Published in ACS Comb Sci on January 03, 2012
Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6. J Med Chem (2008) 1.70
Solution-phase combinatorial libraries: modulating cellular signaling by targeting protein-protein or protein-DNA interactions. Angew Chem Int Ed Engl (2003) 1.66
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Synthesizing our future. Nat Chem (2009) 1.04
Synthetic routes towards enantiomerically pure beta-amino acids. Angew Chem Int Ed Engl (2003) 1.01
Regioselective synthesis and slow-release Suzuki-Miyaura cross-coupling of MIDA boronate-functionalized isoxazoles and triazoles. J Org Chem (2011) 0.95
Efficient and regioselective synthesis of 5-hydroxy-2-isoxazolines: versatile synthons for isoxazoles, beta-lactams, and gamma-amino alcohols. J Org Chem (2010) 0.87
Synthesis of spiro-fused pyrazolidoylisoxazolines. J Org Chem (2011) 0.87
A concise approach to structurally diverse beta-amino acids. J Am Chem Soc (2003) 0.83
3-(2-Benzyloxyphenyl)isoxazoles and isoxazolines: synthesis and evaluation as CFTR activators. Bioorg Med Chem Lett (2003) 0.82
Succinct synthesis of beta-amino acids via chiral isoxazolines. J Am Chem Soc (2005) 0.82
Multicomponent macrocyclization reactions (MCMRs) employing highly reactive acyl ketene and nitrile oxide intermediates. Org Lett (2011) 0.80
Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell (2008) 5.67
Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease. Hepatology (2008) 2.05
Phenylglycine and sulfonamide correctors of defective delta F508 and G551D cystic fibrosis transmembrane conductance regulator chloride-channel gating. Mol Pharmacol (2005) 1.80
Chemical xenobiotics and mitochondrial autoantigens in primary biliary cirrhosis: identification of antibodies against a common environmental, cosmetic, and food additive, 2-octynoic acid. J Immunol (2005) 1.47
Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic-metabolizing bacterium. Hepatology (2003) 1.46
Identification of 2-nonynoic acid, a cosmetic component, as a potential trigger of primary biliary cirrhosis. J Autoimmun (2006) 1.41
Potent s-cis-locked bithiazole correctors of DeltaF508 cystic fibrosis transmembrane conductance regulator cellular processing for cystic fibrosis therapy. J Med Chem (2008) 1.29
Potent, metabolically stable benzopyrimido-pyrrolo-oxazine-dione (BPO) CFTR inhibitors for polycystic kidney disease. J Med Chem (2011) 1.25
C-O bond formation by polyketide synthases. Science (2002) 1.23
Immunization with a xenobiotic 6-bromohexanoate bovine serum albumin conjugate induces antimitochondrial antibodies. J Immunol (2003) 1.21
4'-Methyl-4,5'-bithiazole-based correctors of defective delta F508-CFTR cellular processing. Bioorg Med Chem Lett (2008) 1.16
Stannous chloride in alcohol: a one-pot conversion of 2-nitro-N-arylbenzamides to 2,3-dihydro-1H-quinazoline-4-ones. J Org Chem (2005) 1.15
Induction of primary biliary cirrhosis in guinea pigs following chemical xenobiotic immunization. J Immunol (2007) 1.12
An oxazolo[3,2-b]indazole route to 1H-indazolones. Org Lett (2009) 1.12
Cyanoquinolines with independent corrector and potentiator activities restore ΔPhe508-cystic fibrosis transmembrane conductance regulator chloride channel function in cystic fibrosis. Mol Pharmacol (2011) 1.07
