Published in Kidney Int on January 11, 2012
The uremic toxicity of indoxyl sulfate and p-cresyl sulfate: a systematic review. J Am Soc Nephrol (2014) 1.29
A decreased level of serum soluble Klotho is an independent biomarker associated with arterial stiffness in patients with chronic kidney disease. PLoS One (2013) 1.15
Klotho Protects Against Indoxyl Sulphate-Induced Myocardial Hypertrophy. J Am Soc Nephrol (2015) 0.99
Molecular basis of Klotho: from gene to function in aging. Endocr Rev (2015) 0.99
AST-120 for the management of progression of chronic kidney disease. Int J Nephrol Renovasc Dis (2014) 0.94
Tet1-mediated DNA demethylation regulates neuronal cell death induced by oxidative stress. Sci Rep (2015) 0.91
Cardiorenal syndrome: acute kidney injury secondary to cardiovascular disease and role of protein-bound uraemic toxins. J Physiol (2014) 0.90
Promoter methylation confers kidney-specific expression of the Klotho gene. FASEB J (2012) 0.86
Epigenetics of progression of chronic kidney disease: fact or fantasy? Semin Nephrol (2013) 0.86
Human organic anion transporters function as a high-capacity transporter for p-cresyl sulfate, a uremic toxin. Clin Exp Nephrol (2013) 0.83
Indoxyl Sulfate-Review of Toxicity and Therapeutic Strategies. Toxins (Basel) (2016) 0.82
Elevated Klotho promoter methylation is associated with severity of chronic kidney disease. PLoS One (2013) 0.81
Infection and smoking are associated with decreased plasma concentration of the anti-aging protein, α-klotho. J Perinat Med (2013) 0.80
Impact of fractional phosphate excretion on the relation of FGF23 with outcome in CKD patients. J Nephrol (2015) 0.79
Dialysis-requiring acute kidney injury increases risk of long-term malignancy: a population-based study. J Cancer Res Clin Oncol (2014) 0.79
Protein-bound uremic toxins induce tissue remodeling by targeting the EGF receptor. J Am Soc Nephrol (2014) 0.78
Chronic Kidney Disease and Fibrosis: The Role of Uremic Retention Solutes. Front Med (Lausanne) (2015) 0.78
Klotho preservation via histone deacetylase inhibition attenuates chronic kidney disease-associated bone injury in mice. Sci Rep (2017) 0.78
p-Cresyl Sulfate. Toxins (Basel) (2017) 0.77
DNA hypermethylation in hyperhomocysteinemia contributes to abnormal extracellular matrix metabolism in the kidney. FASEB J (2015) 0.77
Klotho gene silencing promotes pathology in the mdx mouse model of Duchenne muscular dystrophy. Hum Mol Genet (2016) 0.76
DNA methylation is differentially associated with environmental cadmium exposure based on sex and smoking status. Chemosphere (2015) 0.76
Potential application of klotho in human chronic kidney disease. Bone (2017) 0.75
Indoxyl sulfate potentiates skeletal muscle atrophy by inducing the oxidative stress-mediated expression of myostatin and atrogin-1. Sci Rep (2016) 0.75
Rhein reversal of DNA hypermethylation-associated Klotho suppression ameliorates renal fibrosis in mice. Sci Rep (2016) 0.75
The systemic nature of CKD. Nat Rev Nephrol (2017) 0.75
Reduction of Oxidative Stress in Chronic Kidney Disease Does Not Increase Circulating α-Klotho Concentrations. PLoS One (2016) 0.75
Dietary Metabolites and Chronic Kidney Disease. Nutrients (2017) 0.75
Indoxyl Sulfate Enhance the Hypermethylation of Klotho and Promote the Process of Vascular Calcification in Chronic Kidney Disease. Int J Biol Sci (2016) 0.75
The role of epigenetics in renal ageing. Nat Rev Nephrol (2017) 0.75
Adynamic bone disease is a predominant bone pattern in early stages of chronic kidney disease. J Nephrol (2017) 0.75
The gut-kidney axis. Pediatr Nephrol (2016) 0.75
MethPrimer: designing primers for methylation PCRs. Bioinformatics (2002) 14.48
Suppression of aging in mice by the hormone Klotho. Science (2005) 8.11
DNA methylation and cancer. Adv Genet (2010) 3.50
DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. Nat Genet (2002) 3.25
Serum indoxyl sulfate is associated with vascular disease and mortality in chronic kidney disease patients. Clin J Am Soc Nephrol (2009) 2.89
p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney disease. Nephrol Dial Transplant (2010) 2.66
Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients. Kidney Int (2006) 2.64
