Published in PLoS Biol on August 18, 2009
Endocytosis and signalling: intertwining molecular networks. Nat Rev Mol Cell Biol (2009) 5.83
Conformational biosensors reveal GPCR signalling from endosomes. Nature (2013) 3.29
Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome. N Engl J Med (2014) 1.89
Allostery at G protein-coupled receptor homo- and heteromers: uncharted pharmacological landscapes. Pharmacol Rev (2010) 1.89
Retromer terminates the generation of cAMP by internalized PTH receptors. Nat Chem Biol (2011) 1.88
Genetically encodable fluorescent biosensors for tracking signaling dynamics in living cells. Chem Rev (2011) 1.88
Endocytosis and signaling: cell logistics shape the eukaryotic cell plan. Physiol Rev (2012) 1.61
Intracellular cAMP signaling by soluble adenylyl cyclase. Kidney Int (2011) 1.40
Endocytosis promotes rapid dopaminergic signaling. Neuron (2011) 1.35
The role of type 4 phosphodiesterases in generating microdomains of cAMP: large scale stochastic simulations. PLoS One (2010) 1.34
Molecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm. Cell Mol Life Sci (2010) 1.30
G protein-coupled receptor signalling in the cardiac nuclear membrane: evidence and possible roles in physiological and pathophysiological function. J Physiol (2011) 1.27
G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes. J Biol Chem (2015) 1.24
GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling. Cell (2016) 1.18
Spatial encoding of cyclic AMP signaling specificity by GPCR endocytosis. Nat Chem Biol (2014) 1.15
GPCR signaling along the endocytic pathway. Curr Opin Cell Biol (2013) 1.13
Noncanonical control of vasopressin receptor type 2 signaling by retromer and arrestin. J Biol Chem (2013) 1.12
Striatal neurones have a specific ability to respond to phasic dopamine release. J Physiol (2013) 1.10
Use of virtual cell in studies of cellular dynamics. Int Rev Cell Mol Biol (2010) 1.09
Noncanonical GPCR signaling arising from a PTH receptor-arrestin-Gβγ complex. Proc Natl Acad Sci U S A (2013) 1.08
Modulating neuromodulation by receptor membrane traffic in the endocytic pathway. Neuron (2012) 1.07
cAMP and mitochondria. Physiology (Bethesda) (2013) 1.07
Distinct pools of cAMP centre on different isoforms of adenylyl cyclase in pituitary-derived GH3B6 cells. J Cell Sci (2010) 1.06
Structural requirements for PACSIN/Syndapin operation during zebrafish embryonic notochord development. PLoS One (2009) 1.05
Congenital nephrogenic diabetes insipidus: the current state of affairs. Pediatr Nephrol (2012) 1.04
Endosomal generation of cAMP in GPCR signaling. Nat Chem Biol (2014) 1.03
cAMP signaling in subcellular compartments. Pharmacol Ther (2014) 1.02
Pharmacological distinction between soluble and transmembrane adenylyl cyclases. J Pharmacol Exp Ther (2013) 1.02
Persistent cAMP signaling by thyrotropin (TSH) receptors is not dependent on internalization. FASEB J (2010) 0.99
PTH receptor-1 signalling-mechanistic insights and therapeutic prospects. Nat Rev Endocrinol (2015) 0.98
Spatial control of cAMP signalling in health and disease. Curr Opin Pharmacol (2011) 0.98
Formoterol and salmeterol induce a similar degree of β2-adrenoceptor tolerance in human small airways but via different mechanisms. Br J Pharmacol (2011) 0.97
Pituitary adenylate cyclase 1 receptor internalization and endosomal signaling mediate the pituitary adenylate cyclase activating polypeptide-induced increase in guinea pig cardiac neuron excitability. J Neurosci (2013) 0.95
Signaling endosomes: seeing is believing. Curr Opin Cell Biol (2010) 0.95
Non-canonical signaling of the PTH receptor. Trends Pharmacol Sci (2012) 0.95
Divergent modes for cargo-mediated control of clathrin-coated pit dynamics. Mol Biol Cell (2013) 0.93
Thyrotropin receptor stimulates internalization-independent persistent phosphoinositide signaling. Mol Pharmacol (2011) 0.93
Cell biology: Receptor signals come in waves. Nature (2013) 0.93