Oxidative stress caused by pyocyanin impairs CFTR Cl(-) transport in human bronchial epithelial cells. Free Radic Biol Med (2008) 1.05
Pyrazolylthiazole as DeltaF508-cystic fibrosis transmembrane conductance regulator correctors with improved hydrophilicity compared to bithiazoles. J Med Chem (2010) 1.04
CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds. Am J Physiol Lung Cell Mol Physiol (2003) 1.03
A facile synthesis of new 5H-indazolo[3,2-b]benzo[d]-1,3-oxazines via one-pot intramolecular Bis-heterocyclizations. J Org Chem (2007) 1.01
N,N-bond-forming heterocyclization: synthesis of 3-alkoxy-2H-indazoles. J Org Chem (2006) 0.98
The Davis-Beirut reaction: N1,N2-disubstituted-1H-indazolones via 1,6-electrophilic addition to 3-alkoxy-2H-indazoles. Org Lett (2011) 0.97
Synthesis of a library of 2-alkyl-3-alkyloxy-2H-indazole-6-carboxamides. J Comb Chem (2007) 0.96
A one-pot-three-step route to triazolotriazepinoindazolones from oxazolino-2H-indazoles. Org Lett (2012) 0.96
Nucleophilic substitution of oxazino-/oxazolino-/benzoxazin [3,2-b]indazoles: an effective route to 1H-indazolones. Org Lett (2010) 0.96
Carbodiimide-based benzimidazole library method. J Comb Chem (2006) 0.96
Antimitochondrial antibody heterogeneity and the xenobiotic etiology of primary biliary cirrhosis. Hepatology (2013) 0.96
A spiroisoxazolinoproline-based amino acid scaffold for solid phase and one-bead-one-compound library synthesis. J Comb Chem (2007) 0.95
Design and synthesis of a hybrid potentiator-corrector agonist of the cystic fibrosis mutant protein DeltaF508-CFTR. Bioorg Med Chem Lett (2009) 0.95
Environment and primary biliary cirrhosis: electrophilic drugs and the induction of AMA. J Autoimmun (2013) 0.95
Highly potent, water soluble benzimidazole antagonist for activated alpha 4 beta 1 integrin. J Med Chem (2007) 0.93
Orthogonally protected thiazole and isoxazole diamino acids: an efficient synthetic route. Chemistry (2010) 0.93
Intramolecular cycloaddition of azomethine ylides in the preparation of pyrrolidino[2',3':3,4]pyrrolidino[1,2- a]benzimidazoles. Org Lett (2007) 0.93
Xenobiotic-induced loss of tolerance in rabbits to the mitochondrial autoantigen of primary biliary cirrhosis is reversible. J Immunol (2004) 0.92
Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain. Bioorg Med Chem (2003) 0.92
Heterocycle-heterocycle strategies: (2-nitrophenyl)isoxazole precursors to 4-aminoquinolines, 1H-indoles, and quinolin-4(1H)-ones. Org Lett (2013) 0.91
Facile syntheses of novel benzo-1,3-dioxolo-, benzothiazolo-, pyrido-, and quinolino-fused 5H-benzo[d]-pyrazolo[5,1-b][1,3]-oxazines and 1H-pyrazoles. Org Lett (2011) 0.91
Diazocinones: synthesis and conformational analysis. J Org Chem (2006) 0.90
Electrophile-modified lipoic derivatives of PDC-E2 elicits anti-mitochondrial antibody reactivity. J Autoimmun (2011) 0.90
Targeting multiple chorismate-utilizing enzymes with a single inhibitor: validation of a three-stage design. J Med Chem (2010) 0.88
Aminodeoxychorismate synthase inhibitors from one-bead one-compound combinatorial libraries: "staged" inhibitor design. J Med Chem (2006) 0.88
Efficient syntheses of the unknown quinolino[2,3-c]cinnolines; synthesis of neocryptolepines. Org Lett (2010) 0.88
