Mitochondrial mitophagic mechanisms of myocardial matrix metabolism and remodelling.

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Published in Arch Physiol Biochem on December 19, 2011

Authors

Thomas P Vacek1, Jonathan C Vacek, Suresh C Tyagi

Author Affiliations

1: Department of Physiology and Biophysics, School of Medicine, University of Louisville, Louisville, KY 40202, USA.

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The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature (1993) 27.07

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell (1996) 16.73

Molecular characterization of mitochondrial apoptosis-inducing factor. Nature (1999) 14.41

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell (2000) 11.90

Mitochondrial formation of reactive oxygen species. J Physiol (2003) 10.73

Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med (2006) 9.53

Mitochondrial control of cell death. Nat Med (2000) 9.17

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell (2000) 8.69

Endonuclease G is an apoptotic DNase when released from mitochondria. Nature (2001) 6.20

Cardiac malformation in neonatal mice lacking connexin43. Science (1995) 5.51

The urokinase-type plasminogen activator system in cancer metastasis: a review. Int J Cancer (1997) 5.01

Matrix metalloproteinases: they're not just for matrix anymore! Curr Opin Cell Biol (2001) 4.99

A temperature-dependent switch from chaperone to protease in a widely conserved heat shock protein. Cell (1999) 4.78

Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins. Free Radic Biol Med (2004) 3.85

Cytochrome c: functions beyond respiration. Nat Rev Mol Cell Biol (2008) 2.95

Dilated cardiomyopathy in transgenic mice with cardiac-specific overexpression of tumor necrosis factor-alpha. Circ Res (1997) 2.91

Matrix metalloproteinases (MMPs) in health and disease: an overview. Front Biosci (2006) 2.81

Antisera directed against connexin43 peptides react with a 43-kD protein localized to gap junctions in myocardium and other tissues. J Cell Biol (1989) 2.66

Electrophysiological features of the mouse sinoatrial node in relation to connexin distribution. Cardiovasc Res (2001) 2.64

Dietary supplementation with methionine and homocysteine promotes early atherosclerosis but not plaque rupture in ApoE-deficient mice. Arterioscler Thromb Vasc Biol (2001) 2.62

High-resolution optical mapping of the right bundle branch in connexin40 knockout mice reveals slow conduction in the specialized conduction system. Circ Res (2000) 2.61

NADPH oxidase-mediated redox signaling: roles in cellular stress response, stress tolerance, and tissue repair. Pharmacol Rev (2011) 2.53

Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model. J Clin Invest (2001) 2.45

Hypochlorous acid oxygenates the cysteine switch domain of pro-matrilysin (MMP-7). A mechanism for matrix metalloproteinase activation and atherosclerotic plaque rupture by myeloperoxidase. J Biol Chem (2001) 2.40

The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae. Proc Natl Acad Sci U S A (2008) 2.30

Macrophages in human atheroma contain PPARgamma: differentiation-dependent peroxisomal proliferator-activated receptor gamma(PPARgamma) expression and reduction of MMP-9 activity through PPARgamma activation in mononuclear phagocytes in vitro. Am J Pathol (1998) 2.30

Mitochondria-derived reactive oxygen species dilate cerebral arteries by activating Ca2+ sparks. Circ Res (2005) 2.29

Mitochondrial protein import: biochemical and genetic evidence for interaction of matrix hsp70 and the inner membrane protein MIM44. J Cell Biol (1994) 2.28

Matrix metalloproteinases and cardiovascular disease. Circ Res (1995) 2.27

Bleomycin-induced pulmonary fibrosis in fibrinogen-null mice. J Clin Invest (2000) 2.26

Intracellular action of matrix metalloproteinase-2 accounts for acute myocardial ischemia and reperfusion injury. Circulation (2002) 2.25

Plasmin and matrix metalloproteinases in vascular remodeling. Thromb Haemost (2001) 2.24

Slow conduction and enhanced anisotropy increase the propensity for ventricular tachyarrhythmias in adult mice with induced deletion of connexin43. Circulation (2004) 2.23

Regulation of gene expression by reactive oxygen. Annu Rev Pharmacol Toxicol (1999) 2.22

Hyperhomocyst(e)inemia and endothelial dysfunction in IDDM. Diabetes Care (1997) 2.18

Fibrillar collagen and myocardial stiffness in the intact hypertrophied rat left ventricle. Circ Res (1989) 2.14

Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo. J Biol Chem (1999) 2.13

Homocysteine trials--clear outcomes for complex reasons. N Engl J Med (2006) 2.12

Increased expression of matrix metalloproteinases (MMP)-2, MMP-9, and the urokinase-type plasminogen activator is associated with progression from benign to advanced ovarian cancer. Clin Cancer Res (2001) 2.06

Interplay of matrix metalloproteinases, tissue inhibitors of metalloproteinases and their regulators in cardiac matrix remodeling. Cardiovasc Res (2000) 2.05

Total homocysteine in patients with type 1 diabetes. Diabetes Care (2000) 2.04

Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation. Cell Death Differ (2001) 2.03

Mitochondrial redox control of matrix metalloproteinases. Free Radic Biol Med (2004) 2.02

Mitochondrial membrane potential regulates matrix configuration and cytochrome c release during apoptosis. Cell Death Differ (2003) 2.01

Arterial remodeling after coronary angioplasty: a serial intravascular ultrasound study. Circulation (1996) 1.99

Decreased lymphocyte beta-adrenergic-receptor density in patients with heart failure and tolerance to the beta-adrenergic agonist pirbuterol. N Engl J Med (1981) 1.97

Inhibitory role of plasminogen activator inhibitor-1 in arterial wound healing and neointima formation: a gene targeting and gene transfer study in mice. Circulation (1997) 1.91

Regulation of matrix metalloproteinase activity in health and disease. FEBS J (2010) 1.88

Matrix metalloproteinase-9 is necessary for the regulation of smooth muscle cell replication and migration after arterial injury. Circ Res (2002) 1.79

Induction of oxidative stress and disintegrin metalloproteinase in human heart end-stage failure. Am J Physiol Lung Cell Mol Physiol (2002) 1.76

Peroxisome proliferator-activated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappaB signaling, and reduces inflammatory cytokine production in aging. J Biol Chem (1998) 1.76

Intracellular targets of matrix metalloproteinase-2 in cardiac disease: rationale and therapeutic approaches. Annu Rev Pharmacol Toxicol (2007) 1.75

Smooth muscle migration in atherosclerosis and restenosis. J Clin Invest (1997) 1.75

The pathogenesis of coronary artery disease. A possible role for methionine metabolism. J Clin Invest (1976) 1.72

Matrix metalloproteinase-2 (MMP-2) is present in the nucleus of cardiac myocytes and is capable of cleaving poly (ADP-ribose) polymerase (PARP) in vitro. FASEB J (2004) 1.69

Elevated plasma homocysteine level is an independent predictor of coronary heart disease events in patients with type 2 diabetes mellitus. Ann Intern Med (2004) 1.64

Nitric oxide attenuates cardiac myocyte contraction. Am J Physiol (1993) 1.62

Oxidative stress and glutathione in TGF-beta-mediated fibrogenesis. Free Radic Biol Med (2009) 1.61

Myeloperoxidase and plasminogen activator inhibitor 1 play a central role in ventricular remodeling after myocardial infarction. J Exp Med (2003) 1.59

Defective vascular development in connexin 45-deficient mice. Development (2000) 1.57

Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response. Eur J Biochem (2000) 1.56

Mechanical strain induces growth of vascular smooth muscle cells via autocrine action of PDGF. J Cell Biol (1993) 1.55

Myocardial extracellular matrix remodeling in transgenic mice overexpressing tumor necrosis factor alpha can be modulated by anti-tumor necrosis factor alpha therapy. Proc Natl Acad Sci U S A (2000) 1.54

Smooth muscle cells express urokinase during mitogenesis and tissue-type plasminogen activator during migration in injured rat carotid artery. Circ Res (1990) 1.54

The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity. Cell Death Differ (2002) 1.52

The ligands/activators for peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma increase Cu2+,Zn2+-superoxide dismutase and decrease p22phox message expressions in primary endothelial cells. Metabolism (2001) 1.51

Architectural and functional asymmetry of the His-Purkinje system of the murine heart. Cardiovasc Res (2004) 1.51

Activation of matrix metalloproteinase-2 by overexpression of manganese superoxide dismutase in human breast cancer MCF-7 cells involves reactive oxygen species. J Biol Chem (2002) 1.47

Connexins in mammalian heart function. Bioessays (1996) 1.45

Plasma homocysteine and cardiovascular risk in heart failure with and without cardiorenal syndrome. Int J Cardiol (2009) 1.44

