Published in Science on October 11, 2002
Induction of bilirubin clearance by the constitutive androstane receptor (CAR). Proc Natl Acad Sci U S A (2003) 2.44
Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease. Proc Natl Acad Sci U S A (2009) 1.77
A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR. J Clin Invest (2004) 1.64
Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. Pharm Res (2013) 1.62
Targeting blood-brain barrier changes during inflammatory pain: an opportunity for optimizing CNS drug delivery. Ther Deliv (2011) 1.57
Current concepts of mechanisms in drug-induced hepatotoxicity. Curr Med Chem (2009) 1.50
Organotypic liver culture models: meeting current challenges in toxicity testing. Crit Rev Toxicol (2012) 1.46
Retinoid X receptor-alpha-dependent transactivation by a naturally occurring structural variant of human constitutive androstane receptor (NR1I3). Mol Pharmacol (2005) 1.43
Carbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1. J Exp Med (2003) 1.39
Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR. Adv Drug Deliv Rev (2010) 1.38
The peripheral benzodiazepine receptor ligand 1-(2-chlorophenyl-methylpropyl)-3-isoquinoline-carboxamide is a novel antagonist of human constitutive androstane receptor. Mol Pharmacol (2008) 1.38
Cytochrome P450 and xenobiotic receptor humanized mice. Annu Rev Pharmacol Toxicol (2006) 1.36
Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters. Biochem Pharmacol (2012) 1.31
Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicities. Toxicol Sci (2010) 1.29
Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissues. Toxicol Appl Pharmacol (2007) 1.29
Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity. Drug Metab Dispos (2009) 1.26
Role of CAR and PXR in xenobiotic sensing and metabolism. Expert Opin Drug Metab Toxicol (2012) 1.24
A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response. J Clin Invest (2008) 1.22
Alternative splicing affects the function and tissue-specific expression of the human constitutive androstane receptor. Nucl Recept (2004) 1.15
Structure of the murine constitutive androstane receptor complexed to androstenol: a molecular basis for inverse agonism. Mol Cell (2004) 1.11
Activation of the farnesoid X receptor provides protection against acetaminophen-induced hepatic toxicity. Mol Endocrinol (2010) 1.11
Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation. Curr Pharmacogenomics Person Med (2009) 1.10
Corepressors of agonist-bound nuclear receptors. Toxicol Appl Pharmacol (2007) 1.08
Di(2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2. Mol Pharmacol (2009) 1.08
Transcription coactivator peroxisome proliferator-activated receptor-binding protein/mediator 1 deficiency abrogates acetaminophen hepatotoxicity. Proc Natl Acad Sci U S A (2005) 1.06
Targeted drug delivery to treat pain and cerebral hypoxia. Pharmacol Rev (2013) 1.01
CAR2 displays unique ligand binding and RXRalpha heterodimerization characteristics. Drug Metab Dispos (2006) 1.01
The environmental estrogen, nonylphenol, activates the constitutive androstane receptor. Toxicol Sci (2007) 0.97
Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver. Hepatology (2012) 0.97
Targeting xenobiotic receptors PXR and CAR for metabolic diseases. Trends Pharmacol Sci (2012) 0.97
Orphan nuclear receptors as targets for drug development. Pharm Res (2010) 0.97
A concentration addition model for the activation of the constitutive androstane receptor by xenobiotic mixtures. Toxicol Sci (2008) 0.95
Biochemical mechanisms in drug-induced liver injury: certainties and doubts. World J Gastroenterol (2009) 0.95
Thermodynamic characterization of the interaction between CAR-RXR and SRC-1 peptide by isothermal titration calorimetry. Biochemistry (2007) 0.95
Nuclear Receptors as Therapeutic Targets in Liver Disease: Are We There Yet? Annu Rev Pharmacol Toxicol (2016) 0.93
In vivo role of the HNF4alpha AF-1 activation domain revealed by exon swapping. EMBO J (2006) 0.92
Activation of xenobiotic receptors: driving into the nucleus. Expert Opin Drug Metab Toxicol (2010) 0.92
Constitutive androstane receptor agonist, TCPOBOP, attenuates steatohepatitis in the methionine choline-deficient diet-fed mouse. World J Gastroenterol (2007) 0.91
Hepatic drug transporters and nuclear receptors: regulation by therapeutic agents. World J Gastroenterol (2008) 0.90
miR-137 regulates the constitutive androstane receptor and modulates doxorubicin sensitivity in parental and doxorubicin-resistant neuroblastoma cells. Oncogene (2013) 0.90
