The inhibitory effect of manganese on acetylcholinesterase activity enhances oxidative stress and neuroinflammation in the rat brain.

PubWeight™: 1.51‹?› | Rank: Top 4%

🔗 View Article (PMC 3264815)

Published in Toxicology on December 03, 2011

Authors

Dinamene Santos1, Dejan Milatovic, Vanda Andrade, M Camila Batoreu, Michael Aschner, A P Marreilha dos Santos

Author Affiliations

1: I-Med.UL, Department of Toxicology and Food Sciences, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal.

Articles citing this

Brain deposition and neurotoxicity of manganese in adult mice exposed via the drinking water. Arch Toxicol (2013) 1.44

"Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies". BMC Pharmacol Toxicol (2016) 0.86

Cellular manganese content is developmentally regulated in human dopaminergic neurons. Sci Rep (2014) 0.82

Manganese alters rat brain amino acids levels. Biol Trace Elem Res (2012) 0.79

Lead, Arsenic, and Manganese Metal Mixture Exposures: Focus on Biomarkers of Effect. Biol Trace Elem Res (2015) 0.76

The toxic effect of manganese on the acetylcholinesterase activity in rat brains. J Toxicol (2014) 0.76

Comparison between 5-aminosalicylic acid (5-ASA) and para-aminosalicylic acid (4-PAS) as potential protectors against Mn-induced neurotoxicity. Biol Trace Elem Res (2013) 0.76

Evaluation of neurobehavioral and neuroinflammatory end-points in the post-exposure period in rats sub-acutely exposed to manganese. Toxicology (2013) 0.76

Mutation in HFE gene decreases manganese accumulation and oxidative stress in the brain after olfactory manganese exposure. Metallomics (2016) 0.75

Redox dynamics of manganese as a mitochondrial life-death switch. Biochem Biophys Res Commun (2017) 0.75

Perinatal manganese exposure and hydroxyl radical formation in rat brain. Neurotox Res (2014) 0.75

Comments to the Editor concerning the cholinergic response to manganese-induced neurotoxicity, based on the paper entitled "The inhibitory effect of manganese on acetylcholinesterase activity enhances oxidative stress and neuroinflammation in the brain" by Santos et al. Toxicology (2012) 0.75

Articles cited by this

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81

A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol (1961) 45.34

Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol (1990) 11.00

Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis (2000) 5.78

Water manganese exposure and children's intellectual function in Araihazar, Bangladesh. Environ Health Perspect (2006) 3.42

Manganism and idiopathic parkinsonism: similarities and differences. Neurology (1994) 3.34

Mitochondria, oxygen free radicals, disease and ageing. Trends Biochem Sci (2000) 3.04

Manganese toxicity upon overexposure. NMR Biomed (2004) 2.61

Searching for a relationship between manganese and welding and Parkinson's disease. Neurology (2005) 2.20

Nutritional aspects of manganese homeostasis. Mol Aspects Med (2005) 2.03

Possible health effects of high manganese concentration in drinking water. Arch Environ Health (1989) 2.00

Induction of cytoprotective genes through Nrf2/antioxidant response element pathway: a new therapeutic approach for the treatment of inflammatory diseases. Curr Pharm Des (2004) 2.00

Manganese neurotoxicity: a review of clinical features, imaging and pathology. Neurotoxicology (1999) 1.97

Interactions between glutamatergic and monoaminergic systems within the basal ganglia--implications for schizophrenia and Parkinson's disease. Trends Neurosci (1990) 1.91

Manganese action in brain function. Brain Res Brain Res Rev (2003) 1.88

Manganese dosimetry: species differences and implications for neurotoxicity. Crit Rev Toxicol (2005) 1.83

Arsenic and manganese exposure and children's intellectual function. Neurotoxicology (2011) 1.82

Formation of isoprostane-like compounds (neuroprostanes) in vivo from docosahexaenoic acid. J Biol Chem (1998) 1.71

Manganese superoxide dismutase mediates the early release of mitochondrial cytochrome C and subsequent DNA fragmentation after permanent focal cerebral ischemia in mice. J Neurosci (1999) 1.56

Manganese transport in eukaryotes: the role of DMT1. Neurotoxicology (2008) 1.53

Iron interactions and other biological reactions mediating the physiological and toxic actions of manganese. Biochem Pharmacol (2003) 1.48

