Published in Mol Pharmacol on January 10, 2008
Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease. Proc Natl Acad Sci U S A (2009) 1.77
The constitutive androstane receptor is an anti-obesity nuclear receptor that improves insulin sensitivity. J Biol Chem (2009) 1.53
Intestinal microbiota regulate xenobiotic metabolism in the liver. PLoS One (2009) 1.49
The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism. Nucl Recept Signal (2009) 1.41
Pregnane X receptor and constitutive androstane receptor at the crossroads of drug metabolism and energy metabolism. Drug Metab Dispos (2010) 1.18
Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation. Curr Pharmacogenomics Person Med (2009) 1.10
Sterol regulation of metabolism, homeostasis, and development. Annu Rev Biochem (2011) 1.08
Drug metabolism alterations in nonalcoholic fatty liver disease. Drug Metab Rev (2011) 1.07
Pathogenesis of alcoholic liver disease: the role of nuclear receptors. Exp Biol Med (Maywood) (2010) 1.00
PCB153-elicited hepatic responses in the immature, ovariectomized C57BL/6 mice: comparative toxicogenomic effects of dioxin and non-dioxin-like ligands. Toxicol Appl Pharmacol (2009) 1.00
Activation of PXR induces hypercholesterolemia in wild-type and accelerates atherosclerosis in apoE deficient mice. J Lipid Res (2009) 0.98
Attenuated progression of diet-induced steatohepatitis in glutathione-deficient mice. Lab Invest (2010) 0.97
Targeting xenobiotic receptors PXR and CAR for metabolic diseases. Trends Pharmacol Sci (2012) 0.97
Orphan nuclear receptors as targets for drug development. Pharm Res (2010) 0.97
Deficiency of PXR decreases atherosclerosis in apoE-deficient mice. J Lipid Res (2011) 0.96
Activation of pregnane X receptor by pregnenolone 16 α-carbonitrile prevents high-fat diet-induced obesity in AKR/J mice. PLoS One (2012) 0.95
Non-additive hepatic gene expression elicited by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 2,2',4,4',5,5'-hexachlorobiphenyl (PCB153) co-treatment in C57BL/6 mice. Toxicol Appl Pharmacol (2011) 0.89
A functional cross-talk between liver X receptor-α and constitutive androstane receptor links lipogenesis and xenobiotic responses. Mol Pharmacol (2010) 0.88
Maternal nutrition induces pervasive gene expression changes but no detectable DNA methylation differences in the liver of adult offspring. PLoS One (2014) 0.88
Signaling control of the constitutive androstane receptor (CAR). Protein Cell (2014) 0.87
Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers. BMC Genomics (2009) 0.87
Chronic exposure to rifaximin causes hepatic steatosis in pregnane X receptor-humanized mice. Toxicol Sci (2012) 0.85
Role of pregnane X receptor in obesity and glucose homeostasis in male mice. J Biol Chem (2013) 0.83
Prenatal metformin exposure in mice programs the metabolic phenotype of the offspring during a high fat diet at adulthood. PLoS One (2013) 0.83
Evaluation of Aroclor 1260 exposure in a mouse model of diet-induced obesity and non-alcoholic fatty liver disease. Toxicol Appl Pharmacol (2014) 0.82
Deciphering the roles of the constitutive androstane receptor in energy metabolism. Acta Pharmacol Sin (2014) 0.82
Constitutive androstane receptor activation decreases plasma apolipoprotein B-containing lipoproteins and atherosclerosis in low-density lipoprotein receptor-deficient mice. Arterioscler Thromb Vasc Biol (2011) 0.81
Nuclear receptors and nonalcoholic fatty liver disease. Biochim Biophys Acta (2016) 0.81
Insights into CYP2B6-mediated drug-drug interactions. Acta Pharm Sin B (2016) 0.78
Nuclear receptors in nonalcoholic Fatty liver disease. J Lipids (2011) 0.78
Intestinal pregnane X receptor links xenobiotic exposure and hypercholesterolemia. Mol Endocrinol (2015) 0.78
Small-molecule modulators of PXR and CAR. Biochim Biophys Acta (2016) 0.78
Liver transcriptome analysis of Atlantic cod (Gadus morhua) exposed to PCB 153 indicates effects on cell cycle regulation and lipid metabolism. BMC Genomics (2014) 0.77
Novel functions of PXR in cardiometabolic disease. Biochim Biophys Acta (2016) 0.77
Small-molecule modulators of the constitutive androstane receptor. Expert Opin Drug Metab Toxicol (2015) 0.77
Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator Interactions. Front Pharmacol (2016) 0.76
Nigramide J is a novel potent inverse agonist of the human constitutive androstane receptor. Pharmacol Res Perspect (2014) 0.76
Xenobiotic Receptor-Mediated Regulation of Intestinal Barrier Function and Innate Immunity. Nucl Receptor Res (2016) 0.75
