Ser7 phosphorylation of the CTD recruits the RPAP2 Ser5 phosphatase to snRNA genes.

PubWeight™: 1.20‹?› | Rank: Top 10%

🔗 View Article (PMC 3262128)

Published in Mol Cell on December 01, 2011

Authors

Sylvain Egloff1, Justyna Zaborowska, Clélia Laitem, Tamás Kiss, Shona Murphy

Author Affiliations

1: Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.

Articles citing this

The RNA polymerase II CTD coordinates transcription and RNA processing. Genes Dev (2012) 2.55

Threonine-4 of mammalian RNA polymerase II CTD is targeted by Polo-like kinase 3 and required for transcriptional elongation. EMBO J (2012) 1.55

Serine-7 but not serine-5 phosphorylation primes RNA polymerase II CTD for P-TEFb recognition. Nat Commun (2012) 1.49

RNA polymerase II C-terminal domain: Tethering transcription to transcript and template. Chem Rev (2013) 1.35

RNA polymerase II transcription elongation control. Chem Rev (2013) 1.27

Genomic study of RNA polymerase II and III SNAPc-bound promoters reveals a gene transcribed by both enzymes and a broad use of common activators. PLoS Genet (2012) 1.06

An RNAi screen identifies additional members of the Drosophila Integrator complex and a requirement for cyclin C/Cdk8 in snRNA 3'-end formation. RNA (2012) 0.98

Function and control of RNA polymerase II C-terminal domain phosphorylation in vertebrate transcription and RNA processing. Mol Cell Biol (2014) 0.96

The yeast regulator of transcription protein Rtr1 lacks an active site and phosphatase activity. Nat Commun (2012) 0.96

The Integrator complex controls the termination of transcription at diverse classes of gene targets. Cell Res (2015) 0.95

Quantitative proteomics demonstrates that the RNA polymerase II subunits Rpb4 and Rpb7 dissociate during transcriptional elongation. Mol Cell Proteomics (2013) 0.90

RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation. Nat Struct Mol Biol (2014) 0.90

Rtr1 is a dual specificity phosphatase that dephosphorylates Tyr1 and Ser5 on the RNA polymerase II CTD. J Mol Biol (2014) 0.89

SMADs and YAP compete to control elongation of β-catenin:LEF-1-recruited RNAPII during hESC differentiation. Mol Cell (2015) 0.88

Integrator: surprisingly diverse functions in gene expression. Trends Biochem Sci (2015) 0.86

The prefoldin bud27 mediates the assembly of the eukaryotic RNA polymerases in an rpb5-dependent manner. PLoS Genet (2013) 0.86

Non-mRNA 3' end formation: how the other half lives. Wiley Interdiscip Rev RNA (2013) 0.84

Nuclear import of RNA polymerase II is coupled with nucleocytoplasmic shuttling of the RNA polymerase II-associated protein 2. Nucleic Acids Res (2013) 0.84

The C-terminal domain of Rpb1 functions on other RNA polymerase II subunits. Mol Cell (2013) 0.83

Multiple roles for the Ess1 prolyl isomerase in the RNA polymerase II transcription cycle. Mol Cell Biol (2012) 0.83

A novel TBP-TAF complex on RNA polymerase II-transcribed snRNA genes. Transcription (2012) 0.82

Herpes Simplex Virus 1 (HSV-1) ICP22 protein directly interacts with cyclin-dependent kinase (CDK)9 to inhibit RNA polymerase II transcription elongation. PLoS One (2014) 0.82

Tyrosine-1 and threonine-4 phosphorylation marks complete the RNA polymerase II CTD phospho-code. RNA Biol (2012) 0.82

Termination of Transcription of Short Noncoding RNAs by RNA Polymerase II. Annu Rev Biochem (2015) 0.81

The interactome of the atypical phosphatase Rtr1 in Saccharomyces cerevisiae. Mol Biosyst (2014) 0.81

The pol II CTD: new twists in the tail. Nat Struct Mol Biol (2016) 0.79

Rpb4/7 facilitates RNA polymerase II CTD dephosphorylation. Nucleic Acids Res (2014) 0.77

Cross-talk of phosphorylation and prolyl isomerization of the C-terminal domain of RNA Polymerase II. Molecules (2014) 0.76

Phosphatase Rtr1 Regulates Global Levels of Serine 5 RNA Polymerase II C-Terminal Domain Phosphorylation and Cotranscriptional Histone Methylation. Mol Cell Biol (2016) 0.76

Dephosphorylating eukaryotic RNA polymerase II. Biochim Biophys Acta (2016) 0.76

Role of Ser7 phosphorylation of the CTD during transcription of snRNA genes. RNA Biol (2012) 0.76