A functional cross-talk between liver X receptor-α and constitutive androstane receptor links lipogenesis and xenobiotic responses. Mol Pharmacol (2010) 0.88
Drug-metabolizing enzyme, transporter, and nuclear receptor genetically modified mouse models. Drug Metab Rev (2010) 0.88
Constitutive androstane receptor mediates the induction of drug metabolism in mouse models of type 1 diabetes. Hepatology (2009) 0.87
Signaling control of the constitutive androstane receptor (CAR). Protein Cell (2014) 0.87
Genomic modeling of tumor onset and progression in a mouse model of aggressive human liver cancer. Carcinogenesis (2011) 0.86
Proteomic analysis of acetaminophen-induced changes in mitochondrial protein expression using spectral counting. Chem Res Toxicol (2011) 0.85
Role of constitutive androstane receptor in Toll-like receptor-mediated regulation of gene expression of hepatic drug-metabolizing enzymes and transporters. Drug Metab Dispos (2013) 0.84
Gadd45β is an inducible coactivator of transcription that facilitates rapid liver growth in mice. J Clin Invest (2011) 0.84
Lentiviral-mediated RNAi knockdown yields a novel mouse model for studying Cyp2b function. Toxicol Sci (2011) 0.84
Toxicology. Protecting liver from painkiller's lethal dose. Science (2002) 0.83
Acetaminophen modulates P-glycoprotein functional expression at the blood-brain barrier by a constitutive androstane receptor-dependent mechanism. Mol Pharmacol (2013) 0.83
Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium. Nucl Recept Signal (2015) 0.83
Activation of liver X receptor increases acetaminophen clearance and prevents its toxicity in mice. Hepatology (2011) 0.83
Diurnal difference in CAR mRNA expression. Nucl Recept (2004) 0.82
Modulation of xenobiotic receptors by steroids. Molecules (2013) 0.82
Plasticizers May Activate Human Hepatic Peroxisome Proliferator-Activated Receptor α Less Than That of a Mouse but May Activate Constitutive Androstane Receptor in Liver. PPAR Res (2012) 0.81
Polyinosinic-polycytidylic acid suppresses acetaminophen-induced hepatotoxicity independent of type I interferons and toll-like receptor 3. Hepatology (2011) 0.81
Role of nuclear receptor CAR in carbon tetrachloride-induced hepatotoxicity. World J Gastroenterol (2005) 0.80
Studies on the role of metabolic activation in tyrosine kinase inhibitor-dependent hepatotoxicity: induction of CYP3A4 enhances the cytotoxicity of lapatinib in HepaRG cells. Drug Metab Dispos (2013) 0.79
SRC-3 is required for CAR-regulated hepatocyte proliferation and drug metabolism. J Hepatol (2011) 0.79
A human hepatocyte-bearing mouse: an animal model to predict drug metabolism and effectiveness in humans. PPAR Res (2009) 0.78
Small-molecule modulators of PXR and CAR. Biochim Biophys Acta (2016) 0.78
Nuclear Receptors in Drug Metabolism, Drug Response and Drug Interactions. Nucl Receptor Res (2016) 0.77
Small-molecule modulators of the constitutive androstane receptor. Expert Opin Drug Metab Toxicol (2015) 0.77
Development of CINPA1 analogs as novel and potent inverse agonists of constitutive androstane receptor. Eur J Med Chem (2015) 0.77
Genome-wide analysis of human constitutive androstane receptor (CAR) transcriptome in wild-type and CAR-knockout HepaRG cells. Biochem Pharmacol (2015) 0.77
Expression of human CAR splicing variants in BAC-transgenic mice. Toxicol Sci (2012) 0.77
The HR96 activator, atrazine, reduces sensitivity of D. magna to triclosan and DHA. Chemosphere (2015) 0.76
Ortho-aminoazotoluene activates mouse constitutive androstane receptor (mCAR) and increases expression of mCAR target genes. Toxicol Appl Pharmacol (2011) 0.76
Acetaminophen induces accumulation of functional rat CYP3A via polyubiquitination dysfunction. Sci Rep (2016) 0.75
Agonist ligands mediate the transcriptional response of nuclear receptor heterodimers through distinct stoichiometric assemblies with coactivators. J Biol Chem (2014) 0.75
Adamantyl analogues of paracetamol as potent analgesic drugs via inhibition of TRPA1. PLoS One (2014) 0.75
Crystallographic analysis of murine constitutive androstane receptor ligand-binding domain complexed with 5alpha-androst-16-en-3alpha-ol. Acta Crystallogr Sect F Struct Biol Cryst Commun (2004) 0.75
Fasting-Induced Changes in Hepatic P450 Mediated Drug Metabolism Are Largely Independent of the Constitutive Androstane Receptor CAR. PLoS One (2016) 0.75
Bovine NR1I3 gene polymorphisms and its association with feed efficiency traits in Nellore cattle. Meta Gene (2014) 0.75
Role of CYP2B in Phenobarbital-induced Hepatocyte Proliferation in Mice. Drug Metab Dispos (2017) 0.75
Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration. Science (2006) 5.52
