Src inhibitors, PP2 and dasatinib, increase retinoic acid-induced association of Lyn and c-Raf (S259) and enhance MAPK-dependent differentiation of myeloid leukemia cells.

PubWeight™: 1.05‹?› | Rank: Top 15%

🔗 View Article (PMC 3310950)

Published in Leukemia on December 19, 2011

Authors

J Congleton1, R MacDonald, A Yen

Author Affiliations

1: Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA.

Articles citing this

Functions of the Lyn tyrosine kinase in health and disease. Cell Commun Signal (2012) 1.11

Retinoids induce stem cell differentiation via epigenetic changes. Semin Cell Dev Biol (2013) 0.95

Dasatinib accelerates valproic acid-induced acute myeloid leukemia cell death by regulation of differentiation capacity. PLoS One (2014) 0.84

MEK/ERK dependent activation of STAT1 mediates dasatinib-induced differentiation of acute myeloid leukemia. PLoS One (2013) 0.84

EGFR inhibitors exacerbate differentiation and cell cycle arrest induced by retinoic acid and vitamin D3 in acute myeloid leukemia cells. Cell Cycle (2013) 0.83

6-Formylindolo (3,2-b)carbazole (FICZ) enhances retinoic acid (RA)-induced differentiation of HL-60 myeloblastic leukemia cells. Mol Cancer (2013) 0.83

The Src-family kinase inhibitor PP2 rescues inducible differentiation events in emergent retinoic acid-resistant myeloblastic leukemia cells. PLoS One (2013) 0.82

Nuclear Raf-1 kinase regulates the CXCR5 promoter by associating with NFATc3 to drive retinoic acid-induced leukemic cell differentiation. FEBS J (2014) 0.81

A novel piperazine derivative potently induces caspase-dependent apoptosis of cancer cells via inhibition of multiple cancer signaling pathways. Am J Transl Res (2013) 0.80

Induction of TGF-β1 synthesis by macrophages in response to apoptotic cells requires activation of the scavenger receptor CD36. PLoS One (2013) 0.80

The HER2 inhibitor TAK165 Sensitizes Human Acute Myeloid Leukemia Cells to Retinoic Acid-Induced Myeloid Differentiation by activating MEK/ERK mediated RARα/STAT1 axis. Sci Rep (2016) 0.80

Phosphorylation of c-Cbl and p85 PI3K driven by all-trans retinoic acid and CD38 depends on Lyn kinase activity. Cell Signal (2014) 0.79

Radotinib Induces Apoptosis of CD11b+ Cells Differentiated from Acute Myeloid Leukemia Cells. PLoS One (2015) 0.78

Retinoid Chemoprevention: Who Can Benefit? Curr Pharmacol Rep (2015) 0.78

Retinoic acid therapy resistance progresses from unilineage to bilineage in HL-60 leukemic blasts. PLoS One (2014) 0.77

SRC family kinase inhibitors antagonize the toxicity of multiple serotypes of botulinum neurotoxin in human embryonic stem cell-derived motor neurons. Neurotox Res (2015) 0.76

6-Formylindolo(3,2-b)Carbazole (FICZ) Modulates the Signalsome Responsible for RA-Induced Differentiation of HL-60 Myeloblastic Leukemia Cells. PLoS One (2015) 0.75

The AhR agonist VAF347 augments retinoic acid-induced differentiation in leukemia cells. FEBS Open Bio (2015) 0.75

Potential role of nuclear receptor ligand all-trans retinoic acids in the treatment of fungal keratitis. Int J Ophthalmol (2015) 0.75

Lyn, a tyrosine kinase closely linked to the differentiation status of primary acute myeloid leukemia blasts, associates with negative regulation of all-trans retinoic acid (ATRA) and dihydroxyvitamin D3 (VD3)-induced HL-60 cells differentiation. Cancer Cell Int (2016) 0.75

Src Family Kinase Inhibitor PP2 Has Different Effects on All-Trans-Retinoic Acid or Arsenic Trioxide-Induced Differentiation of an Acute Promyelocytic Leukemia Cell Line. Cancer Res Treat (2013) 0.75

GW5074 and PP2 kinase inhibitors implicate nontraditional c-Raf and Lyn function as drivers of retinoic acid-induced maturation. Cell Signal (2015) 0.75

Articles cited by this

Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine. Cell (1996) 7.81

Coordinating ERK/MAPK signalling through scaffolds and inhibitors. Nat Rev Mol Cell Biol (2005) 7.07

