Published in Nat Genet on February 01, 2008
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The PhenX Toolkit: get the most from your measures. Am J Epidemiol (2011) 4.19
A public resource facilitating clinical use of genomes. Proc Natl Acad Sci U S A (2012) 3.72
The Scientific Foundation for personal genomics: recommendations from a National Institutes of Health-Centers for Disease Control and Prevention multidisciplinary workshop. Genet Med (2009) 2.91
Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture. Ann Intern Med (2009) 2.80
Phenopedia and Genopedia: disease-centered and gene-centered views of the evolving knowledge of human genetic associations. Bioinformatics (2009) 2.59
Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand. Arthritis Rheum (2009) 2.47
Contemporary epidemiology of renal cell cancer. Cancer J (2008) 2.40
Next generation genome-wide association tool: design and coverage of a high-throughput European-optimized SNP array. Genomics (2011) 2.31
Invited commentary: from genome-wide association studies to gene-environment-wide interaction studies--challenges and opportunities. Am J Epidemiol (2008) 2.20
Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseases. Am J Epidemiol (2009) 2.15
Future health applications of genomics: priorities for communication, behavioral, and social sciences research. Am J Prev Med (2010) 1.98
Inherited variation at chromosome 12p13.33, including RAD52, influences the risk of squamous cell lung carcinoma. Cancer Discov (2011) 1.87
GWASdb: a database for human genetic variants identified by genome-wide association studies. Nucleic Acids Res (2011) 1.87
Replication of past candidate loci for common diseases and phenotypes in 100 genome-wide association studies. Eur J Hum Genet (2010) 1.79
GAPscreener: an automatic tool for screening human genetic association literature in PubMed using the support vector machine technique. BMC Bioinformatics (2008) 1.75
Cancer GAMAdb: database of cancer genetic associations from meta-analyses and genome-wide association studies. Eur J Hum Genet (2011) 1.69
Generating genome-scale candidate gene lists for pharmacogenomics. Clin Pharmacol Ther (2009) 1.66
Translational research in cancer genetics: the road less traveled. Public Health Genomics (2009) 1.65
Assessing and managing risk when sharing aggregate genetic variant data. Nat Rev Genet (2011) 1.62
Genome-Wide Methylation Study Identifies an IL-13-induced Epigenetic Signature in Asthmatic Airways. Am J Respir Crit Care Med (2016) 1.56
Knowledge integration at the center of genomic medicine. Genet Med (2012) 1.54
Synopsis and data synthesis of genetic association studies in hypertension for the adrenergic receptor family genes: the CUMAGAS-HYPERT database. Am J Hypertens (2009) 1.51
Insights into TREM2 biology by network analysis of human brain gene expression data. Neurobiol Aging (2013) 1.49
FXR antagonism of NSAIDs contributes to drug-induced liver injury identified by systems pharmacology approach. Sci Rep (2015) 1.47
Comparing genotyping algorithms for Illumina's Infinium whole-genome SNP BeadChips. BMC Bioinformatics (2011) 1.45
Genetic vulnerability and susceptibility to substance dependence. Neuron (2011) 1.40
The COPD genetic association compendium: a comprehensive online database of COPD genetic associations. Hum Mol Genet (2009) 1.35
Tilting at quixotic trait loci (QTL): an evolutionary perspective on genetic causation. Genetics (2008) 1.33
High trans-ethnic replicability of GWAS results implies common causal variants. PLoS Genet (2013) 1.32
Gene Prospector: an evidence gateway for evaluating potential susceptibility genes and interacting risk factors for human diseases. BMC Bioinformatics (2008) 1.31
Gene-environment interactions in cancer epidemiology: a National Cancer Institute Think Tank report. Genet Epidemiol (2013) 1.27
Genotator: a disease-agnostic tool for genetic annotation of disease. BMC Med Genomics (2010) 1.24
Genetic variants and the risk of gestational diabetes mellitus: a systematic review. Hum Reprod Update (2013) 1.21
Genome-wide significant associations for variants with minor allele frequency of 5% or less--an overview: A HuGE review. Am J Epidemiol (2010) 1.21
Likelihood ratios for genome medicine. Genome Med (2010) 1.20
Large numbers of genetic variants considered to be pathogenic are common in asymptomatic individuals. Hum Mutat (2013) 1.20
