Published in J Clin Invest on December 27, 2011
TGF-β signaling in myeloid cells is required for tumor metastasis. Cancer Discov (2013) 1.76
The p38/MK2-driven exchange between tristetraprolin and HuR regulates AU-rich element-dependent translation. PLoS Genet (2012) 1.50
Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways. Nat Immunol (2012) 1.49
Noncoding RNA and its associated proteins as regulatory elements of the immune system. Nat Immunol (2014) 1.15
Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo. Proc Natl Acad Sci U S A (2013) 1.02
Defective TGF-β signaling in bone marrow-derived cells prevents hedgehog-induced skin tumors. Cancer Res (2013) 1.00
Antagonistic function of the RNA-binding protein HuR and miR-200b in post-transcriptional regulation of vascular endothelial growth factor-A expression and angiogenesis. J Biol Chem (2012) 0.94
Changes in cellular mRNA stability, splicing, and polyadenylation through HuR protein sequestration by a cytoplasmic RNA virus. Cell Rep (2013) 0.91
The RNA-binding protein HuR is essential for the B cell antibody response. Nat Immunol (2015) 0.91
RNA-binding proteins as a point of convergence of the PI3K and p38 MAPK pathways. Front Immunol (2012) 0.89
RNA-binding protein HuR promotes growth of small intestinal mucosa by activating the Wnt signaling pathway. Mol Biol Cell (2014) 0.89
Intestinal epithelial HuR modulates distinct pathways of proliferation and apoptosis and attenuates small intestinal and colonic tumor development. Cancer Res (2014) 0.83
Tristetraprolin binding site atlas in the macrophage transcriptome reveals a switch for inflammation resolution. Mol Syst Biol (2016) 0.82
MicroRNA buffering and altered variance of gene expression in response to Salmonella infection. PLoS One (2014) 0.82
The mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through posttranscriptional regulation of the proto-oncogene PIM1 in pancreatic cancer cells. Oncogene (2015) 0.81
Conditional knockout of the RNA-binding protein HuR in CD4⁺ T cells reveals a gene dosage effect on cytokine production. Mol Med (2014) 0.80
The flip-flop HuR: part of the problem or the solution in fighting cancer? J Clin Invest (2011) 0.80
Cell-Type Specific Determinants of NRAMP1 Expression in Professional Phagocytes. Biology (Basel) (2013) 0.79
RNA binding protein HuR is Translocated in Astrocytes Following Spinal Cord Injury and Promotes the Inflammatory Response. J Neurotrauma (2016) 0.78
Identification of RNA-binding Proteins in Macrophages by Interactome Capture. Mol Cell Proteomics (2016) 0.77
RNA binding proteins as regulators of immune cell biology. Clin Exp Immunol (2015) 0.77
Protein segregase meddles in remodeling of mRNA-protein complexes. Genes Dev (2013) 0.76
GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancer. Cell Death Differ (2017) 0.75
The Assembly of EDC4 and Dcp1a into Processing Bodies Is Critical for the Translational Regulation of IL-6. PLoS One (2015) 0.75
Exome sequencing of a colorectal cancer family reveals shared mutation pattern and predisposition circuitry along tumor pathways. Front Genet (2015) 0.75
HuR Enhances Early Restitution of the Intestinal Epithelium by Increasing Cdc42 Translation. Mol Cell Biol (2016) 0.75
Current Evidence and Future Perspectives on HuR and Breast Cancer Development, Prognosis, and Treatment. Neoplasia (2016) 0.75
Post-transcriptional Regulation of Immunological Responses through Riboclustering. Front Immunol (2016) 0.75
Post-transcriptional regulation of cytokine and growth factor signaling in cancer. Cytokine Growth Factor Rev (2016) 0.75
Genome-wide map of RNA degradation kinetics patterns in dendritic cells after LPS stimulation facilitates identification of primary sequence and secondary structure motifs in mRNAs. BMC Genomics (2016) 0.75
Cancer-related inflammation. Nature (2008) 34.21
Immunity, inflammation, and cancer. Cell (2010) 28.27
Exploring the full spectrum of macrophage activation. Nat Rev Immunol (2008) 26.08
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The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol (2004) 19.38
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Alternative activation of macrophages: mechanism and functions. Immunity (2010) 12.43
RNA regulons: coordination of post-transcriptional events. Nat Rev Genet (2007) 10.12
Chemically induced mouse models of intestinal inflammation. Nat Protoc (2007) 8.65
HuR and mRNA stability. Cell Mol Life Sci (2001) 8.06
