The molecular scaffold KSR1 regulates the proliferative and oncogenic potential of cells.

PubWeight™: 1.86‹?› | Rank: Top 3%

🔗 View Article (PMC 400485)

Published in Mol Cell Biol on May 01, 2004

Authors

Robert L Kortum1, Robert E Lewis

Author Affiliations

1: Eppley Institute for Cancer Research, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-6805, USA.

Articles citing this

AMPK as a metabolic tumor suppressor: control of metabolism and cell growth. Future Oncol (2010) 2.11

Functional proteomics to dissect tyrosine kinase signalling pathways in cancer. Nat Rev Cancer (2010) 1.97

Protein scaffolds in MAP kinase signalling. Cell Signal (2008) 1.94

Signaling dynamics of the KSR1 scaffold complex. Proc Natl Acad Sci U S A (2009) 1.76

Raf family kinases: old dogs have learned new tricks. Genes Cancer (2011) 1.72

IQGAP1 modulates activation of B-Raf. Proc Natl Acad Sci U S A (2007) 1.57

KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity. Cell Metab (2009) 1.53

KSR2 is a calcineurin substrate that promotes ERK cascade activation in response to calcium signals. Mol Cell (2009) 1.39

Elevating the levels of Sox2 in embryonal carcinoma cells and embryonic stem cells inhibits the expression of Sox2:Oct-3/4 target genes. Nucleic Acids Res (2007) 1.37

The molecular scaffold kinase suppressor of Ras 1 (KSR1) regulates adipogenesis. Mol Cell Biol (2005) 1.35

GILZ mediates the antiproliferative activity of glucocorticoids by negative regulation of Ras signaling. J Clin Invest (2007) 1.32

Theoretical and experimental analysis links isoform-specific ERK signalling to cell fate decisions. Mol Syst Biol (2009) 1.31

Compact integration factor methods in high spatial dimensions. J Comput Phys (2008) 1.31

Extracellular signal-regulated kinase regulates clathrin-independent endosomal trafficking. Mol Biol Cell (2005) 1.30

Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis. J Clin Invest (2012) 1.25

RAF inhibitor-induced KSR1/B-RAF binding and its effects on ERK cascade signaling. Curr Biol (2011) 1.22

Essential role of B-Raf in oligodendrocyte maturation and myelination during postnatal central nervous system development. J Cell Biol (2008) 1.14

Freud-1/Aki1, a novel PDK1-interacting protein, functions as a scaffold to activate the PDK1/Akt pathway in epidermal growth factor signaling. Mol Cell Biol (2008) 1.13

MAPK scaffold IQGAP1 binds the EGF receptor and modulates its activation. J Biol Chem (2011) 1.09

Selective role for RGS12 as a Ras/Raf/MEK scaffold in nerve growth factor-mediated differentiation. EMBO J (2007) 1.08

Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins. PLoS Comput Biol (2008) 1.07

Compact integration factor methods for complex domains and adaptive mesh refinement. J Comput Phys (2010) 1.07

SILAC-based phosphoproteomics reveals an inhibitory role of KSR1 in p53 transcriptional activity via modulation of DBC1. Br J Cancer (2013) 1.06

Four-dimensional dynamics of MAPK information processing systems. Wiley Interdiscip Rev Syst Biol Med (2010) 1.06

RACK1 and CIS mediate the degradation of BimEL in cancer cells. J Biol Chem (2008) 1.05

Kinase suppressor of Ras 2 (KSR2) regulates tumor cell transformation via AMPK. Mol Cell Biol (2012) 1.05

Src inhibitors, PP2 and dasatinib, increase retinoic acid-induced association of Lyn and c-Raf (S259) and enhance MAPK-dependent differentiation of myeloid leukemia cells. Leukemia (2011) 1.05

The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence. Mol Cell Biol (2006) 1.01