Xenobiotics and autoimmunity: does acetaminophen cause primary biliary cirrhosis? Trends Mol Med (2012) 0.88
OBOC small-molecule combinatorial library encoded by halogenated mass-tags. Org Lett (2004) 0.87
Isoxazolodihydropyridinones: 1,3-dipolar cycloaddition of nitrile oxides onto 2,4-dioxopiperidines. ACS Comb Sci (2012) 0.87
Synthesis of spiro-fused pyrazolidoylisoxazolines. J Org Chem (2011) 0.87
Comparison of solid-phase and solution-phase chiral auxiliaries in the alkylation/iodolactonization sequence to gamma-butyrolactones. J Org Chem (2002) 0.87
Design and synthesis of propeller-shaped dispiroisoxazolinopiperidinochromanones. J Comb Chem (2008) 0.86
Autoreactivity to lipoate and a conjugated form of lipoate in primary biliary cirrhosis. Gastroenterology (2003) 0.86
Structure-activity relationships of cyanoquinolines with corrector-potentiator activity in ΔF508 cystic fibrosis transmembrane conductance regulator protein. J Med Chem (2012) 0.86
Parallel Synthesis of bis-heterocyclic isoxazolylmethyl- and isoxazolinylmethylpyrazoles. J Comb Chem (2010) 0.85
A novel route to fully substituted 1H-pyrazoles. J Org Chem (2005) 0.85
One-pot, two-step cascade synthesis of quinazolinotriazolobenzodiazepines. Org Lett (2012) 0.84
Facile synthesis of glycosylated Fmoc amino acid building blocks assisted by microwave irradiation. Carbohydr Res (2010) 0.83
Selectively targeting T- and B-cell lymphomas: a benzothiazole antagonist of alpha4beta1 integrin. J Med Chem (2009) 0.83
Selective nucleophilic chemistry in the synthesis of 5-carbamoyl-3-sulfanylmethylisoxazole-4-carboxylic acids. J Comb Chem (2007) 0.83
Asymmetric catalysis: resin-bound hydroxyprolylthreonine derivatives in enamine-mediated reactions. Angew Chem Int Ed Engl (2008) 0.83
7-Substituted 8-aza-7-deazaadenosines for modification of the siRNA major groove. Org Biomol Chem (2012) 0.83
Antimitochondrial antibody recognition and structural integrity of the inner lipoyl domain of the E2 subunit of pyruvate dehydrogenase complex. J Immunol (2013) 0.82
Microwave-mediated heterocyclization to benzimidazo[2,1-b]quinazolin-12(5H)-ones. J Org Chem (2007) 0.82
Isoxazolopyrimidines as Novel ΔF508-CFTR Correctors. Synlett (2010) 0.82
Multicomponent assembly of highly substituted indoles by dual palladium-catalyzed coupling reactions. Angew Chem Int Ed Engl (2012) 0.82
3-(2-Benzyloxyphenyl)isoxazoles and isoxazolines: synthesis and evaluation as CFTR activators. Bioorg Med Chem Lett (2003) 0.82
Microwave-assisted synthesis of 3-nitroindoles from N-aryl enamines via intramolecular arene-alkene coupling. Org Lett (2012) 0.81
Halogenated benzimidazole carboxamides target integrin alpha4beta1 on T-cell and B-cell lymphomas. Cancer Res (2010) 0.80
Multicomponent macrocyclization reactions (MCMRs) employing highly reactive acyl ketene and nitrile oxide intermediates. Org Lett (2011) 0.80
Functional fluorescently labeled bithiazole ΔF508-CFTR corrector imaged in whole body slices in mice. Bioconjug Chem (2011) 0.80
Versatile "traceless" sulfone linker for SPOS: preparation of isoxazolinopyrrole 2-carboxylates. J Org Chem (2002) 0.80
Quinoxalino[2,3-c]cinnolines and their 5-N-oxide: alkoxylation of methyl-substituted quinoxalino[2,3-c]cinnolines to acetals and orthoesters. J Org Chem (2011) 0.80
