Published in FASEB J on November 15, 2002
Regulation and function of the FGF23/klotho endocrine pathways. Physiol Rev (2012) 1.97
Life extension factor klotho enhances cognition. Cell Rep (2014) 1.81
Klotho and aging. Biochim Biophys Acta (2009) 1.58
Vascular calcification and osteoporosis--from clinical observation towards molecular understanding. Osteoporos Int (2006) 1.42
Klotho. Pflugers Arch (2010) 1.34
Dopamine D1 receptors regulate protein synthesis-dependent long-term recognition memory via extracellular signal-regulated kinase 1/2 in the prefrontal cortex. Learn Mem (2007) 1.21
Emerging roles of the neuronal nucleolus. Trends Neurosci (2012) 1.18
Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model. Hum Mol Genet (2009) 1.18
Overview of the FGF23-Klotho axis. Pediatr Nephrol (2009) 1.15
Role of Klotho in aging, phosphate metabolism, and CKD. Am J Kidney Dis (2011) 1.15
Klotho, phosphate and FGF-23 in ageing and disturbed mineral metabolism. Nat Rev Nephrol (2013) 1.12
Suppression of Klotho expression by protein-bound uremic toxins is associated with increased DNA methyltransferase expression and DNA hypermethylation. Kidney Int (2012) 1.11
A potential link between phosphate and aging--lessons from Klotho-deficient mice. Mech Ageing Dev (2010) 1.10
The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS. J Neurosci (2013) 1.08
Aripiprazole ameliorates phencyclidine-induced impairment of recognition memory through dopamine D1 and serotonin 5-HT1A receptors. Psychopharmacology (Berl) (2008) 1.08
Damaging effects of a high-fat diet to the brain and cognition: a review of proposed mechanisms. Nutr Neurosci (2013) 1.03
Promoter methylation and age-related downregulation of Klotho in rhesus monkey. Age (Dordr) (2011) 1.01
The neuroprotective effect of Klotho is mediated via regulation of members of the redox system. J Biol Chem (2014) 1.00
α-Klotho protects against oxidative damage in pulmonary epithelia. Am J Physiol Lung Cell Mol Physiol (2014) 1.00
Nuclear localization of Klotho in brain: an anti-aging protein. Neurobiol Aging (2012) 0.96
Neurobiology of cognitive aging: insights from imaging genetics. Biol Psychol (2008) 0.96
Klotho endows hepatoma cells with resistance to anoikis via VEGFR2/PAK1 activation in hepatocellular carcinoma. PLoS One (2013) 0.95
Klotho in the cerebrospinal fluid of adults with and without Alzheimer's disease. Neurosci Lett (2013) 0.95
A phosphate-centric paradigm for pathophysiology and therapy of chronic kidney disease. Kidney Int Suppl (2011) (2013) 0.94
A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice. PLoS One (2011) 0.92
Aging-related kidney damage is associated with a decrease in klotho expression and an increase in superoxide production. Age (Dordr) (2010) 0.91
Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice. J Neurosci (2015) 0.91
Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging. Neuropsychopharmacology (2013) 0.89
Small-molecule Klotho enhancers as novel treatment of neurodegeneration. Future Med Chem (2012) 0.89
Neurotoxic mechanisms of DNA damage: focus on transcriptional inhibition. J Neurochem (2010) 0.88
Expression of klotho mRNA and protein in rat brain parenchyma from early postnatal development into adulthood. Brain Res (2013) 0.87
β2 adrenergic receptor, protein kinase A (PKA) and c-Jun N-terminal kinase (JNK) signaling pathways mediate tau pathology in Alzheimer disease models. J Biol Chem (2013) 0.87
MicroRNA-339 and microRNA-556 regulate Klotho expression in vitro. Age (Dordr) (2013) 0.83
Skeletal muscle as a regulator of the longevity protein, Klotho. Front Physiol (2014) 0.83
Frontiers of model animals for neuroscience: two prosperous aging model animals for promoting neuroscience research. Exp Anim (2013) 0.80
1,25(OH)2D3 Deficiency Induces Colon Inflammation via Secretion of Senescence-Associated Inflammatory Cytokines. PLoS One (2016) 0.80
Melatonin attenuates memory impairment induced by Klotho gene deficiency via interactive signaling between MT2 receptor, ERK, and Nrf2-related antioxidant potential. Int J Neuropsychopharmacol (2014) 0.79