Manganese-enhanced MRI: an exceptional tool in translational neuroimaging. Schizophr Bull (2008) 1.30

Anticholinesterase toxicity and oxidative stress. ScientificWorldJournal (2006) 1.27

Brain regional quantification of F-ring and D-/E-ring isoprostanes and neuroprostanes in Alzheimer's disease. Am J Pathol (2001) 1.26

Manganese neurotoxicity: a focus on the neonate. Pharmacol Ther (2006) 1.26

Speciation of manganese in cells and mitochondria: a search for the proximal cause of manganese neurotoxicity. Neurotoxicology (2006) 1.25

Manganese (Mn) transport across the rat blood-brain barrier: saturable and transferrin-dependent transport mechanisms. Brain Res Bull (1994) 1.25

Role of reactive oxygen species in LPS-induced production of prostaglandin E2 in microglia. J Neurochem (2004) 1.24

Alteration of serum concentrations of manganese, iron, ferritin, and transferrin receptor following exposure to welding fumes among career welders. Neurotoxicology (2005) 1.24

Neurologic effects of manganese in humans: a review. Int J Occup Environ Health (2003) 1.24

Oxidative damage and neurodegeneration in manganese-induced neurotoxicity. Toxicol Appl Pharmacol (2009) 1.23

Manganese neurotoxicity and glutamate-GABA interaction. Neurochem Int (2003) 1.20

Manganese neurotoxicity: lessons learned from longitudinal studies in nonhuman primates. Environ Health Perspect (2008) 1.19

Oxidative basis of manganese neurotoxicity. Ann N Y Acad Sci (2004) 1.16

Isoprostanes. J Lipid Res (2008) 1.14

Oxidative stress and mitochondrial-mediated apoptosis in dopaminergic cells exposed to methylcyclopentadienyl manganese tricarbonyl. J Pharmacol Exp Ther (2002) 1.14

Nicotinic effect of acetylcholine on the release of newly synthesized (3H)dopamine in rat striatal slices and cat caudate nucleus. Brain Res (1976) 1.13

Formation of novel D-ring and E-ring isoprostane-like compounds (D4/E4-neuroprostanes) in vivo from docosahexaenoic acid. Biochemistry (2000) 1.09

Manganese exposure and induced oxidative stress in the rat brain. Sci Total Environ (2004) 1.08

A brief history of the neurobehavioral toxicity of manganese: some unanswered questions. Neurotoxicology (1999) 1.07

Manganese cumulative exposure and symptoms: a follow-up study of alloy workers. Neurotoxicology (2008) 1.06

CR6-interacting factor 1 (CRIF1) regulates NF-E2-related factor 2 (NRF2) protein stability by proteasome-mediated degradation. J Biol Chem (2010) 1.04

Release of newly synthesized dopamine from dopamine-containing terminals in the striatum of the rat. Proc Natl Acad Sci U S A (1969) 1.02

Measuring brain manganese and iron accumulation in rats following 14 weeks of low-dose manganese treatment using atomic absorption spectroscopy and magnetic resonance imaging. Toxicol Sci (2008) 1.02

Influence of the route of administration and the chemical form (MnCl2, MnO2) on the absorption and cerebral distribution of manganese in rats. Arch Toxicol (1997) 1.02

Structure-function relationships in iron and manganese superoxide dismutases. Free Radic Res Commun (1991) 1.01

Mitochondrial-dependent manganese neurotoxicity in rat primary astrocyte cultures. Brain Res (2008) 0.99

Enhanced autoxidation of dopamine as a possible basis of manganese neurotoxicity. Neurotoxicology (1981) 0.99

Modulation of cholinergic systems by manganese. Neurotoxicology (2007) 0.98

Manganese-induced reactive oxygen species: comparison between Mn+2 and Mn+3. Neurodegeneration (1995) 0.98

Tyrosine phosphorylation controls nuclear export of Fyn, allowing Nrf2 activation of cytoprotective gene expression. FASEB J (2010) 0.98

Measurement of isoprostanes as markers of oxidative stress in neuronal tissue. Curr Protoc Toxicol (2009) 0.97

Recent advances in the biochemistry and clinical relevance of the isoprostane pathway. Lipids (2005) 0.96

