Published in Neurochem Int on May 13, 2003
Manganese: recent advances in understanding its transport and neurotoxicity. Toxicol Appl Pharmacol (2007) 2.17
Role of manganese in neurodegenerative diseases. J Trace Elem Med Biol (2011) 1.73
The inhibitory effect of manganese on acetylcholinesterase activity enhances oxidative stress and neuroinflammation in the rat brain. Toxicology (2011) 1.51
Brain deposition and neurotoxicity of manganese in adult mice exposed via the drinking water. Arch Toxicol (2013) 1.44
Protein kinase Cdelta is a key downstream mediator of manganese-induced apoptosis in dopaminergic neuronal cells. J Pharmacol Exp Ther (2004) 1.44
Effects of chronic manganese exposure on cognitive and motor functioning in non-human primates. Brain Res (2006) 1.27
Developing a bidirectional academic-community partnership with an Appalachian-American community for environmental health research and risk communication. Environ Health Perspect (2011) 1.24
Oxidative damage and neurodegeneration in manganese-induced neurotoxicity. Toxicol Appl Pharmacol (2009) 1.23
Ferroportin is a manganese-responsive protein that decreases manganese cytotoxicity and accumulation. J Neurochem (2009) 1.23
Metals, oxidative stress and neurodegeneration: a focus on iron, manganese and mercury. Neurochem Int (2012) 0.99
Microglia enhance manganese chloride-induced dopaminergic neurodegeneration: role of free radical generation. Exp Neurol (2009) 0.92
Manganese disrupts astrocyte glutamine transporter expression and function. J Neurochem (2009) 0.90
Novel high-throughput assay to assess cellular manganese levels in a striatal cell line model of Huntington's disease confirms a deficit in manganese accumulation. Neurotoxicology (2011) 0.87
Manganese-Induced Parkinsonism and Parkinson's Disease: Shared and Distinguishable Features. Int J Environ Res Public Health (2015) 0.86
Cellular fura-2 manganese extraction assay (CFMEA). Curr Protoc Toxicol (2011) 0.84
Mechanism of Mn(II)-mediated dysregulation of glutamine-glutamate cycle: focus on glutamate turnover. J Neurochem (2012) 0.84
Selenium protects neonates against neurotoxicity from prenatal exposure to manganese. PLoS One (2014) 0.84
Toxic elements in groundwater of Lagos and Ogun States, Southwest, Nigeria and their human health risk assessment. Environ Monit Assess (2015) 0.83
Incorporating genetics and genomics in risk assessment for inhaled manganese: from data to policy. Neurotoxicology (2009) 0.82
Gut microbiome in health and disease: Linking the microbiome-gut-brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases. Pharmacol Ther (2015) 0.82
The toxic effect of manganese on the acetylcholinesterase activity in rat brains. J Toxicol (2014) 0.76
Mechanisms of divalent metal toxicity in affective disorders. Toxicology (2015) 0.76
Rationale, design and baseline results of the Guangxi manganese-exposed workers healthy cohort (GXMEWHC) study. BMJ Open (2014) 0.76
Changes in Brain Metallome/Metabolome Pattern due to a Single i.v. Injection of Manganese in Rats. PLoS One (2015) 0.75
Sodium p-Aminosalicylic Acid Reverses Sub-Chronic Manganese-Induced Impairments of Spatial Learning and Memory Abilities in Rats, but Fails to Restore γ-Aminobutyric Acid Levels. Int J Environ Res Public Health (2017) 0.75
Drosophila melanogaster - an embryonic model for studying behavioral and biochemical effects of manganese exposure. EXCLI J (2014) 0.75
The Influence of Manganese and Glutamine Intake on Antioxidants and Neurotransmitter Amino Acids Levels in Rats' Brain. Neurochem Res (2016) 0.75
Potable water quality monitoring of primary schools in Magura district, Bangladesh: children's health risk assessment. Environ Monit Assess (2016) 0.75
Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology. Toxicol Sci (2008) 2.49
Manganese neurotoxicity may underlie the association between early life iron deficiency and impaired spatial cognition in neonatal piglets. J Nutr (2013) 2.16
Nutritional aspects of manganese homeostasis. Mol Aspects Med (2005) 2.03
Manganese neurotoxicity. Ann N Y Acad Sci (2004) 1.94