Protective effect of selaginellin on glutamate-induced cytotoxicity and apoptosis in differentiated PC12 cells. Naunyn Schmiedebergs Arch Pharmacol (2009) 0.79
Functional evaluation of the apoptosome in renal cell carcinoma. Br J Cancer (2003) 0.78
Growth Hormone-Releaser Diet Attenuates Cognitive Dysfunction in Klotho Mutant Mice via Insulin-Like Growth Factor-1 Receptor Activation in a Genetic Aging Model. Endocrinol Metab (Seoul) (2014) 0.78
Altered KLOTHO and NF-κB-TNF-α Signaling Are Correlated with Nephrectomy-Induced Cognitive Impairment in Rats. PLoS One (2015) 0.78
Effects of NK-4 in a transgenic mouse model of Alzheimer's disease. PLoS One (2012) 0.78
Genetic Variants in KLOTHO Associate With Cognitive Function in the Oldest Old Group. J Gerontol A Biol Sci Med Sci (2015) 0.78
Development and characterization of monoclonal antibodies to detect klotho. Monoclon Antib Immunodiagn Immunother (2014) 0.78
Inorganic Phosphate Activates the AKT/mTORC1 Pathway and Shortens the Life Span of an α‑Klotho-Deficient Model. J Am Soc Nephrol (2016) 0.77
Secreted and Transmembrane αKlotho Isoforms Have Different Spatio-Temporal Profiles in the Brain during Aging and Alzheimer's Disease Progression. PLoS One (2015) 0.77
Identifying aging-related genes in mouse hippocampus using gateway nodes. BMC Syst Biol (2014) 0.76
The age-regulating protein klotho is vital to sustain retinal function. Invest Ophthalmol Vis Sci (2013) 0.76
1,25(OH)2D3 dependent overt hyperactivity phenotype in klotho-hypomorphic mice. Sci Rep (2016) 0.75
Associations between the antioxidant network and emotional intelligence: a preliminary study. PLoS One (2014) 0.75
Population Difference in the Associations of KLOTH Promoter Methylation with Mild Cognitive Impairment in Xinjiang Uygur and Han Populations. PLoS One (2015) 0.75
2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside Promotes Expression of the Longevity Gene Klotho. Oxid Med Cell Longev (2016) 0.75
G-395A polymorphism in the promoter region of the KLOTHO gene associates with reduced cognitive impairment among the oldest old. Age (Dordr) (2016) 0.75
Intervention Effect of Electroacupuncture Combined with EPCs Transplantation on the Mice in Aging Model. Evid Based Complement Alternat Med (2015) 0.75
Klotho regulates CA1 hippocampal synaptic plasticity. Neuroscience (2017) 0.75
Klotho: a humeral mediator in CSF and plasma that influences longevity and susceptibility to multiple complex disorders, including depression. Transl Psychiatry (2016) 0.75
Klotho sensitive regulation of dendritic cell functions by vitamin E. Biol Res (2016) 0.75
The SAMP8 mouse for investigating memory and the role of insulin in the brain. Exp Gerontol (2016) 0.75
Reduction of Oxidative Stress in Chronic Kidney Disease Does Not Increase Circulating α-Klotho Concentrations. PLoS One (2016) 0.75
Acute lung injury complicating acute kidney injury: A model of endogenous αKlotho deficiency and distant organ dysfunction. Bone (2017) 0.75
The Role of Ghrelin and Ghrelin Signaling in Aging. Int J Mol Sci (2017) 0.75
Klotho regulates postnatal neurogenesis and protects against age-related spatial memory loss. Neurobiol Aging (2017) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Functional hierarchy and reversibility within the murine spermatogenic stem cell compartment. Science (2010) 3.33
PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1. Nat Cell Biol (2005) 3.30
Bone marrow stromal cells generate muscle cells and repair muscle degeneration. Science (2005) 2.89
The basic helix-loop-helix factor olig2 is essential for the development of motoneuron and oligodendrocyte lineages. Curr Biol (2002) 2.74
alpha-Klotho as a regulator of calcium homeostasis. Science (2007) 2.71
Cdk5 phosphorylates and stabilizes p27kip1 contributing to actin organization and cortical neuronal migration. Nat Cell Biol (2005) 2.61
Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits. Neuron (2010) 2.53
CD38 is critical for social behaviour by regulating oxytocin secretion. Nature (2007) 2.44
Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects. Biochem Biophys Res Commun (2010) 2.20
The first round of mouse spermatogenesis is a distinctive program that lacks the self-renewing spermatogonia stage. Development (2006) 2.07
Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids. Science (2013) 2.04
Formal protocol for emergency treatment of ruptured intracranial aneurysms to reduce in-hospital rebleeding and improve clinical outcomes. J Neurosurg (2014) 2.04
Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression. Circulation (2004) 2.00
Fasudil is a superior vasodilator for the internal thoracic artery in coronary surgery. Ann Thorac Surg (2013) 1.99
The in vivo roles of STEF/Tiam1, Rac1 and JNK in cortical neuronal migration. EMBO J (2003) 1.92
High prevalence of leukoaraiosis in cerebral magnetic resonance images of patients on peritoneal dialysis. Am J Kidney Dis (2007) 1.88
Origin of climbing fiber neurons and their developmental dependence on Ptf1a. J Neurosci (2007) 1.84
RAGE-mediated signaling contributes to intraneuronal transport of amyloid-beta and neuronal dysfunction. Proc Natl Acad Sci U S A (2009) 1.74
Brain-derived neurotrophic factor/TrkB signaling in memory processes. J Pharmacol Sci (2003) 1.73
Relevant use of Klotho in FGF19 subfamily signaling system in vivo. Proc Natl Acad Sci U S A (2010) 1.66
Olig2-positive progenitors in the embryonic spinal cord give rise not only to motoneurons and oligodendrocytes, but also to a subset of astrocytes and ependymal cells. Dev Biol (2006) 1.64
Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells. Mol Biol Cell (2008) 1.63
Angiogenesis and vasculogenesis are impaired in the precocious-aging klotho mouse. Circulation (2004) 1.61
Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides. J Biol Chem (2003) 1.57
Vascular risk factors and oxidative stress as independent predictors of asymptomatic atherosclerosis in adult patients with epilepsy. Epilepsy Res (2007) 1.57
A translocation causing increased alpha-klotho level results in hypophosphatemic rickets and hyperparathyroidism. Proc Natl Acad Sci U S A (2008) 1.56
Inflammation induces mitochondrial dysfunction and dopaminergic neurodegeneration in the nigrostriatal system. J Neurochem (2007) 1.55
Correlation between hyperphosphatemia and type II Na-Pi cotransporter activity in klotho mice. Am J Physiol Renal Physiol (2006) 1.53
Comparison of mesenchymal stem cells from adipose tissue and bone marrow for ischemic stroke therapy. Cytotherapy (2011) 1.52
Isolation and characterization of patient-derived, toxic, high mass amyloid beta-protein (Abeta) assembly from Alzheimer disease brains. J Biol Chem (2009) 1.52
Ultrastructure of internal limiting membrane removed during plasmin-assisted vitrectomy from eyes with diabetic macular edema. Ophthalmology (2004) 1.48
Usefulness of soluble dietary fiber for the treatment of diarrhea during enteral nutrition in elderly patients. Nutrition (2002) 1.48
Crystal structures of cyclohexanone monooxygenase reveal complex domain movements and a sliding cofactor. J Am Chem Soc (2009) 1.46
Effects of single therapeutic doses of promethazine, fexofenadine and olopatadine on psychomotor function and histamine-induced wheal- and flare-responses: a randomized double-blind, placebo-controlled study in healthy volunteers. Arch Dermatol Res (2011) 1.43
Acute serious rebleeding after angiographically successful coil embolization of ruptured cerebral aneurysms. Acta Neurochir (Wien) (2010) 1.42
Role for brain-derived neurotrophic factor in learning and memory. Life Sci (2002) 1.38
Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function. J Biol Chem (2006) 1.37
Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse. Hum Mol Genet (2011) 1.36
Production and functions of IL-17 in microglia. J Neuroimmunol (2007) 1.34
Retinoic acid metabolism links the periodical differentiation of germ cells with the cycle of Sertoli cells in mouse seminiferous epithelium. Mech Dev (2011) 1.34
Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and forced swimming tests. Nat Genet (2009) 1.33
Oral vaccination with a viral vector containing Abeta cDNA attenuates age-related Abeta accumulation and memory deficits without causing inflammation in a mouse Alzheimer model. FASEB J (2007) 1.31
