Published in Nat Rev Mol Cell Biol on February 01, 2006
Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases. Microbiol Mol Biol Rev (2011) 5.02
Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action. Microbiol Mol Biol Rev (2006) 4.13
Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. Curr Opin Cell Biol (2009) 3.15
The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration. Cell (2009) 2.72
mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype. Nat Cell Biol (2015) 2.48
Retracted The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling. PLoS Biol (2006) 2.42
Targeting innate immunity protein kinase signalling in inflammation. Nat Rev Drug Discov (2009) 2.01
DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization. Mol Cell (2010) 1.78
The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK. Mol Cell Biol (2006) 1.73
MAP kinase pathways: the first twenty years. Biochim Biophys Acta (2006) 1.65
Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b. Proc Natl Acad Sci U S A (2011) 1.62
Activation of calcium/calmodulin-dependent protein kinase II in obesity mediates suppression of hepatic insulin signaling. Cell Metab (2013) 1.61
Post-transcriptional control during chronic inflammation and cancer: a focus on AU-rich elements. Cell Mol Life Sci (2010) 1.58
Functional analysis of KSRP interaction with the AU-rich element of interleukin-8 and identification of inflammatory mRNA targets. Mol Cell Biol (2007) 1.56
The p38/MK2-driven exchange between tristetraprolin and HuR regulates AU-rich element-dependent translation. PLoS Genet (2012) 1.50
Molecular basis of MAPK-activated protein kinase 2:p38 assembly. Proc Natl Acad Sci U S A (2007) 1.40
Normal endothelial but impaired arterial development in MAP-Kinase activated protein kinase 2 (MK2) deficient mice. Vasc Cell (2016) 1.38
MAPK p38 regulates transcriptional activity of NF-kappaB in primary human astrocytes via acetylation of p65. J Immunol (2007) 1.31
RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1. J Biol Chem (2009) 1.30
Specificity of linear motifs that bind to a common mitogen-activated protein kinase docking groove. Sci Signal (2012) 1.25
Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ). J Neuroinflammation (2011) 1.25
HMGB1 induces human lung endothelial cell cytoskeletal rearrangement and barrier disruption. Microvasc Res (2010) 1.24
Identification of tumor-associated autoantigens for the diagnosis of colorectal cancer in serum using high density protein microarrays. Mol Cell Proteomics (2009) 1.24
Reactive oxygen species and hematopoietic stem cell senescence. Int J Hematol (2011) 1.24
Pot1 and cell cycle progression cooperate in telomere length regulation. Nat Struct Mol Biol (2007) 1.23
Role of the RNA-binding protein tristetraprolin in glucocorticoid-mediated gene regulation. J Immunol (2008) 1.20
IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling. Genes Dev (2012) 1.20
Myeloid cell expression of the RNA-binding protein HuR protects mice from pathologic inflammation and colorectal carcinogenesis. J Clin Invest (2011) 1.15
Regulation of mRNA translation by signaling pathways. Cold Spring Harb Perspect Biol (2012) 1.13
p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8⁺ T cells. J Clin Invest (2014) 1.13
Identifying protein construct variants with increased crystallization propensity--a case study. Protein Sci (2006) 1.12
Cell entry and cAMP imaging of anthrax edema toxin. EMBO J (2006) 1.09
The p38 MAP Kinase Family as Regulators of Proinflammatory Cytokine Production in Degenerative Diseases of the CNS. Aging Dis (2010) 1.09
The Role of p38 MAPK and Its Substrates in Neuronal Plasticity and Neurodegenerative Disease. J Signal Transduct (2012) 1.08
Design of a bioactive cell-penetrating peptide: when a transduction domain does more than transduce. J Pept Sci (2009) 1.08
Stress induced gene expression: a direct role for MAPKAP kinases in transcriptional activation of immediate early genes. Nucleic Acids Res (2010) 1.04
The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation. Elife (2015) 1.04