Severely reduced production of klotho in human chronic renal failure kidney. Biochem Biophys Res Commun (2001) 2.63
The role of mammalian DNA methyltransferases in the regulation of gene expression. Cell Mol Biol Lett (2005) 2.32
Oxidative stress, DNA methylation and carcinogenesis. Cancer Lett (2008) 2.27
Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer. Oncogene (2008) 1.97
Impact of inflammation on epigenetic DNA methylation - a novel risk factor for cardiovascular disease? J Intern Med (2007) 1.97
Amelioration of progressive renal injury by genetic manipulation of Klotho gene. Proc Natl Acad Sci U S A (2007) 1.83
Epigenetic regulation and the pathogenesis of systemic lupus erythematosus. Transl Res (2008) 1.71
Klotho as a regulator of oxidative stress and senescence. Biol Chem (2008) 1.68
Klotho and aging. Biochim Biophys Acta (2009) 1.58
Klotho reduces apoptosis in experimental ischaemic acute renal failure. Nephrol Dial Transplant (2005) 1.55
P-cresylsulphate, the main in vivo metabolite of p-cresol, activates leucocyte free radical production. Nephrol Dial Transplant (2006) 1.53
Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress. FASEB J (2002) 1.52
Molecular cloning of rat klotho cDNA: markedly decreased expression of klotho by acute inflammatory stress. Biochem Biophys Res Commun (1998) 1.50
The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma. Mol Cancer (2010) 1.39
Silencing of the metastasis suppressor RECK by RAS oncogene is mediated by DNA methyltransferase 3b-induced promoter methylation. Cancer Res (2006) 1.35
Oncostatin M, a cytokine released by activated mononuclear cells, induces epithelial cell-myofibroblast transdifferentiation via Jak/Stat pathway activation. J Am Soc Nephrol (2004) 1.30
New insights into uremic toxicity. Curr Opin Nephrol Hypertens (2008) 1.21
Klotho RNAi induces premature senescence of human cells via a p53/p21 dependent pathway. FEBS Lett (2006) 1.19
Beyond genetics: epigenetic code in chronic kidney disease. Kidney Int (2010) 1.18
Oxidative stress modulates DNA methylation during melanocyte anchorage blockade associated with malignant transformation. Neoplasia (2007) 1.15
Indoxyl sulfate inhibits nitric oxide production and cell viability by inducing oxidative stress in vascular endothelial cells. Am J Nephrol (2009) 1.14
Development of DNA methyltransferase inhibitors for the treatment of neoplastic diseases. Curr Med Chem (2009) 1.11
Differential requirement for DNA methyltransferase 1 in maintaining human cancer cell gene promoter hypermethylation. Cancer Res (2006) 1.09
STAT3 attenuates EGFR-mediated ERK activation and cell survival during oxidant stress in mouse proximal tubular cells. Kidney Int (2006) 1.08
Burden of chronic kidney disease: an international perspective. Adv Chronic Kidney Dis (2010) 1.07
p66shc inhibits pro-survival epidermal growth factor receptor/ERK signaling during severe oxidative stress in mouse renal proximal tubule cells. J Biol Chem (2008) 1.06
Loss of Klotho during melanoma progression leads to increased filamin cleavage, increased Wnt5A expression, and enhanced melanoma cell motility. Pigment Cell Melanoma Res (2010) 1.00
Uremia induces abnormal oxygen consumption in tubules and aggravates chronic hypoxia of the kidney via oxidative stress. Am J Physiol Renal Physiol (2010) 0.97
Expression of Klotho protein in the inner ear. Hear Res (2002) 0.96
Association between global leukocyte DNA methylation, renal function, carotid intima-media thickness and plasma homocysteine in patients with stage 2-4 chronic kidney disease. Nephrol Dial Transplant (2008) 0.95
Transcriptional activation of the human Klotho gene by epidermal growth factor in HEK293 cells; role of Egr-1. Gene (2010) 0.95
Indoxyl sulfate downregulates renal expression of Klotho through production of ROS and activation of nuclear factor-ĸB. Am J Nephrol (2011) 0.95
Indoxyl sulfate reduces klotho expression and promotes senescence in the kidneys of hypertensive rats. J Ren Nutr (2011) 0.94
An oral sorbent, AST-120, increases Klotho expression and inhibits cell senescence in the kidney of uremic rats. Am J Nephrol (2009) 0.92