Regulation of Raf-1 by direct feedback phosphorylation. Mol Cell (2005) 5.88

Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Nat Cell Biol (2007) 4.75

Identification of the major phosphorylation sites of the Raf-1 kinase. J Biol Chem (1993) 2.70

FLT3 mutations: biology and treatment. Hematology Am Soc Hematol Educ Program (2006) 2.02

The molecular scaffold KSR1 regulates the proliferative and oncogenic potential of cells. Mol Cell Biol (2004) 1.86

Signaling dynamics of the KSR1 scaffold complex. Proc Natl Acad Sci U S A (2009) 1.76

Protein kinase CK2 in health and disease: From birth to death: the role of protein kinase CK2 in the regulation of cell proliferation and survival. Cell Mol Life Sci (2009) 1.70

CK2 Is a component of the KSR1 scaffold complex that contributes to Raf kinase activation. Curr Biol (2006) 1.69

Differential feedback regulation of the MAPK cascade underlies the quantitative differences in EGF and NGF signalling in PC12 cells. FEBS Lett (2000) 1.65

The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells. EMBO J (2002) 1.55

Retinoic acid induced mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase-dependent MAP kinase activation needed to elicit HL-60 cell differentiation and growth arrest. Cancer Res (1998) 1.52

Dasatinib: a tyrosine kinase inhibitor for the treatment of chronic myelogenous leukemia and philadelphia chromosome-positive acute lymphoblastic leukemia. Clin Ther (2007) 1.47

A critical role for Lyn in acute myeloid leukemia. Blood (2007) 1.40

Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells. Blood (2008) 1.37

Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf. Oncogene (2003) 1.37

Activation of Src kinases p53/56lyn and p59hck by p210bcr/abl in myeloid cells. Cancer Res (1996) 1.36

Phosphorylation regulates KSR1 stability, ERK activation, and cell proliferation. J Biol Chem (2004) 1.31

Effects of dasatinib on SRC kinase activity and downstream intracellular signaling in primitive chronic myelogenous leukemia hematopoietic cells. Cancer Res (2008) 1.30

Noncatalytic function of ERK1/2 can promote Raf/MEK/ERK-mediated growth arrest signaling. J Biol Chem (2009) 1.18

Src family kinases as mediators of endothelial permeability: effects on inflammation and metastasis. Cell Tissue Res (2008) 1.16

A MAPK-positive feedback mechanism for BLR1 signaling propels retinoic acid-triggered differentiation and cell cycle arrest. J Biol Chem (2007) 1.16

Lyn is an important component of the signal transduction pathway specific to FLT3/ITD and can be a therapeutic target in the treatment of AML with FLT3/ITD. Leukemia (2007) 1.11

Src family tyrosine kinases are activated by Flt3 and are involved in the proliferative effects of leukemia-associated Flt3 mutations. Exp Hematol (2005) 1.09

Expression of the fgr protooncogene product as a function of myelomonocytic cell maturation. J Cell Biol (1989) 1.06

Inhibition of Src family kinases enhances retinoic acid induced gene expression and myeloid differentiation. Mol Cancer Ther (2007) 1.05

c-Cbl interacts with CD38 and promotes retinoic acid-induced differentiation and G0 arrest of human myeloblastic leukemia cells. Cancer Res (2008) 1.02

Dasatinib inhibits the growth of molecularly heterogeneous myeloid leukemias. Clin Cancer Res (2010) 1.01

The regulatory subunit of protein kinase CK2 is a specific A-Raf activator. FEBS Lett (1997) 1.00

Treatment options for patients with chronic myeloid leukemia who are resistant to or unable to tolerate imatinib. Clin Ther (2010) 0.98

Dasatinib promotes ATRA-induced differentiation of AML cells. Leukemia (2009) 0.97

Lyn and Fgr protein-tyrosine kinases prevent apoptosis during retinoic acid-induced granulocytic differentiation of HL-60 cells. J Biol Chem (1996) 0.97

Retinoic acid induces nuclear accumulation of Raf1 during differentiation of HL-60 cells. Exp Cell Res (2009) 0.96

Tyrosine phosphorylation of protein kinase CK2 by Src-related tyrosine kinases correlates with increased catalytic activity. Biochem J (2003) 0.95

Expression of src family genes during monocytic differentiation of HL-60 cells. J Immunol (1991) 0.94

Autocatalytic tyrosine-phosphorylation of protein kinase CK2 alpha and alpha' subunits: implication of Tyr182. Biochem J (2001) 0.94

Expression of activated RAF accelerates cell differentiation and RB protein down-regulation but not hypophosphorylation. Eur J Cell Biol (1994) 0.93