Role of heme oxygenase-1 in the regulation of manganese superoxide dismutase gene expression in oxidatively-challenged astroglia. J Cell Physiol (2000) 0.92

Measurement of products of docosahexaenoic acid peroxidation, neuroprostanes, and neurofurans. Methods Enzymol (2007) 0.91

Brain regional distribution of glutamic acid decarboxylase, choline acetyltransferase, and acetylcholinesterase in the rat: effects of chronic manganese chloride administration after two years. J Neurochem (1981) 0.89

Behavioral effects of subchronic inorganic manganese exposure in rats. Am J Ind Med (2007) 0.89

Reduced mitochondrial manganese-superoxide dismutase activity exacerbates glutamate toxicity in cultured mouse cortical neurons. Brain Res (1998) 0.88

Brain manganese accumulation following systemic administration of different forms. Arch Toxicol (1985) 0.88

Prolactin is a peripheral marker of manganese neurotoxicity. Brain Res (2011) 0.87

Taurine prevents enhancement of acetylcholinesterase activity induced by acute ethanol exposure and decreases the level of markers of oxidative stress in zebrafish brain. Neuroscience (2010) 0.87

Hypermanganesemia in patients receiving total parenteral nutrition. JPEN J Parenter Enteral Nutr (1999) 0.87

Tremor and seizures associated with chronic manganese intoxication. Brain Dev (1999) 0.86

Isoprostanes as biomarkers and mediators of oxidative injury in infant and adult central nervous system diseases. Curr Neurovasc Res (2004) 0.85

Influence of dietary manganese on the pharmacokinetics of inhaled manganese sulfate in male CD rats. Toxicol Sci (2001) 0.84

Factor analysis of rat behavior in an open field test. Neurosci Behav Physiol (1989) 0.84

Hydrogen peroxide regulates the cholinergic signal in a concentration dependent manner. Life Sci (2007) 0.84

Enhanced striatal acetylcholine release by chlorpromazine and its reversal by apomorphine. Brain Res (1973) 0.84

Differences in the neurotoxic effects of manganese during development and aging: some observations on brain regional neurotransmitter and non-neurotransmitter metabolism in a developmental rat model of chronic manganese encephalopathy. Neurotoxicology (1984) 0.83

Bioaccumulation and locomotor effects of manganese sulfate in Sprague-Dawley rats following subchronic (90 days) inhalation exposure. Toxicol Appl Pharmacol (2005) 0.83

Performance alterations associated with occupational exposure to manganese--a meta-analysis. Neurotoxicology (2009) 0.83

Effects of inhaled manganese on biomarkers of oxidative stress in the rat brain. Neurotoxicology (2006) 0.83

Spectrophotometry of carnitine in biological fluids and tissue with a Cobas Bio centrifugal analyzer. Clin Chem (1986) 0.83

Bioaccumulation and locomotor effects of manganese phosphate/sulfate mixture in Sprague-Dawley rats following subchronic (90 days) inhalation exposure. Toxicol Appl Pharmacol (2003) 0.82

Behavioral effects of chronic manganese administration in rats: locomotor activity studies. Neurobehav Toxicol Teratol (1987) 0.81

Vitamin E decreased the activity of acetylcholinesterase and level of lipid peroxidation in brain of rats exposed to aged and diluted sidestream smoke. Nicotine Tob Res (2011) 0.81

The effect of chronic manganese administration on some neurochemical and physiological variables in neonatal rats. Gen Pharmacol (1981) 0.81

Effects of short-term exposure to manganese on the adult rat brain antioxidant status and the activities of acetylcholinesterase, (Na,K)-ATPase and Mg-ATPase: modulation by L-cysteine. Basic Clin Pharmacol Toxicol (2008) 0.80

Manganese intoxication decreases the expression of manganoproteins in the rat basal ganglia: an immunohistochemical study. Brain Res Bull (2007) 0.80

Behavioral effects of adult rats concurrently exposed to high doses of oral manganese and restraint stress. Toxicology (2005) 0.80

Chronic manganese intake induces changes in the motor activity of rats. Exp Neurol (1984) 0.80

Seizure associated with total parenteral nutrition-related hypermanganesemia. Pediatr Neurol (2007) 0.79