Bovine NR1I3 gene polymorphisms and its association with feed efficiency traits in Nellore cattle. Meta Gene (2014) 0.75
Regulation of PXR and CAR by protein-protein interaction and signaling crosstalk. Expert Opin Drug Metab Toxicol (2016) 0.75
Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration. Science (2006) 5.52
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest (2004) 4.65
A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature (2011) 4.44
Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha. Cell (2005) 3.54
Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice. Blood (2007) 3.52
Redundant pathways for negative feedback regulation of bile acid production. Dev Cell (2002) 3.51
Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Invest (2006) 3.44
Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor. Cancer Res (2007) 3.37
The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors. Nat Immunol (2011) 2.81
Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response. Hepatology (2008) 2.79
Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms. Blood (2014) 2.72
Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR. Science (2002) 2.66
Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms. Blood (2010) 2.61
Molecular characterization of the role of orphan receptor small heterodimer partner in development of fatty liver. Hepatology (2007) 2.53
Induction of bilirubin clearance by the constitutive androstane receptor (CAR). Proc Natl Acad Sci U S A (2003) 2.44
The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+). Mol Cell (2011) 2.36
Alterations in xenobiotic metabolism in the long-lived Little mice. Aging Cell (2007) 2.35
Retracted Deficiency of G-protein-coupled bile acid receptor Gpbar1 (TGR5) enhances chemically induced liver carcinogenesis. Hepatology (2013) 2.16
Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. Nat Struct Mol Biol (2005) 2.03
A natural product that lowers cholesterol as an antagonist ligand for FXR. Science (2002) 1.99
Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism. Endocrinology (2004) 1.89
Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption. Cell Metab (2011) 1.89
The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes. Cell Metab (2005) 1.89
Orphan receptor small heterodimer partner suppresses tumorigenesis by modulating cyclin D1 expression and cellular proliferation. Hepatology (2008) 1.83
Gadd45beta is induced through a CAR-dependent, TNF-independent pathway in murine liver hyperplasia. Hepatology (2005) 1.82
Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor. Mol Endocrinol (2005) 1.79
Induction of drug metabolism: the role of nuclear receptors. Pharmacol Rev (2003) 1.78
Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease. Proc Natl Acad Sci U S A (2009) 1.77
The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor κ light-chain enhancer of activated B cells (NF-κB) in mice. Hepatology (2011) 1.71
NUBIScan, an in silico approach for prediction of nuclear receptor response elements. Mol Endocrinol (2002) 1.67
miR-194 is a marker of hepatic epithelial cells and suppresses metastasis of liver cancer cells in mice. Hepatology (2010) 1.66
A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR. J Clin Invest (2004) 1.64
A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification. Mol Pharmacol (2004) 1.59
FXR: a metabolic regulator and cell protector. Cell Res (2008) 1.59
All-trans-retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade. Hepatology (2014) 1.59
Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury. Proc Natl Acad Sci U S A (2005) 1.57
Deletion of IFNγ enhances hepatocarcinogenesis in FXR knockout mice. J Hepatol (2012) 1.51
Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas. Mol Endocrinol (2009) 1.49
Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. J Biol Chem (2004) 1.46
Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner. J Biol Chem (2001) 1.46
The allele burden of JAK2 mutations remains stable over several years in patients with myeloproliferative disorders. Haematologica (2008) 1.45
Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in mice. PLoS One (2010) 1.45
Resistance of SHP-null mice to bile acid-induced liver damage. J Biol Chem (2003) 1.44
The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity. J Biol Chem (2004) 1.38
Stigmasterol, a soy lipid-derived phytosterol, is an antagonist of the bile acid nuclear receptor FXR. Pediatr Res (2007) 1.38
Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR. Mol Endocrinol (2004) 1.36
Differential regulation of the orphan nuclear receptor small heterodimer partner (SHP) gene promoter by orphan nuclear receptor ERR isoforms. J Biol Chem (2001) 1.34
Liver receptor homolog-1, an emerging metabolic modulator. Front Biosci (2008) 1.32
Farnesoid X receptor alleviates age-related proliferation defects in regenerating mouse livers by activating forkhead box m1b transcription. Hepatology (2010) 1.29
Stimulation of AMP-activated protein kinase is essential for the induction of drug metabolizing enzymes by phenobarbital in human and mouse liver. Mol Pharmacol (2006) 1.29
Phosphorylation of the hinge domain of the nuclear hormone receptor LRH-1 stimulates transactivation. J Biol Chem (2006) 1.29
Loss of orphan receptor small heterodimer partner sensitizes mice to liver injury from obstructive cholestasis. Hepatology (2008) 1.28
Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR. Arch Biochem Biophys (2005) 1.27
Rosiglitazone attenuates age- and diet-associated nonalcoholic steatohepatitis in male low-density lipoprotein receptor knockout mice. Hepatology (2010) 1.27
Three haplotypes associated with CYP2A6 phenotypes in Caucasians. Pharmacogenet Genomics (2005) 1.26
Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor. Cancer Res (2007) 1.25
FXR regulates liver repair after CCl4-induced toxic injury. Mol Endocrinol (2010) 1.23
Bmal1 and β-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced β-cell failure in mice. Mol Cell Biol (2013) 1.22
C-Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia. Hepatology (2008) 1.22
GUGULIPID: a natural cholesterol-lowering agent. Annu Rev Nutr (2003) 1.21
CREB-binding protein/p300 co-activation of crystallin gene expression. J Biol Chem (2002) 1.20
Farnesoid X receptor protects liver cells from apoptosis induced by serum deprivation in vitro and fasting in vivo. Mol Endocrinol (2008) 1.20
Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis. J Clin Invest (2010) 1.17
Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine. Clin Pharmacol Ther (2006) 1.15
MicroRNA-26a targets ten eleven translocation enzymes and is regulated during pancreatic cell differentiation. Proc Natl Acad Sci U S A (2013) 1.14
Small heterodimer partner, an orphan nuclear receptor, augments peroxisome proliferator-activated receptor gamma transactivation. J Biol Chem (2001) 1.13
Pregnane X receptor is a target of farnesoid X receptor. J Biol Chem (2006) 1.13
In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMP-activated protein kinase. Proc Natl Acad Sci U S A (2007) 1.13
TGR5: a novel target for weight maintenance and glucose metabolism. Exp Diabetes Res (2011) 1.12
A regulatory science perspective on warfarin therapy: a pharmacogenetic opportunity. J Clin Pharmacol (2009) 1.10
Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in β-cells. Islets (2011) 1.09
The Nrf2 activator oltipraz also activates the constitutive androstane receptor. Drug Metab Dispos (2008) 1.08
Hepatocarcinogenesis in FXR-/- mice mimics human HCC progression that operates through HNF1α regulation of FXR expression. Mol Endocrinol (2012) 1.08
Circadian dysregulation disrupts bile acid homeostasis. PLoS One (2009) 1.07
Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene. Pharmacogenetics (2004) 1.06
Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins. Hepatology (2006) 1.06
Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice. Toxicol Appl Pharmacol (2012) 1.06
Significance and mechanism of CYP7a1 gene regulation during the acute phase of liver regeneration. Mol Endocrinol (2008) 1.05
Promotion of liver regeneration/repair by farnesoid X receptor in both liver and intestine in mice. Hepatology (2012) 1.04
Sox9, a master regulator of chondrogenesis, distinguishes mesenchymal chondrosarcoma from other small blue round cell tumors. Hum Pathol (2003) 1.03
Nuclear receptors constitutive androstane receptor and pregnane X receptor activate a drug-responsive enhancer of the murine 5-aminolevulinic acid synthase gene. J Biol Chem (2003) 1.03
Farnesoid X receptor protects hepatocytes from injury by repressing miR-199a-3p, which increases levels of LKB1. Gastroenterology (2012) 1.03
Retracted Orphan receptor small heterodimer partner is an important mediator of glucose homeostasis. Mol Endocrinol (2006) 1.03
Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells. Mol Oncol (2012) 1.02
Nuclear bile acid receptor FXR in the hepatic regeneration. Biochim Biophys Acta (2010) 1.02