Actin-Sorting Nexin 27 (SNX27)-Retromer Complex Mediates Rapid Parathyroid Hormone Receptor Recycling. J Biol Chem (2016) 0.92
Spatially restricted G protein-coupled receptor activity via divergent endocytic compartments. J Biol Chem (2013) 0.92
The impact of long-term exposure to space environment on adult mammalian organisms: a study on mouse thyroid and testis. PLoS One (2012) 0.92
Chaperoning G protein-coupled receptors: from cell biology to therapeutics. Endocr Rev (2014) 0.91
A negative allosteric modulator demonstrates biased antagonism of the follicle stimulating hormone receptor. Mol Cell Endocrinol (2010) 0.89
VIP, CRF, and PACAP act at distinct receptors to elicit different cAMP/PKA dynamics in the neocortex. Cereb Cortex (2010) 0.89
Biophysical techniques for detection of cAMP and cGMP in living cells. Int J Mol Sci (2013) 0.88
Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in mouse ovarian follicles. Proc Natl Acad Sci U S A (2015) 0.86
Type 10 soluble adenylyl cyclase is overexpressed in prostate carcinoma and controls proliferation of prostate cancer cells. J Biol Chem (2012) 0.86
cAMP signaling microdomains and their observation by optical methods. Front Cell Neurosci (2014) 0.86
Genetically encoded fluorescent biosensors for live-cell visualization of protein phosphorylation. Chem Biol (2014) 0.85
Location-dependent signaling of the group 1 metabotropic glutamate receptor mGlu5. Mol Pharmacol (2014) 0.85
Visualization of cyclic nucleotide dynamics in neurons. Front Cell Neurosci (2014) 0.85
Extra-long Gαs variant XLαs protein escapes activation-induced subcellular redistribution and is able to provide sustained signaling. J Biol Chem (2011) 0.85
Sorting nexin 1 loss results in D5 dopamine receptor dysfunction in human renal proximal tubule cells and hypertension in mice. J Biol Chem (2012) 0.84
GPCR Signaling and Trafficking: The Long and Short of It. Trends Endocrinol Metab (2016) 0.83
PACAP-induced ERK activation in HEK cells expressing PAC1 receptors involves both receptor internalization and PKC signaling. Am J Physiol Cell Physiol (2014) 0.83
Axial tubule junctions control rapid calcium signaling in atria. J Clin Invest (2016) 0.83
Role of soluble adenylyl cyclase in the heart. Am J Physiol Heart Circ Physiol (2011) 0.83
Targeting the thyroid-stimulating hormone receptor with small molecule ligands and antibodies. Expert Opin Ther Targets (2015) 0.83
Dynamic kisspeptin receptor trafficking modulates kisspeptin-mediated calcium signaling. Mol Endocrinol (2013) 0.83
Selective regulation of MAP kinase signaling by an endomembrane phosphatidylinositol 4-kinase. J Biol Chem (2011) 0.83
International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors--family B G protein-coupled receptors. Pharmacol Rev (2015) 0.83
Temporally resolved cAMP monitoring in endothelial cells uncovers a thrombin-induced [cAMP] elevation mediated via the Ca²+-dependent production of prostacyclin. J Physiol (2010) 0.82
Gαs regulates the post-endocytic sorting of G protein-coupled receptors. Nat Commun (2014) 0.82
Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung. Pharmaceuticals (Basel) (2012) 0.82
The role of soluble adenylyl cyclase in neurite outgrowth. Biochim Biophys Acta (2014) 0.81
A long lasting β1 adrenergic receptor stimulation of cAMP/protein kinase A (PKA) signal in cardiac myocytes. J Biol Chem (2014) 0.80
Persistent signaling by thyrotropin-releasing hormone receptors correlates with G-protein and receptor levels. FASEB J (2012) 0.80
Eosinophil crystalloid granules: structure, function, and beyond. J Leukoc Biol (2012) 0.80
Inhibition of follicle-stimulating hormone-induced preovulatory follicles in rats treated with a nonsteroidal negative allosteric modulator of follicle-stimulating hormone receptor. Biol Reprod (2014) 0.80
Phenotypic regulation of the sphingosine 1-phosphate receptor miles apart by G protein-coupled receptor kinase 2. Biochemistry (2015) 0.80