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest (2004) 4.65
A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature (2011) 4.44
FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis. Cancer Cell (2011) 3.58
Redundant pathways for negative feedback regulation of bile acid production. Dev Cell (2002) 3.51
TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. Immunity (2002) 3.46
Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Invest (2006) 3.44
Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor. Cancer Res (2007) 3.37
The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors. Nat Immunol (2011) 2.81
Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response. Hepatology (2008) 2.79
Molecular characterization of the role of orphan receptor small heterodimer partner in development of fatty liver. Hepatology (2007) 2.53
Rapid diversification of cell signaling phenotypes by modular domain recombination. Science (2010) 2.49
Induction of bilirubin clearance by the constitutive androstane receptor (CAR). Proc Natl Acad Sci U S A (2003) 2.44
Alterations in xenobiotic metabolism in the long-lived Little mice. Aging Cell (2007) 2.35
Expression, localization, and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel disease. J Immunol (2003) 2.21
Retracted Deficiency of G-protein-coupled bile acid receptor Gpbar1 (TGR5) enhances chemically induced liver carcinogenesis. Hepatology (2013) 2.16
Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma. Genome Res (2013) 2.12
Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. Nat Struct Mol Biol (2005) 2.03
A natural product that lowers cholesterol as an antagonist ligand for FXR. Science (2002) 1.99
Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism. Endocrinology (2004) 1.89
Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption. Cell Metab (2011) 1.89
The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes. Cell Metab (2005) 1.89
TL1A synergizes with IL-12 and IL-18 to enhance IFN-gamma production in human T cells and NK cells. J Immunol (2004) 1.85
Orphan receptor small heterodimer partner suppresses tumorigenesis by modulating cyclin D1 expression and cellular proliferation. Hepatology (2008) 1.83
Gadd45beta is induced through a CAR-dependent, TNF-independent pathway in murine liver hyperplasia. Hepatology (2005) 1.82
Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor. Mol Endocrinol (2005) 1.79
Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease. Proc Natl Acad Sci U S A (2009) 1.77
The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor κ light-chain enhancer of activated B cells (NF-κB) in mice. Hepatology (2011) 1.71
miR-194 is a marker of hepatic epithelial cells and suppresses metastasis of liver cancer cells in mice. Hepatology (2010) 1.66
A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR. J Clin Invest (2004) 1.64
Regulation of PPARgamma coactivator 1alpha (PGC-1alpha) signaling by an estrogen-related receptor alpha (ERRalpha) ligand. Proc Natl Acad Sci U S A (2004) 1.60
A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification. Mol Pharmacol (2004) 1.59
FXR: a metabolic regulator and cell protector. Cell Res (2008) 1.59
All-trans-retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade. Hepatology (2014) 1.59
Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury. Proc Natl Acad Sci U S A (2005) 1.57
Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase. J Biol Chem (2003) 1.54
Potential role for TL1A, the new TNF-family member and potent costimulator of IFN-gamma, in mucosal inflammation. Clin Immunol (2004) 1.52
Deletion of IFNγ enhances hepatocarcinogenesis in FXR knockout mice. J Hepatol (2012) 1.51
A reassessment of a classic neuroprotective combination therapy for spinal cord injured rats: LPS/pregnenolone/indomethacin. Exp Neurol (2011) 1.49
Minireview: Evolution of NURSA, the Nuclear Receptor Signaling Atlas. Mol Endocrinol (2009) 1.49
Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. J Biol Chem (2004) 1.46
Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner. J Biol Chem (2001) 1.46
Low expression of LOC285194 is associated with poor prognosis in colorectal cancer. J Transl Med (2013) 1.45
Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in mice. PLoS One (2010) 1.45
Resistance of SHP-null mice to bile acid-induced liver damage. J Biol Chem (2003) 1.44
Soluble TNF-like cytokine (TL1A) production by immune complexes stimulated monocytes in rheumatoid arthritis. J Immunol (2007) 1.44
Remission of rheumatoid arthritis and potential determinants: a national multi-center cross-sectional survey. Clin Rheumatol (2014) 1.41