Detecting purely epistatic multi-locus interactions by an omnibus permutation test on ensembles of two-locus analyses. BMC Bioinformatics (2009) 1.13
ALFRED: an allele frequency resource for research and teaching. Nucleic Acids Res (2011) 1.12
Schizophrenia susceptibility genes directly implicated in the life cycles of pathogens: cytomegalovirus, influenza, herpes simplex, rubella, and Toxoplasma gondii. Schizophr Bull (2008) 1.10
A quality assessment of genetic association studies supporting susceptibility and outcome in acute lung injury. Crit Care (2008) 1.08
Development and evaluation of a genetic risk score for obesity. Biodemography Soc Biol (2013) 1.08
GWAS Integrator: a bioinformatics tool to explore human genetic associations reported in published genome-wide association studies. Eur J Hum Genet (2011) 1.08
A database for curating the associations between killer cell immunoglobulin-like receptors and diseases in worldwide populations. Database (Oxford) (2013) 1.05
Toward modernizing the systematic review pipeline in genetics: efficient updating via data mining. Genet Med (2012) 1.04
ERGR: An ethanol-related gene resource. Nucleic Acids Res (2008) 1.04
Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci. Hypertension (2013) 1.03
Gene-environment interactions in asthma and allergy: the end of the beginning? Curr Opin Allergy Clin Immunol (2010) 1.03
The genetic epidemiology of idiopathic scoliosis. Eur Spine J (2012) 1.02
Genomic convergence of genome-wide investigations for complex traits. Ann Hum Genet (2009) 1.01
Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies. Arthritis Rheumatol (2014) 1.00
PUMA: a unified framework for penalized multiple regression analysis of GWAS data. PLoS Comput Biol (2013) 1.00
Candidate genes involved in neural plasticity and the risk for attention-deficit hyperactivity disorder: a meta-analysis of 8 common variants. J Psychiatry Neurosci (2009) 0.98
Genome-wide association studies in pharmacogenomics: untapped potential for translation. Genome Med (2009) 0.98
GWASdb v2: an update database for human genetic variants identified by genome-wide association studies. Nucleic Acids Res (2015) 0.96
Convergence of genome-wide association and candidate gene studies for alcoholism. Alcohol Clin Exp Res (2012) 0.96
A vector space model approach to identify genetically related diseases. J Am Med Inform Assoc (2012) 0.96
A kinesin-1 binding motif in vaccinia virus that is widespread throughout the human genome. EMBO J (2011) 0.96
The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins. Database (Oxford) (2016) 0.95
FLAGS, frequently mutated genes in public exomes. BMC Med Genomics (2014) 0.94
Cellular dissection of psoriasis for transcriptome analyses and the post-GWAS era. BMC Med Genomics (2014) 0.93
Cytokine and cytokine receptor genes of the adaptive immune response are differentially associated with breast cancer risk in American women of African and European ancestry. Int J Cancer (2013) 0.93
Collaboratively charting the gene-to-phenotype network of human congenital heart defects. Genome Med (2010) 0.92
Single-Nucleotide Polymorphisms Within MicroRNAs Sequences and Their 3' UTR Target Sites May Regulate Gene Expression in Gastrointestinal Tract Cancers. Iran Red Crescent Med J (2014) 0.92
Type 2 diabetes genetic association database manually curated for the study design and odds ratio. BMC Med Inform Decis Mak (2010) 0.92
Prioritization of epilepsy associated candidate genes by convergent analysis. PLoS One (2011) 0.92
Multi-omic landscape of rheumatoid arthritis: re-evaluation of drug adverse effects. Front Cell Dev Biol (2014) 0.92
The geometric increase in meta-analyses from China in the genomic era. PLoS One (2013) 0.91
Beyond accuracy: creating interoperable and scalable text-mining web services. Bioinformatics (2016) 0.91
The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog). Nucleic Acids Res (2016) 0.91
iLOCi: a SNP interaction prioritization technique for detecting epistasis in genome-wide association studies. BMC Genomics (2012) 0.90
Innate immunity pathways and breast cancer Risk in African American and European-American women in the Women's Circle of Health Study (WCHS). PLoS One (2013) 0.90
Identification of genetic associations of SP110/MYBBP1A/RELA with pulmonary tuberculosis in the Chinese Han population. Hum Genet (2012) 0.90
Integrating genetics and social science: genetic risk scores. Biodemography Soc Biol (2014) 0.89