Vertebrate Ssu72 regulates and coordinates 3'-end formation of RNAs transcribed by RNA polymerase II. PLoS One (2014) 0.76

Structure of Saccharomyces cerevisiae Rtr1 reveals an active site for an atypical phosphatase. Sci Signal (2016) 0.76

RIMA-Dependent Nuclear Accumulation of IYO Triggers Auxin-Irreversible Cell Differentiation in Arabidopsis. Plant Cell (2017) 0.75

Articles cited by this

Progression through the RNA polymerase II CTD cycle. Mol Cell (2009) 5.62

7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes. Nature (2001) 5.11

Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Mol Cell (2007) 4.58

Transcribing RNA polymerase II is phosphorylated at CTD residue serine-7. Science (2007) 4.18

Cracking the RNA polymerase II CTD code. Trends Genet (2008) 4.00

Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Cell (2005) 3.66

Serine-7 of the RNA polymerase II CTD is specifically required for snRNA gene expression. Science (2007) 3.36

"Cotranscriptionality": the transcription elongation complex as a nexus for nuclear transactions. Mol Cell (2009) 3.28

Uniform transitions of the general RNA polymerase II transcription complex. Nat Struct Mol Biol (2010) 3.25

The CTD code. Nat Struct Biol (2003) 3.00

RNA polymerase II C-terminal domain required for enhancer-driven transcription. Nature (1995) 2.78

Formation of the 3' end of U1 snRNA is directed by a conserved sequence located downstream of the coding region. EMBO J (1985) 2.69

TFIIH kinase places bivalent marks on the carboxy-terminal domain of RNA polymerase II. Mol Cell (2009) 2.61

Small nuclear RNA genes: a model system to study fundamental mechanisms of transcription. J Biol Chem (2001) 2.57

Ssu72 Is an RNA polymerase II CTD phosphatase. Mol Cell (2004) 2.25

Gene-specific RNA polymerase II phosphorylation and the CTD code. Nat Struct Mol Biol (2010) 2.22

TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II. Mol Cell Biol (2009) 2.20

A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. J Biol Chem (2003) 1.93

Phosphorylation of the yeast Rpb1 C-terminal domain at serines 2, 5, and 7. J Biol Chem (2009) 1.89

Chemical-genomic dissection of the CTD code. Nat Struct Mol Biol (2010) 1.76

Streamlined analysis schema for high-throughput identification of endogenous protein complexes. Proc Natl Acad Sci U S A (2010) 1.72

Rtr1 is a CTD phosphatase that regulates RNA polymerase II during the transition from serine 5 to serine 2 phosphorylation. Mol Cell (2009) 1.68

P-TEFb is not an essential elongation factor for the intronless human U2 snRNA and histone H2b genes. EMBO J (2005) 1.66

A CPSF-73 homologue is required for cell cycle progression but not cell growth and interacts with a protein having features of CPSF-100. Mol Cell Biol (2005) 1.65

Molecular evolution of the RNA polymerase II CTD. Trends Genet (2008) 1.64

Role of the mammalian RNA polymerase II C-terminal domain (CTD) nonconsensus repeats in CTD stability and cell proliferation. Mol Cell Biol (2005) 1.55

The C-terminal domain of pol II and a DRB-sensitive kinase are required for 3' processing of U2 snRNA. EMBO J (2003) 1.50

Expression of human snRNA genes from beginning to end. Biochem Soc Trans (2008) 1.39

U6 snRNA maturation and stability. Exp Cell Res (1996) 1.36

The integrator complex recognizes a new double mark on the RNA polymerase II carboxyl-terminal domain. J Biol Chem (2010) 1.33

Transcription of the human U2 snRNA genes continues beyond the 3' box in vivo. EMBO J (1999) 1.32

Characterization of the CTD phosphatase Fcp1 from fission yeast. Preferential dephosphorylation of serine 2 versus serine 5. J Biol Chem (2002) 1.28

Chromatin structure is implicated in "late" elongation checkpoints on the U2 snRNA and beta-actin genes. Mol Cell Biol (2009) 1.23

Role for the Ssu72 C-terminal domain phosphatase in RNA polymerase II transcription elongation. Mol Cell Biol (2006) 1.17

A subset of Drosophila integrator proteins is essential for efficient U7 snRNA and spliceosomal snRNA 3'-end formation. Mol Cell Biol (2010) 1.13

RNA polymerase II C-terminal heptarepeat domain Ser-7 phosphorylation is established in a mediator-dependent fashion. J Biol Chem (2009) 1.12