Potential neuropsychological profiles in welders occupationally exposed to manganese: an examination of effect size patterns. J Clin Exp Neuropsychol (2007) 0.78

The ontogeny of acetylcholinesterase activities in rat brain regions and the effect of chronic treatment with manganese chloride. J Neurochem (1982) 0.78

Water intake and brain choline-acetyltransferase and acetylcholinesterase activites in manganese treated rats. Neurobehav Toxicol Teratol (1981) 0.77

Quantification of F2-isoprostanes by gas chromatography/mass spectrometry as a measure of oxidant stress. Curr Protoc Toxicol (2005) 0.77

Effect of manganese on enzymes in rat brain. Acta Pharmacol Toxicol (Copenh) (1974) 0.77

Nature and mechanisms of cholinergic-monoaminergic interactions in the brain. Life Sci (1977) 0.76

Regulation of nigrostriatal and tuberoinfundibular-hypophyseal dopaminergic neurons. Prog Neurobiol (1979) 0.76

The effects of manganese on the cholinergic receptor in vivo and in vitro may be mediated through modulation of free radicals. Neurotoxicology (1984) 0.76

Involvement of manganese in physiological and biochemical processes: an overview. Neurotoxicology (1984) 0.76

Articles by these authors

Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology. Toxicol Sci (2008) 2.49

Manganese neurotoxicity may underlie the association between early life iron deficiency and impaired spatial cognition in neonatal piglets. J Nutr (2013) 2.16

Nutritional aspects of manganese homeostasis. Mol Aspects Med (2005) 2.03

Manganese neurotoxicity. Ann N Y Acad Sci (2004) 1.94

Peripheral F2-isoprostanes and F4-neuroprostanes are not increased in Alzheimer's disease. Ann Neurol (2002) 1.79

Role of manganese in neurodegenerative diseases. J Trace Elem Med Biol (2011) 1.73

Mefloquine neurotoxicity is mediated by non-receptor tyrosine kinase. Neurotoxicology (2011) 1.56

Brain barrier systems: a new frontier in metal neurotoxicological research. Toxicol Appl Pharmacol (2003) 1.55

Manganese transport in eukaryotes: the role of DMT1. Neurotoxicology (2008) 1.53

Neuronal oxidative damage from activated innate immunity is EP2 receptor-dependent. J Neurochem (2002) 1.44

Developmental neuropathology of environmental agents. Annu Rev Pharmacol Toxicol (2004) 1.28

Oxidative stress in MeHg-induced neurotoxicity. Toxicol Appl Pharmacol (2011) 1.28

Anticholinesterase toxicity and oxidative stress. ScientificWorldJournal (2006) 1.27

Manganese neurotoxicity: a focus on the neonate. Pharmacol Ther (2006) 1.26

Speciation of manganese in cells and mitochondria: a search for the proximal cause of manganese neurotoxicity. Neurotoxicology (2006) 1.25

Extracellular dopamine potentiates mn-induced oxidative stress, lifespan reduction, and dopaminergic neurodegeneration in a BLI-3-dependent manner in Caenorhabditis elegans. PLoS Genet (2010) 1.23

Oxidative damage and neurodegeneration in manganese-induced neurotoxicity. Toxicol Appl Pharmacol (2009) 1.23

Manganese accumulates in iron-deficient rat brain regions in a heterogeneous fashion and is associated with neurochemical alterations. Biol Trace Elem Res (2002) 1.23

Ferroportin is a manganese-responsive protein that decreases manganese cytotoxicity and accumulation. J Neurochem (2009) 1.23

Interactions between excessive manganese exposures and dietary iron-deficiency in neurodegeneration. Environ Toxicol Pharmacol (2005) 1.22

Down-regulation of early ionotrophic glutamate receptor subunit developmental expression as a mechanism for observed plasticity deficits following gestational exposure to benzo(a)pyrene. Neurotoxicology (2007) 1.22

Manganese neurotoxicity and glutamate-GABA interaction. Neurochem Int (2003) 1.20

Glutathione modulation influences methyl mercury induced neurotoxicity in primary cell cultures of neurons and astrocytes. Neurotoxicology (2006) 1.20

Manganese induces oxidative impairment in cultured rat astrocytes. Toxicol Sci (2007) 1.20