Vitamin D3-driven signals for myeloid cell differentiation--implications for differentiation therapy. Leuk Res (2009) 1.00

Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26. Mol Cell Biol (2006) 0.98

Nonvisual arrestins function as simple scaffolds assembling the MKK4-JNK3α2 signaling complex. Biochemistry (2011) 0.97

The mitogen-activated protein kinase scaffold KSR1 is required for recruitment of extracellular signal-regulated kinase to the immunological synapse. Mol Cell Biol (2009) 0.96

How scaffolds shape MAPK signaling: what we know and opportunities for systems approaches. Front Physiol (2012) 0.94

A ceramide-binding C1 domain mediates kinase suppressor of ras membrane translocation. Cell Physiol Biochem (2009) 0.93

Inflammatory bowel disease reveals the kinase activity of KSR1. J Clin Invest (2004) 0.93

Kinase suppressor of ras 1 (KSR1) regulates PGC1α and estrogen-related receptor α to promote oncogenic Ras-dependent anchorage-independent growth. Mol Cell Biol (2011) 0.93

KSR1 is overexpressed in endometrial carcinoma and regulates proliferation and TRAIL-induced apoptosis by modulating FLIP levels. Am J Pathol (2011) 0.91

MicroRNA-497 inhibits tumor growth and increases chemosensitivity to 5-fluorouracil treatment by targeting KSR1. Oncotarget (2016) 0.85

Arrestin-3 binds c-Jun N-terminal kinase 1 (JNK1) and JNK2 and facilitates the activation of these ubiquitous JNK isoforms in cells via scaffolding. J Biol Chem (2013) 0.85

The interplay of double phosphorylation and scaffolding in MAPK pathways. J Theor Biol (2011) 0.85

Negative feedback regulation of the ERK1/2 MAPK pathway. Cell Mol Life Sci (2016) 0.81

Deconstructing signaling in three dimensions. Biochemistry (2014) 0.81

A CC-SAM, for coiled coil-sterile α motif, domain targets the scaffold KSR-1 to specific sites in the plasma membrane. Sci Signal (2012) 0.79

AMPK Promotes Aberrant PGC1β Expression To Support Human Colon Tumor Cell Survival. Mol Cell Biol (2015) 0.79

Regulation of glucose homeostasis by KSR1 and MARK2. PLoS One (2011) 0.79

Arrestin-dependent activation of JNK family kinases. Handb Exp Pharmacol (2014) 0.78

Simulating EGFR-ERK signaling control by scaffold proteins KSR and MP1 reveals differential ligand-sensitivity co-regulated by Cbl-CIN85 and endophilin. PLoS One (2011) 0.78

KSR1 is required for cell cycle reinitiation following DNA damage. J Biol Chem (2009) 0.78

Caveolin-1 is required for kinase suppressor of Ras 1 (KSR1)-mediated extracellular signal-regulated kinase 1/2 activation, H-RasV12-induced senescence, and transformation. Mol Cell Biol (2014) 0.77

The LIM-only protein FHL2 mediates ras-induced transformation through cyclin D1 and p53 pathways. PLoS One (2008) 0.77

Three-state kinetic mechanism for scaffold-mediated signal transduction. Phys Rev E Stat Nonlin Soft Matter Phys (2008) 0.77

The KSR2-calcineurin complex regulates STIM1-ORAI1 dynamics and store-operated calcium entry (SOCE). Mol Biol Cell (2014) 0.77

praja2 regulates KSR1 stability and mitogenic signaling. Cell Death Dis (2016) 0.77

Transcriptome analysis of follicles reveals the importance of autophagy and hormones in regulating broodiness of Zhedong white goose. Sci Rep (2016) 0.75

KSR1 and EPHB4 Regulate Myc and PGC1β To Promote Survival of Human Colon Tumors. Mol Cell Biol (2016) 0.75

Signaling cascades modulate the speed of signal propagation through space. PLoS One (2009) 0.75