Involvement of a Rac activator,P-Rex1, in neurotrophin-derived signaling and neuronal migration. J Neurosci (2005) 1.31
Early detection of abnormal prion protein in genetic human prion diseases now possible using real-time QUIC assay. PLoS One (2013) 1.30
Social isolation rearing-induced impairment of the hippocampal neurogenesis is associated with deficits in spatial memory and emotion-related behaviors in juvenile mice. J Neurochem (2007) 1.26
Phencyclidine animal models of schizophrenia: approaches from abnormality of glutamatergic neurotransmission and neurodevelopment. Neurochem Int (2007) 1.24
Characterization of STEF, a guanine nucleotide exchange factor for Rac1, required for neurite growth. J Biol Chem (2001) 1.21
Dopamine D1 receptors regulate protein synthesis-dependent long-term recognition memory via extracellular signal-regulated kinase 1/2 in the prefrontal cortex. Learn Mem (2007) 1.21
CREB phosphorylation as a molecular marker of memory processing in the hippocampus for spatial learning. Behav Brain Res (2002) 1.20
Role of oxidative stress in epileptic seizures. Neurochem Int (2011) 1.20
Roles of STEF/Tiam1, guanine nucleotide exchange factors for Rac1, in regulation of growth cone morphology. Mol Cell Neurosci (2003) 1.19
A natural scavenger of peroxynitrites, rosmarinic acid, protects against impairment of memory induced by Abeta(25-35). Behav Brain Res (2007) 1.19
Decreased renal α-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion. Kidney Int (2012) 1.19
Role of tumor necrosis factor-alpha in methamphetamine-induced drug dependence and neurotoxicity. J Neurosci (2004) 1.19
New prospective payment system in Japan. Am J Health Syst Pharm (2005) 1.18
Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-acetylcholinesterase and anti-oxidative activities in mice. Eur J Pharmacol (2010) 1.17
Involvement of a dysfunctional dopamine-D1/N-methyl-d-aspartate-NR1 and Ca2+/calmodulin-dependent protein kinase II pathway in the impairment of latent learning in a model of schizophrenia induced by phencyclidine. Mol Pharmacol (2007) 1.17
Involvement of BDNF receptor TrkB in spatial memory formation. Learn Mem (2003) 1.17
Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus. J Neurosci (2011) 1.17
Quantitative evaluation of liver function with MRI Using Gd-EOB-DTPA. Korean J Radiol (2005) 1.17
Mechanism of action of aripiprazole predicts clinical efficacy and a favourable side-effect profile. J Psychopharmacol (2004) 1.16
Mouse brains deficient in neuronal PDGF receptor-beta develop normally but are vulnerable to injury. J Neurochem (2006) 1.16
Behavioral abnormality and pharmacologic response in social isolation-reared mice. Behav Brain Res (2009) 1.14
Generation of monoclonal antibody recognized by the GXXXG motif (glycine zipper) of prion protein. Hybridoma (Larchmt) (2006) 1.13
Chronic restraint stress impairs neurogenesis and hippocampus-dependent fear memory in mice: possible involvement of a brain-specific transcription factor Npas4. J Neurochem (2010) 1.13
Regulations of methamphetamine reward by extracellular signal-regulated kinase 1/2/ets-like gene-1 signaling pathway via the activation of dopamine receptors. Mol Pharmacol (2004) 1.12
Improvement by minocycline of methamphetamine-induced impairment of recognition memory in mice. Psychopharmacology (Berl) (2007) 1.12
Identification of a novel mouse membrane-bound family 1 glycosidase-like protein, which carries an atypical active site structure. Biochim Biophys Acta (2002) 1.10
Mechanism of systemically injected interferon-alpha impeding monoamine biosynthesis in rats: role of nitric oxide as a signal crossing the blood-brain barrier. Brain Res (2003) 1.10
Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood. Behav Brain Res (2009) 1.09
Disrupted transforming growth factor-beta signaling in spinal and bulbar muscular atrophy. J Neurosci (2010) 1.09
Aripiprazole ameliorates phencyclidine-induced impairment of recognition memory through dopamine D1 and serotonin 5-HT1A receptors. Psychopharmacology (Berl) (2008) 1.08
Beta-amyloid (1-42)-induced learning and memory deficits in mice: involvement of oxidative burdens in the hippocampus and cerebral cortex. Behav Brain Res (2004) 1.07