Soluble adenylyl cyclase is necessary and sufficient to overcome the block of axonal growth by myelin-associated factors. J Neurosci (2014) 0.80
Molecular Pharmacology of δ-Opioid Receptors. Pharmacol Rev (2016) 0.80
Endocytic profiles of δ-opioid receptor ligands determine the duration of rapid but not sustained cAMP responses. Mol Pharmacol (2013) 0.79
When two keys fit one lock, surprises follow. Nat Chem Biol (2009) 0.79
Non-traditional roles of G protein-coupled receptors in basic cell biology. Mol Biosyst (2013) 0.79
Impairment of adenylyl cyclase 2 function and expression in hypoxanthine phosphoribosyltransferase-deficient rat B103 neuroblastoma cells as model for Lesch-Nyhan disease: BODIPY-forskolin as pharmacological tool. Naunyn Schmiedebergs Arch Pharmacol (2012) 0.79
The α-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the β2-Adrenergic Receptor. J Biol Chem (2016) 0.79
Investigating signaling consequences of GPCR trafficking in the endocytic pathway. Methods Enzymol (2014) 0.78
Histamine receptors of cones and horizontal cells in Old World monkey retinas. J Comp Neurol (2012) 0.78
Model Organisms in G Protein-Coupled Receptor Research. Mol Pharmacol (2015) 0.78
In-vivo detection of binary PKA network interactions upon activation of endogenous GPCRs. Sci Rep (2015) 0.78
Quaternary structures of opsin in live cells revealed by FRET spectrometry. Biochem J (2016) 0.78
Targeting protein-protein interactions in complexes organized by A kinase anchoring proteins. Front Pharmacol (2015) 0.77
Regulation of Constitutive GPR3 Signaling and Surface Localization by GRK2 and β-arrestin-2 Overexpression in HEK293 Cells. PLoS One (2013) 0.77
Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII. Cardiovasc Res (2015) 0.77
Genetically-encoded tools for cAMP probing and modulation in living systems. Front Pharmacol (2015) 0.77
Neuroprotective role of prostaglandin PGE2 EP2 receptor in hemin-mediated toxicity. Neurotoxicology (2014) 0.77
ARF6 Is an Actionable Node that Orchestrates Oncogenic GNAQ Signaling in Uveal Melanoma. Cancer Cell (2016) 0.77
Spatial resolution of cAMP signaling by soluble adenylyl cyclase. J Cell Biol (2016) 0.76
Studying GPCR/cAMP pharmacology from the perspective of cellular structure. Front Pharmacol (2015) 0.76
Distinct G protein-coupled receptor recycling pathways allow spatial control of downstream G protein signaling. J Cell Biol (2016) 0.76
Inside job: ligand-receptor pharmacology beneath the plasma membrane. Acta Pharmacol Sin (2013) 0.76
Modeling of spatially-restricted intracellular signaling. Wiley Interdiscip Rev Syst Biol Med (2011) 0.76
Functional consequences of glucagon-like peptide-1 receptor cross-talk and trafficking. J Biol Chem (2014) 0.76
Involvement of F-actin in chaperonin-containing t-complex 1 beta regulating mouse mesangial cell functions in a glucose-induction cell model. Exp Diabetes Res (2011) 0.76
Proliferation in cardiac fibroblasts induced by β1-adrenoceptor autoantibody and the underlying mechanisms. Sci Rep (2016) 0.75
Signaling: retromer arrests receptor on the run. Nat Chem Biol (2011) 0.75
Persistent cAMP signaling by TSH receptors revealed by phosphodiesterase inhibition. Thyroid (2013) 0.75
Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene (1991) 38.64
'Green mice' as a source of ubiquitous green cells. FEBS Lett (1997) 17.06
Dynasore, a cell-permeable inhibitor of dynamin. Dev Cell (2006) 13.15
Seven-transmembrane receptors. Nat Rev Mol Cell Biol (2002) 11.50
Cell-signalling dynamics in time and space. Nat Rev Mol Cell Biol (2006) 7.25
AKAP signalling complexes: focal points in space and time. Nat Rev Mol Cell Biol (2004) 6.97
The Virtual Cell: a software environment for computational cell biology. Trends Biotechnol (2001) 5.36
Signal transduction and endocytosis: close encounters of many kinds. Nat Rev Mol Cell Biol (2002) 5.05
Highly inclined thin illumination enables clear single-molecule imaging in cells. Nat Methods (2008) 5.01