Parameterizing cell-to-cell regulatory heterogeneities via stochastic transcriptional profiles. Proc Natl Acad Sci U S A (2014) 1.01
MK2 SUMOylation regulates actin filament remodeling and subsequent migration in endothelial cells by inhibiting MK2 kinase and HSP27 phosphorylation. Blood (2010) 1.00
MK2-dependent p38b signalling protects Drosophila hindgut enterocytes against JNK-induced apoptosis under chronic stress. PLoS Genet (2011) 1.00
Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling. Mol Cell Biol (2013) 0.99
MAPK-activated protein kinase 2 differentially regulates plasmodium falciparum glycosylphosphatidylinositol-induced production of tumor necrosis factor-{alpha} and interleukin-12 in macrophages. J Biol Chem (2009) 0.98
The p38/MK2/Hsp25 pathway is required for BMP-2-induced cell migration. PLoS One (2011) 0.97
Regulation of vascular endothelial growth factor-induced endothelial cell migration by LIM kinase 1-mediated phosphorylation of annexin 1. J Biol Chem (2010) 0.96
Docking of PRAK/MK5 to the atypical MAPKs ERK3 and ERK4 defines a novel MAPK interaction motif. J Biol Chem (2009) 0.96
Phosphorylation of lysophosphatidylcholine acyltransferase 2 at Ser34 enhances platelet-activating factor production in endotoxin-stimulated macrophages. J Biol Chem (2010) 0.96
A novel role for MAPKAPK2 in morphogenesis during zebrafish development. PLoS Genet (2009) 0.95
A rit GTPase-p38 mitogen-activated protein kinase survival pathway confers resistance to cellular stress. Mol Cell Biol (2011) 0.94
Signaling by p38 MAPK stimulates nuclear localization of the microprocessor component p68 for processing of selected primary microRNAs. Sci Signal (2013) 0.94
Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity. Proc Natl Acad Sci U S A (2013) 0.94
A novel cell permeant peptide inhibitor of MAPKAP kinase II inhibits intimal hyperplasia in a human saphenous vein organ culture model. J Vasc Surg (2010) 0.94
Kaposin-B enhances the PROX1 mRNA stability during lymphatic reprogramming of vascular endothelial cells by Kaposi's sarcoma herpes virus. PLoS Pathog (2010) 0.91
Modulation of mitogen-activated protein kinase-activated protein kinase 3 by hepatitis C virus core protein. J Virol (2013) 0.91
The regulation of Th1 responses by the p38 MAPK. J Immunol (2010) 0.91
Physiological roles of mitogen-activated-protein-kinase-activated p38-regulated/activated protein kinase. World J Biol Chem (2011) 0.91
Peptide inhibitors of MK2 show promise for inhibition of abdominal adhesions. J Surg Res (2011) 0.90
p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins. J Biol Chem (2010) 0.90
The p38-MK2-HuR pathway potentiates EGFRvIII-IL-1β-driven IL-6 secretion in glioblastoma cells. Oncogene (2014) 0.89
Inhibition of the protein kinase MK-2 protects podocytes from nephrotic syndrome-related injury. Am J Physiol Renal Physiol (2011) 0.89
Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies. Cancer Metastasis Rev (2015) 0.89
Inactivation of p38 MAPK during liver regeneration. Int J Biochem Cell Biol (2010) 0.88
p38 and OGT sequestration into viral inclusion bodies in cells infected with human respiratory syncytial virus suppresses MK2 activities and stress granule assembly. J Virol (2012) 0.87
p38 MAP kinases in the heart. Gene (2015) 0.86
The non-classical MAP kinase ERK3 controls T cell activation. PLoS One (2014) 0.86
Transgenic mice expressing constitutive active MAPKAPK5 display gender-dependent differences in exploration and activity. Behav Brain Funct (2007) 0.86
Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5. J Mol Signal (2012) 0.86
Muscle fatigue: MK2 signaling and myofibroblast differentiation. Am J Respir Cell Mol Biol (2007) 0.86
MK5 activates Rag transcription via Foxo1 in developing B cells. J Exp Med (2013) 0.86
MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells. EMBO J (2009) 0.85
MAPK-activated protein kinase 2 contributes to Clostridium difficile-associated inflammation. Infect Immun (2012) 0.85
The MK2/3 cascade regulates AMPAR trafficking and cognitive flexibility. Nat Commun (2014) 0.84
Use of Cell-Penetrating Peptides in Dendritic Cell-Based Vaccination. Immune Netw (2016) 0.84
