99

Erbin regulates NRG1 signaling and myelination. Proc Natl Acad Sci U S A (2009) 0.98

Erbin inhibits transforming growth factor beta signaling through a novel Smad-interacting domain. Mol Cell Biol (2007) 0.98

Ligand targeting of EphA2 enhances keratinocyte adhesion and differentiation via desmoglein 1. Mol Biol Cell (2010) 0.97

Chronic wound state exacerbated by oxidative stress in Pax6+/- aniridia-related keratopathy. J Pathol (2008) 0.95

Shoc2 is targeted to late endosomes and required for Erk1/2 activation in EGF-stimulated cells. PLoS One (2012) 0.95

Plakoglobin rescues adhesive defects induced by ectodomain truncation of the desmosomal cadherin desmoglein 1: implications for exfoliative toxin-mediated skin blistering. Am J Pathol (2010) 0.95

Erbin and the NF2 tumor suppressor Merlin cooperatively regulate cell-type-specific activation of PAK2 by TGF-beta. Dev Cell (2009) 0.95

The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression. J Biol Chem (2001) 0.93

Screening for EphB signaling effectors using SILAC with a linear ion trap-orbitrap mass spectrometer. J Proteome Res (2008) 0.90

Internalization of EGF receptor following lipid rafts disruption in keratinocytes is delayed and dependent on p38 MAPK activation. J Cell Physiol (2008) 0.90

ERBIN associates with p0071, an armadillo protein, at cell-cell junctions of epithelial cells. Genes Cells (2002) 0.88

Mutation analysis of the SHOC2 gene in Noonan-like syndrome and in hematologic malignancies. J Hum Genet (2010) 0.88

Ras and calcium signaling pathways converge at Raf1 via the Shoc2 scaffold protein. Mol Biol Cell (2010) 0.88

Temporal smad7 transgene induction in mouse epidermis accelerates skin wound healing. Am J Pathol (2011) 0.88

A nonsense mutation in the desmoglein 1 gene underlies striate keratoderma. Exp Dermatol (2003) 0.87

Striate palmoplantar keratoderma resulting from a frameshift mutation in the desmoglein 1 gene. J Dermatol Sci (2006) 0.87

Comparative analysis of the expression of ERBIN and Erb-B2 in normal human skin and cutaneous carcinomas. Br J Dermatol (2005) 0.87

β2-AR-induced Her2 transactivation mediated by Erbin confers protection from apoptosis in cardiomyocytes. Int J Cardiol (2012) 0.85

The desmoglein-specific cytoplasmic region is intrinsically disordered in solution and interacts with multiple desmosomal protein partners. J Mol Biol (2008) 0.84

The C-terminal unique region of desmoglein 2 inhibits its internalization via tail-tail interactions. J Cell Biol (2012) 0.84

Differential expression of phosphorylated extracellular signal-regulated kinase 1/2, phosphorylated p38 mitogen-activated protein kinase and nuclear factor-kappaB p105/p50 in chronic inflammatory skin diseases. J Dermatol (2009) 0.84

Sur8/Shoc2 involves both inhibition of differentiation and maintenance of self-renewal of neural progenitor cells via modulation of extracellular signal-regulated kinase signaling. Stem Cells (2011) 0.83

Mutations in the desmoglein 1 gene in five Pakistani families with striate palmoplantar keratoderma. J Dermatol Sci (2009) 0.81

Palmitoylation of ERBIN is required for its plasma membrane localization. Genes Cells (2008) 0.81

Mutation in DSG1 causing autosomal dominant striate palmoplantar keratoderma. Br J Dermatol (2009) 0.80

The classical nuclear localization signal receptor, importin-alpha, is required for efficient transition through the G1/S stage of the cell cycle in Saccharomyces cerevisiae. Genetics (2008) 0.80

The PDZ protein erbin modulates beta-catenin-dependent transcription. Eur Surg Res (2008) 0.80

Diffuse nonepidermolytic palmoplantar keratoderma caused by a recurrent nonsense mutation in DSG1. Arch Dermatol (2005) 0.79

Novel mutations in DSG1 causing striate palmoplantar keratoderma. Clin Exp Dermatol (2008) 0.79

ERBIN is a new SARA-interacting protein: competition between SARA and SMAD2 and SMAD3 for binding to ERBIN. J Cell Sci (2011) 0.78

Visualisation by electron microscopy of the unique part of the cytoplasmic domain of a desmoglein, a cadherin-like protein of the desmosome type of cell junction. FEBS Lett (1994) 0.78