Novel single chain cAMP sensors for receptor-induced signal propagation. J Biol Chem (2004) 5.00
Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes. Science (2002) 4.96
Fluorescence ratio imaging of cyclic AMP in single cells. Nature (1991) 4.45
G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization. J Biol Chem (1998) 4.37
Not just a sink: endosomes in control of signal transduction. Curr Opin Cell Biol (2004) 4.15
Receptor-mediated activation of heterotrimeric G-proteins in living cells. Science (2001) 4.04
The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways. Nature (2005) 3.82
Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks. Cell (2008) 3.79
Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1. Neuron (2004) 3.65
Local and global cytosolic Ca2+ oscillations in exocrine cells evoked by agonists and inositol trisphosphate. Cell (1993) 3.53
Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. Proc Natl Acad Sci U S A (2004) 3.31
Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome. Cell (2006) 3.11
Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell (2005) 3.01
Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator. EMBO Rep (2004) 2.98
Quantitative cell biology with the Virtual Cell. Trends Cell Biol (2003) 2.91
Quantification of low density lipoprotein and transferrin endocytic sorting HEp2 cells using confocal microscopy. J Cell Sci (1994) 2.88
Measurement of the millisecond activation switch of G protein-coupled receptors in living cells. Nat Biotechnol (2003) 2.84
Cyclic AMP imaging in adult cardiac myocytes reveals far-reaching beta1-adrenergic but locally confined beta2-adrenergic receptor-mediated signaling. Circ Res (2006) 2.66
Calcium ions, active zones and synaptic transmitter release. Trends Neurosci (1988) 2.66
Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases. Circ Res (2004) 2.58
Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes. Nature (2005) 2.54
Signaling on the endocytic pathway. Curr Opin Cell Biol (2007) 2.53
Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons. Science (1993) 2.51
Endocytosis conducts the cell signaling orchestra. Cell (2006) 2.48
The thyrotropin receptor and the regulation of thyrocyte function and growth. Endocr Rev (1992) 2.44
A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cell. Proc Natl Acad Sci U S A (2001) 2.36
A genetically encoded, fluorescent indicator for cyclic AMP in living cells. Nat Cell Biol (2000) 2.34
Cyclic nucleotide-gated channels colocalize with adenylyl cyclase in regions of restricted cAMP diffusion. J Gen Physiol (2000) 2.25
cAMP compartmentation is responsible for a local activation of cardiac Ca2+ channels by beta-adrenergic agonists. Proc Natl Acad Sci U S A (1996) 2.03
Fluorescent sensors for rapid monitoring of intracellular cGMP. Nat Methods (2006) 1.96
Sequestration and recycling of beta 2-adrenergic receptors permit receptor resensitization. Mol Pharmacol (1995) 1.93
Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway. Circ Res (2005) 1.91
G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes. J Biol Chem (2005) 1.82
PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases. J Cell Biol (2006) 1.81
Derivation of mouse embryonic stem cells. Nat Protoc (2006) 1.76
Spatiotemporal dynamics of guanosine 3',5'-cyclic monophosphate revealed by a genetically encoded, fluorescent indicator. Proc Natl Acad Sci U S A (2001) 1.74
Phosphodiesterase 4D forms a cAMP diffusion barrier at the apical membrane of the airway epithelium. J Biol Chem (2004) 1.73
Computational cell biology: spatiotemporal simulation of cellular events. Annu Rev Biophys Biomol Struct (2001) 1.73
Accessory proteins for G proteins: partners in signaling. Annu Rev Pharmacol Toxicol (2006) 1.68
Imaging of cAMP levels and protein kinase A activity reveals that retinal waves drive oscillations in second-messenger cascades. J Neurosci (2006) 1.67
Cyclic AMP diffusion coefficient in frog olfactory cilia. Biophys J (1999) 1.54