Facile one-pot assembly of imidazotriazolobenzodiazepines via indium(III)-catalyzed multicomponent reactions. Org Lett (2013) 0.79
ABSOLUTE CONFIGURATION AND BIOLOGICAL PROPERTIES OF ENANTIOMERS OF CFTR INHIBITOR BPO-27. ACS Med Chem Lett (2013) 0.79
The Davis-Beirut Reaction: a novel entry into 2H-indazoles and indazolones. Recent biological activity of indazoles. Mini Rev Med Chem (2012) 0.79
A library of 3-aryl-4,5-dihydroisoxazole-5-carboxamides. J Comb Chem (2007) 0.79
Sulfamoyl-4-oxoquinoline-3-carboxamides: novel potentiators of defective DeltaF508-cystic fibrosis transmembrane conductance regulator chloride channel gating. Bioorg Med Chem Lett (2005) 0.79
Controlling Selectivity for Cycloadditions of Nitrones and Alkenes Tethered by Benzimidazoles: Combining Experiment and Theory. European J Org Chem (2009) 0.79
Acid and base catalyzed Davis-Beirut reaction: experimental and theoretical mechanistic studies and synthesis of novel 3-amino-2H-indazoles. Tetrahedron Lett (2012) 0.78
Constrained bithiazoles: small molecule correctors of defective ΔF508-CFTR protein trafficking. J Med Chem (2014) 0.78
Synthesis of thiazolo- and 7,8-dihydrothiazolo[4,5-e]benzoisoxazoles. J Comb Chem (2009) 0.78
Synthesis and biological activity of 2-(4,5-dihydroisoxazol-5-yl)-1,3,4-oxadiazoles. Bioorg Med Chem Lett (2009) 0.78
Click-based synthesis of triazolobithiazole ΔF508-CFTR correctors for cystic fibrosis. Bioorg Med Chem (2012) 0.78
Slow-binding human serine racemase inhibitors from high-throughput screening of combinatorial libraries. J Med Chem (2006) 0.77
Cyclic azacyanines: experimental and computational studies on spectroscopic properties and unique reactivity. J Fluoresc (2014) 0.77
Mechanisms for formation of diazocinones, pyridazines, and pyrazolines from tetrazines--oxyanion-accelerated pericyclic cascades? J Org Chem (2009) 0.77
Identification of inhibitors against interaction between pro-inflammatory sPLA2-IIA protein and integrin αvβ3. Bioorg Med Chem Lett (2012) 0.76
Davis-Beirut reaction: route to thiazolo-, thiazino-, and thiazepino-2H-indazoles. J Org Chem (2014) 0.76
Activation of CFTR by UCCF-029 and genistein. Bioorg Med Chem Lett (2008) 0.76
Fluorinated ΔF508-CFTR correctors and potentiators for PET imaging. Bioorg Med Chem Lett (2012) 0.75
Synthesis of substituted chromanones: an organocatalytic aldol/oxa-Michael reaction. Org Lett (2010) 0.75
A rapid and efficient route to benzazole heterocycles. Nat Protoc (2010) 0.75
Ethyl 1-benzyl-1,2,3,3a,4,10b-hexa-hydro-pyrrolo-[2',3':3,4]pyrrolo-[1,2-a]benzimidazole-2-carboxyl-ate. Acta Crystallogr Sect E Struct Rep Online (2011) 0.75
3-(Arylthiomethyl)isoxazole-4,5-dicarboxamides: chemoselective nucleophilic chemistry and insecticidal activity. J Agric Food Chem (2009) 0.75
Triazolbenzo[d]thiazoles: efficient synthesis and biological evaluation as neuroprotective agents. Bioorg Med Chem Lett (2012) 0.75
Unusual Friedlander reactions: a route to novel quinoxaline-based heterocycles. Org Lett (2012) 0.75
Correction to "Diverting Reactive Intermediates Toward Unusual Chemistry: Unexpected Anthranil Products from Davis-Beirut Reaction". J Org Chem (2017) 0.75
Cyclopenta[b]pyrroles from triazines: synthetic and mechanistic studies. Org Lett (2010) 0.75