Src tyrosine kinase inhibitor PP2 markedly enhances Ras-independent activation of Raf-1 protein kinase by phorbol myristate acetate and H2O2. J Biol Chem (2004) 0.88

ATRA-induced HL-60 myeloid leukemia cell differentiation depends on the CD38 cytosolic tail needed for membrane localization, but CD38 enzymatic activity is unnecessary. Exp Cell Res (2010) 0.87

Kinase suppressor of Ras transphosphorylates c-Raf-1. Biochem Biophys Res Commun (2009) 0.82

Dasatinib in imatinib-resistant or -intolerant CML patients: data from the clinical practice of 6 hematological centers in the Czech Republic. Neoplasma (2010) 0.81

Dasatinib induces long-term remission in imatinib-resistant Philadelphia chromosome-positive acute megakaryoblastic leukemia but fails to prevent development of central nervous system progression. Leuk Res (2010) 0.81

Kinase suppressor of Ras 1 is required for full ERK activation in thymocytes but not for thymocyte selection. Eur J Immunol (2010) 0.81

Articles by these authors

(truncated to the top 100)

High-throughput development and characterization of a genomewide collection of gene-based single nucleotide polymorphism markers by chip-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Proc Natl Acad Sci U S A (2001) 4.31

Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product. Science (1989) 3.63

Career advice for doctors with a chronic illness. BMJ (2001) 2.61

Saw palmetto extracts for treatment of benign prostatic hyperplasia: a systematic review. JAMA (1998) 2.46

Herpesvirus-like DNA sequences in non-Kaposi's sarcoma skin lesions of transplant patients. Lancet (1995) 2.36

The alcohol use disorders identification test (AUDIT) in a college sample. Int J Addict (1991) 2.20

A celebration of women in anaesthesia 1894-1994. J R Soc Med (1995) 2.16

Human herpesvirus 8 DNA sequences in blistering skin from patients with pemphigus. Arch Dermatol (1997) 2.12

Time to talk about rape. BMJ (2000) 2.11

Early versus deferred androgen suppression in the treatment of advanced prostatic cancer. Cochrane Database Syst Rev (2002) 2.07

Demonstration of immune complexes in spontaneous and histamine-induced lesions and in normal skin of patients with leukocytoclastic angitis. J Invest Dermatol (1975) 1.81

Terazosin for benign prostatic hyperplasia. Cochrane Database Syst Rev (2002) 1.65

The cost to global health of drug company profits. West J Med (2001) 1.61

Antenatal care of low risk obstetric patients by midwives. A randomised controlled trial. Med J Aust (1992) 1.60

Exploration of Victoria crater by the Mars rover Opportunity. Science (2009) 1.56

Development, characterization, and initial evaluations of S1. A new chromogenic cephalosporin for beta-lactamase detection. Diagn Microbiol Infect Dis (1995) 1.42

Character of shed blood in cardiac and thoracic surgery patients: implications for reinfusion. Can J Surg (1994) 1.38

Regulation of MCL1 through a serum response factor/Elk-1-mediated mechanism links expression of a viability-promoting member of the BCL2 family to the induction of hematopoietic cell differentiation. J Biol Chem (1999) 1.35

Ultrastructure of the human dermal microcirculation. II. The capillary loops of the dermal papillae. J Invest Dermatol (1977) 1.29

Human megakaryocyte stimulation of proliferation of bone marrow fibroblasts. Blood (1981) 1.28

Exponential 3T3 cells escape in mid-G1 from their high serum requirement. Exp Cell Res (1978) 1.28

Magnitude, duration, quality, and function of pneumococcal vaccine responses in elderly adults. J Infect Dis (1998) 1.26

Application of membrane-based dendrimer/DNA complexes for solid phase transfection in vitro and in vivo. Biomaterials (2000) 1.26

Expression of the c-myc protooncogene in human prostatic carcinoma and benign prostatic hyperplasia. Cancer Res (1986) 1.25

Aeolian processes at the Mars Exploration Rover Meridiani Planum landing site. Nature (2005) 1.23

Role of nuclear size in cell growth initiation. Science (1979) 1.23

Providing clean water: lessons from Bangladesh. BMJ (2001) 1.22

Arrested states produced by isoleucine deprivation and their relationship to the low serum produced arrested state in Swiss 3T3 cells. Exp Cell Res (1978) 1.18

Ultrastructure of the human dermal microcirculation: the horizontal plexus of the papillary dermis. J Invest Dermatol (1976) 1.17

Diagnosis and treatment of chronic abacterial prostatitis: a systematic review. Ann Intern Med (2000) 1.16