Kinase suppressor of Ras (KSR1) modulates multiple kit-ligand-dependent mast cell functions. Exp Hematol (2011) 0.75

Differential localization of A-Raf regulates MST2-mediated apoptosis during epithelial differentiation. Cell Death Differ (2016) 0.75

Kinase Suppressor of Ras 2 (KSR2) expression in the brain regulates energy balance and glucose homeostasis. Mol Metab (2016) 0.75

Tyr728 in the kinase domain of the murine kinase suppressor of RAS 1 regulates binding and activation of the mitogen-activated protein kinase kinase. J Biol Chem (2013) 0.75

The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors. Oncogene (2015) 0.75

Coordinating ERK signaling via the molecular scaffold Kinase Suppressor of Ras. F1000Res (2017) 0.75

Articles cited by this

Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. J Cell Biol (1963) 29.15

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell (1995) 21.15

Mammalian MAP kinase signalling cascades. Nature (2001) 18.89

Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J (1996) 16.68

Molecular interpretation of ERK signal duration by immediate early gene products. Nat Cell Biol (2002) 6.05

Mitogen-activated protein kinases: specific messages from ubiquitous messengers. Mol Cell Biol (1999) 5.93

Multiple Ras functions can contribute to mammalian cell transformation. Cell (1995) 5.24

A mammalian scaffold complex that selectively mediates MAP kinase activation. Science (1998) 4.78

A cytoplasmic inhibitor of the JNK signal transduction pathway. Science (1997) 4.56

MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade. Science (1998) 4.45

Distinct requirements for Ras oncogenesis in human versus mouse cells. Genes Dev (2002) 4.30

Mathematical models of protein kinase signal transduction. Mol Cell (2002) 4.08

Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP. Nature (1999) 3.99

Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties. Proc Natl Acad Sci U S A (2000) 3.95

KSR, a novel protein kinase required for RAS signal transduction. Cell (1995) 3.27

The JIP group of mitogen-activated protein kinase scaffold proteins. Mol Cell Biol (1999) 3.18

Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction. Dev Cell (2002) 2.98

Signal transduction: hanging on a scaffold. Curr Opin Cell Biol (2000) 2.96

Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals. Trends Biochem Sci (1998) 2.83

The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction. Cell (1995) 2.74

Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation. Mol Cell Biol (1996) 2.69

The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans. Cell (1995) 2.65

Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo. Mol Cell Biol (2002) 2.54

C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1. Mol Cell (2001) 2.47

KSR modulates signal propagation within the MAPK cascade. Genes Dev (1996) 2.46

KSR is a scaffold required for activation of the ERK/MAPK module. Genes Dev (2002) 2.40

Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling. Biochem Pharmacol (2002) 2.39

A role for the Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation. J Biol Chem (1996) 2.06

Multiple ras effector pathways contribute to G(1) cell cycle progression. J Biol Chem (1999) 2.05

Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK. Curr Biol (1998) 2.02

Growth-factor-dependent mitogenesis requires two distinct phases of signalling. Nat Cell Biol (2001) 1.99

Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression. Mol Cell Biol (1999) 1.96

Specificity of MAP kinase signaling in yeast differentiation involves transient versus sustained MAPK activation. Mol Cell (2001) 1.94

Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization. Mol Cell Biol (1999) 1.91

KSR: a MAPK scaffold of the Ras pathway? J Cell Sci (2001) 1.90

Murine Ksr interacts with MEK and inhibits Ras-induced transformation. Curr Biol (1998) 1.80

The protein kinase KSR interacts with 14-3-3 protein and Raf. Curr Biol (1997) 1.73

KSR stimulates Raf-1 activity in a kinase-independent manner. Proc Natl Acad Sci U S A (1997) 1.72

Computer-based analysis of the binding steps in protein complex formation. Proc Natl Acad Sci U S A (1997) 1.67