Role of manganese in neurodegenerative diseases. J Trace Elem Med Biol (2011) 1.73
Mefloquine neurotoxicity is mediated by non-receptor tyrosine kinase. Neurotoxicology (2011) 1.56
Brain barrier systems: a new frontier in metal neurotoxicological research. Toxicol Appl Pharmacol (2003) 1.55
Manganese transport in eukaryotes: the role of DMT1. Neurotoxicology (2008) 1.53
The inhibitory effect of manganese on acetylcholinesterase activity enhances oxidative stress and neuroinflammation in the rat brain. Toxicology (2011) 1.51
Developmental neuropathology of environmental agents. Annu Rev Pharmacol Toxicol (2004) 1.28
Oxidative stress in MeHg-induced neurotoxicity. Toxicol Appl Pharmacol (2011) 1.28
Anticholinesterase toxicity and oxidative stress. ScientificWorldJournal (2006) 1.27
Manganese neurotoxicity: a focus on the neonate. Pharmacol Ther (2006) 1.26
Speciation of manganese in cells and mitochondria: a search for the proximal cause of manganese neurotoxicity. Neurotoxicology (2006) 1.25
Extracellular dopamine potentiates mn-induced oxidative stress, lifespan reduction, and dopaminergic neurodegeneration in a BLI-3-dependent manner in Caenorhabditis elegans. PLoS Genet (2010) 1.23
Oxidative damage and neurodegeneration in manganese-induced neurotoxicity. Toxicol Appl Pharmacol (2009) 1.23
Manganese accumulates in iron-deficient rat brain regions in a heterogeneous fashion and is associated with neurochemical alterations. Biol Trace Elem Res (2002) 1.23
Ferroportin is a manganese-responsive protein that decreases manganese cytotoxicity and accumulation. J Neurochem (2009) 1.23
Interactions between excessive manganese exposures and dietary iron-deficiency in neurodegeneration. Environ Toxicol Pharmacol (2005) 1.22
Down-regulation of early ionotrophic glutamate receptor subunit developmental expression as a mechanism for observed plasticity deficits following gestational exposure to benzo(a)pyrene. Neurotoxicology (2007) 1.22
Glutathione modulation influences methyl mercury induced neurotoxicity in primary cell cultures of neurons and astrocytes. Neurotoxicology (2006) 1.20
Manganese induces oxidative impairment in cultured rat astrocytes. Toxicol Sci (2007) 1.20
Basal ganglia intensity indices and diffusion weighted imaging in manganese-exposed welders. Occup Environ Med (2012) 1.17
Mechanisms of methylmercury-induced neurotoxicity: evidence from experimental studies. Life Sci (2011) 1.16
In vivo measurement of brain GABA concentrations by magnetic resonance spectroscopy in smelters occupationally exposed to manganese. Environ Health Perspect (2010) 1.16
Metallothionein in the central nervous system: Roles in protection, regeneration and cognition. Neurotoxicology (2008) 1.15
Neuroprotection by tamoxifen in focal cerebral ischemia is not mediated by an agonist action at estrogen receptors but is associated with antioxidant activity. Exp Neurol (2007) 1.15
SyM-BBB: a microfluidic Blood Brain Barrier model. Lab Chip (2013) 1.12
SMF-1, SMF-2 and SMF-3 DMT1 orthologues regulate and are regulated differentially by manganese levels in C. elegans. PLoS One (2009) 1.11
Iron deficient and manganese supplemented diets alter metals and transporters in the developing rat brain. Toxicol Sci (2006) 1.11
Manganese exposure among smelting workers: blood manganese-iron ratio as a novel tool for manganese exposure assessment. Biomarkers (2009) 1.11
Roles of glutamine in neurotransmission. Neuron Glia Biol (2011) 1.11
Globus pallidus: a target brain region for divalent metal accumulation associated with dietary iron deficiency. J Nutr Biochem (2004) 1.09
Manganese exposure and induced oxidative stress in the rat brain. Sci Total Environ (2004) 1.08
Manganese-induced cytotoxicity in dopamine-producing cells. Neurotoxicology (2004) 1.08
Prenatal methylmercury exposure hampers glutathione antioxidant system ontogenesis and causes long-lasting oxidative stress in the mouse brain. Toxicol Appl Pharmacol (2007) 1.07
Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia. J Neurochem (2009) 1.06