Ultrastructure of the capillary loops in the dermal papillae of psoriasis. J Invest Dermatol (1977) 1.15

The kinetic significance of cell size, I. Variation of cell cycle parameters with size measured at mitosis. Exp Cell Res (1975) 1.10

Microcirculation in psoriatic skin. J Invest Dermatol (1974) 1.09

Liposomes can mimic virus membranes. Nature (1974) 1.06

Laser prostatectomy for benign prostatic obstruction. Cochrane Database Syst Rev (2004) 1.06

The Opportunity Rover's Athena science investigation at Meridiani Planum, Mars. Science (2004) 1.03

Chemistry of rocks and soils at Meridiani Planum from the Alpha Particle X-ray Spectrometer. Science (2004) 1.01

Control of HL-60 cell differentiation lineage specificity, a late event occurring after precommitment. Cancer Res (1987) 1.01

beta-sitosterol for the treatment of benign prostatic hyperplasia: a systematic review. BJU Int (1999) 1.00

Myeloid differentiation and retinoblastoma phosphorylation changes in HL-60 cells induced by retinoic acid receptor- and retinoid X receptor-selective retinoic acid analogs. Blood (1996) 0.99

Involvement of the 5' proximal coding sequences of hepatitis C virus with internal initiation of viral translation. Biochem Biophys Res Commun (1998) 0.98

Practising evidence-based medicine: the design and implementation of a multidisciplinary team-driven extubation protocol. Crit Care (2001) 0.98

Detection of silica-rich deposits on Mars. Science (2008) 0.97

Control of HL-60 myeloid differentiation. Evidence of uncoupled growth and differentiation control, S-phase specificity, and two-step regulation. Exp Cell Res (1985) 0.96

The endometrial ablator: a new instrument. Obstet Gynecol (1994) 0.96

Herpesvirus-like DNA sequences in classic Kaposi's sarcomas. J Med Virol (1995) 0.95

Phytotherapy for benign prostatic hyperplasia. Public Health Nutr (2000) 0.94

Five-alpha-reductase Inhibitors for prostate cancer prevention. Cochrane Database Syst Rev (2008) 0.93

Retinoic acid causes MEK-dependent RAF phosphorylation through RARalpha plus RXR activation in HL-60 cells. Differentiation (2001) 0.93

Alternative modes of population growth inhibition in a human lymphoid cell line growing in suspension. Exp Cell Res (1977) 0.93

The Spirit Rover's Athena science investigation at Gusev Crater, Mars. Science (2004) 0.92

Jarosite and hematite at Meridiani Planum from Opportunity's Mossbauer Spectrometer. Science (2004) 0.91

Control of HL-60 monocytic differentiation. Different pathways and uncoupled expression of differentiation markers. Exp Cell Res (1987) 0.91

Retinoic acid-induced blr1 expression requires RARalpha, RXR, and MAPK activation and uses ERK2 but not JNK/SAPK to accelerate cell differentiation. Eur J Cell Biol (2001) 0.91

Retinoic acid-induced blr1 expression promotes ERK2 activation and cell differentiation in HL-60 cells. Exp Cell Res (2000) 0.91

Red cell 2,3-diphosphoglycerate and oxygen affinity. Anaesthesia (1977) 0.90

Detection of human herpesvirus-8 DNA in Kaposi's sarcomas from iatrogenically immunosuppressed patients. J Am Acad Dermatol (1998) 0.90

Dr Doughty's technique for the location of the epidural space. Anaesthesia (1983) 0.89

Retinoic acid induced HL-60 myeloid differentiation: dependence of early and late events on isomeric structure. Leuk Res (1986) 0.88

Dependence of HL-60 myeloid cell differentiation on continuous and split retinoic acid exposures: precommitment memory associated with altered nuclear structure. J Cell Physiol (1984) 0.88

The water exchange method for colonoscopy-effect of coaching. J Interv Gastroenterol (2012) 0.88

Congenital disorder of glycosylation type 1a: three siblings with a mild neurological phenotype. J Clin Neurosci (2007) 0.87

Beta-sitosterols for benign prostatic hyperplasia. Cochrane Database Syst Rev (2000) 0.87

Pygeum africanum for the treatment of patients with benign prostatic hyperplasia: a systematic review and quantitative meta-analysis. Am J Med (2000) 0.87

Hydroxyurea indices precommitment during retinoic induced HL-60 terminal myeloid differentiation: possible involvement of gene amplification. Leuk Res (1987) 0.86

Clinical pharmacology of polyethylene glycol-L-asparaginase. Drug Metab Dispos (1986) 0.86

