Published in Trends Neurosci on December 16, 2011
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Strong association of de novo copy number mutations with sporadic schizophrenia. Nat Genet (2008) 10.19
Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia. Nat Genet (2004) 4.71
Exome sequencing supports a de novo mutational paradigm for schizophrenia. Nat Genet (2011) 4.67
Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model. Nat Genet (2008) 3.76
Spontaneous neural activity is required for the establishment and maintenance of the olfactory sensory map. Neuron (2004) 3.50
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Impaired hippocampal-prefrontal synchrony in a genetic mouse model of schizophrenia. Nature (2010) 2.92
Evidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia. Nat Genet (2004) 2.77
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22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia. Nat Rev Neurosci (2010) 2.54
A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition. Proc Natl Acad Sci U S A (2008) 2.37
Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice. Proc Natl Acad Sci U S A (2006) 2.32
Palmitoylation-dependent neurodevelopmental deficits in a mouse model of 22q11 microdeletion. Nat Neurosci (2008) 1.92
Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia. Proc Natl Acad Sci U S A (2002) 1.92
Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice. Nat Neurosci (2005) 1.91
Site-specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal cortex and dorsal striatum. J Neurosci (2007) 1.75
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Elucidating the genetic architecture of familial schizophrenia using rare copy number variant and linkage scans. Proc Natl Acad Sci U S A (2009) 1.73
Deficiency of Dgcr8, a gene disrupted by the 22q11.2 microdeletion, results in altered short-term plasticity in the prefrontal cortex. Proc Natl Acad Sci U S A (2011) 1.65
Genetic variation in the 22q11 locus and susceptibility to schizophrenia. Proc Natl Acad Sci U S A (2002) 1.60
Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit. Proc Natl Acad Sci U S A (2003) 1.54
Brain catecholamine metabolism in catechol-O-methyltransferase (COMT)-deficient mice. Eur J Neurosci (2002) 1.51
Akt1 deficiency affects neuronal morphology and predisposes to abnormalities in prefrontal cortex functioning. Proc Natl Acad Sci U S A (2006) 1.44
Genetic modulation of BDNF signaling affects the outcome of axonal competition in vivo. Curr Biol (2007) 1.40
S-nitrosylation and S-palmitoylation reciprocally regulate synaptic targeting of PSD-95. Neuron (2011) 1.35
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Genomewide scan in families with schizophrenia from the founder population of Afrikaners reveals evidence for linkage and uniparental disomy on chromosome 1. Am J Hum Genet (2004) 1.34
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Effect of dopamine uptake inhibition on brain catecholamine levels and locomotion in catechol-O-methyltransferase-disrupted mice. J Pharmacol Exp Ther (2002) 1.19
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The best of times, the worst of times for psychiatric disease. Nat Neurosci (2012) 1.18
Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving mice. J Neurochem (2010) 1.17
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Altered axonal targeting and short-term plasticity in the hippocampus of Disc1 mutant mice. Proc Natl Acad Sci U S A (2011) 1.09
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Molecules, signaling, and schizophrenia. Curr Top Behav Neurosci (2010) 0.91
Evidence for altered hippocampal function in a mouse model of the human 22q11.2 microdeletion. Mol Cell Neurosci (2011) 0.86
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Exploratory and habituation phenotype of heterozygous and homozygous COMT knockout mice. Behav Brain Res (2007) 0.84
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Analysis of prepulse inhibition in mouse lines overexpressing 22q11.2 orthologues. Int J Neuropsychopharmacol (2009) 0.83
Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes. Int J Neuropsychopharmacol (2011) 0.83
Increase in free choice oral ethanol self-administration in catechol-o-methyltransferase gene-disrupted male mice. Basic Clin Pharmacol Toxicol (2008) 0.80
Physiological and behavioural responsivity to stress and anxiogenic stimuli in COMT-deficient mice. Behav Brain Res (2011) 0.80
Sexual dimorphisms in the immune system of catechol-O-methyltransferase knockout mice. Immunobiology (2012) 0.79
Sex-dependent compensated oxidative stress in the mouse liver upon deletion of catechol O-methyltransferase. Biochem Pharmacol (2009) 0.78
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Lack of increased oxidative stress in catechol-O-methyltransferase (COMT)-deficient mice. Naunyn Schmiedebergs Arch Pharmacol (2004) 0.78
Catechol-O-methyltransferase is dispensable for vascular protection by estradiol in mouse models of atherosclerosis and neointima formation. Endocrinology (2011) 0.77
Stress-induced analgesia and morphine responses are changed in catechol-O-methyltransferase-deficient male mice. Basic Clin Pharmacol Toxicol (2008) 0.77
Copy number variation and psychiatric disease risk. Methods Mol Biol (2012) 0.76
Reduced natriuretic response to acute sodium loading in COMT gene deleted mice. BMC Physiol (2002) 0.75
A transient inhibition and permanent lack of catechol-O-methyltransferase have minor effects on feeding pattern of female rodents. Basic Clin Pharmacol Toxicol (2011) 0.75