Disruption of ERBB2IP is not associated with dystrophic epidermolysis bullosa in both father and son carrying a balanced 5;13 translocation. J Invest Dermatol (2005) 0.76

Terminal differentiation and mitogen-activated protein kinase signaling in human cholesteatoma epithelium. Otol Neurotol (2006) 0.76

Articles by these authors

Revealing modular organization in the yeast transcriptional network. Nat Genet (2002) 6.73

Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosis. Nat Genet (2004) 3.13

Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy. Circ Res (2006) 2.95

Revised nomenclature and classification of inherited ichthyoses: results of the First Ichthyosis Consensus Conference in Sorèze 2009. J Am Acad Dermatol (2010) 2.87

Desmosomes: new perspectives on a classic. J Invest Dermatol (2007) 2.78

Working out the strength and flexibility of desmosomes. Nat Rev Mol Cell Biol (2004) 2.63

Molecular analysis of 250 patients with autosomal recessive congenital ichthyosis: evidence for mutation hotspots in ALOXE3 and allelic heterogeneity in ALOX12B. J Invest Dermatol (2009) 2.58

Absence of intraepidermal glycosyltransferase ppGalNac-T3 expression in familial tumoral calcinosis. Am J Dermatopathol (2005) 2.09

p120 catenin associates with kinesin and facilitates the transport of cadherin-catenin complexes to intercellular junctions. J Cell Biol (2003) 2.02

Structures of two intermediate filament-binding fragments of desmoplakin reveal a unique repeat motif structure. Nat Struct Biol (2002) 1.97

Mutations in ABCA12 underlie the severe congenital skin disease harlequin ichthyosis. Am J Hum Genet (2005) 1.97

Interactions between ankyrin-G, Plakophilin-2, and Connexin43 at the cardiac intercalated disc. Circ Res (2011) 1.95

Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis. Nat Rev Mol Cell Biol (2011) 1.94

Plakins: a family of versatile cytolinker proteins. Trends Cell Biol (2002) 1.91

Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling. J Biol Chem (2002) 1.84

Intermediate filament-membrane attachments function synergistically with actin-dependent contacts to regulate intercellular adhesive strength. J Cell Biol (2002) 1.83

Regulation of desmosome assembly and adhesion. Semin Cell Dev Biol (2004) 1.74

Desmoglein 1-dependent suppression of EGFR signaling promotes epidermal differentiation and morphogenesis. J Cell Biol (2009) 1.73

cis-Acting determinants of heterochromatin formation on Drosophila melanogaster chromosome four. Mol Cell Biol (2004) 1.71

Inflammatory peeling skin syndrome caused by a mutation in CDSN encoding corneodesmosin. J Invest Dermatol (2010) 1.71

A deleterious mutation in SAMD9 causes normophosphatemic familial tumoral calcinosis. Am J Hum Genet (2006) 1.57

Autosomal recessive ichthyosis with hypotrichosis caused by a mutation in ST14, encoding type II transmembrane serine protease matriptase. Am J Hum Genet (2007) 1.56

Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly. J Cell Biol (2008) 1.47

A comparative study of immunohistochemistry and electron microscopy used in the diagnosis of epidermolysis bullosa. Am J Dermatopathol (2003) 1.44

A novel homozygous missense mutation in FGF23 causes Familial Tumoral Calcinosis associated with disseminated visceral calcification. Hum Genet (2005) 1.43

Desmoplakin regulates desmosome hyperadhesion. J Invest Dermatol (2011) 1.41

Reply to ultrastructural study of the clinically uninvolved skin in familial tumoral calcinosis caused by mutations in GALNT3. Am J Dermatopathol (2006) 1.40

Identification of a recurrent mutation in GALNT3 demonstrates that hyperostosis-hyperphosphatemia syndrome and familial tumoral calcinosis are allelic disorders. J Mol Med (Berl) (2004) 1.40

Hyperphosphatemic familial tumoral calcinosis caused by a mutation in GALNT3 in a European kindred. J Hum Genet (2006) 1.38

Epidermal growth factor receptor inhibition promotes desmosome assembly and strengthens intercellular adhesion in squamous cell carcinoma cells. J Biol Chem (2004) 1.37

Defining desmosomal plakophilin-3 interactions. J Cell Biol (2003) 1.36

Desmoplakin assembly dynamics in four dimensions: multiple phases differentially regulated by intermediate filaments and actin. J Cell Biol (2005) 1.35