Association between IL6 -174G/C and cancer: A meta-analysis of 105,482 individuals. Exp Ther Med (2012) 0.89
Recent human evolution has shaped geographical differences in susceptibility to disease. BMC Genomics (2011) 0.89
Autworks: a cross-disease network biology application for Autism and related disorders. BMC Med Genomics (2012) 0.88
Genome-wide polygenic scoring for a 14-year long-term average depression phenotype. Brain Behav (2014) 0.88
The need for genetic variant naming standards in published abstracts of human genetic association studies. BMC Res Notes (2009) 0.87
A meta-analysis of three polymorphisms in the endothelial nitric oxide synthase gene (NOS3) and their effect on the risk of diabetic nephropathy. Hum Genet (2010) 0.87
Importance of different types of prior knowledge in selecting genome-wide findings for follow-up. Genet Epidemiol (2013) 0.87
Varietas: a functional variation database portal. Database (Oxford) (2010) 0.87
Genome-wide prediction and functional characterization of the genetic basis of autism spectrum disorder. Nat Neurosci (2016) 0.87
IGENT: efficient entropy based algorithm for genome-wide gene-gene interaction analysis. BMC Med Genomics (2014) 0.85
Network-based SNP meta-analysis identifies joint and disjoint genetic features across common human diseases. BMC Genomics (2012) 0.85
Text mining in cancer gene and pathway prioritization. Cancer Inform (2014) 0.85
The functional MDM2 T309G genetic variant but not P53 Arg72Pro polymorphism is associated with risk of sarcomas: a meta-analysis. J Cancer Res Clin Oncol (2011) 0.84
Evidence for novel genetic loci associated with metabolic traits in Yup'ik people. Am J Hum Biol (2013) 0.84
Haplotype structure enables prioritization of common markers and candidate genes in autism spectrum disorder. Transl Psychiatry (2013) 0.84
Genetics of complex respiratory diseases: implications for pathophysiology and pharmacology studies. Br J Pharmacol (2011) 0.83
Insights into pathophysiology of dystropy through the analysis of gene networks: an example of bronchial asthma and tuberculosis. Immunogenetics (2014) 0.83
mESAdb: microRNA expression and sequence analysis database. Nucleic Acids Res (2011) 0.83
Synopsis and meta-analysis of genetic association studies in osteoporosis for the focal adhesion family genes: the CUMAGAS-OSTEOporosis information system. BMC Med (2011) 0.83
Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis. JCI Insight (2016) 0.82
Network graph analysis of gene-gene interactions in genome-wide association study data. Genomics Inform (2012) 0.82
Evaluation of the global association between cholesterol-associated polymorphisms and Alzheimer's disease suggests a role for rs3846662 and HMGCR splicing in disease risk. Mol Neurodegener (2011) 0.82
Genetic variants in one-carbon metabolism genes and breast cancer risk in European American and African American women. Int J Cancer (2015) 0.82
The Human Genome Project, and recent advances in personalized genomics. Risk Manag Healthc Policy (2015) 0.82
Progress and future aspects in genetics of human hypertension. Curr Hypertens Rep (2013) 0.82
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science (2009) 10.78
Regulation of cellular metabolism by protein lysine acetylation. Science (2010) 10.55
The continuum of translation research in genomic medicine: how can we accelerate the appropriate integration of human genome discoveries into health care and disease prevention? Genet Med (2007) 9.48
Letting the genome out of the bottle--will we get our wish? N Engl J Med (2008) 9.10
Deploying whole genome sequencing in clinical practice and public health: meeting the challenge one bin at a time. Genet Med (2011) 8.48
Implications of small effect sizes of individual genetic variants on the design and interpretation of genetic association studies of complex diseases. Am J Epidemiol (2006) 7.66
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet (2008) 6.71
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell (2006) 6.15
PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42. Cell (2007) 5.84
Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell (2010) 5.73
Randomized phase II trial of Onartuzumab in combination with erlotinib in patients with advanced non-small-cell lung cancer. J Clin Oncol (2013) 5.21
Assessment of cumulative evidence on genetic associations: interim guidelines. Int J Epidemiol (2007) 4.96