Role of astrocytes in brain function and disease. Toxicol Pathol (2010) 1.06
Pathophysiology of manganese-associated neurotoxicity. Neurotoxicology (2011) 1.06
A manganese-enhanced diet alters brain metals and transporters in the developing rat. Toxicol Sci (2006) 1.05
Methylmercury induces acute oxidative stress, altering Nrf2 protein level in primary microglial cells. Toxicol Sci (2010) 1.05
The effects of manganese on glutamate, dopamine and gamma-aminobutyric acid regulation. Neurochem Int (2006) 1.05
Estrogen and tamoxifen reverse manganese-induced glutamate transporter impairment in astrocytes. J Neurochem (2009) 1.04
Manganese-induced dopaminergic neurodegeneration: insights into mechanisms and genetics shared with Parkinson's disease. Chem Rev (2009) 1.04
Prenatal exposure to benzo(a)pyrene impairs later-life cortical neuronal function. Neurotoxicology (2008) 1.03
Determining the oxidation states of manganese in NT2 cells and cultured astrocytes. Neurobiol Aging (2005) 1.03
Methylmercury induces oxidative injury, alterations in permeability and glutamine transport in cultured astrocytes. Brain Res (2006) 1.03
Manganese Is Essential for Neuronal Health. Annu Rev Nutr (2015) 1.03
Modulatory effect of glutathione status and antioxidants on methylmercury-induced free radical formation in primary cultures of cerebral astrocytes. Brain Res Mol Brain Res (2005) 1.03
The methylmercury-L-cysteine conjugate is a substrate for the L-type large neutral amino acid transporter. J Neurochem (2008) 1.02
Measuring brain manganese and iron accumulation in rats following 14 weeks of low-dose manganese treatment using atomic absorption spectroscopy and magnetic resonance imaging. Toxicol Sci (2008) 1.02
Methylmercury-induced reactive oxygen species formation in neonatal cerebral astrocytic cultures is attenuated by antioxidants. Brain Res Mol Brain Res (2003) 1.01
Prenatal polycyclic aromatic hydrocarbon exposure leads to behavioral deficits and downregulation of receptor tyrosine kinase, MET. Toxicol Sci (2010) 1.00
Manganese causes differential regulation of glutamate transporter (GLAST) taurine transporter and metallothionein in cultured rat astrocytes. Neurotoxicology (2002) 1.00
Disease-toxicant screen reveals a neuroprotective interaction between Huntington's disease and manganese exposure. J Neurochem (2009) 1.00
Mitochondrial-dependent manganese neurotoxicity in rat primary astrocyte cultures. Brain Res (2008) 0.99
Metals, oxidative stress and neurodegeneration: a focus on iron, manganese and mercury. Neurochem Int (2012) 0.99
Manganese inhalation by rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity. Toxicol Sci (2007) 0.99
Increased manganese uptake by primary astrocyte cultures with altered iron status is mediated primarily by divalent metal transporter. Neurotoxicology (2005) 0.99
Estrogen and tamoxifen protect against Mn-induced toxicity in rat cortical primary cultures of neurons and astrocytes. Toxicol Sci (2009) 0.98
Manganese (Mn) and iron (Fe): interdependency of transport and regulation. Neurotox Res (2009) 0.98
Modulation of cholinergic systems by manganese. Neurotoxicology (2007) 0.98
Protection of DFP-induced oxidative damage and neurodegeneration by antioxidants and NMDA receptor antagonist. Toxicol Appl Pharmacol (2009) 0.98
Methylmercury-induced alterations in astrocyte functions are attenuated by ebselen. Neurotoxicology (2011) 0.98
Measurement of isoprostanes as markers of oxidative stress in neuronal tissue. Curr Protoc Toxicol (2009) 0.97
Leaching of trace elements from biological tissue by formalin fixation. Biol Trace Elem Res (2007) 0.97
GPR30 regulates glutamate transporter GLT-1 expression in rat primary astrocytes. J Biol Chem (2012) 0.96
Mefloquine induces oxidative stress and neurodegeneration in primary rat cortical neurons. Neurotoxicology (2010) 0.96
Free radical formation in cerebral cortical astrocytes in culture induced by methylmercury. Brain Res Mol Brain Res (2004) 0.96
Retracted Polymorphic ventricular tachycardia and abnormal Ca2+ handling in very-long-chain acyl-CoA dehydrogenase null mice. Am J Physiol Heart Circ Physiol (2007) 0.96