Discriminating roles of desmosomal cadherins: beyond desmosomal adhesion. J Dermatol Sci (2006) 1.32

Plakoglobin suppresses keratinocyte motility through both cell-cell adhesion-dependent and -independent mechanisms. Proc Natl Acad Sci U S A (2005) 1.29

Alopecia, neurological defects, and endocrinopathy syndrome caused by decreased expression of RBM28, a nucleolar protein associated with ribosome biogenesis. Am J Hum Genet (2008) 1.27

Desmoglein-2: a novel regulator of apoptosis in the intestinal epithelium. Mol Biol Cell (2007) 1.27

Normophosphatemic familial tumoral calcinosis is caused by deleterious mutations in SAMD9, encoding a TNF-alpha responsive protein. J Invest Dermatol (2007) 1.25

A novel missense mutation in SLC5A2 encoding SGLT2 underlies autosomal-recessive renal glucosuria and aminoaciduria. Kidney Int (2005) 1.21

Naegeli-Franceschetti-Jadassohn syndrome and dermatopathia pigmentosa reticularis: two allelic ectodermal dysplasias caused by dominant mutations in KRT14. Am J Hum Genet (2006) 1.21

Down-regulation of SNAIL suppresses MIN mouse tumorigenesis: modulation of apoptosis, proliferation, and fractal dimension. Mol Cancer Ther (2004) 1.21

The differentiation-dependent desmosomal cadherin desmoglein 1 is a novel caspase-3 target that regulates apoptosis in keratinocytes. J Biol Chem (2005) 1.17

Coordinated expression of desmoglein 1 and desmocollin 1 regulates intercellular adhesion. Differentiation (2004) 1.17

SERKAL syndrome: an autosomal-recessive disorder caused by a loss-of-function mutation in WNT4. Am J Hum Genet (2008) 1.16

Familial pityriasis rubra pilaris is caused by mutations in CARD14. Am J Hum Genet (2012) 1.16

Mechanisms of plakoglobin-dependent adhesion: desmosome-specific functions in assembly and regulation by epidermal growth factor receptor. J Biol Chem (2005) 1.15

Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus. Mol Biol Cell (2003) 1.14

Desmosomes at a glance. J Cell Sci (2009) 1.14

Plakophilins: multifunctional scaffolds for adhesion and signaling. Curr Opin Cell Biol (2009) 1.13

Olmsted syndrome: mutilating palmoplantar keratoderma with periorificial keratotic plaques. J Am Acad Dermatol (2005) 1.11

Familial tumoral calcinosis and the role of O-glycosylation in the maintenance of phosphate homeostasis. Biochim Biophys Acta (2008) 1.10

ABCA12 is the major harlequin ichthyosis gene. J Invest Dermatol (2006) 1.08

Plakoglobin regulates cell motility through Rho- and fibronectin-dependent Src signaling. J Cell Sci (2010) 1.08

The alopecias associated with vitamin D-dependent rickets type IIA and with hairless gene mutations: a comparative clinical, histologic, and immunohistochemical study. Arch Dermatol (2005) 1.07

Functional characterization of SAMD9, a protein deficient in normophosphatemic familial tumoral calcinosis. J Invest Dermatol (2010) 1.07

The nuclear RhoA exchange factor Net1 interacts with proteins of the Dlg family, affects their localization, and influences their tumor suppressor activity. Mol Cell Biol (2007) 1.07

EGFR and ADAMs cooperate to regulate shedding and endocytic trafficking of the desmosomal cadherin desmoglein 2. Mol Biol Cell (2008) 1.07

The barrier function of skin: how to keep a tight lid on water loss. Trends Cell Biol (2002) 1.06

Analysis of RhoA and Rho GEF activity in whole cells and the cell nucleus. Nat Protoc (2011) 1.05

Infantile mitochondrial hepatopathy is a cardinal feature of MEGDEL syndrome (3-methylglutaconic aciduria type IV with sensorineural deafness, encephalopathy and Leigh-like syndrome) caused by novel mutations in SERAC1. Am J Med Genet A (2013) 1.04

Down-regulation of the tumor suppressor gene C-terminal Src kinase: an early event during premalignant colonic epithelial hyperproliferation. FEBS Lett (2005) 1.04

Plakophilin 2 couples actomyosin remodeling to desmosomal plaque assembly via RhoA. Mol Biol Cell (2010) 1.04