The yeast capping enzyme represses RNA polymerase II transcription. Mol Cell (2002) 1.07

Rtr1 is the Saccharomyces cerevisiae homolog of a novel family of RNA polymerase II-binding proteins. Eukaryot Cell (2008) 0.99

The Integrator subunits function in hematopoiesis by modulating Smad/BMP signaling. Development (2009) 0.95

Articles by these authors

Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs. EMBO J (2002) 4.48

Cracking the RNA polymerase II CTD code. Trends Genet (2008) 4.00

Serine-7 of the RNA polymerase II CTD is specifically required for snRNA gene expression. Science (2007) 3.36

U1 snRNA associates with TFIIH and regulates transcriptional initiation. Nat Struct Biol (2002) 3.25

Modification of Sm small nuclear RNAs occurs in the nucleoplasmic Cajal body following import from the cytoplasm. EMBO J (2003) 2.67

Human telomerase RNA and box H/ACA scaRNAs share a common Cajal body-specific localization signal. J Cell Biol (2004) 2.49

Updating the RNA polymerase CTD code: adding gene-specific layers. Trends Genet (2012) 1.95

The Hsp90 chaperone controls the biogenesis of L7Ae RNPs through conserved machinery. J Cell Biol (2008) 1.95

Cell cycle-dependent recruitment of telomerase RNA and Cajal bodies to human telomeres. Mol Biol Cell (2005) 1.93

A common sequence motif determines the Cajal body-specific localization of box H/ACA scaRNAs. EMBO J (2003) 1.87

Human box H/ACA pseudouridylation guide RNA machinery. Mol Cell Biol (2004) 1.85

P-TEFb is not an essential elongation factor for the intronless human U2 snRNA and histone H2b genes. EMBO J (2005) 1.66

Regulation of polymerase II transcription by 7SK snRNA: two distinct RNA elements direct P-TEFb and HEXIM1 binding. Mol Cell Biol (2006) 1.59

A Cajal body-specific pseudouridylation guide RNA is composed of two box H/ACA snoRNA-like domains. Nucleic Acids Res (2002) 1.56

Dynamic remodelling of human 7SK snRNP controls the nuclear level of active P-TEFb. EMBO J (2007) 1.52

The C-terminal domain of pol II and a DRB-sensitive kinase are required for 3' processing of U2 snRNA. EMBO J (2003) 1.50

Analysis of the structure of human telomerase RNA in vivo. Nucleic Acids Res (2002) 1.49

U17/snR30 is a ubiquitous snoRNA with two conserved sequence motifs essential for 18S rRNA production. Mol Cell Biol (2004) 1.42

Elevated plasma hemoglobin levels increase nitric oxide consumption in experimental and clinical acute pulmonary thromboembolism. Crit Care Med (2013) 1.42

Expression of human snRNA genes from beginning to end. Biochem Soc Trans (2008) 1.39

Structural and functional characterization of human telomerase RNA processing and cajal body localization signals. Mol Cell (2007) 1.35

The integrator complex recognizes a new double mark on the RNA polymerase II carboxyl-terminal domain. J Biol Chem (2010) 1.33

Chromatin structure is implicated in "late" elongation checkpoints on the U2 snRNA and beta-actin genes. Mol Cell Biol (2009) 1.23

In vitro study of the insulin-mimetic behaviour of vanadium(IV, V) coordination compounds. J Biol Inorg Chem (2001) 1.21

Controlling cellular P-TEFb activity by the HIV-1 transcriptional transactivator Tat. PLoS Pathog (2010) 1.16

Cotranscriptional recognition of human intronic box H/ACA snoRNAs occurs in a splicing-independent manner. Mol Cell Biol (2006) 1.11

Human U1 snRNA forms a new chromatin-associated snRNP with TAF15. EMBO Rep (2009) 1.08

18S rRNA processing requires base pairings of snR30 H/ACA snoRNA to eukaryote-specific 18S sequences. EMBO J (2009) 1.08

The 3' ends of human pre-snRNAs are produced by RNA polymerase II CTD-dependent RNA processing. EMBO J (2003) 1.04

Differentially expressed, variant U1 snRNAs regulate gene expression in human cells. Genome Res (2012) 1.02

Human intron-encoded Alu RNAs are processed and packaged into Wdr79-associated nucleoplasmic box H/ACA RNPs. Genes Dev (2012) 1.01

Impact of alpha interferon and ribavirin on the function of maturing dendritic cells. Antimicrob Agents Chemother (2004) 1.00

Children's views of hospitalization: an exploratory study of data collection. J Child Health Care (2003) 1.00