Reduction of adenylate cyclase activity in lysates of human platelets by the alpha-adrenergic component of epinephrine. J Cyclic Nucleotide Res (1977) 1.54
Compartmentation of cyclic nucleotide signaling in the heart: the role of A-kinase anchoring proteins. Circ Res (2006) 1.48
Optical techniques to analyze real-time activation and signaling of G-protein-coupled receptors. Trends Pharmacol Sci (2008) 1.46
Relaxing the actin cytoskeleton for adhesion and movement with Ena/VASP. J Cell Biol (2008) 1.34
Compartmentalization of adenylate cyclase and cAMP signalling. Biochem Soc Trans (2005) 1.32
Long-term synaptic facilitation in the absence of short-term facilitation in Aplysia neurons. Science (1993) 1.30
Phosphodiesterases and compartmentalized cAMP signalling in the heart. Eur J Cell Biol (2006) 1.30
Thyroid-specific enhancer-binding protein/NKX2.1 is required for the maintenance of ordered architecture and function of the differentiated thyroid. Mol Endocrinol (2006) 1.29
Restricted diffusion of a freely diffusible second messenger: mechanisms underlying compartmentalized cAMP signalling. Biochem Soc Trans (2006) 1.22
Monitoring of cAMP synthesis and degradation in living cells. Physiology (Bethesda) (2006) 1.20
Intracellular chloride channels: determinants of function in the endosomal pathway. Sci STKE (2004) 1.20
Molecular cloning, characterization, and dynamics of rat formiminotransferase cyclodeaminase, a Golgi-associated 58-kDa protein. J Biol Chem (1998) 1.19
Photoaffinity labeling of A1-adenosine receptors. J Biol Chem (1985) 1.11
Theoretical analyses of the functioning of the high- and low-Km cyclic nucleotide phosphodiesterases in the regulation of the concentration of adenosine 3',5'-cyclic monophosphate in animal cells. J Theor Biol (1980) 1.11
Thyrotropin receptor trafficking relies on the hScrib-betaPIX-GIT1-ARF6 pathway. EMBO J (2005) 1.10
The ocular albinism type 1 (OA1) protein and the evidence for an intracellular signal transduction system involved in melanosome biogenesis. Pigment Cell Res (2005) 1.10
Fluorescent indicators for cyclic GMP based on cyclic GMP-dependent protein kinase Ialpha and green fluorescent proteins. Anal Chem (2000) 1.08
Role of heterotrimeric GTP binding proteins in vesicular protein transport: indications for both classical and alternative G protein cycles. FEBS Lett (1995) 1.07
Beta-adrenergic- and muscarinic receptor-induced changes in cAMP activity in adult cardiac myocytes detected with FRET-based biosensor. Am J Physiol Cell Physiol (2005) 1.07
Role of endocytosis in signalling and regulation of G-protein-coupled receptors. Biochem Soc Trans (2001) 1.04
Monitoring receptor signaling by intramolecular FRET. Curr Opin Pharmacol (2007) 1.03
Functional localization of cAMP signalling in cardiac myocytes. Biochem Soc Trans (2006) 0.99
Giving space to cell signaling. Cell (2008) 0.99
Immunohistochemical localization of adenylyl cyclase in rat brain indicates a highly selective concentration at synapses. Proc Natl Acad Sci U S A (1995) 0.95
Thyroid-stimulating hormone binding to beef thyroid membranes. Relation to adenylate cyclase activity. J Biol Chem (1974) 0.94
The human thyrotropin receptor is predominantly internalized by beta-arrestin 2. Endocrinology (2006) 0.93
Selective modulation of protein kinase A I and II reveals distinct roles in thyroid cell gene expression and growth. Mol Endocrinol (2006) 0.92
Measurement of cAMP accumulation in Chinese hamster ovary cells transfected with the recombinant human TSH receptor (CHO-R): a new bioassay for human thyrotropin. J Endocrinol Invest (1993) 0.92
Internalization and recycling pathways of the thyrotropin receptor. Mol Endocrinol (1999) 0.89
Imaging cyclic AMP changes in pancreatic islets of transgenic reporter mice. PLoS One (2008) 0.89
Thyrocyte integration, and thyroid folliculogenesis and tissue regeneration: perspective for thyroid tissue engineering. Pathol Int (2001) 0.86