Inhibition of matrix metalloproteinase activity inhibits smooth muscle cell migration but not neointimal thickening after arterial injury. Circ Res (1996) 1.44

The effect of folic acid supplementation on carotid intima-media thickness in patients with cardiovascular risk: a randomized, placebo-controlled trial. Int J Cardiol (2009) 1.42

Patterns of myocardial fibrosis. J Mol Cell Cardiol (1989) 1.41

Gating properties of heterotypic gap junction channels formed of connexins 40, 43, and 45. Biophys J (2006) 1.40

Matrix metalloproteinase 3 is present in the cell nucleus and is involved in apoptosis. Am J Pathol (2006) 1.36

NF-kappaB-induced oxidative stress contributes to mitochondrial and cardiac dysfunction in type II diabetes. Cardiovasc Res (2009) 1.35

Angiotensin II and endothelin-1 regulate MAP kinases through different redox-dependent mechanisms in human vascular smooth muscle cells. J Hypertens (2004) 1.34

Connexin45 expression is preferentially associated with the ventricular conduction system in mouse and rat heart. Circ Res (1998) 1.34

PAI-1, fibrosis, and the elusive provisional fibrin matrix. J Clin Invest (2000) 1.32

Lipophilic HMG-CoA reductase inhibitor has an anti-inflammatory effect: reduction of MRNA levels for interleukin-1beta, interleukin-6, cyclooxygenase-2, and p22phox by regulation of peroxisome proliferator-activated receptor alpha (PPARalpha) in primary endothelial cells. Life Sci (2000) 1.30

Loss or inhibition of uPA or MMP-9 attenuates LV remodeling and dysfunction after acute pressure overload in mice. Am J Pathol (2005) 1.30

Contributions of hyperhomocysteinemia to atherosclerosis: Causal relationship and potential mechanisms. Biofactors (2009) 1.29

Mechanical transduction of nitric oxide synthesis in the beating heart. Circ Res (1997) 1.27

Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia. J Biol Chem (2000) 1.27

Transgenic MMP-2 expression induces latent cardiac mitochondrial dysfunction. Biochem Biophys Res Commun (2007) 1.23

Manganese superoxide dismutase signals matrix metalloproteinase expression via H2O2-dependent ERK1/2 activation. J Biol Chem (2001) 1.23

Alteration of NMDA NR1 receptors within the paraventricular nucleus of hypothalamus in rats with heart failure. Circ Res (2003) 1.22

Increased expression of plasminogen activator inhibitor-1 in cardiomyocytes contributes to cardiac fibrosis after myocardial infarction. Am J Pathol (2004) 1.22

Adrenergic regulation of myocardial apoptosis. Cardiovasc Res (2000) 1.18

Collagen phenotypes during development and regression of myocardial hypertrophy in spontaneously hypertensive rats. Circ Res (1990) 1.18

Myocardial stiffness is attributed to alterations in cross-linked collagen rather than total collagen or phenotypes in spontaneously hypertensive rats. Circulation (1997) 1.18

NMDA receptor activation induces mitochondrial dysfunction, oxidative stress and apoptosis in cultured neonatal rat cardiomyocytes. Physiol Res (2006) 1.17

Connexin30.2 containing gap junction channels decelerate impulse propagation through the atrioventricular node. Proc Natl Acad Sci U S A (2006) 1.17

Effects of homocysteine on endothelial nitric oxide production. Am J Physiol Renal Physiol (2000) 1.17

Mitochondrial matrix metalloproteinase activation decreases myocyte contractility in hyperhomocysteinemia. Am J Physiol Heart Circ Physiol (2008) 1.17

Turnover rates of different collagen types measured by isotope ratio mass spectrometry. Biochim Biophys Acta (1992) 1.16

Matrix metalloproteinase-1 associates with intracellular organelles and confers resistance to lamin A/C degradation during apoptosis. Am J Pathol (2005) 1.14

Induction of oxidative stress by homocyst(e)ine impairs endothelial function. J Cell Biochem (2001) 1.14

Homocysteine-mediated activation and mitochondrial translocation of calpain regulates MMP-9 in MVEC. Am J Physiol Heart Circ Physiol (2006) 1.13

Impaired conduction in the bundle branches of mouse hearts lacking the gap junction protein connexin40. Circulation (2001) 1.13

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