Published in Fam Cancer on September 01, 2012
The genetic basis of Lynch syndrome and its implications for clinical practice and risk management. Appl Clin Genet (2014) 0.84
Surveillance for urinary tract cancer in Lynch syndrome. Fam Cancer (2013) 0.75
New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology (1999) 11.94
The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC). Dis Colon Rectum (1991) 9.82
Cancer risk in mutation carriers of DNA-mismatch-repair genes. Int J Cancer (1999) 6.73
Guidelines for the clinical management of Lynch syndrome (hereditary non-polyposis cancer). J Med Genet (2007) 4.62
Role of DNA mismatch repair defects in the pathogenesis of human cancer. J Clin Oncol (2003) 3.70
Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis. Gastroenterology (1996) 3.54
Mutations associated with HNPCC predisposition -- Update of ICG-HNPCC/INSiGHT mutation database. Dis Markers (2004) 3.03
The risk of extra-colonic, extra-endometrial cancer in the Lynch syndrome. Int J Cancer (2008) 2.95
Small (< or = 3-cm) renal masses: detection with CT versus US and pathologic correlation. Radiology (1996) 2.90
Detection of bladder cancer using a point-of-care proteomic assay. JAMA (2005) 2.88
MSH2 mutation carriers are at higher risk of cancer than MLH1 mutation carriers: a study of hereditary nonpolyposis colorectal cancer families. J Clin Oncol (2001) 2.71
Hereditary nonpolyposis colorectal cancer (Lynch syndrome). An updated review. Cancer (1996) 2.44
Upper urinary tract urothelial cell carcinomas and other urological malignancies involved in the hereditary nonpolyposis colorectal cancer (lynch syndrome) tumor spectrum. Eur Urol (2008) 2.32
Urine markers for bladder cancer surveillance: a systematic review. Eur Urol (2005) 1.90
Urinary tract cancer and hereditary nonpolyposis colorectal cancer: risks and screening options. J Urol (1998) 1.69
Urine based markers of urological malignancy. J Urol (2001) 1.61
Management of extracolonic tumours in patients with Lynch syndrome. Lancet Oncol (2009) 1.53
The accuracy of urinary cytology in daily practice. Cancer (1999) 1.46
Hereditary renal cancers. Radiology (2003) 1.31
Risk of urothelial bladder cancer in Lynch syndrome is increased, in particular among MSH2 mutation carriers. J Med Genet (2010) 1.30
The genetics of HNPCC: application to diagnosis and screening. Crit Rev Oncol Hematol (2006) 1.11
Differential cancer predisposition in Lynch syndrome: insights from molecular analysis of brain and urinary tract tumors. Carcinogenesis (2008) 1.02
Screening for urinary tract cancer with urine cytology in Lynch syndrome and familial colorectal cancer. Fam Cancer (2008) 1.01
Mutation sharing, predominant involvement of the MLH1 gene and description of four novel mutations in hereditary nonpolyposis colorectal cancer. Mutations in brief no. 144. Online. Hum Mutat (1998) 0.98
Ultrasound of the kidney: obstruction and medical diseases. Eur Radiol (2001) 0.95
Ultrasound of renal tumors. Eur Radiol (2001) 0.85
[Value of ultrasound in early diagnosis of renal cell carcinoma]. Urologe A (2000) 0.79
Towards a rational strategy for the surveillance of patients with Lynch syndrome (hereditary non-polyposis colon cancer) for upper tract transitional cell carcinoma. BJU Int (2010) 0.77
Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial. Lancet (2011) 6.77
The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling. Nat Genet (2009) 5.65
Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome. N Engl J Med (2008) 3.76
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk. Nat Genet (2012) 3.19
The risk of extra-colonic, extra-endometrial cancer in the Lynch syndrome. Int J Cancer (2008) 2.95
Low-level microsatellite instability in most colorectal carcinomas. Cancer Res (2002) 2.87
Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts. Gut (2013) 2.86