Size matters: just how big is BIG?: Quantifying realistic sample size requirements for human genome epidemiology. Int J Epidemiol (2008) 4.53
How many genes underlie the occurrence of common complex diseases in the population? Int J Epidemiol (2005) 4.46
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. PLoS Genet (2012) 4.27
Sodium and potassium intake and mortality among US adults: prospective data from the Third National Health and Nutrition Examination Survey. Arch Intern Med (2011) 4.22
The emergence of translational epidemiology: from scientific discovery to population health impact. Am J Epidemiol (2010) 4.04
Can family history be used as a tool for public health and preventive medicine? Genet Med (2002) 3.76
National Institutes of Health approaches to dissemination and implementation science: current and future directions. Am J Public Health (2012) 3.72
Development and validation of a CGH microarray for clinical cytogenetic diagnosis. Genet Med (2005) 3.39
A critical appraisal of the scientific basis of commercial genomic profiles used to assess health risks and personalize health interventions. Am J Hum Genet (2008) 3.25
Genetic test evaluation: information needs of clinicians, policy makers, and the public. Am J Epidemiol (2002) 3.23
Recommendations for returning genomic incidental findings? We need to talk! Genet Med (2013) 3.23
A road map for efficient and reliable human genome epidemiology. Nat Genet (2006) 3.21
Phase I study of trastuzumab-DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2-positive metastatic breast cancer. J Clin Oncol (2010) 3.06
What is the clinical utility of genetic testing? Genet Med (2006) 3.01
Research priorities for evaluating family history in the prevention of common chronic diseases. Am J Prev Med (2003) 2.99
The Scientific Foundation for personal genomics: recommendations from a National Institutes of Health-Centers for Disease Control and Prevention multidisciplinary workshop. Genet Med (2009) 2.91
Improving validation practices in "omics" research. Science (2011) 2.73
On the synthesis and interpretation of consistent but weak gene-disease associations in the era of genome-wide association studies. Int J Epidemiol (2006) 2.66
Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc Natl Acad Sci U S A (2004) 2.66
Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome. Mol Cell (2012) 2.54
Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice. Science (2013) 2.49
Strengthening the reporting of genetic association studies (STREGA): an extension of the strengthening the reporting of observational studies in epidemiology (STROBE) statement. J Clin Epidemiol (2009) 2.45
Family history in public health practice: a genomic tool for disease prevention and health promotion. Annu Rev Public Health (2010) 2.43
STrengthening the REporting of Genetic Association Studies (STREGA): an extension of the STROBE statement. PLoS Med (2009) 2.39
Phosphatidylinositol-3,4,5-trisphosphate regulates the formation of the basolateral plasma membrane in epithelial cells. Nat Cell Biol (2006) 2.39
The impact of genotype frequencies on the clinical validity of genomic profiling for predicting common chronic diseases. Genet Med (2007) 2.34
Tracking the epidemiology of human genes in the literature: the HuGE Published Literature database. Am J Epidemiol (2006) 2.34
Epithelial polarity and tubulogenesis in vitro. Trends Cell Biol (2003) 2.31
Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction. Mol Cell (2011) 2.29
Most published research findings are false-but a little replication goes a long way. PLoS Med (2007) 2.26
Family history and prevalence of diabetes in the U.S. population: the 6-year results from the National Health and Nutrition Examination Survey (1999-2004). Diabetes Care (2007) 2.22
Developing Family Healthware, a family history screening tool to prevent common chronic diseases. Prev Chronic Dis (2008) 2.20
Health care provider and consumer awareness, perceptions, and use of direct-to-consumer personal genomic tests, United States, 2008. Genet Med (2009) 2.17
DNA banking for epidemiologic studies: a review of current practices. Epidemiology (2002) 2.16
The path from genome-based research to population health: development of an international public health genomics network. Genet Med (2006) 2.15
Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseases. Am J Epidemiol (2009) 2.15