Transgenic fruit-flies expressing a FRET-based sensor for in vivo imaging of cAMP dynamics. Cell Signal (2007) 0.86
The v-Ki-Ras oncogene alters cAMP nuclear signaling by regulating the location and the expression of cAMP-dependent protein kinase IIbeta. J Biol Chem (1996) 0.85
The expression of the thyroid-stimulating hormone (TSH) receptor and the cAMP-dependent protein kinase RII beta regulatory subunit confers TSH-cAMP-dependent growth to mouse fibroblasts. J Biol Chem (2003) 0.84
One-step isolation of plasma membrane proteins using magnetic beads with immobilized concanavalin A. Protein Expr Purif (2008) 0.83
The localization and activity of cAMP-dependent protein kinase affect cell cycle progression in thyroid cells. J Biol Chem (2000) 0.83
Phagocytosis induced by thyrotropin in cultured thyroid cells is associated with myosin light chain dephosphorylation and stress fiber disruption. J Cell Biol (1993) 0.82
Nycthemeral patterns of thyroid hormones and their relationships with thyrotropin variations and sleep structure. J Endocrinol Invest (1994) 0.82
Actin stress fiber disruption and tropomyosin isoform switching in normal thyroid epithelial cells stimulated by thyrotropin and phorbol esters. Exp Cell Res (1989) 0.81
Expression of multiple adenylyl cyclase isoforms in human and dog thyroid. Mol Cell Endocrinol (2000) 0.80
Adenylyl cyclase co-distribution with the CaBPs, calbindin-D28 and calretinin, varies with cell type: assessment with the fluorescent dye, BODIPY forskolin, in enteric ganglia. Cell Tissue Res (1998) 0.78
Differential involvement of the actin cytoskeleton in differentiation and mitogenesis of thyroid cells: inactivation of Rho proteins contributes to cyclic adenosine monophosphate-dependent gene expression but prevents mitogenesis. Endocrinology (2005) 0.78
Clathrin-independent endocytosis of ubiquitinated cargos. Proc Natl Acad Sci U S A (2005) 5.37
Novel single chain cAMP sensors for receptor-induced signal propagation. J Biol Chem (2004) 5.00
Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments. J Cell Biol (2006) 3.95
A block of autophagy in lysosomal storage disorders. Hum Mol Genet (2007) 3.28
PML regulates apoptosis at endoplasmic reticulum by modulating calcium release. Science (2010) 3.21
A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells. Nat Methods (2005) 3.11
Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation. Science (2010) 2.99
Measurement of the millisecond activation switch of G protein-coupled receptors in living cells. Nat Biotechnol (2003) 2.84
Widespread receptivity to neuropeptide PDF throughout the neuronal circadian clock network of Drosophila revealed by real-time cyclic AMP imaging. Neuron (2008) 2.73
Cyclic AMP imaging in adult cardiac myocytes reveals far-reaching beta1-adrenergic but locally confined beta2-adrenergic receptor-mediated signaling. Circ Res (2006) 2.66
International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the recognition and nomenclature of G protein-coupled receptor heteromultimers. Pharmacol Rev (2007) 2.62
Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases. Circ Res (2004) 2.58
Gi protein activation in intact cells involves subunit rearrangement rather than dissociation. Proc Natl Acad Sci U S A (2003) 2.52
Conformational cross-talk between alpha2A-adrenergic and mu-opioid receptors controls cell signaling. Nat Chem Biol (2008) 2.51
Building a new conceptual framework for receptor heteromers. Nat Chem Biol (2009) 2.41
Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2. Nature (2003) 2.38
Feedback inhibition of catecholamine release by two different alpha2-adrenoceptor subtypes prevents progression of heart failure. Circulation (2002) 2.10
Dynamics of receptor/G protein coupling in living cells. EMBO J (2005) 2.06
Analysis of receptor oligomerization by FRAP microscopy. Nat Methods (2009) 2.06
Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines. J Biol Chem (2001) 2.06