Basal ganglia intensity indices and diffusion weighted imaging in manganese-exposed welders. Occup Environ Med (2012) 1.17

Mechanisms of methylmercury-induced neurotoxicity: evidence from experimental studies. Life Sci (2011) 1.16

In vivo measurement of brain GABA concentrations by magnetic resonance spectroscopy in smelters occupationally exposed to manganese. Environ Health Perspect (2010) 1.16

Neuronal oxidative damage and dendritic degeneration following activation of CD14-dependent innate immune response in vivo. J Neuroinflammation (2004) 1.15

Metallothionein in the central nervous system: Roles in protection, regeneration and cognition. Neurotoxicology (2008) 1.15

Neuroprotection by tamoxifen in focal cerebral ischemia is not mediated by an agonist action at estrogen receptors but is associated with antioxidant activity. Exp Neurol (2007) 1.15

SyM-BBB: a microfluidic Blood Brain Barrier model. Lab Chip (2013) 1.12

SMF-1, SMF-2 and SMF-3 DMT1 orthologues regulate and are regulated differentially by manganese levels in C. elegans. PLoS One (2009) 1.11

Roles of glutamine in neurotransmission. Neuron Glia Biol (2011) 1.11

Iron deficient and manganese supplemented diets alter metals and transporters in the developing rat brain. Toxicol Sci (2006) 1.11

Manganese exposure among smelting workers: blood manganese-iron ratio as a novel tool for manganese exposure assessment. Biomarkers (2009) 1.11

Globus pallidus: a target brain region for divalent metal accumulation associated with dietary iron deficiency. J Nutr Biochem (2004) 1.09

Manganese exposure and induced oxidative stress in the rat brain. Sci Total Environ (2004) 1.08

Manganese-induced cytotoxicity in dopamine-producing cells. Neurotoxicology (2004) 1.08

Prenatal methylmercury exposure hampers glutathione antioxidant system ontogenesis and causes long-lasting oxidative stress in the mouse brain. Toxicol Appl Pharmacol (2007) 1.07

Role of astrocytes in brain function and disease. Toxicol Pathol (2010) 1.06

Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia. J Neurochem (2009) 1.06

Pathophysiology of manganese-associated neurotoxicity. Neurotoxicology (2011) 1.06

A manganese-enhanced diet alters brain metals and transporters in the developing rat. Toxicol Sci (2006) 1.05

Methylmercury induces acute oxidative stress, altering Nrf2 protein level in primary microglial cells. Toxicol Sci (2010) 1.05

The effects of manganese on glutamate, dopamine and gamma-aminobutyric acid regulation. Neurochem Int (2006) 1.05

Estrogen and tamoxifen reverse manganese-induced glutamate transporter impairment in astrocytes. J Neurochem (2009) 1.04

Manganese-induced dopaminergic neurodegeneration: insights into mechanisms and genetics shared with Parkinson's disease. Chem Rev (2009) 1.04

Prenatal exposure to benzo(a)pyrene impairs later-life cortical neuronal function. Neurotoxicology (2008) 1.03

Determining the oxidation states of manganese in NT2 cells and cultured astrocytes. Neurobiol Aging (2005) 1.03

Methylmercury induces oxidative injury, alterations in permeability and glutamine transport in cultured astrocytes. Brain Res (2006) 1.03

Modulatory effect of glutathione status and antioxidants on methylmercury-induced free radical formation in primary cultures of cerebral astrocytes. Brain Res Mol Brain Res (2005) 1.03

Manganese Is Essential for Neuronal Health. Annu Rev Nutr (2015) 1.03

The methylmercury-L-cysteine conjugate is a substrate for the L-type large neutral amino acid transporter. J Neurochem (2008) 1.02

Measuring brain manganese and iron accumulation in rats following 14 weeks of low-dose manganese treatment using atomic absorption spectroscopy and magnetic resonance imaging. Toxicol Sci (2008) 1.02

Methylmercury-induced reactive oxygen species formation in neonatal cerebral astrocytic cultures is attenuated by antioxidants. Brain Res Mol Brain Res (2003) 1.01

Prenatal polycyclic aromatic hydrocarbon exposure leads to behavioral deficits and downregulation of receptor tyrosine kinase, MET. Toxicol Sci (2010) 1.00

