Published in Free Radic Res on February 22, 2012
Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer. Elife (2014) 1.39
Pulmonary oxidative stress, inflammation and cancer: respirable particulate matter, fibrous dusts and ozone as major causes of lung carcinogenesis through reactive oxygen species mechanisms. Int J Environ Res Public Health (2013) 1.26
Mitochondrial and nuclear DNA damage and repair in age-related macular degeneration. Int J Mol Sci (2013) 1.13
G-quadruplex folds of the human telomere sequence alter the site reactivity and reaction pathway of guanine oxidation compared to duplex DNA. Chem Res Toxicol (2013) 1.01
RNA virus population diversity, an optimum for maximal fitness and virulence. J Biol Chem (2014) 1.00
Reconciliation of chemical, enzymatic, spectroscopic and computational data to assign the absolute configuration of the DNA base lesion spiroiminodihydantoin. J Am Chem Soc (2013) 0.97
Rates of chemical cleavage of DNA and RNA oligomers containing guanine oxidation products. Chem Res Toxicol (2015) 0.95
Regulation of DNA glycosylases and their role in limiting disease. Free Radic Res (2012) 0.87
Influence of 8-oxoguanosine on the fine structure of DNA studied with biasing-potential replica exchange simulations. Biophys J (2013) 0.84
NEIL2 protects against oxidative DNA damage induced by sidestream smoke in human cells. PLoS One (2014) 0.82
Formation and processing of DNA damage substrates for the hNEIL enzymes. Free Radic Biol Med (2016) 0.81
The influence of the occupational exposure to heavy metals and tobacco smoke on the selected oxidative stress markers in smelters. Biol Trace Elem Res (2014) 0.80
Role of Oxidative RNA Damage in Chronic-Degenerative Diseases. Oxid Med Cell Longev (2015) 0.79
Computational studies of electronic circular dichroism spectra predict absolute configuration assignments for the guanine oxidation product 5-carboxamido-5-formamido-2-iminohydantoin. Tetrahedron Lett (2015) 0.79
The Impact of Non-Enzymatic Reactions and Enzyme Promiscuity on Cellular Metabolism during (Oxidative) Stress Conditions. Biomolecules (2015) 0.79
Structure and stereochemistry of the base excision repair glycosylase MutY reveal a mechanism similar to retaining glycosidases. Nucleic Acids Res (2015) 0.78
Novel diet-related mouse model of colon cancer parallels human colon cancer. World J Gastrointest Oncol (2014) 0.78
Local DNA dynamics shape mutational patterns of mononucleotide repeats in human genomes. Nucleic Acids Res (2015) 0.77
pH-Dependent Equilibrium between 5-Guanidinohydantoin and Iminoallantoin Affects Nucleotide Insertion Opposite the DNA Lesion. J Org Chem (2015) 0.76
Protective effect of KI in mtDNA in porcine thyroid: comparison with KIO₃ and nDNA. Eur J Nutr (2014) 0.76
Role of Bacillus subtilis DNA Glycosylase MutM in Counteracting Oxidatively Induced DNA Damage and in Stationary-Phase-Associated Mutagenesis. J Bacteriol (2015) 0.76
Human Telomere G-Quadruplexes with Five Repeats Accommodate 8-Oxo-7,8-dihydroguanine by Looping out the DNA Damage. ACS Chem Biol (2015) 0.76
The Origin of Life: Models and Data. J Mol Evol (2017) 0.75
DNA Damage in Chronic Kidney Disease: Evaluation of Clinical Biomarkers. Oxid Med Cell Longev (2016) 0.75
Spirodi(iminohydantoin) products from oxidation of 2'-deoxyguanosine in the presence of NH4Cl in nucleoside and oligodeoxynucleotide contexts. J Org Chem (2015) 0.75
Atmospheric-Pressure Cold Plasma Induces Transcriptional Changes in Ex Vivo Human Corneas. PLoS One (2015) 0.75
TP53 Modulates Oxidative Stress in Gata1(+) Erythroid Cells. Stem Cell Reports (2017) 0.75
Klenow Fragment Discriminates against the Incorporation of the Hyperoxidized dGTP Lesion Spiroiminodihydantoin into DNA. Chem Res Toxicol (2015) 0.75
An automated Fpg-based FADU method for the detection of oxidative DNA lesions and screening of antioxidants. Toxicology (2013) 0.75
Sequencing DNA for the Oxidatively Modified Base 8-Oxo-7,8-Dihydroguanine. Methods Enzymol (2017) 0.75
Reverse Transcription Past Products of Guanine Oxidation in RNA Leads to Insertion of A and C opposite 8-Oxo-7,8-dihydroguanine and A and G opposite 5-Guanidinohydantoin and Spiroiminodihydantoin Diastereomers. Biochemistry (2017) 0.75
Frying oils with high natural or added antioxidants content, which protect against postprandial oxidative stress, also protect against DNA oxidation damage. Eur J Nutr (2016) 0.75
Translating the histone code. Science (2001) 56.77
The language of covalent histone modifications. Nature (2000) 44.92
Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature (1991) 9.70
TLC1: template RNA component of Saccharomyces cerevisiae telomerase. Science (1994) 9.08
Monovalent cation-induced structure of telomeric DNA: the G-quartet model. Cell (1989) 7.83
