| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor.
|
Cancer Res
|
2007
|
3.37
|
|
2
|
Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response.
|
Hepatology
|
2008
|
2.79
|
|
3
|
Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR.
|
Science
|
2002
|
2.66
|
|
4
|
Alterations in xenobiotic metabolism in the long-lived Little mice.
|
Aging Cell
|
2007
|
2.35
|
|
5
|
Retracted
Deficiency of G-protein-coupled bile acid receptor Gpbar1 (TGR5) enhances chemically induced liver carcinogenesis.
|
Hepatology
|
2013
|
2.16
|
|
6
|
Gadd45beta is induced through a CAR-dependent, TNF-independent pathway in murine liver hyperplasia.
|
Hepatology
|
2005
|
1.82
|
|
7
|
Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease.
|
Proc Natl Acad Sci U S A
|
2009
|
1.77
|
|
8
|
The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor κ light-chain enhancer of activated B cells (NF-κB) in mice.
|
Hepatology
|
2011
|
1.71
|
|
9
|
miR-194 is a marker of hepatic epithelial cells and suppresses metastasis of liver cancer cells in mice.
|
Hepatology
|
2010
|
1.66
|
|
10
|
FXR: a metabolic regulator and cell protector.
|
Cell Res
|
2008
|
1.59
|
|
11
|
Deletion of IFNγ enhances hepatocarcinogenesis in FXR knockout mice.
|
J Hepatol
|
2012
|
1.51
|
|
12
|
The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity.
|
J Biol Chem
|
2004
|
1.38
|
|
13
|
Farnesoid X receptor alleviates age-related proliferation defects in regenerating mouse livers by activating forkhead box m1b transcription.
|
Hepatology
|
2010
|
1.29
|
|
14
|
Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression.
|
Mol Pharmacol
|
2008
|
1.24
|
|
15
|
FXR regulates liver repair after CCl4-induced toxic injury.
|
Mol Endocrinol
|
2010
|
1.23
|
|
16
|
C-Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia.
|
Hepatology
|
2008
|
1.22
|
|
17
|
Farnesoid X receptor protects liver cells from apoptosis induced by serum deprivation in vitro and fasting in vivo.
|
Mol Endocrinol
|
2008
|
1.20
|
|
18
|
MicroRNA-26a targets ten eleven translocation enzymes and is regulated during pancreatic cell differentiation.
|
Proc Natl Acad Sci U S A
|
2013
|
1.14
|
|
19
|
TGR5: a novel target for weight maintenance and glucose metabolism.
|
Exp Diabetes Res
|
2011
|
1.12
|
|
20
|
The Nrf2 activator oltipraz also activates the constitutive androstane receptor.
|
Drug Metab Dispos
|
2008
|
1.08
|
|
21
|
Hepatocarcinogenesis in FXR-/- mice mimics human HCC progression that operates through HNF1α regulation of FXR expression.
|
Mol Endocrinol
|
2012
|
1.08
|
|
22
|
Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins.
|
Hepatology
|
2006
|
1.06
|
|
23
|
Significance and mechanism of CYP7a1 gene regulation during the acute phase of liver regeneration.
|
Mol Endocrinol
|
2008
|
1.05
|
|
24
|
Promotion of liver regeneration/repair by farnesoid X receptor in both liver and intestine in mice.
|
Hepatology
|
2012
|
1.04
|
|
25
|
Sox9, a master regulator of chondrogenesis, distinguishes mesenchymal chondrosarcoma from other small blue round cell tumors.
|
Hum Pathol
|
2003
|
1.03
|
|
26
|
Farnesoid X receptor protects hepatocytes from injury by repressing miR-199a-3p, which increases levels of LKB1.
|
Gastroenterology
|
2012
|
1.03
|
|
27
|
Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells.
|
Mol Oncol
|
2012
|
1.02
|
|
28
|
Nuclear bile acid receptor FXR in the hepatic regeneration.
|
Biochim Biophys Acta
|
2010
|
1.02
|
|
29
|
CaMKII γ, a critical regulator of CML stem/progenitor cells, is a target of the natural product berbamine.
|
Blood
|
2012
|
1.02
|
|
30
|
FXR protects lung from lipopolysaccharide-induced acute injury.
|
Mol Endocrinol
|
2011
|
1.00
|
|
31
|
FXR, a target for different diseases.
|
Histol Histopathol
|
2008
|
0.97
|
|
32
|
The environmental estrogen, nonylphenol, activates the constitutive androstane receptor.
|
Toxicol Sci
|
2007
|
0.97
|
|
33
|
Induction of multidrug resistance protein 3 (mrp3) in vivo is independent of constitutive androstane receptor.
|
Drug Metab Dispos
|
2003
|
0.97
|
|
34
|
Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver.
|
Hepatology
|
2012
|
0.97
|
|
35
|
Downregulation of nuclear receptor FXR is associated with multiple malignant clinicopathological characteristics in human hepatocellular carcinoma.
|
Am J Physiol Gastrointest Liver Physiol
|
2012
|
0.95
|
|
36
|
MicroRNA-26a regulates insulin sensitivity and metabolism of glucose and lipids.
|
J Clin Invest
|
2015
|
0.95
|
|
37
|
Berbamine inhibits the growth of liver cancer cells and cancer-initiating cells by targeting Ca²⁺/calmodulin-dependent protein kinase II.
|
Mol Cancer Ther
|
2013
|
0.90
|
|
38
|
Bile Acid Receptors and Liver Cancer.
|
Curr Pathobiol Rep
|
2012
|
0.88
|
|
39
|
Molecular mechanism of liver cancer.
|
Anticancer Agents Med Chem
|
2011
|
0.87
|
|
40
|
Insufficient bile acid signaling impairs liver repair in CYP27(-/-) mice.
|
J Hepatol
|
2011
|
0.84
|
|
41
|
Loss of B7-H1 expression by recipient parenchymal cells leads to expansion of infiltrating donor CD8+ T cells and persistence of graft-versus-host disease.
|
J Immunol
|
2011
|
0.83
|
|
42
|
Ginsenoside Rb1 protects rat retinal ganglion cells against hypoxia and oxidative stress.
|
Mol Med Rep
|
2013
|
0.83
|
|
43
|
Low-molecular-weight fibroblast growth factor 2 attenuates hepatic fibrosis by epigenetic down-regulation of Delta-like1.
|
Hepatology
|
2015
|
0.82
|
|
44
|
The nuclear receptor CAR modulates alcohol-induced liver injury.
|
Lab Invest
|
2011
|
0.81
|
|
45
|
Farnesoid X receptor antagonizes JNK signaling pathway in liver carcinogenesis by activating SOD3.
|
Mol Endocrinol
|
2014
|
0.80
|
|
46
|
Gender dictates the nuclear receptor-mediated regulation of CYP3A44.
|
Drug Metab Dispos
|
2006
|
0.77
|
|
47
|
Mitochondrial ND5 12338T>C variant is associated with maternally inherited hypertrophic cardiomyopathy in a Chinese pedigree.
|
Gene
|
2012
|
0.76
|
|
48
|
Oxaliplatin but not irinotecan impairs posthepatectomy liver regeneration in a murine model.
|
Int J Hepatol
|
2011
|
0.75
|