Klotho insufficiency causes decrease of ribosomal RNA gene transcription activity, cytoplasmic RNA and rough ER in the spinal anterior horn cells. Acta Neuropathol (2005) 0.90
Determination of uremic solutes in biological fluids of chronic kidney disease patients by HPLC assay. J Chromatogr B Analyt Technol Biomed Life Sci (2011) 0.90
Uremic toxins: a new focus on an old subject. Semin Dial (2005) 0.84
Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry. Mol Cell (2007) 4.54
Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection. J Exp Med (2004) 4.52
HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol. Proc Natl Acad Sci U S A (2005) 3.82
Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases. Mol Cell (2008) 3.49
The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues. Nat Immunol (2002) 3.45
An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides. Nat Immunol (2002) 3.22
p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney disease. Nephrol Dial Transplant (2010) 2.66
Multidisciplinary predialysis education decreases the incidence of dialysis and reduces mortality--a controlled cohort study based on the NKF/DOQI guidelines. Nephrol Dial Transplant (2009) 2.01
Enhancement of epithelial sodium channel expression in renal cortical collecting ducts cells by advanced glycation end products. Nephrol Dial Transplant (2006) 1.59
Fibroblast growth factor 23: a possible cause of left ventricular hypertrophy in hemodialysis patients. Am J Med Sci (2009) 1.52
Aliskiren reduced renal fibrosis in mice with chronic ischemic kidney injury--beyond the direct renin inhibition. Hypertens Res (2011) 1.46
Salt loss and hyponatraemia in a patient with syphilitic nephritis. Nephrol Dial Transplant (2005) 1.45
Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1. Nat Struct Mol Biol (2011) 1.42
Early hemoperfusion may improve survival of severely paraquat-poisoned patients. PLoS One (2012) 1.28
The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1. PLoS One (2008) 1.23
Uremic toxins induce kidney fibrosis by activating intrarenal renin-angiotensin-aldosterone system associated epithelial-to-mesenchymal transition. PLoS One (2012) 1.22
Depression and suicide risk in hemodialysis patients with chronic renal failure. Psychosomatics (2010) 1.21
Epidermal growth factor and transforming growth factor-beta1 enhance HK-2 cell migration through a synergistic increase of matrix metalloproteinase and sustained activation of ERK signaling pathway. Exp Cell Res (2007) 1.16
The Leptospira outer membrane protein LipL32 induces tubulointerstitial nephritis-mediated gene expression in mouse proximal tubule cells. J Am Soc Nephrol (2002) 1.15
Serum free p-cresyl sulfate levels predict cardiovascular and all-cause mortality in elderly hemodialysis patients--a prospective cohort study. Nephrol Dial Transplant (2011) 1.10
Therapeutic effect of topical gamma-linolenic acid on refractory uremic pruritus. Am J Kidney Dis (2006) 1.01
The impact of self-management support on the progression of chronic kidney disease--a prospective randomized controlled trial. Nephrol Dial Transplant (2011) 1.00
Long-term modality-related mortality analysis in incident dialysis patients. Perit Dial Int (2009) 0.98
p-Cresol sulfate and indoxyl sulfate induce similar cellular inflammatory gene expressions in cultured proximal renal tubular cells. Nephrol Dial Transplant (2012) 0.98
Commercial cadaveric renal transplant: an ethical rather than medical issue. Clin Transplant (2006) 0.95
Adults with late stage 3 chronic kidney disease are at high risk for prevalent silent brain infarction: a population-based study. Stroke (2011) 0.94
Clinical distinction and evaluation of leptospirosis in Taiwan--a case-control study. J Nephrol (2005) 0.93
Inhibition of the P2X7 receptor reduces cystogenesis in PKD. J Am Soc Nephrol (2011) 0.91
In younger dialysis patients, automated peritoneal dialysis is associated with better long-term patient and technique survival than is continuous ambulatory peritoneal dialysis. Perit Dial Int (2011) 0.89
Leptospiral membrane proteins stimulate pro-inflammatory chemokines secretion by renal tubule epithelial cells through toll-like receptor 2 and p38 mitogen activated protein kinase. Nephrol Dial Transplant (2005) 0.89