TL1A-induced NF-kappaB activation and c-IAP2 production prevent DR3-mediated apoptosis in TF-1 cells. J Biol Chem (2003) 1.40
The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity. J Biol Chem (2004) 1.38
Stigmasterol, a soy lipid-derived phytosterol, is an antagonist of the bile acid nuclear receptor FXR. Pediatr Res (2007) 1.38
Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR. Mol Endocrinol (2004) 1.36
Differential regulation of the orphan nuclear receptor small heterodimer partner (SHP) gene promoter by orphan nuclear receptor ERR isoforms. J Biol Chem (2001) 1.34
Liver receptor homolog-1, an emerging metabolic modulator. Front Biosci (2008) 1.32
The M-Ras-RA-GEF-2-Rap1 pathway mediates tumor necrosis factor-alpha dependent regulation of integrin activation in splenocytes. Mol Biol Cell (2007) 1.30
Farnesoid X receptor alleviates age-related proliferation defects in regenerating mouse livers by activating forkhead box m1b transcription. Hepatology (2010) 1.29
Phosphorylation of the hinge domain of the nuclear hormone receptor LRH-1 stimulates transactivation. J Biol Chem (2006) 1.29
Loss of orphan receptor small heterodimer partner sensitizes mice to liver injury from obstructive cholestasis. Hepatology (2008) 1.28
Rosiglitazone attenuates age- and diet-associated nonalcoholic steatohepatitis in male low-density lipoprotein receptor knockout mice. Hepatology (2010) 1.27
Adamantyl-substituted retinoid-related molecules bind small heterodimer partner and modulate the Sin3A repressor. Cancer Res (2007) 1.25
Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression. Mol Pharmacol (2008) 1.24
FXR regulates liver repair after CCl4-induced toxic injury. Mol Endocrinol (2010) 1.23
Bmal1 and β-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced β-cell failure in mice. Mol Cell Biol (2013) 1.22
C-Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia. Hepatology (2008) 1.22
Steroid receptor RNA activator stimulates proliferation as well as apoptosis in vivo. Mol Cell Biol (2003) 1.22
Inflammatory myofibroblastic tumor successfully treated with chemotherapy and nonsteroidals: a case report. World J Gastroenterol (2012) 1.21
GUGULIPID: a natural cholesterol-lowering agent. Annu Rev Nutr (2003) 1.21
CREB-binding protein/p300 co-activation of crystallin gene expression. J Biol Chem (2002) 1.20
Farnesoid X receptor protects liver cells from apoptosis induced by serum deprivation in vitro and fasting in vivo. Mol Endocrinol (2008) 1.20
NG2 colocalizes with axons and is expressed by a mixed cell population in spinal cord lesions. J Neuropathol Exp Neurol (2006) 1.19
Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis. J Clin Invest (2010) 1.17
The PPAR gamma agonist Pioglitazone improves anatomical and locomotor recovery after rodent spinal cord injury. Exp Neurol (2007) 1.16
Synthesis, crystal structure, vibration spectral, and DFT studies of 4-aminoantipyrine and its derivatives. Molecules (2013) 1.14
FoxM1B regulates NEDD4-1 expression, leading to cellular transformation and full malignant phenotype in immortalized human astrocytes. Cancer Res (2010) 1.14
MicroRNA-26a targets ten eleven translocation enzymes and is regulated during pancreatic cell differentiation. Proc Natl Acad Sci U S A (2013) 1.14
Small heterodimer partner, an orphan nuclear receptor, augments peroxisome proliferator-activated receptor gamma transactivation. J Biol Chem (2001) 1.13
TGR5: a novel target for weight maintenance and glucose metabolism. Exp Diabetes Res (2011) 1.12
KLF4-mediated negative regulation of IFITM3 expression plays a critical role in colon cancer pathogenesis. Clin Cancer Res (2011) 1.11
Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in β-cells. Islets (2011) 1.09
3C-like proteinase from SARS coronavirus catalyzes substrate hydrolysis by a general base mechanism. Biochemistry (2004) 1.08
The Nrf2 activator oltipraz also activates the constitutive androstane receptor. Drug Metab Dispos (2008) 1.08
Hepatocarcinogenesis in FXR-/- mice mimics human HCC progression that operates through HNF1α regulation of FXR expression. Mol Endocrinol (2012) 1.08
Enhanced axonal growth into a spinal cord contusion injury site in a strain of mouse (129X1/SvJ) with a diminished inflammatory response. J Comp Neurol (2004) 1.08
TPX2 is a novel prognostic marker for the growth and metastasis of colon cancer. J Transl Med (2013) 1.07
Circadian dysregulation disrupts bile acid homeostasis. PLoS One (2009) 1.07
Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins. Hepatology (2006) 1.06