Endovascular procedures for cerebrovenous disorders. Acta Neurochir Suppl (2008) 0.86

Trazodone for erectile dysfunction: a systematic review and meta-analysis. BJU Int (2003) 0.86

Serenoa repens for benign prostatic hyperplasia. Cochrane Database Syst Rev (2000) 0.86

Terazosin for treating symptomatic benign prostatic obstruction: a systematic review of efficacy and adverse effects. BJU Int (2002) 0.86

Role of the calmodulin inhibitor trifluoperazine on the induction and expression of cell cycle traverse perturbations and cytotoxicity of daunorubicin and doxorubicin (adriamycin) in doxorubicin-resistant P388 mouse leukaemia cells. Br J Cancer (1986) 0.86

The use of glass wool as an attachment surface for studying phenotypic changes in Pseudomonas aeruginosa biofilms by two-dimensional gel electrophoresis. Proteomics (2001) 0.85

Opposing effects of androgen and estrogen on pituitary-adrenal function in nonpregnant primates. Biol Reprod (2000) 0.84

Downregulation of topoisomerase IIbeta in myeloid leukemia cell lines leads to activation of apoptosis following all-trans retinoic acid-induced differentiation/growth arrest. Leukemia (2006) 0.84

T-cell control of B-cell proliferation uncoupled from differentiation. Cell Immunol (1982) 0.84

Endothelial cell cycle kinetics. Changes in culture and correlation with endothelial properties. Lab Invest (1984) 0.84

Side effects associated with pneumococcal vaccination. Am J Infect Control (1997) 0.84

Quantitation of some DNA precursor data. Nat New Biol (1972) 0.84

Laser laparoscopic adhesiolysis. J Gynecol Surg (1990) 0.84

Chemistry of rocks and soils in Gusev Crater from the alpha particle x-ray spectrometer. Science (2004) 0.83

Control of cell differentiation during proliferation. I. Monocytic differentiation of HL-60 promyelocytes. Exp Cell Res (1983) 0.83

Menopausal-type symptoms among breast cancer patients on aromatase inhibitor therapy. Climacteric (2011) 0.83

Uncoupling lymphocyte proliferation from differentiation: dissimilar dose-response relations for pokeweed mitogen-induced proliferation and differentiation of normal human lymphocytes. Cell Immunol (1981) 0.83

Spotlight on lasers. A look at potential benefits. J Am Dent Assoc (1991) 0.82

Characterization of a transglutaminase expressed in human pancreatic adenocarcinoma cells. Eur J Cell Biol (1993) 0.82

Evidence for cell cycle phase-specific initiation of a program of HL-60 cell myeloid differentiation mediated by inducer uptake. Cancer Res (1984) 0.82

Increased c-myc RNA levels associated with the precommitment state during HL-60 myeloid differentiation. Cancer Res (1986) 0.82

Increased myometrial contracture frequency at 96-140 days accelerates fetal cardiovascular maturation. Am J Physiol Heart Circ Physiol (2000) 0.82

Basaltic rocks analyzed by the Spirit Rover in Gusev Crater. Science (2004) 0.81

A novel approach to tracheostomal collapse: the use of an endoluminal Palmaz stent. Int J Pediatr Otorhinolaryngol (1998) 0.81

Characterization of a vitamin D3-resistant human chronic myelogenous leukemia cell line. Blood (1994) 0.80

Serum-stimulated 3T3 cells undertake a histidinol-sensitive process which G1 cells do not. Exp Cell Res (1978) 0.80

Mineralogy at Gusev Crater from the Mössbauer spectrometer on the Spirit Rover. Science (2004) 0.80

An RXR-selective analog attenuates the RAR alpha-selective analog-induced differentiation and non-G1-restricted growth arrest of NB4 cells. Exp Cell Res (1997) 0.80

Serum-free media for a human lymphocyte cell line and for pwm-stimulated peripheral blood lymphocytes: requirements for insulin, transferrin and albumin. Immunol Lett (1983) 0.80

WHO says tobacco industry "used" institute to undermine its policies. BMJ (2001) 0.79

Congenital smooth muscle hamartoma presenting as a linear atrophic plaque: case report and review of the literature. Pediatr Dermatol (1996) 0.79

Disseminated congenital candidiasis in a premature infant. Arch Dermatol (1999) 0.79

Cloning of fresh lymphoma cells. Med Pediatr Oncol (1981) 0.79

Biliary concentrations of fluconazole in a patient with candidal cholecystitis: case report. Clin Infect Dis (1992) 0.79