Monocyte chemoattractant protein-1 (MCP-1): an overview. J Interferon Cytokine Res (2009) 7.83
AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. Cell (2001) 7.79
Inflammation and colon cancer. Gastroenterology (2010) 6.32
Macrophage polarization comes of age. Immunity (2005) 5.67
RNA granules: post-transcriptional and epigenetic modulators of gene expression. Nat Rev Mol Cell Biol (2009) 4.57
The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. J Exp Med (2010) 4.37
Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability. Mol Cell (2011) 4.29
Phagocyte partnership during the onset and resolution of inflammation. Nat Rev Immunol (2010) 4.07
Post-transcriptional control of cytokine production. Nat Immunol (2008) 3.30
Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype. J Immunol (2008) 3.07
MAPKAP kinases - MKs - two's company, three's a crowd. Nat Rev Mol Cell Biol (2006) 2.80
HuR: post-transcriptional paths to malignancy. RNA Biol (2005) 2.38
HuR as a negative posttranscriptional modulator in inflammation. Mol Cell (2005) 2.27
MKP-1 mRNA stabilization and translational control by RNA-binding proteins HuR and NF90. Mol Cell Biol (2008) 2.26
Analysis of turnover and translation regulatory RNA-binding protein expression through binding to cognate mRNAs. Mol Cell Biol (2007) 2.24
RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha. Mol Cell Biol (2007) 2.20
Post-transcriptional regulons coordinate the initiation and resolution of inflammation. Nat Rev Immunol (2010) 2.08
Translational control of cytochrome c by RNA-binding proteins TIA-1 and HuR. Mol Cell Biol (2006) 2.05
LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages. FASEB J (2009) 1.99
Monocyte chemoattractant protein-1 is sufficient for the chemotaxis of monocytes and lymphocytes in transgenic mice but requires an additional stimulus for inflammatory activation. J Immunol (1997) 1.99
Bacterial lipopolysaccharide rapidly inhibits expression of C-C chemokine receptors in human monocytes. J Exp Med (1997) 1.97
The mRNA binding proteins HuR and tristetraprolin regulate cyclooxygenase 2 expression during colon carcinogenesis. Gastroenterology (2009) 1.92
Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR. Cell Signal (2008) 1.84
The RNA-binding protein Elavl1/HuR is essential for placental branching morphogenesis and embryonic development. Mol Cell Biol (2009) 1.78
Suppression of ulcerative colitis in mice by orally available inhibitors of sphingosine kinase. Dig Dis Sci (2007) 1.72
Decoding ARE-mediated decay: is microRNA part of the equation? J Cell Biol (2008) 1.60
Essential role of the RNA-binding protein HuR in progenitor cell survival in mice. J Clin Invest (2009) 1.58
Blockade of a chemokine, CCL2, reduces chronic colitis-associated carcinogenesis in mice. Cancer Res (2009) 1.51
IL-10-induced TNF-alpha mRNA destabilization is mediated via IL-10 suppression of p38 MAP kinase activation and inhibition of HuR expression. FASEB J (2006) 1.50
Lung-specific overexpression of CC chemokine ligand (CCL) 2 enhances the host defense to Streptococcus pneumoniae infection in mice: role of the CCL2-CCR2 axis. J Immunol (2007) 1.41
MicroRNA-101 targets MAPK phosphatase-1 to regulate the activation of MAPKs in macrophages. J Immunol (2010) 1.38
Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR. Nat Chem Biol (2007) 1.36
The simultaneous blockade of chemokine receptors CCR2, CCR5 and CXCR3 by a non-peptide chemokine receptor antagonist protects mice from dextran sodium sulfate-mediated colitis. Int Immunol (2005) 1.34
Control of thymic T cell maturation, deletion and egress by the RNA-binding protein HuR. J Immunol (2009) 1.25
Critical role of MCP-1 in the pathogenesis of experimental colitis in the context of immune and enterochromaffin cells. Am J Physiol Gastrointest Liver Physiol (2006) 1.20
Tumor formation in a mouse model of colitis-associated colon cancer does not require COX-1 or COX-2 expression. Carcinogenesis (2010) 1.15
HuR regulates the expression of stress-sensitive genes and mediates inflammatory response in human umbilical vein endothelial cells. Proc Natl Acad Sci U S A (2010) 1.11
Selective inhibition of expression of the chemokine receptor CCR2 in human monocytes by IFN-gamma. J Immunol (1998) 1.11
Chemokine transcripts as targets of the RNA-binding protein HuR in human airway epithelium. J Immunol (2011) 1.09
Properties of the regulatory RNA-binding protein HuR and its role in controlling miRNA repression. Adv Exp Med Biol (2010) 1.05