Neonatal rat primary microglia: isolation, culturing, and selected applications. Curr Protoc Toxicol (2010) 0.95
The importance of glutamate, glycine, and gamma-aminobutyric acid transport and regulation in manganese, mercury and lead neurotoxicity. Toxicol Appl Pharmacol (2005) 0.94
Characterization of the effects of methylmercury on Caenorhabditis elegans. Toxicol Appl Pharmacol (2009) 0.94
A chronic iron-deficient/high-manganese diet in rodents results in increased brain oxidative stress and behavioral deficits in the morris water maze. Neurotox Res (2009) 0.93
Comparative study on the response of rat primary astrocytes and microglia to methylmercury toxicity. Glia (2011) 0.93
Transforming growth factor-α mediates estrogen-induced upregulation of glutamate transporter GLT-1 in rat primary astrocytes. Glia (2012) 0.92
Role of astrocytes in manganese mediated neurotoxicity. BMC Pharmacol Toxicol (2013) 0.92
Diphenyl diselenide, a simple organoselenium compound, decreases methylmercury-induced cerebral, hepatic and renal oxidative stress and mercury deposition in adult mice. Brain Res Bull (2008) 0.92
trans-10,cis-12-Conjugated linoleic acid instigates inflammation in human adipocytes compared with preadipocytes. J Biol Chem (2010) 0.92
Methylmercury toxicity and Nrf2-dependent detoxification in astrocytes. Toxicol Sci (2008) 0.92
Disease-toxicant interactions in manganese exposed Huntington disease mice: early changes in striatal neuron morphology and dopamine metabolism. PLoS One (2012) 0.92
Hormetic effect of methylmercury on Caenorhabditis elegans. Toxicol Appl Pharmacol (2010) 0.92
Changes in dietary iron exacerbate regional brain manganese accumulation as determined by magnetic resonance imaging. Toxicol Sci (2010) 0.92
Measurement of isoprostanes as markers of oxidative stress. Methods Mol Biol (2011) 0.91
Prostanoid signaling: dual role for prostaglandin E2 in neurotoxicity. Neurotoxicology (2011) 0.91
Altered manganese homeostasis and manganese toxicity in a Huntington's disease striatal cell model are not explained by defects in the iron transport system. Toxicol Sci (2010) 0.91
Utility of Caenorhabditis elegans in high throughput neurotoxicological research. Neurotoxicol Teratol (2008) 0.91
Manganese in health and disease. Met Ions Life Sci (2013) 0.91
Developmental aspects of blood-brain barrier (BBB) and rat brain endothelial (RBE4) cells as in vitro model for studies on chlorpyrifos transport. Neurotoxicology (2003) 0.91
Pharmacology and toxicology of astrocyte-neuron glutamate transport and cycling. J Pharmacol Exp Ther (2002) 0.90
Mitochondrial dysfunction induced by different organochalchogens is mediated by thiol oxidation and is not dependent of the classical mitochondrial permeability transition pore opening. Toxicol Sci (2010) 0.90
Revelations from the Nematode Caenorhabditis elegans on the Complex Interplay of Metal Toxicological Mechanisms. J Toxicol (2011) 0.90
Manganese neurotoxicity and the role of reactive oxygen species. Free Radic Biol Med (2013) 0.90
Manganese disrupts astrocyte glutamine transporter expression and function. J Neurochem (2009) 0.90
A model for the analysis of competitive relaxation effects of manganese and iron in vivo. NMR Biomed (2009) 0.90
Comparative study of quercetin and its two glycoside derivatives quercitrin and rutin against methylmercury (MeHg)-induced ROS production in rat brain slices. Arch Toxicol (2009) 0.89
Protective effect of Melissa officinalis aqueous extract against Mn-induced oxidative stress in chronically exposed mice. Brain Res Bull (2011) 0.89
Stressed-induced TMEM135 protein is part of a conserved genetic network involved in fat storage and longevity regulation in Caenorhabditis elegans. PLoS One (2010) 0.89
Metal-induced neurodegeneration in C. elegans. Front Aging Neurosci (2013) 0.89
Comparative study on methyl- and ethylmercury-induced toxicity in C6 glioma cells and the potential role of LAT-1 in mediating mercurial-thiol complexes uptake. Neurotoxicology (2013) 0.89