Published in J Mol Med (Berl) on January 08, 2012
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Analysis of repetitive element DNA methylation by MethyLight. Nucleic Acids Res (2005) 6.49
Amount and distribution of 5-methylcytosine in human DNA from different types of tissues of cells. Nucleic Acids Res (1982) 4.61
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Large-scale structure of genomic methylation patterns. Genome Res (2005) 4.11
Global DNA methylation level in whole blood as a biomarker in head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev (2007) 4.01
Distinctive pattern of LINE-1 methylation level in normal tissues and the association with carcinogenesis. Oncogene (2004) 3.50
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Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes. Mol Cell Biol (2001) 2.88
LINE-1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. Int J Cancer (2008) 2.87
Analysis of changes in DNA sequence copy number by comparative genomic hybridization in archival paraffin-embedded tumor samples. Am J Pathol (1994) 2.86
DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukemia. Cancer Res (2006) 2.69
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Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice. Oncogene (2007) 2.22
A systematic analysis of LINE-1 endonuclease-dependent retrotranspositional events causing human genetic disease. Hum Genet (2005) 2.10
Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers. Am J Pathol (2000) 2.03
The relationship between global methylation level, loss of heterozygosity, and microsatellite instability in sporadic colorectal cancer. Clin Cancer Res (2005) 1.85
Colorectal cancer screening: prospects for molecular stool analysis. Nat Rev Cancer (2005) 1.64
DNA hypomethylation in the origin and pathogenesis of human diseases. Cell Mol Life Sci (2009) 1.62
DNA methylation within the normal colorectal mucosa is associated with pathway-specific predisposition to cancer. Oncogene (2009) 1.53
Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors. Mol Cancer (2010) 1.50
Aberrant DNA methylation in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency. Gastroenterology (2010) 1.46
Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression. Gut (2010) 1.44
Colon cancer: it's CIN or CIMP. Clin Cancer Res (2008) 1.41
LINE dancing in the human genome: transposable elements and disease. Genome Med (2009) 1.33
CpG island density and its correlations with genomic features in mammalian genomes. Genome Biol (2008) 1.30
Epigenetic phenotypes distinguish microsatellite-stable and -unstable colorectal cancers. Proc Natl Acad Sci U S A (1999) 1.28
Comparison of CpG island hypermethylation and repetitive DNA hypomethylation in premalignant stages of gastric cancer, stratified for Helicobacter pylori infection. J Pathol (2009) 1.23
Epigenetic signatures of familial cancer are characteristic of tumor type and family category. Cancer Res (2008) 1.15
LINE-1 methylation is inherited in familial testicular cancer kindreds. BMC Med Genet (2010) 1.11
CpG islands: their potential as biomarkers for cancer. Expert Rev Mol Diagn (2007) 1.09
Molecular analysis of endometrial tumorigenesis: importance of complex hyperplasia regardless of atypia. Clin Cancer Res (2009) 1.07
Is gastric cancer part of the tumour spectrum of hereditary non-polyposis colorectal cancer? A molecular genetic study. Gut (2007) 1.03
Lynch syndrome (hereditary nonpolyposis colorectal cancer) diagnostics. J Natl Cancer Inst (2007) 2.77
PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers. Am J Pathol (2002) 2.16
Molecular analysis of familial endometrial carcinoma: a manifestation of hereditary nonpolyposis colorectal cancer or a separate syndrome? J Clin Oncol (2005) 1.93
Ten years after mutation testing for Lynch syndrome: cancer incidence and outcome in mutation-positive and mutation-negative family members. J Clin Oncol (2009) 1.92
Functional significance and clinical phenotype of nontruncating mismatch repair variants of MLH1. Gastroenterology (2005) 1.70
Biallelic inactivation of fumarate hydratase (FH) occurs in nonsyndromic uterine leiomyomas but is rare in other tumors. Am J Pathol (2004) 1.37
Development of colorectal tumors in colonoscopic surveillance in Lynch syndrome. Gastroenterology (2007) 1.36
Distinct epigenetic phenotypes in seminomatous and nonseminomatous testicular germ cell tumors. Oncogene (2002) 1.32
Patterns of PIK3CA alterations in familial colorectal and endometrial carcinoma. Int J Cancer (2007) 1.31
Comprehensive characterization of HNPCC-related colorectal cancers reveals striking molecular features in families with no germline mismatch repair gene mutations. Oncogene (2005) 1.22
Endometrial and colorectal tumors from patients with hereditary nonpolyposis colon cancer display different patterns of microsatellite instability. Am J Pathol (2002) 1.19