The transcriptional repressor Nab1 is a specific regulator of pathological cardiac hypertrophy. Nat Med (2005) 2.02
Validation of a standardized method for enumerating circulating endothelial cells and progenitors: flow cytometry and molecular and ultrastructural analyses. Clin Cancer Res (2009) 2.00
Fluorescent sensors for rapid monitoring of intracellular cGMP. Nat Methods (2006) 1.96
Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome. N Engl J Med (2014) 1.89
The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential. J Biol Chem (2004) 1.86
Determination of onset of sexual maturation and mating behavior by melanocortin receptor 4 polymorphisms. Curr Biol (2010) 1.82
A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans. Nat Cell Biol (2004) 1.82
Single-molecule analysis of fluorescently labeled G-protein-coupled receptors reveals complexes with distinct dynamics and organization. Proc Natl Acad Sci U S A (2012) 1.82
G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives. Pharmacol Rev (2014) 1.82
Identification of new variants of human BMP15 gene in a large cohort of women with premature ovarian failure. J Clin Endocrinol Metab (2006) 1.81
Interplay of Ca2+ and cAMP signaling in the insulin-secreting MIN6 beta-cell line. J Biol Chem (2005) 1.80
Inhibition of Na(+)-H(+) exchange prevents hypertrophy, fibrosis, and heart failure in beta(1)-adrenergic receptor transgenic mice. Circ Res (2002) 1.79
Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte. Development (2009) 1.78
Direct evidence for a beta 1-adrenergic receptor-directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy. J Clin Invest (2004) 1.77
Premature ovarian failure. Orphanet J Rare Dis (2006) 1.75
Hypergonadotropic ovarian failure associated with an inherited mutation of human bone morphogenetic protein-15 (BMP15) gene. Am J Hum Genet (2004) 1.72
Sweet taste receptor expressed in pancreatic beta-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion. PLoS One (2009) 1.71
Luteinizing hormone signaling in preovulatory follicles involves early activation of the epidermal growth factor receptor pathway. Mol Endocrinol (2008) 1.71
Signaling by internalized G-protein-coupled receptors. Trends Pharmacol Sci (2010) 1.70
Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes. J Am Coll Cardiol (2013) 1.68
Hypogonadotropic hypogonadism as a presenting feature of late-onset X-linked adrenal hypoplasia congenita. J Clin Endocrinol Metab (2002) 1.68
Relationships between EGFR signaling-competent and endocytosis-competent membrane microdomains. Mol Biol Cell (2005) 1.67
Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism. Proc Natl Acad Sci U S A (2005) 1.63
Molecular basis of inverse agonism in a G protein-coupled receptor. Nat Chem Biol (2005) 1.60
A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy. Nat Med (2008) 1.56
G Protein activation without subunit dissociation depends on a G{alpha}(i)-specific region. J Biol Chem (2005) 1.55
Assessing FRET using spectral techniques. Cytometry A (2013) 1.53
Gs activation is time-limiting in initiating receptor-mediated signaling. J Biol Chem (2006) 1.52
Spatiotemporal dynamics of beta-adrenergic cAMP signals and L-type Ca2+ channel regulation in adult rat ventricular myocytes: role of phosphodiesterases. Circ Res (2008) 1.50
Beta-arrestin binding to the beta2-adrenergic receptor requires both receptor phosphorylation and receptor activation. J Biol Chem (2005) 1.50
Optical techniques to analyze real-time activation and signaling of G-protein-coupled receptors. Trends Pharmacol Sci (2008) 1.46
FRET measurements of intracellular cAMP concentrations and cAMP analog permeability in intact cells. Nat Protoc (2011) 1.45
A 7-year experience with low blood TSH cutoff levels for neonatal screening reveals an unsuspected frequency of congenital hypothyroidism (CH). Clin Endocrinol (Oxf) (2009) 1.45
