Published in Clin Chem Lab Med on July 01, 2012
Interleukin-6 mediates the platelet abnormalities and thrombogenesis associated with experimental colitis. Am J Pathol (2013) 0.84
Determination of ATP and ADP Secretion from Human and Mouse Platelets by an HPLC Assay. Transfus Med Hemother (2013) 0.84
Optoacoustic spectroscopy for real-time monitoring of strongly light-absorbing solutions in applications to analytical chemistry. Photoacoustics (2013) 0.79
The sGC stimulator riociguat inhibits platelet function in washed platelets but not in whole blood. Br J Pharmacol (2015) 0.76
The fibrate gemfibrozil is a NO- and haem-independent activator of soluble guanylyl cyclase: in vitro studies. Br J Pharmacol (2015) 0.75
Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition. Blood (2016) 0.75
Platelet-collagen interaction: is GPVI the central receptor? Blood (2003) 3.81
A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2. Blood (2005) 2.90
JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia. Blood (2010) 2.83
Widespread receptivity to neuropeptide PDF throughout the neuronal circadian clock network of Drosophila revealed by real-time cyclic AMP imaging. Neuron (2008) 2.73
Persistent cAMP-signals triggered by internalized G-protein-coupled receptors. PLoS Biol (2009) 2.59
Effects of angiotensin II infusion on the expression and function of NAD(P)H oxidase and components of nitric oxide/cGMP signaling. Circ Res (2002) 2.56
Conformational cross-talk between alpha2A-adrenergic and mu-opioid receptors controls cell signaling. Nat Chem Biol (2008) 2.51
The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways. Blood (2012) 2.47
The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade. J Biol Chem (2007) 2.24
Decreased renal corin expression contributes to sodium retention in proteinuric kidney diseases. Kidney Int (2010) 2.11
Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow. J Biol Chem (2005) 2.07
GPIb-dependent platelet activation is dependent on Src kinases but not MAP kinase or cGMP-dependent kinase. Blood (2003) 2.05
Dual role of collagen in factor XII-dependent thrombus formation. Blood (2009) 2.01
Fluorescent sensors for rapid monitoring of intracellular cGMP. Nat Methods (2006) 1.96
Resistance to thienopyridines: clinical detection of coronary stent thrombosis by monitoring of vasodilator-stimulated phosphoprotein phosphorylation. Catheter Cardiovasc Interv (2003) 1.95
Integrin alpha2beta1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCgamma2. J Cell Biol (2003) 1.84
Cyclic GMP-dependent protein kinases and the cardiovascular system: insights from genetically modified mice. Circ Res (2003) 1.82
Interplay of Ca2+ and cAMP signaling in the insulin-secreting MIN6 beta-cell line. J Biol Chem (2005) 1.80
Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte. Development (2009) 1.78
Role for peroxynitrite in the inhibition of prostacyclin synthase in nitrate tolerance. J Am Coll Cardiol (2003) 1.73
Sweet taste receptor expressed in pancreatic beta-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion. PLoS One (2009) 1.71
Platelet protein interactions: map, signaling components, and phosphorylation groundstate. Arterioscler Thromb Vasc Biol (2008) 1.71
Signaling by internalized G-protein-coupled receptors. Trends Pharmacol Sci (2010) 1.70
A novel thromboxane A2 receptor D304N variant that abrogates ligand binding in a patient with a bleeding diathesis. Blood (2009) 1.70
Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes. J Am Coll Cardiol (2013) 1.68
A germline mutation in BLOC1S3/reduced pigmentation causes a novel variant of Hermansky-Pudlak syndrome (HPS8). Am J Hum Genet (2005) 1.68
Combined in vivo depletion of glycoprotein VI and C-type lectin-like receptor 2 severely compromises hemostasis and abrogates arterial thrombosis in mice. Arterioscler Thromb Vasc Biol (2013) 1.68
Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane. Blood (2013) 1.65
Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism. Proc Natl Acad Sci U S A (2005) 1.63
Enrichment of FLI1 and RUNX1 mutations in families with excessive bleeding and platelet dense granule secretion defects. Blood (2013) 1.60
The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat. Proc Natl Acad Sci U S A (2004) 1.57
Presynaptic and postsynaptic roles of NO, cGK, and RhoA in long-lasting potentiation and aggregation of synaptic proteins. Neuron (2005) 1.54
Assessing FRET using spectral techniques. Cytometry A (2013) 1.53
Gs activation is time-limiting in initiating receptor-mediated signaling. J Biol Chem (2006) 1.52
Single L-type Ca(2+) channel regulation by cGMP-dependent protein kinase type I in adult cardiomyocytes from PKG I transgenic mice. Cardiovasc Res (2003) 1.51
Spatiotemporal dynamics of beta-adrenergic cAMP signals and L-type Ca2+ channel regulation in adult rat ventricular myocytes: role of phosphodiesterases. Circ Res (2008) 1.50
CLEC-2 activates Syk through dimerization. Blood (2010) 1.49
Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function. Blood (2013) 1.49
Thrombin and collagen induce a feedback inhibitory signaling pathway in platelets involving dissociation of the catalytic subunit of protein kinase A from an NFkappaB-IkappaB complex. J Biol Chem (2010) 1.47
Optical techniques to analyze real-time activation and signaling of G-protein-coupled receptors. Trends Pharmacol Sci (2008) 1.46
Adhesion of human and mouse platelets to collagen under shear: a unifying model. FASEB J (2005) 1.46
Normalization of nomenclature for peptide motifs as ligands of modular protein domains. FEBS Lett (2002) 1.46
Physiology and pathophysiology of vascular signaling controlled by guanosine 3',5'-cyclic monophosphate-dependent protein kinase [corrected]. Circulation (2003) 1.45
FRET measurements of intracellular cAMP concentrations and cAMP analog permeability in intact cells. Nat Protoc (2011) 1.45
A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function. J Exp Med (2010) 1.45
Real-time optical recording of beta1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol. J Clin Invest (2007) 1.44
PKCalpha regulates platelet granule secretion and thrombus formation in mice. J Clin Invest (2009) 1.41
Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen. J Biol Chem (2004) 1.40
ADP-induced platelet aggregation frequently fails to detect impaired clopidogrel-responsiveness in patients with coronary artery disease compared to a P2Y12-specific assay. Thromb Haemost (2008) 1.40
Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling. J Biol Chem (2002) 1.39
Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins. Blood (2003) 1.39
Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. Mol Cell Proteomics (2005) 1.38
A critical role for phospholipase Cgamma2 in alphaIIbbeta3-mediated platelet spreading. J Biol Chem (2003) 1.36
Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4. Free Radic Biol Med (2005) 1.36
Renal cells activate the platelet receptor CLEC-2 through podoplanin. Biochem J (2008) 1.35
Regulation of proplatelet formation and platelet release by integrin alpha IIb beta3. Blood (2006) 1.35
Cytoskeleton assembly at endothelial cell-cell contacts is regulated by alphaII-spectrin-VASP complexes. J Cell Biol (2008) 1.35
Vasodilator-stimulated phosphoprotein regulates proliferation and growth inhibition by nitric oxide in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2004) 1.31
DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets. J Virol (2006) 1.31
EVH1 domains: structure, function and interactions. FEBS Lett (2002) 1.31
Real-time monitoring of the PDE2 activity of live cells: hormone-stimulated cAMP hydrolysis is faster than hormone-stimulated cAMP synthesis. J Biol Chem (2004) 1.30
CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development. Blood (2011) 1.30