Epigenetic signatures of familial cancer are characteristic of tumor type and family category. Cancer Res (2008) 1.15
Adenomatous polyposis families that screen APC mutation-negative by conventional methods are genetically heterogeneous. J Clin Oncol (2005) 1.14
The genetics of HNPCC: application to diagnosis and screening. Crit Rev Oncol Hematol (2006) 1.11
BMPR1A mutations in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency. Gastroenterology (2011) 1.10
Reducing the risk of type 2 diabetes with nutrition and physical activity - efficacy and implementation of lifestyle interventions in Finland. Public Health Nutr (2010) 1.09
Molecular analysis of endometrial tumorigenesis: importance of complex hyperplasia regardless of atypia. Clin Cancer Res (2009) 1.07
Breast carcinoma and Lynch syndrome: molecular analysis of tumors arising in mutation carriers, non-carriers, and sporadic cases. Breast Cancer Res (2012) 1.05
p53 codon 72 and MDM2 SNP309 polymorphisms and age of colorectal cancer onset in Lynch syndrome. Clin Cancer Res (2005) 1.01
HNPCC mutation MLH1 P648S makes the functional protein unstable, and homozygosity predisposes to mild neurofibromatosis type 1. Genes Chromosomes Cancer (2004) 1.00
Pathogenicity of the hereditary colorectal cancer mutation hMLH1 del616 linked to shortage of the functional protein. Gastroenterology (2003) 0.99
Genome profiles of familial/bilateral and sporadic testicular germ cell tumors. Genes Chromosomes Cancer (2002) 0.99
Pathogenicity of MSH2 missense mutations is typically associated with impaired repair capability of the mutated protein. Gastroenterology (2006) 0.97
BRAF mutation in sporadic colorectal cancer and Lynch syndrome. Virchows Arch (2013) 0.96
Promoter-specific alterations of APC are a rare cause for mutation-negative familial adenomatous polyposis. Genes Chromosomes Cancer (2014) 0.93
Little evidence for involvement of MLH3 in colorectal cancer predisposition. Int J Cancer (2003) 0.93
Lynch syndrome and related familial colorectal cancers. Crit Rev Oncog (2008) 0.90
Somatic FGF9 mutations in colorectal and endometrial carcinomas associated with membranous beta-catenin. Hum Mutat (2008) 0.89
Mosaic AZF deletions and susceptibility to testicular tumors. Mutat Res (2002) 0.88
Clinicopathological characterization and genomic aberrations in subcutaneous panniculitis-like T-cell lymphoma. J Invest Dermatol (2008) 0.87
Distinct genetic and epigenetic signatures of colorectal cancers according to ethnic origin. Cancer Epidemiol Biomarkers Prev (2011) 0.87
APC and beta-catenin protein expression patterns in HNPCC-related endometrial and colorectal cancers. Fam Cancer (2005) 0.84
Psychosocial consequences of predictive genetic testing for Lynch syndrome and associations to surveillance behaviour in a 7-year follow-up study. Fam Cancer (2013) 0.84
Distinct molecular profiles in Lynch syndrome-associated and sporadic ovarian carcinomas. Int J Cancer (2013) 0.84
Cutaneous T-cell lymphoma-associated lung cancers show chromosomal aberrations differing from primary lung cancer. Genes Chromosomes Cancer (2008) 0.83
Truncation of MBD4 predisposes to reciprocal chromosomal translocations and alters the response to therapeutic agents in colon cancer cells. DNA Repair (Amst) (2007) 0.83
The complex genotype-phenotype relationship in familial adenomatous polyposis. Eur J Gastroenterol Hepatol (2004) 0.83
Molecular basis and diagnostics of hereditary colorectal cancers. Ann Med (2004) 0.83
Differential roles of EPS8 in carcinogenesis: loss of protein expression in a subset of colorectal carcinoma and adenoma. World J Gastroenterol (2012) 0.81
Restoring mismatch repair does not stop the formation of reciprocal translocations in the colon cancer cell line HCA7 but further destabilizes chromosome number. Oncogene (2005) 0.80
Epigenetic analysis of sporadic and Lynch-associated ovarian cancers reveals histology-specific patterns of DNA methylation. Epigenetics (2014) 0.80
Assessment of feasibility of workplace health promotion. Prev Med (2002) 0.79
3'-UTR poly(T/U) tract deletions and altered expression of EWSR1 are a hallmark of mismatch repair-deficient cancers. Cancer Res (2013) 0.78
Uroepithelial and kidney carcinoma in Lynch syndrome. Fam Cancer (2012) 0.77
The importance of functional testing in the genetic assessment of Muir-Torre syndrome, a clinical subphenotype of HNPCC. Int J Oncol (2006) 0.76
Cancer-predicting gene expression changes in colonic mucosa of Western diet fed Mlh1+/- mice. PLoS One (2013) 0.76
Three new mutations in hereditary nonpolyposis colorectal cancer (Lynch syndrome II) in Uruguay. Cancer Genet Cytogenet (2003) 0.75
[Epigenetic modifications in cancer]. Duodecim (2012) 0.75
Disorders of DNA repair mechanisms and their clinical significance. Duodecim (1) 0.75
Y chromosome instability in lymphoproliferative disorders. Mutat Res (2003) 0.75