Targeted deletion of the integrin beta4 signaling domain suppresses laminin-5-dependent nuclear entry of mitogen-activated protein kinases and NF-kappaB, causing defects in epidermal growth and migration. Mol Cell Biol (2005) 1.44
Real-time optical recording of beta1-adrenergic receptor activation reveals supersensitivity of the Arg389 variant to carvedilol. J Clin Invest (2007) 1.44
Role of GPR30 in testicular germ cell tumors: a potential new anticancer target. Cancer Biol Ther (2011) 1.43
X chromosome monosomy: a common mechanism for autoimmune diseases. J Immunol (2005) 1.41
TTP specifically regulates the internalization of the transferrin receptor. Cell (2005) 1.41
Biallelic inactivation of the dual oxidase maturation factor 2 (DUOXA2) gene as a novel cause of congenital hypothyroidism. J Clin Endocrinol Metab (2007) 1.41
Cardiac hypertrophy: targeting Raf/MEK/ERK1/2-signaling. Int J Biochem Cell Biol (2009) 1.39
Internalization determinants of the parathyroid hormone receptor differentially regulate beta-arrestin/receptor association. J Biol Chem (2001) 1.37
Altered calcium handling is critically involved in the cardiotoxic effects of chronic beta-adrenergic stimulation. Circulation (2004) 1.36
The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptor. Development (2010) 1.36
Pituitary tumours: TSH-secreting adenomas. Best Pract Res Clin Endocrinol Metab (2009) 1.35
Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement. Nat Genet (2012) 1.34
Differential control of adrenal and sympathetic catecholamine release by alpha 2-adrenoceptor subtypes. Mol Endocrinol (2003) 1.33
Amyloid precursor protein and Presenilin1 interact with the adaptor GRB2 and modulate ERK 1,2 signaling. J Biol Chem (2007) 1.31
Real-time monitoring of the PDE2 activity of live cells: hormone-stimulated cAMP hydrolysis is faster than hormone-stimulated cAMP synthesis. J Biol Chem (2004) 1.30
Intracellular entrapment of wild-type TSH receptor by oligomerization with mutants linked to dominant TSH resistance. Hum Mol Genet (2005) 1.30
Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function. Proc Natl Acad Sci U S A (2006) 1.29
Fluorescent labeling of tetracysteine-tagged proteins in intact cells. Nat Protoc (2010) 1.28
Dynamic partitioning into lipid rafts controls the endo-exocytic cycle of the alphaL/beta2 integrin, LFA-1, during leukocyte chemotaxis. Mol Biol Cell (2005) 1.25
A dynamic podosome-like structure of epithelial cells. Exp Cell Res (2004) 1.25
Systemic inflammation and neurodegeneration in a mouse model of multiple sulfatase deficiency. Proc Natl Acad Sci U S A (2007) 1.25
Type 4 phosphodiesterase plays different integrating roles in different cellular domains in pyramidal cortical neurons. J Neurosci (2010) 1.24
Plasticity of surface structures and β(2)-adrenergic receptor localization in failing ventricular cardiomyocytes during recovery from heart failure. Circ Heart Fail (2012) 1.23
An alternate translation initiation site circumvents an amino-terminal DAX1 nonsense mutation leading to a mild form of X-linked adrenal hypoplasia congenita. J Clin Endocrinol Metab (2003) 1.23
A novel mutation in the bone morphogenetic protein 15 gene causing defective protein secretion is associated with both increased ovulation rate and sterility in Lacaune sheep. Endocrinology (2006) 1.22
Monitoring of cAMP synthesis and degradation in living cells. Physiology (Bethesda) (2006) 1.20
Differential signaling of the endogenous agonists at the beta2-adrenergic receptor. J Biol Chem (2010) 1.20
Activator protein-1 and smad proteins synergistically regulate human follicle-stimulating hormone beta-promoter activity. Endocrinology (2008) 1.19
Multidrug resistance-associated protein 4 regulates cAMP-dependent signaling pathways and controls human and rat SMC proliferation. J Clin Invest (2008) 1.19
Persistent cAMP signaling by internalized TSH receptors occurs in thyroid but not in HEK293 cells. FASEB J (2012) 1.17
GPCR and G proteins: drug efficacy and activation in live cells. Mol Endocrinol (2009) 1.16