Invited commentary: genes, environment, and hybrid vigor. Am J Epidemiol (2009) 2.15
Cell-polarity dynamics controls the mechanism of lumen formation in epithelial morphogenesis. Curr Biol (2008) 2.13
Genomic profiling to promote a healthy lifestyle: not ready for prime time. Nat Genet (2003) 2.11
Evolution of the "drivers" of translational cancer epidemiology: analysis of funded grants and the literature. Am J Epidemiol (2015) 2.04
Future health applications of genomics: priorities for communication, behavioral, and social sciences research. Am J Prev Med (2010) 1.98
Do we need genomic research for the prevention of common diseases with environmental causes? Am J Epidemiol (2005) 1.92
The associations between race and geographic area and quality-of-care indicators in patients approaching ESRD. Clin J Am Soc Nephrol (2013) 1.87
Improving the prediction of complex diseases by testing for multiple disease-susceptibility genes. Am J Hum Genet (2003) 1.85
Genomics and the prevention and control of common chronic diseases: emerging priorities for public health action. Prev Chronic Dis (2005) 1.84
Required sample size and nonreplicability thresholds for heterogeneous genetic associations. Proc Natl Acad Sci U S A (2008) 1.84
On the use of population attributable fraction to determine sample size for case-control studies of gene-environment interaction. Epidemiology (2003) 1.82
STrengthening the REporting of Genetic Association studies (STREGA)--an extension of the STROBE statement. Eur J Clin Invest (2009) 1.82
Awareness and utilization of BRCA1/2 testing among U.S. primary care physicians. Am J Prev Med (2011) 1.80
The SOX2 response program in glioblastoma multiforme: an integrated ChIP-seq, expression microarray, and microRNA analysis. BMC Genomics (2011) 1.79
From public health emergency to public health service: the implications of evolving criteria for newborn screening panels. Pediatrics (2006) 1.77
Population-based study of the prevalence of family history of cancer: implications for cancer screening and prevention. Genet Med (2006) 1.77
GAPscreener: an automatic tool for screening human genetic association literature in PubMed using the support vector machine technique. BMC Bioinformatics (2008) 1.75
The next generation of large-scale epidemiologic research: implications for training cancer epidemiologists. Am J Epidemiol (2014) 1.73
"Drivers" of translational cancer epidemiology in the 21st century: needs and opportunities. Cancer Epidemiol Biomarkers Prev (2013) 1.72
Cancer GAMAdb: database of cancer genetic associations from meta-analyses and genome-wide association studies. Eur J Hum Genet (2011) 1.69
Family history of type 2 diabetes: a population-based screening tool for prevention? Genet Med (2006) 1.67
Impact of violations and deviations in Hardy-Weinberg equilibrium on postulated gene-disease associations. Am J Epidemiol (2006) 1.67
Application of support vector machine modeling for prediction of common diseases: the case of diabetes and pre-diabetes. BMC Med Inform Decis Mak (2010) 1.66
Managed care, hospice use, site of death, and medical expenditures in the last year of life. Arch Intern Med (2002) 1.65
Tumor-induced osteomalacia: an important cause of adult-onset hypophosphatemic osteomalacia in China: Report of 39 cases and review of the literature. J Bone Miner Res (2012) 1.63
Challenges of translating genetic tests into clinical and public health practice. Nat Rev Genet (2009) 1.62
The emergence of networks in human genome epidemiology: challenges and opportunities. Epidemiology (2007) 1.61
Age-specific seroprevalence of HIV, hepatitis B virus, and hepatitis C virus infection among injection drug users admitted to drug treatment in 6 US cities. Am J Public Health (2002) 1.61
Morphological and biochemical analysis of Rac1 in three-dimensional epithelial cell cultures. Methods Enzymol (2006) 1.59
Age structure changes and extraordinary lifespan in wild medfly populations. Aging Cell (2008) 1.57
An epidemiologic assessment of genomic profiling for measuring susceptibility to common diseases and targeting interventions. Genet Med (2004) 1.57
Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets. J Biol Chem (2005) 1.56
Knowledge integration at the center of genomic medicine. Genet Med (2012) 1.54
Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994. Am J Epidemiol (2008) 1.53