Definition of RNA polymerase II CoTC terminator elements in the human genome. Cell Rep (2013) 0.98

Ets-1 binds cooperatively to the palindromic Ets-binding sites in the p53 promoter. Biochem Biophys Res Commun (2008) 0.96

3'-box-dependent processing of human pre-U1 snRNA requires a combination of RNA and protein co-factors. Nucleic Acids Res (2004) 0.93

Sleep, anxiety and challenging behaviour in children with intellectual disability and/or autism spectrum disorder. Res Dev Disabil (2011) 0.93

BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II. Oncogene (2004) 0.92

Parallel computational subunits in dentate granule cells generate multiple place fields. PLoS Comput Biol (2009) 0.90

Intrinsic and synaptic mechanisms determining the timing of neuron population activity during hippocampal theta oscillation. J Neurophysiol (2006) 0.90

RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP. Nucleic Acids Res (2013) 0.89

Human snRNA genes use polyadenylation factors to promote efficient transcription termination. Nucleic Acids Res (2013) 0.88

Utp23p is required for dissociation of snR30 small nucleolar RNP from preribosomal particles. Nucleic Acids Res (2011) 0.87

Age-dependent disruption in hippocampal θ oscillation in amyloid-β overproducing transgenic mice. Neurobiol Aging (2012) 0.87

Comparative solution equilibrium studies of anticancer gallium(III) complexes of 8-hydroxyquinoline and hydroxy(thio)pyrone ligands. J Inorg Biochem (2012) 0.87

Integrating snoRNP assembly with mRNA biogenesis. EMBO Rep (2006) 0.86

Interaction of Triapine and related thiosemicarbazones with iron(III)/(II) and gallium(III): a comparative solution equilibrium study. Dalton Trans (2011) 0.86

Robust path integration in the entorhinal grid cell system with hippocampal feed-back. Biol Cybern (2009) 0.85

Genetic characterization of a novel picornavirus distantly related to the marine mammal-infecting aquamaviruses in a long-distance migrant bird species, European roller (Coracias garrulus). J Gen Virol (2013) 0.85

Characterization of the binding sites of the anticancer ruthenium(III) complexes KP1019 and KP1339 on human serum albumin via competition studies. J Biol Inorg Chem (2012) 0.84

Mammalian HCA66 protein is required for both ribosome synthesis and centriole duplication. Nucleic Acids Res (2012) 0.83

A novel TBP-TAF complex on RNA polymerase II-transcribed snRNA genes. Transcription (2012) 0.82

Lipophilicity of kinetically labile metal complexes through the example of antidiabetic Zn(II) and VO(IV) compounds. J Pharm Biomed Anal (2010) 0.82

Role of the C-terminal domain of RNA polymerase II in expression of small nuclear RNA genes. Biochem Soc Trans (2008) 0.82

Interaction of proteins with promoter elements of the human U2 snRNA genes in vivo. Gene (2003) 0.81

Interaction of Al(III) with the peptides AspAsp and AspAspAsp. J Inorg Biochem (2003) 0.80

Two pyridine derivatives as potential Cu(II) and Zn(II) chelators in therapy for Alzheimer's disease. Dalton Trans (2009) 0.80

N,N'-ethylenebis(pyridoxylideneiminato) and N,N'-ethylenebis(pyridoxylaminato): synthesis, characterization, potentiometric, spectroscopic, and DFT studies of their vanadium(IV) and vanadium(V) complexes. Chemistry (2004) 0.80

Biodistribution of anti-diabetic Zn(II) complexes in human serum and in vitro protein-binding studies by means of CZE-ICP-MS. Electrophoresis (2009) 0.80

Interactions of Aluminum(III) with Phosphates. Inorg Chem (1996) 0.80

Biospeciation of various antidiabetic V(IV)O compounds in serum. Dalton Trans (2009) 0.79

Hippocampal theta rhythms from a computational perspective: code generation, mood regulation and navigation. Neural Netw (2005) 0.79

Platelet aggregation in severe sepsis. J Thromb Thrombolysis (2011) 0.79

Identification and complete genome analysis of kobuvirus in faecal samples of European roller (Coracias garrulus): for the first time in a bird. Arch Virol (2014) 0.79

Distance coding strategies based on the entorhinal grid cell system. Neural Netw (2009) 0.79

The systems V(IV)O(2+)-glutathione and related ligands: a potentiometric and spectroscopic study. J Biol Inorg Chem (2001) 0.79

Pharmacological and computational analysis of alpha-subunit preferential GABA(A) positive allosteric modulators on the rat septo-hippocampal activity. Neuropharmacology (2006) 0.78