Proteinase suppression by E-cadherin-mediated cell-cell attachment in premalignant oral keratinocytes. J Biol Chem (2002) 1.02

Defective lamellar granule secretion in arthrogryposis, renal dysfunction, and cholestasis syndrome caused by a mutation in VPS33B. Arch Dermatol (2008) 1.02

Inducible nitric oxide synthase (iNOS) mediates the early increase of blood supply (EIBS) in colon carcinogenesis. FEBS Lett (2007) 1.01

Intermediate filament assembly: dynamics to disease. Trends Cell Biol (2008) 1.01

The calcium ATPase SERCA2 regulates desmoplakin dynamics and intercellular adhesive strength through modulation of PKCα signaling. FASEB J (2010) 1.01

In vitro analysis of LIPH mutations causing hypotrichosis simplex: evidence confirming the role of lipase H and lysophosphatidic acid in hair growth. J Invest Dermatol (2009) 1.00

The chemopreventive bioflavonoid apigenin inhibits prostate cancer cell motility through the focal adhesion kinase/Src signaling mechanism. Cancer Prev Res (Phila) (2009) 1.00

Structure, function, and regulation of desmosomes. Prog Mol Biol Transl Sci (2013) 1.00

ADULT syndrome caused by a mutation previously associated with EEC syndrome. Pediatr Dermatol (2010) 0.99

New insights into the molecular basis of desmoplakin- and desmin-related cardiomyopathies. J Cell Sci (2006) 0.99

Desmosomal cadherins utilize distinct kinesins for assembly into desmosomes. J Cell Biol (2011) 0.98

The immigration delay disease: adermatoglyphia-inherited absence of epidermal ridges. J Am Acad Dermatol (2010) 0.98

Comparative analysis of armadillo family proteins in the regulation of a431 epithelial cell junction assembly, adhesion and migration. J Invest Dermatol (2004) 0.98

Targeting of p0071 to desmosomes and adherens junctions is mediated by different protein domains. J Cell Sci (2003) 0.96

Sphingosine 1-phosphate receptor 2 signals through leukemia-associated RhoGEF (LARG), to promote smooth muscle cell differentiation. Arterioscler Thromb Vasc Biol (2010) 0.96

Short stature, onychodysplasia, facial dysmorphism, and hypotrichosis syndrome is caused by a POC1A mutation. Am J Hum Genet (2012) 0.96

Identification of mutations in the human hairless gene in two new families with congenital atrichia. Arch Dermatol Res (2007) 0.96

Ordered assembly of the adhesive and electrochemical connections within newly formed intercalated disks in primary cultures of adult rat cardiomyocytes. J Biomed Biotechnol (2010) 0.96

Desmosome assembly and dynamics. Trends Cell Biol (2013) 0.96

A comparison of anti-desmoglein antibodies and indirect immunofluorescence in the serodiagnosis of pemphigus vulgaris. Int J Dermatol (2005) 0.95

Plakoglobin rescues adhesive defects induced by ectodomain truncation of the desmosomal cadherin desmoglein 1: implications for exfoliative toxin-mediated skin blistering. Am J Pathol (2010) 0.95

A novel mutation in RASA1 causes capillary malformation and limb enlargement. Arch Dermatol Res (2008) 0.95

Enhancement of UVB-induced apoptosis by apigenin in human keratinocytes and organotypic keratinocyte cultures. Cancer Res (2008) 0.94

Loss of SNAP29 impairs endocytic recycling and cell motility. PLoS One (2010) 0.93

Detection of differentially expressed basal cell proteins by mass spectrometry. Mol Cell Proteomics (2009) 0.92

GALNT3, a gene associated with hyperphosphatemic familial tumoral calcinosis, is transcriptionally regulated by extracellular phosphate and modulates matrix metalloproteinase activity. Biochim Biophys Acta (2008) 0.92

In vitro methods for investigating desmoplakin-intermediate filament interactions and their role in adhesive strength. Methods Cell Biol (2004) 0.92

A mutation in LIPN, encoding epidermal lipase N, causes a late-onset form of autosomal-recessive congenital ichthyosis. Am J Hum Genet (2011) 0.92

A missense mutation in CDH3, encoding P-cadherin, causes hypotrichosis with juvenile macular dystrophy. J Invest Dermatol (2002) 0.92

RIN2 deficiency results in macrocephaly, alopecia, cutis laxa, and scoliosis: MACS syndrome. Am J Hum Genet (2009) 0.92