Anaemia management in patients with chronic kidney disease: Taiwan practice guidelines. Nephrology (Carlton) (2014) 0.86
Early identification of leptospirosis as an ignored cause of multiple organ dysfunction syndrome. Shock (2012) 0.86
Ventricular function and all-cause mortality in chronic kidney disease patients with angiographic coronary artery disease. J Nephrol (2010) 0.86
Extra-renal abscess in chronic hemodialysis patients. Ren Fail (2002) 0.86
Leptospiral outer membrane protein induces extracellular matrix accumulation through a TGF-beta1/Smad-dependent pathway. J Am Soc Nephrol (2006) 0.85
Extreme hyperphosphatemia and hypocalcemic coma associated with phosphate enema. Intern Med (2008) 0.85
Extrapulmonary tuberculosis in chronic hemodialysis patients. Ren Fail (2003) 0.84
Effect of oral ferric citrate on serum phosphorus in hemodialysis patients: multicenter, randomized, double-blind, placebo-controlled study. J Nephrol (2014) 0.84
Transforming growth factor-beta1 decreases epithelial sodium channel functionality in renal collecting duct cells via a Smad4-dependent pathway. Nephrol Dial Transplant (2007) 0.83
Hypoglycemia in diabetic patients undergoing chronic hemodialysis. Ther Apher Dial (2009) 0.83
Regulation of the catalytic behaviour of L-form starch phosphorylase from sweet potato roots by proteolysis. Physiol Plant (2002) 0.83
Interaction of estrogen and progesterone in the regulation of sodium channels in collecting tubular cells. Chang Gung Med J (2007) 0.83
Leukemoid reaction after methotrexate-induced pancytopenia in a patient undergoing continuous ambulatory peritoneal dialysis. Chang Gung Med J (2007) 0.83
Does hepatitis C virus affect the reactivation of hepatitis B virus following renal transplantation? Nephrol Dial Transplant (2006) 0.83
Association between cold dialysis and cardiovascular survival in hemodialysis patients. Nephrol Dial Transplant (2011) 0.83
Higher serum potassium level associated with late stage chronic kidney disease. Chang Gung Med J (2011) 0.82
Effects of cyclosporine, tacrolimus and rapamycin on renal calcium transport and vitamin D metabolism. Am J Nephrol (2011) 0.82
Creatine monohydrate treatment alleviates muscle cramps associated with haemodialysis. Nephrol Dial Transplant (2002) 0.82
Real-time three-dimensional echocardiography provides advanced haemodynamic information associated with intra-dialytic hypotension in patients with autonomic dysfunction. Nephrol Dial Transplant (2009) 0.82
Echocardiographic assessment of structural and functional cardiac remodeling in patients with predialysis chronic kidney disease. Echocardiography (2010) 0.82
Re-evaluating the predictive roles of metabolic complications and clinical outcome according to eGFR levels--a four-years prospective cohort study in Taiwan. BMC Nephrol (2013) 0.81
Ciclosporin reduces paracellin-1 expression and magnesium transport in thick ascending limb cells. Nephrol Dial Transplant (2007) 0.81
Guillain-Barré syndrome associated with minimal change glomerulopathy and tubular dysfunction - related to acetone-based organic solvent? Am J Nephrol (2002) 0.81
Factors associated with mortality from non-occlusive mesenteric ischemia in dialysis patients. Ren Fail (2009) 0.80
Three-dimensional echocardiographic assessment of left ventricular remodeling in predialysis chronic kidney disease patients. J Nephrol (2012) 0.80
Plastidial starch phosphorylase in sweet potato roots is proteolytically modified by protein-protein interaction with the 20S proteasome. PLoS One (2012) 0.80
Leptospira santorosai Serovar Shermani detergent extract induces an increase in fibronectin production through a Toll-like receptor 2-mediated pathway. Infect Immun (2010) 0.80
Patient able to stay on peritoneal dialysis after retroperitoneal-approach radical nephrectomy. Perit Dial Int (2012) 0.80
Low serum acylated ghrelin levels are associated with the development of cardiovascular disease in hemodialysis patients. Intern Med (2010) 0.80
Association between uremic toxins and depression in patients with chronic kidney disease undergoing maintenance hemodialysis. Gen Hosp Psychiatry (2012) 0.79