Rit-mediated stress resistance involves a p38-mitogen- and stress-activated protein kinase 1 (MSK1)-dependent cAMP response element-binding protein (CREB) activation cascade. J Biol Chem (2012) 0.83
Cell type-specific targeting dissociates the therapeutic from the adverse effects of protein kinase inhibition in allergic skin disease. Proc Natl Acad Sci U S A (2012) 0.83
Mitogen-activated protein kinase-activated protein kinases 2 and 3 regulate SERCA2a expression and fiber type composition to modulate skeletal muscle and cardiomyocyte function. Mol Cell Biol (2013) 0.83
The catalytic activity of the mitogen-activated protein kinase extracellular signal-regulated kinase 3 is required to sustain CD4+ CD8+ thymocyte survival. Mol Cell Biol (2014) 0.83
Phosphorylation of protein inhibitor of activated STAT1 (PIAS1) by MAPK-activated protein kinase-2 inhibits endothelial inflammation via increasing both PIAS1 transrepression and SUMO E3 ligase activity. Arterioscler Thromb Vasc Biol (2012) 0.82
Carprofen induction of p75NTR-dependent apoptosis via the p38 mitogen-activated protein kinase pathway in prostate cancer cells. Mol Cancer Ther (2008) 0.82
p38MAPK/MK2-mediated phosphorylation of RBM7 regulates the human nuclear exosome targeting complex. RNA (2014) 0.82
Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway. Sci Rep (2016) 0.82
Muscle RING-finger 2 and 3 maintain striated-muscle structure and function. J Cachexia Sarcopenia Muscle (2015) 0.81
Distinct roles of MK2 and MK5 in cAMP/PKA- and stress/p38MAPK-induced heat shock protein 27 phosphorylation. J Mol Signal (2011) 0.81
Activation of p38 MAP kinase and JNK pathways by UVA irradiation. Photochem Photobiol Sci (2011) 0.81
Serine residue 115 of MAPK-activated protein kinase MK5 is crucial for its PKA-regulated nuclear export and biological function. Cell Mol Life Sci (2010) 0.81
KappaB-Ras is a nuclear-cytoplasmic small GTPase that inhibits NF-kappaB activation through the suppression of transcriptional activation of p65/RelA. J Biol Chem (2010) 0.81
The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinases (MAPKAPKs) in Inflammation. Genes (Basel) (2013) 0.81
MAP-Kinase Activated Protein Kinase 2 Links Endothelial Activation and Monocyte/macrophage Recruitment in Arteriogenesis. PLoS One (2015) 0.81
Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer. Genes Dev (2016) 0.81
The MAP kinase-activated protein kinase 2 (MK2) contributes to the Shiga toxin-induced inflammatory response. Cell Microbiol (2009) 0.81
Characterization of the expression and regulation of MK5 in the murine ventricular myocardium. Cell Signal (2010) 0.80
Structural and functional basis for p38-MK2-activated Rsk signaling in toll-like receptor-stimulated dendritic cells. Mol Cell Biol (2014) 0.80
Tumor progression locus 2 (Tpl2) kinase as a novel therapeutic target for cancer: double-sided effects of Tpl2 on cancer. Int J Mol Sci (2015) 0.79
Binding affinity prediction for ligands and receptors forming tautomers and ionization species: inhibition of mitogen-activated protein kinase-activated protein kinase 2 (MK2). J Med Chem (2012) 0.79
Mnk1 and 2 are dispensable for T cell development and activation but important for the pathogenesis of experimental autoimmune encephalomyelitis. J Immunol (2012) 0.79
Sexual Dimorphism in MAPK-Activated Protein Kinase-2 (MK2) Regulation of RANKL-Induced Osteoclastogenesis in Osteoclast Progenitor Subpopulations. PLoS One (2015) 0.79
Chk-ing in and Chk-ing out: kinase compartmentalization comes to checkpoint control. Mol Cell (2010) 0.78
Absence of a human DnaJ protein hTid-1S correlates with aberrant actin cytoskeleton organization in lesional psoriatic skin. J Biol Chem (2012) 0.78
Intensity dependent confidence intervals on microarray measurements of differentially expressed genes: a case study of the effect of MK5, FKRP and TAF4 on the transcriptome. Gene Regul Syst Bio (2007) 0.78
p38- and MK2-dependent signalling promotes stress-induced centriolar satellite remodelling via 14-3-3-dependent sequestration of CEP131/AZI1. Nat Commun (2015) 0.78