Regulation of CCR2 chemokine receptor mRNA stability. J Leukoc Biol (1997) 0.98
Cytoplasmic expression of HuR is related to cyclooxygenase-2 expression in colon cancer. Cancer Res Treat (2009) 0.96
Induction of a fibrogenic response in mouse colon by overexpression of monocyte chemoattractant protein 1. Gut (2005) 0.92
Increased expression of cytoplasmic HuR in familial adenomatous polyposis. Cancer Biol Ther (2007) 0.91
Post-transcriptional regulators in inflammation: exploring new avenues in biological therapeutics. Ernst Schering Found Symp Proc (2006) 0.79
HuR as a negative posttranscriptional modulator in inflammation. Mol Cell (2005) 2.27
Generation and characterization of p38beta (MAPK11) gene-targeted mice. Mol Cell Biol (2005) 2.19
Identification of high frequency of Y chromosome deletions in patients with sex chromosome mosaicism and correlation with the clinical phenotype and Y-chromosome instability. Am J Med Genet A (2005) 2.01
Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases. J Exp Med (2008) 1.98
The RNA-binding protein Elavl1/HuR is essential for placental branching morphogenesis and embryonic development. Mol Cell Biol (2009) 1.78
Bioinformatic and functional analysis of RNA secondary structure elements among different genera of human and animal caliciviruses. Nucleic Acids Res (2008) 1.63
Ghrelin's role on gastrointestinal tract cancer. Surg Oncol (2009) 1.55
Structural insights into the transcriptional and translational roles of Ebp1. EMBO J (2007) 1.37
Control of thymic T cell maturation, deletion and egress by the RNA-binding protein HuR. J Immunol (2009) 1.25
Role of beta7 integrin and the chemokine/chemokine receptor pair CCL25/CCR9 in modeled TNF-dependent Crohn's disease. Gastroenterology (2008) 1.23
ATX expression and LPA signalling are vital for the development of the nervous system. Dev Biol (2010) 1.18
Transmembrane TNF protects mutant mice against intracellular bacterial infections, chronic inflammation and autoimmunity. Eur J Immunol (2006) 1.17
Inactivation of the deubiquitinase CYLD in hepatocytes causes apoptosis, inflammation, fibrosis, and cancer. Cancer Cell (2012) 1.09
Functional analysis of RNA structures present at the 3' extremity of the murine norovirus genome: the variable polypyrimidine tract plays a role in viral virulence. J Virol (2010) 1.03
Truncation of the catalytic domain of the cylindromatosis tumor suppressor impairs lung maturation. Neoplasia (2009) 0.94
Posttranscriptional regulation of TNF mRNA: a paradigm of signal-dependent mRNA utilization and its relevance to pathology. Curr Dir Autoimmun (2010) 0.92
Ghrelin: a potential therapeutic target for cancer. Regul Pept (2010) 0.89
The RNA-binding protein ELAVL1/HuR is essential for mouse spermatogenesis, acting both at meiotic and postmeiotic stages. Mol Biol Cell (2011) 0.88
Prognostic significance of metallothionein expression in renal cell carcinoma. World J Surg Oncol (2005) 0.84
Stabilization of Dll1 mRNA by Elavl1/HuR in neuroepithelial cells undergoing mitosis. Mol Biol Cell (2011) 0.83
HuR maintains a replicative life span by repressing the ARF tumor suppressor. Mol Cell Biol (2013) 0.82
Thymocyte-specific truncation of the deubiquitinating domain of CYLD impairs positive selection in a NF-kappaB essential modulator-dependent manner. J Immunol (2010) 0.82
Detection of unusual mutation within the VP1 region of different re-isolates of poliovirus Sabin vaccine. Virus Genes (2006) 0.81
Genomic analysis of recombinant sabin clinical isolates. Virus Genes (2006) 0.79
Therapeutic value of melatonin in an experimental model of liver injury and regeneration. J Pineal Res (2006) 0.79
HuR controls lung branching morphogenesis and mesenchymal FGF networks. Dev Biol (2011) 0.78
Decoding the functions of post-transcriptional regulators in the determination of inflammatory states: focus on macrophage activation. Wiley Interdiscip Rev Syst Biol Med (2012) 0.77
Vaccine derived bi- and multi-recombinant Sabin strains. Virus Genes (2007) 0.77
Truncation of the deubiquitinating domain of CYLD in myelomonocytic cells attenuates inflammatory responses. PLoS One (2011) 0.76
ASCertaining cytoskeletal rearrangements in antigen presentation and migration. Nat Immunol (2011) 0.75
Liver hypertrophy after percutaneous portal vein embolization: comparison of N-butyl-2-cyanocrylate versus sodium acrylate-vinyl alcohol copolymer particles in a swine model. Cardiovasc Intervent Radiol (2010) 0.75
Functional genetic and genomic analysis of modeled arthritis. Adv Exp Med Biol (2007) 0.75