Cancer risk in hereditary nonpolyposis colorectal cancer syndrome: later age of onset. Gastroenterology (2005) 2.80
Lynch syndrome (hereditary nonpolyposis colorectal cancer) diagnostics. J Natl Cancer Inst (2007) 2.77
Early-onset renal cell carcinoma as a novel extraparaganglial component of SDHB-associated heritable paraganglioma. Am J Hum Genet (2003) 2.43
Explaining the familial colorectal cancer risk associated with mismatch repair (MMR)-deficient and MMR-stable tumors. Clin Cancer Res (2007) 2.24
PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers. Am J Pathol (2002) 2.16
SMAD4 levels and response to 5-fluorouracil in colorectal cancer. Clin Cancer Res (2005) 2.05
Molecular analysis of familial endometrial carcinoma: a manifestation of hereditary nonpolyposis colorectal cancer or a separate syndrome? J Clin Oncol (2005) 1.93
Ten years after mutation testing for Lynch syndrome: cancer incidence and outcome in mutation-positive and mutation-negative family members. J Clin Oncol (2009) 1.92
Functional significance and clinical phenotype of nontruncating mismatch repair variants of MLH1. Gastroenterology (2005) 1.70
Surveillance for endometrial cancer in hereditary nonpolyposis colorectal cancer syndrome. Int J Cancer (2007) 1.67
Allelic imbalance at rs6983267 suggests selection of the risk allele in somatic colorectal tumor evolution. Cancer Res (2008) 1.59
Gene-expression profiling predicts recurrence in Dukes' C colorectal cancer. Gastroenterology (2005) 1.56
SMAD4 as a prognostic marker in colorectal cancer. Clin Cancer Res (2005) 1.50
The beta-tail domain (betaTD) regulates physiologic ligand binding to integrin CD11b/CD18. Blood (2006) 1.40
Proportion and phenotype of MYH-associated colorectal neoplasia in a population-based series of Finnish colorectal cancer patients. Am J Pathol (2003) 1.38
Biallelic inactivation of fumarate hydratase (FH) occurs in nonsyndromic uterine leiomyomas but is rare in other tumors. Am J Pathol (2004) 1.37
Development of colorectal tumors in colonoscopic surveillance in Lynch syndrome. Gastroenterology (2007) 1.36
Distinct epigenetic phenotypes in seminomatous and nonseminomatous testicular germ cell tumors. Oncogene (2002) 1.32
Patterns of PIK3CA alterations in familial colorectal and endometrial carcinoma. Int J Cancer (2007) 1.31
Large genomic rearrangements and germline epimutations in Lynch syndrome. Int J Cancer (2009) 1.24
Genetic alterations in the peritumoral stromal cells of malignant and borderline epithelial ovarian tumors as indicated by allelic imbalance on chromosome 3p. Int J Cancer (2004) 1.23
Sharing genetic risk with next generation: mutation-positive parents' communication with their offspring in Lynch Syndrome. Fam Cancer (2011) 1.23
Prevalence of adenomas and hyperplastic polyps in mismatch repair mutation carriers among CAPP2 participants: report by the colorectal adenoma/carcinoma prevention programme 2. J Clin Oncol (2008) 1.23
Comprehensive characterization of HNPCC-related colorectal cancers reveals striking molecular features in families with no germline mismatch repair gene mutations. Oncogene (2005) 1.22
Unregulated smooth-muscle myosin in human intestinal neoplasia. Proc Natl Acad Sci U S A (2008) 1.20
Endometrial and colorectal tumors from patients with hereditary nonpolyposis colon cancer display different patterns of microsatellite instability. Am J Pathol (2002) 1.19
Altered expression of MLH1, MSH2, and MSH6 in predisposition to hereditary nonpolyposis colorectal cancer. J Clin Oncol (2003) 1.18
Epigenetic signatures of familial cancer are characteristic of tumor type and family category. Cancer Res (2008) 1.15
Adenomatous polyposis families that screen APC mutation-negative by conventional methods are genetically heterogeneous. J Clin Oncol (2005) 1.14
The genetics of HNPCC: application to diagnosis and screening. Crit Rev Oncol Hematol (2006) 1.11