A review of inherited platelet disorders with guidelines for their management on behalf of the UKHCDO. Br J Haematol (2006) 1.30
Evaluation of participants with suspected heritable platelet function disorders including recommendation and validation of a streamlined agonist panel. Blood (2012) 1.29
Syk-dependent phosphorylation of CLEC-2: a novel mechanism of hem-immunoreceptor tyrosine-based activation motif signaling. J Biol Chem (2010) 1.29
Murine GPVI stimulates weak integrin activation in PLCgamma2-/- platelets: involvement of PLCgamma1 and PI3-kinase. Blood (2003) 1.26
Phosphoproteome of resting human platelets. J Proteome Res (2007) 1.24
Type 4 phosphodiesterase plays different integrating roles in different cellular domains in pyramidal cortical neurons. J Neurosci (2010) 1.24
AMP-activated protein kinase impairs endothelial actin cytoskeleton assembly by phosphorylating vasodilator-stimulated phosphoprotein. J Biol Chem (2006) 1.23
GPVI levels in platelets: relationship to platelet function at high shear. Blood (2003) 1.23
Plasticity of surface structures and β(2)-adrenergic receptor localization in failing ventricular cardiomyocytes during recovery from heart failure. Circ Heart Fail (2012) 1.23
Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear. PLoS One (2010) 1.22
Segregation of platelet aggregatory and procoagulant microdomains in thrombus formation: regulation by transient integrin activation. Arterioscler Thromb Vasc Biol (2007) 1.22
Calcium-dependent membrane association sensitizes soluble guanylyl cyclase to nitric oxide. Nat Cell Biol (2002) 1.21
Functional and biochemical analysis of endothelial (dys)function and NO/cGMP signaling in human blood vessels with and without nitroglycerin pretreatment. Circulation (2002) 1.21
Towards complete analysis of the platelet proteome. Proteomics (2002) 1.21
Multidrug resistance-associated protein 4 regulates cAMP-dependent signaling pathways and controls human and rat SMC proliferation. J Clin Invest (2008) 1.19
Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI. Blood (2005) 1.19
Interaction of the plasma membrane Ca2+ pump 4b/CI with the Ca2+/calmodulin-dependent membrane-associated kinase CASK. J Biol Chem (2003) 1.19
JAK2V617F leads to intrinsic changes in platelet formation and reactivity in a knock-in mouse model of essential thrombocythemia. Blood (2013) 1.18
Reference curves for aggregation and ATP secretion to aid diagnose of platelet-based bleeding disorders: effect of inhibition of ADP and thromboxane A(2) pathways. Platelets (2007) 1.17
Critical role for ERK1/2 in bone marrow and fetal liver-derived primary megakaryocyte differentiation, motility, and proplatelet formation. Exp Hematol (2009) 1.16
GPCR and G proteins: drug efficacy and activation in live cells. Mol Endocrinol (2009) 1.16
Gene transfer of cGMP-dependent protein kinase I enhances the antihypertrophic effects of nitric oxide in cardiomyocytes. Hypertension (2002) 1.16
Actin binding of human LIM and SH3 protein is regulated by cGMP- and cAMP-dependent protein kinase phosphorylation on serine 146. J Biol Chem (2003) 1.16
Critical role of Src-Syk-PLC{gamma}2 signaling in megakaryocyte migration and thrombopoiesis. Blood (2010) 1.15
Bile acid-induced arrhythmia is mediated by muscarinic M2 receptors in neonatal rat cardiomyocytes. PLoS One (2010) 1.15
Platelet NAD(P)H-oxidase-generated ROS production regulates alphaIIbbeta3-integrin activation independent of the NO/cGMP pathway. Blood (2005) 1.15
A novel role for PECAM-1 in megakaryocytokinesis and recovery of platelet counts in thrombocytopenic mice. Blood (2007) 1.15
Vav1, but not Vav2, contributes to platelet aggregation by CRP and thrombin, but neither is required for regulation of phospholipase C. Blood (2002) 1.15
Tec regulates platelet activation by GPVI in the absence of Btk. Blood (2003) 1.14
The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis. Blood (2009) 1.13