Disease-toxicant screen reveals a neuroprotective interaction between Huntington's disease and manganese exposure. J Neurochem (2009) 1.00

Manganese causes differential regulation of glutamate transporter (GLAST) taurine transporter and metallothionein in cultured rat astrocytes. Neurotoxicology (2002) 1.00

Mitochondrial-dependent manganese neurotoxicity in rat primary astrocyte cultures. Brain Res (2008) 0.99

Metals, oxidative stress and neurodegeneration: a focus on iron, manganese and mercury. Neurochem Int (2012) 0.99

Increased manganese uptake by primary astrocyte cultures with altered iron status is mediated primarily by divalent metal transporter. Neurotoxicology (2005) 0.99

Manganese inhalation by rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity. Toxicol Sci (2007) 0.99

Estrogen and tamoxifen protect against Mn-induced toxicity in rat cortical primary cultures of neurons and astrocytes. Toxicol Sci (2009) 0.98

Protection of DFP-induced oxidative damage and neurodegeneration by antioxidants and NMDA receptor antagonist. Toxicol Appl Pharmacol (2009) 0.98

Modulation of cholinergic systems by manganese. Neurotoxicology (2007) 0.98

Manganese (Mn) and iron (Fe): interdependency of transport and regulation. Neurotox Res (2009) 0.98

Methylmercury-induced alterations in astrocyte functions are attenuated by ebselen. Neurotoxicology (2011) 0.98

Measurement of isoprostanes as markers of oxidative stress in neuronal tissue. Curr Protoc Toxicol (2009) 0.97

Leaching of trace elements from biological tissue by formalin fixation. Biol Trace Elem Res (2007) 0.97

Copper accumulation and lipid oxidation precede inflammation and myelin lesions in N,N-diethyldithiocarbamate peripheral myelinopathy. Toxicol Appl Pharmacol (2008) 0.97

GPR30 regulates glutamate transporter GLT-1 expression in rat primary astrocytes. J Biol Chem (2012) 0.96

Mefloquine induces oxidative stress and neurodegeneration in primary rat cortical neurons. Neurotoxicology (2010) 0.96

Free radical formation in cerebral cortical astrocytes in culture induced by methylmercury. Brain Res Mol Brain Res (2004) 0.96

Retracted Polymorphic ventricular tachycardia and abnormal Ca2+ handling in very-long-chain acyl-CoA dehydrogenase null mice. Am J Physiol Heart Circ Physiol (2007) 0.96

Neonatal rat primary microglia: isolation, culturing, and selected applications. Curr Protoc Toxicol (2010) 0.95

The importance of glutamate, glycine, and gamma-aminobutyric acid transport and regulation in manganese, mercury and lead neurotoxicity. Toxicol Appl Pharmacol (2005) 0.94

Characterization of the effects of methylmercury on Caenorhabditis elegans. Toxicol Appl Pharmacol (2009) 0.94

A chronic iron-deficient/high-manganese diet in rodents results in increased brain oxidative stress and behavioral deficits in the morris water maze. Neurotox Res (2009) 0.93

Comparative study on the response of rat primary astrocytes and microglia to methylmercury toxicity. Glia (2011) 0.93

Transforming growth factor-α mediates estrogen-induced upregulation of glutamate transporter GLT-1 in rat primary astrocytes. Glia (2012) 0.92

Role of astrocytes in manganese mediated neurotoxicity. BMC Pharmacol Toxicol (2013) 0.92

Methylmercury toxicity and Nrf2-dependent detoxification in astrocytes. Toxicol Sci (2008) 0.92

Diphenyl diselenide, a simple organoselenium compound, decreases methylmercury-induced cerebral, hepatic and renal oxidative stress and mercury deposition in adult mice. Brain Res Bull (2008) 0.92

trans-10,cis-12-Conjugated linoleic acid instigates inflammation in human adipocytes compared with preadipocytes. J Biol Chem (2010) 0.92

Disease-toxicant interactions in manganese exposed Huntington disease mice: early changes in striatal neuron morphology and dopamine metabolism. PLoS One (2012) 0.92

Hormetic effect of methylmercury on Caenorhabditis elegans. Toxicol Appl Pharmacol (2010) 0.92