BMPR1A mutations in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency. Gastroenterology (2011) 1.10
Reducing the risk of type 2 diabetes with nutrition and physical activity - efficacy and implementation of lifestyle interventions in Finland. Public Health Nutr (2010) 1.09
Serum HCG beta, CA 72-4 and CEA are independent prognostic factors in colorectal cancer. Int J Cancer (2002) 1.09
Candidate driver genes in microsatellite-unstable colorectal cancer. Int J Cancer (2011) 1.08
Molecular analysis of endometrial tumorigenesis: importance of complex hyperplasia regardless of atypia. Clin Cancer Res (2009) 1.07
Breast carcinoma and Lynch syndrome: molecular analysis of tumors arising in mutation carriers, non-carriers, and sporadic cases. Breast Cancer Res (2012) 1.05
Frequent gene dosage alterations in stromal cells of epithelial ovarian carcinomas. Int J Cancer (2006) 1.05
Elevated hyaluronan concentration without hyaluronidase activation in malignant epithelial ovarian tumors. Cancer Res (2002) 1.03
Exome sequencing reveals frequent inactivating mutations in ARID1A, ARID1B, ARID2 and ARID4A in microsatellite unstable colorectal cancer. Int J Cancer (2014) 1.02
Preferential amplification of AURKA 91A (Ile31) in familial colorectal cancers. Int J Cancer (2006) 1.02
Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial. Lancet Oncol (2012) 1.01
Low-penetrance susceptibility variants in familial colorectal cancer. Cancer Epidemiol Biomarkers Prev (2010) 1.01
p53 codon 72 and MDM2 SNP309 polymorphisms and age of colorectal cancer onset in Lynch syndrome. Clin Cancer Res (2005) 1.01
Background mutation frequency in microsatellite-unstable colorectal cancer. Cancer Res (2007) 1.00
Carbonic anhydrase IX is highly expressed in hereditary nonpolyposis colorectal cancer. Cancer Epidemiol Biomarkers Prev (2007) 1.00
LINE-1 hypomethylation in familial and sporadic cancer. J Mol Med (Berl) (2012) 1.00
HNPCC mutation MLH1 P648S makes the functional protein unstable, and homozygosity predisposes to mild neurofibromatosis type 1. Genes Chromosomes Cancer (2004) 1.00
Pathogenicity of the hereditary colorectal cancer mutation hMLH1 del616 linked to shortage of the functional protein. Gastroenterology (2003) 0.99
Genome profiles of familial/bilateral and sporadic testicular germ cell tumors. Genes Chromosomes Cancer (2002) 0.99
Eleven candidate susceptibility genes for common familial colorectal cancer. PLoS Genet (2013) 0.98
Colorectal pretumor progression before and after loss of DNA mismatch repair. Am J Pathol (2004) 0.97
Pathogenicity of MSH2 missense mutations is typically associated with impaired repair capability of the mutated protein. Gastroenterology (2006) 0.97
Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2. Gastroenterology (2004) 0.96
Survival in women with MMR mutations and ovarian cancer: a multicentre study in Lynch syndrome kindreds. J Med Genet (2009) 0.96
BRAF mutation in sporadic colorectal cancer and Lynch syndrome. Virchows Arch (2013) 0.96
EXO1 variants occur commonly in normal population: evidence against a role in hereditary nonpolyposis colorectal cancer. Cancer Res (2003) 0.94
A prospective randomized controlled multicenter trial comparing antibiotic therapy with appendectomy in the treatment of uncomplicated acute appendicitis (APPAC trial). BMC Surg (2013) 0.94
Promoter-specific alterations of APC are a rare cause for mutation-negative familial adenomatous polyposis. Genes Chromosomes Cancer (2014) 0.93
Mutations in the circadian gene CLOCK in colorectal cancer. Mol Cancer Res (2010) 0.93
Little evidence for involvement of MLH3 in colorectal cancer predisposition. Int J Cancer (2003) 0.93
Causes of death of mutation carriers in Finnish Lynch syndrome families. Fam Cancer (2012) 0.92
Identification of candidate oncogenes in human colorectal cancers with microsatellite instability. Gastroenterology (2013) 0.92