Routing MAP kinase cascades. Science (1998) 1.63

Signaling pathways in Ras-mediated tumorigenicity and metastasis. Proc Natl Acad Sci U S A (1998) 1.63

Deficiency of kinase suppressor of Ras1 prevents oncogenic ras signaling in mice. Cancer Res (2003) 1.60

Kinase suppressor of Ras inhibits the activation of extracellular ligand-regulated (ERK) mitogen-activated protein (MAP) kinase by growth factors, activated Ras, and Ras effectors. J Biol Chem (1998) 1.48

C. elegans ksr-1 and ksr-2 have both unique and redundant functions and are required for MPK-1 ERK phosphorylation. Curr Biol (2002) 1.46

The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling Elk-1 phosphorylation from MAP kinase activation. EMBO J (1998) 1.45

Identification of B-KSR1, a novel brain-specific isoform of KSR1 that functions in neuronal signaling. Mol Cell Biol (2000) 1.39

What do scaffold proteins really do? Sci STKE (2000) 1.39

Assembly of the Drosophila phototransduction cascade into a signalling complex shapes elementary responses. Nature (1998) 1.32

Ras-dependent regulation of c-Jun phosphorylation is mediated by the Ral guanine nucleotide exchange factor-Ral pathway. Mol Cell Biol (2000) 1.24

Critical contribution of linker proteins to Raf kinase activation. J Biol Chem (2001) 1.15

Ras signals to the cell cycle machinery via multiple pathways to induce anchorage-independent growth. Mol Cell Biol (1998) 1.05

Phosphorylation regulates the nucleocytoplasmic distribution of kinase suppressor of Ras. J Biol Chem (2001) 0.98

Articles by these authors

Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo. Mol Cell Biol (2002) 2.54

Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP. Nature (2004) 1.87

KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity. Cell Metab (2009) 1.53

Ras subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteins. Mol Cell Biol (2008) 1.50

The molecular scaffold kinase suppressor of Ras 1 (KSR1) regulates adipogenesis. Mol Cell Biol (2005) 1.35

Phosphorylation regulates KSR1 stability, ERK activation, and cell proliferation. J Biol Chem (2004) 1.31

Extracellular signal-regulated kinase regulates clathrin-independent endosomal trafficking. Mol Biol Cell (2005) 1.30

KIBRA protein phosphorylation is regulated by mitotic kinase aurora and protein phosphatase 1. J Biol Chem (2011) 1.14

The formin-homology-domain-containing protein FHOD1 enhances cell migration. J Cell Sci (2003) 1.13

Kinase suppressor of Ras 2 (KSR2) regulates tumor cell transformation via AMPK. Mol Cell Biol (2012) 1.05

Effects of B-Myb on gene transcription: phosphorylation-dependent activity ans acetylation by p300. J Biol Chem (2001) 1.02

The molecular scaffold kinase suppressor of Ras 1 is a modifier of RasV12-induced and replicative senescence. Mol Cell Biol (2006) 1.01

Essential role for Dnmt1 in the prevention and maintenance of MYC-induced T-cell lymphomas. Mol Cell Biol (2013) 1.00

The MAPK scaffold kinase suppressor of Ras is involved in ERK activation by stress and proinflammatory cytokines and induction of arthritis. J Immunol (2006) 0.99

Phosphorylation regulates the nucleocytoplasmic distribution of kinase suppressor of Ras. J Biol Chem (2001) 0.98

Aberrant myeloid marker expression in precursor B-cell and T-cell leukemias. Exp Mol Pathol (2007) 0.97

The mitogen-activated protein kinase scaffold KSR1 is required for recruitment of extracellular signal-regulated kinase to the immunological synapse. Mol Cell Biol (2009) 0.96

Using functional signature ontology (FUSION) to identify mechanisms of action for natural products. Sci Signal (2013) 0.94