Biochemical characterization of the small ubiquitin-like modifiers of Chlamydomonas reinhardtii. Planta (2010) 0.78
The molecular determinants of NEDD8 specific recognition by human SENP8. PLoS One (2011) 0.78
The relationship between psychological factors, inflammation, and nutrition in patients with chronic renal failure undergoing hemodialysis. Int J Psychiatry Med (2012) 0.78
A nationwide survey of clinical characteristics, management, and outcomes of acute kidney injury (AKI) - patients with and without preexisting chronic kidney disease have different prognoses. Medicine (Baltimore) (2016) 0.77
Impact of HCV infection on first cadaveric renal transplantation, a single center experience. Clin Transplant (2004) 0.77
Positive dialysate gram stain predicts outcome of empirical antibiotic therapy for peritoneal dialysis-associated peritonitis. Ther Apher Dial (2010) 0.77
High body mass index is not associated with coronary artery disease in angina patients with chronic kidney disease: a coronary angiography study. Am J Med Sci (2008) 0.77
Western blotting by thin-film direct coating. Anal Chem (2014) 0.77
Successful hemoperfusion and plasma exchange in acute hepatic failure due to snake bile intoxication. Chang Gung Med J (2008) 0.77
The value of pharyngeal scintigraphy in predicting videofluoroscopic findings. Am J Phys Med Rehabil (2013) 0.77
Improvement of clinical outcome by early nephrology referral in type II diabetics on hemodialysis. Ren Fail (2003) 0.77
Ureteral endometriosis with obstructive uropathy. Intern Med (2010) 0.76
Icodextrin dialysate improves nutritional and inflammatory profiles in peritoneal dialysis patients. Ren Fail (2009) 0.76
Hemojuvelin modulates iron stress during acute kidney injury: improved by furin inhibitor. Antioxid Redox Signal (2013) 0.76
Acute renal failure induced by bentazone: 2 case reports and a comprehensive review. J Nephrol (2008) 0.76
Lack of association between plasma dehydroepiandrosterone sulfate (DHEA-S) levels and depression in hemodialysis patients: a cross-sectional study. Exp Gerontol (2009) 0.76
Risk factors of gender for renal progression in patients with early chronic kidney disease. Medicine (Baltimore) (2016) 0.75
Low plasma DHEA-S increases mortality risk among male hemodialysis patients. Exp Gerontol (2012) 0.75
Patient education: an efficient adjuvant therapy for hyperphosphatemia in hemodialysis patients. Ren Fail (2008) 0.75
The combination of sirolimus and cyclosporine does not delay initial renal graft function recovery. Ren Fail (2008) 0.75
Lactobacillus peritonitis: a rare cause of peritonitis in peritoneal dialysis patients. Ren Fail (2004) 0.75
Lower prevalence of depression in hemodialysis patients who use polysulfone dialyzers. Am J Nephrol (2009) 0.75
Efficacy of Predicting Videofluoroscopic Results in Dysphagic Patients with Severe Cerebral Palsy Using the Mann Assessment of Swallowing Ability. Am J Phys Med Rehabil (2016) 0.75
Excellent prognosis of culture negative endocarditis in hemodialysis patients: a case series. Ren Fail (2007) 0.75
Hypercalcemia in prostate cancer with positive neuron-specific enolase stain. Ren Fail (2004) 0.75
A young female with Spitzer-Weinstein syndrome diagnosed by thiazide test. Ren Fail (2007) 0.75
Global DNA methylation not increased in chronic hemodialysis patients: a case-control study. Ren Fail (2012) 0.75
Postpartum hemorrhage complicated with irreversible renal failure and central diabetes insipidus. Ren Fail (2002) 0.75
Cyclosporine decreases prostaglandin E2 production in mouse medullary thick ascending limb cultured cells. Transpl Int (2005) 0.75
Renal transplantation reversed intractable hypotension in a diabetic patient. Diabetes Care (2007) 0.75
Subcutaneous continuous erythropoietin receptor activator conversion provides practical advantages and potential convenience for peritoneal dialysis patients. Perit Dial Int (2011) 0.75
Axillary artery to contralateral axillary vein graft fistula in chronic hemodialysis patients. Ren Fail (2003) 0.75
Successful treatment of idiopathic membranous glomerulonephritis complicated with renal vein thrombosis with FK506. Ren Fail (2002) 0.75
Human immunodeficiency virus (HIV) infection screening in a dialysis unit. Ren Fail (2007) 0.75