Assembly of human small nuclear RNA gene-specific transcription factor IIIB complex de novo on and off promoter. J Biol Chem (2002) 0.77

Vanadate complexes in serum: a speciation modeling study. Dalton Trans (2009) 0.77

Al(III)-binding ability of an octapeptide and its phosphorylated derivative. J Inorg Biochem (2006) 0.77

L- and D-proline thiosemicarbazone conjugates: coordination behavior in solution and the effect of copper(II) coordination on their antiproliferative activity. Inorg Chem (2012) 0.77

Interaction of vanadium(IV) with human serum apo-transferrin. J Inorg Biochem (2013) 0.77

Interactions of the carrier ligands of antidiabetic metal complexes with human serum albumin: a combined spectroscopic and separation approach with molecular modeling studies. Bioorg Med Chem (2011) 0.76

Effects of the γ-secretase inhibitor semagacestat on hippocampal neuronal network oscillation. Front Pharmacol (2013) 0.76

Chemical speciation of insulinomimetic VO(IV) complexes of pyridine-N-oxide derivatives: binary and ternary systems. J Inorg Biochem (2003) 0.76

[RuII(η⁵-C₅H₅)(bipy)(PPh₃)]⁺, a promising large spectrum antitumor agent: cytotoxic activity and interaction with human serum albumin. J Inorg Biochem (2012) 0.76

Salicylamide and salicylglycine oxidovanadium complexes with insulin-mimetic properties. J Inorg Biochem (2011) 0.76

Bis- and tris(pyridyl)amine-oxidovanadium complexes: characteristics and insulin-mimetic potential. Dalton Trans (2009) 0.76

[Pancreatic cancer or autoimmune pancreatitis: endosonography as a diagnostic reviser]. Orv Hetil (2013) 0.76

Vanadium(IV/V) speciation of pyridine-2,6-dicarboxylic acid and 4-hydroxy-pyridine-2,6-dicarboxylic acid complexes: potentiometry, EPR spectroscopy and comparison across oxidation states. J Inorg Biochem (2003) 0.76

How do glutamatergic and GABAergic cells contribute to synchronization in the medial septum? J Comput Neurosci (2006) 0.76

Solution equilibria of anticancer ruthenium(II)-(η(6)-p-cymene)-hydroxy(thio)pyr(id)one complexes: impact of sulfur vs. oxygen donor systems on the speciation and bioactivity. J Inorg Biochem (2013) 0.76

Histidine-rich branched peptides as Cu(II) and Zn(II) chelators with potential therapeutic application in Alzheimer's disease. Dalton Trans (2011) 0.76

Complete genome characterization of mosavirus (family Picornaviridae) identified in droppings of a European roller (Coracias garrulus) in Hungary. Arch Virol (2014) 0.76

A new family of insulin-mimetic vanadium complexes derived from 5-carboalkoxypicolinates. Chemistry (2003) 0.76

AC/D(eA)C rocks the polymerases. Mol Cell (2013) 0.75

Two proteins with different functions are derived from the KlHEM13 gene. Eukaryot Cell (2011) 0.75

Caspase cleavage of Ets-1 p51 generates fragments with transcriptional dominant-negative function. Biochem J (2010) 0.75

Oxovanadium(IV) complexes of salicyl-L-aspartic acid and salicylglycyl-L-aspartic acid. Dalton Trans (2005) 0.75

A novel V(IV)O-pyrimidinone complex: synthesis, solution speciation and human serum protein binding. Dalton Trans (2013) 0.75

Anxiolytic drugs and altered hippocampal theta rhythms: the quantitative systems pharmacological approach. Network (2014) 0.75

Tris-(hydroxyamino)triazines: high-affinity chelating tridentate O,N,O-hydroxylamine ligand for the cis-V(V)O2(+) cation. Dalton Trans (2010) 0.75

Evaluation of the binding of oxovanadium(IV) to human serum albumin. Dalton Trans (2012) 0.75

[Frequency and possible reasons for the loss of response to biological therapy in Crohn's disease after a one-year treatment period]. Orv Hetil (2011) 0.75

Aminoacid-derivatised picolinato-oxidovanadium(IV) complexes: characterisation, speciation and ex vivo insulin-mimetic potential. J Inorg Biochem (2008) 0.75

Complex formation between Ca(II), Mg(II), Al(III) ions and salicylglycine. Bioinorg Chem Appl (2003) 0.75

An in vitro study of interactions between insulin-mimetic zinc(II) complexes and selected plasma components. J Inorg Biochem (2006) 0.75

Interactions of insulin-mimetic zinc(II) complexes with cell constituents: glutathione and ATP. J Inorg Biochem (2008) 0.75