Kinase suppressor of ras 1 (KSR1) regulates PGC1α and estrogen-related receptor α to promote oncogenic Ras-dependent anchorage-independent growth. Mol Cell Biol (2011) 0.93

Expression of kinase suppressor of Ras1 enhances cisplatin-induced extracellular signal-regulated kinase activation and cisplatin sensitivity. Cancer Res (2005) 0.91

KSR1 is overexpressed in endometrial carcinoma and regulates proliferation and TRAIL-induced apoptosis by modulating FLIP levels. Am J Pathol (2011) 0.91

Function of CD80 and CD86 on monocyte- and stem cell-derived dendritic cells. Exp Mol Pathol (2003) 0.87

Toll-like receptors, cytokines and HIV-1. Exp Mol Pathol (2007) 0.86

The fate of renal allografts hinges on responses of the microvascular endothelium. Exp Mol Pathol (2012) 0.85

Aberrant expression of CD7, CD56, and CD79a antigens in acute myeloid leukemias. Exp Mol Pathol (2005) 0.84

HLA DRB1*1503 allelic haplotype predominance and associated immunodysregulation in systemic lupus erythematosus. Exp Mol Pathol (2011) 0.83

Toll-like receptor and chemokine receptor expression in HIV-infected T lymphocyte subsets. Exp Mol Pathol (2009) 0.82

Differential cytokine and Toll-like receptor expression in leukemia. Exp Mol Pathol (2007) 0.81

IMP modulates KSR1-dependent multivalent complex formation to specify ERK1/2 pathway activation and response thresholds. J Biol Chem (2008) 0.81

Circulating tumor cells (CTCs) from metastatic breast cancer patients linked to decreased immune function and response to treatment. Exp Mol Pathol (2013) 0.80

Immunological enhancement revisited. Exp Mol Pathol (2002) 0.80

Regulation of glucose homeostasis by KSR1 and MARK2. PLoS One (2011) 0.79

Decreased humoral antibody episodes of acute renal allograft rejection in recipients expressing the HLA-DQβ1*0202 allele. Exp Mol Pathol (2012) 0.78

KSR1 is required for cell cycle reinitiation following DNA damage. J Biol Chem (2009) 0.78

Costimulatory function of umbilical cord blood CD14+ and CD34+ derived dendritic cells. Exp Mol Pathol (2003) 0.77

Quantitative analysis of adhesion molecules on cellular constituents of the human uterine microenvironment under the influence of estrogen and progesterone. Exp Mol Pathol (2002) 0.77

Zap-70 and CD38 as predictors of IgVH mutation in CLL. Exp Mol Pathol (2007) 0.76

Direct-care staff body mass index in a state mental hospital: staff obesity may impair role modeling for patients. Prog Neuropsychopharmacol Biol Psychiatry (2005) 0.76

Immunologic research: Publishing knowledge of the future today!: the first three decades. Immunol Res (2012) 0.76

Dendritic cell differentiation and proliferation: enhancement by tumor necrosis factor-alpha. Exp Mol Pathol (2003) 0.76

B-Myb repressor function is regulated by cyclin A phosphorylation and sequences within the C-terminal domain. Oncogene (2003) 0.76

DRβ1*1501, DQβ1*0602 donor allelic haplotype and humoral antibody episodes of acute renal allograft rejection. Exp Mol Pathol (2010) 0.75

The use of a structured interview guide in veterinary college admissions. J Vet Med Educ (2008) 0.75

Julius M. Cruse: his rendezvous with immunology. Immunol Res (2013) 0.75

Antigenic transformation in plasma cell dyscrasia. Exp Mol Pathol (2006) 0.75

Diminished CD10, CD13, and CD15 expression in a differentiated granulocyte population in CML. Exp Mol Pathol (2007) 0.75

Serial monitoring of humoral antibody-mediated rejection of cardiac allografts by C4d staining of interstitial capillaries. Exp Mol Pathol (2008) 0.75