Inherited variants of MYH associated with somatic G:C-->T:A mutations in colorectal tumors. Nat Genet (2002) 7.00
Calculating thermodynamic data for transitions of any molecularity from equilibrium melting curves. Biopolymers (1987) 6.96
8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions. J Biol Chem (1992) 6.20
MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis. Nature (1992) 5.54
Radical causes of cancer. Nat Rev Cancer (2003) 5.45
Base-excision repair of oxidative DNA damage. Nature (2007) 5.44
Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH. N Engl J Med (2003) 4.88
Trinucleotide repeats that expand in human disease form hairpin structures in vitro. Cell (1995) 4.35
Runaway telomere elongation caused by telomerase RNA gene mutations. Nature (1995) 4.34
The unusual mutagenic specificity of an E. Coli mutator gene. Proc Natl Acad Sci U S A (1966) 4.26
Oxidative Nucleobase Modifications Leading to Strand Scission. Chem Rev (1998) 4.07
In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei. Proc Natl Acad Sci U S A (2001) 3.97
Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome. Biochemistry (1990) 3.94
Normal human chromosomes have long G-rich telomeric overhangs at one end. Genes Dev (1997) 3.42
Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase eta. Nat Genet (2000) 3.39
DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression. Science (2008) 3.09
Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation. Nat Chem Biol (2006) 3.08
OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells. Nature (2007) 3.03
Chemistry of Glycosylases and Endonucleases Involved in Base-Excision Repair. Chem Rev (1998) 2.93
A repair system for 8-oxo-7,8-dihydrodeoxyguanine. Biochemistry (1992) 2.65
Passing the baton in base excision repair. Nat Struct Biol (2000) 2.65
Mechanisms of formation, genotoxicity, and mutation of guanine oxidation products. Chem Res Toxicol (2006) 2.62
NMR structural studies of the ionizing radiation adduct 7-hydro-8-oxodeoxyguanosine (8-oxo-7H-dG) opposite deoxyadenosine in a DNA duplex. 8-Oxo-7H-dG(syn).dA(anti) alignment at lesion site. Biochemistry (1991) 2.59
mutM, a second mutator locus in Escherichia coli that generates G.C----T.A transversions. J Bacteriol (1988) 2.57
Single-stranded shuttle phagemid for mutagenesis studies in mammalian cells: 8-oxoguanine in DNA induces targeted G.C-->T.A transversions in simian kidney cells. Proc Natl Acad Sci U S A (1993) 2.55
Site-specific mutagenesis using a gapped duplex vector: a study of translesion synthesis past 8-oxodeoxyguanosine in E. coli. Mutat Res (1991) 2.54
Biallelic germline mutations in MYH predispose to multiple colorectal adenoma and somatic G:C-->T:A mutations. Hum Mol Genet (2002) 2.48
Ultraviolet radiation-mediated damage to cellular DNA. Mutat Res (2005) 2.46
Trinucleotide repeats associated with human disease. Nucleic Acids Res (1997) 2.35
X-ray structure of a DNA decamer containing 7,8-dihydro-8-oxoguanine. Proc Natl Acad Sci U S A (1995) 2.30
MutM, a protein that prevents G.C----T.A transversions, is formamidopyrimidine-DNA glycosylase. Nucleic Acids Res (1991) 2.26
Mechanisms for DNA charge transport. Chem Rev (2010) 2.16
Influence of the oxidatively damaged adduct 8-oxodeoxyguanosine on the conformation, energetics, and thermodynamic stability of a DNA duplex. Biochemistry (1995) 2.09
NMR studies of a DNA containing 8-hydroxydeoxyguanosine. Nucleic Acids Res (1991) 2.03
Establishing the background level of base oxidation in human lymphocyte DNA: results of an interlaboratory validation study. FASEB J (2004) 2.01
Crystal structure of a DNA duplex containing 8-hydroxydeoxyguanine-adenine base pairs. Biochemistry (1994) 2.01
The hydantoin lesions formed from oxidation of 7,8-dihydro-8-oxoguanine are potent sources of replication errors in vivo. Biochemistry (2003) 1.92
Oxidative damage to DNA: formation, measurement, and biological significance. Rev Physiol Biochem Pharmacol (1997) 1.91
Stepwise translocation of Dpo4 polymerase during error-free bypass of an oxoG lesion. PLoS Biol (2006) 1.89
Hairpin properties of single-stranded DNA containing a GC-rich triplet repeat: (CTG)15. Nucleic Acids Res (1995) 1.84
Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process. FEBS Lett (2005) 1.82
Mammalian telomeres and telomerase. Curr Opin Cell Biol (2000) 1.70
Assays for determining lesion bypass efficiency and mutagenicity of site-specific DNA lesions in vivo. Methods Enzymol (2006) 1.70
Multistranded DNA structures. Curr Opin Struct Biol (1999) 1.63
Modification of DNA bases in mammalian chromatin by radiation-generated free radicals. Biochemistry (1990) 1.63
Replication-dependent instability at (CTG) x (CAG) repeat hairpins in human cells. Nat Chem Biol (2010) 1.62
In vitro nucleotide misinsertion opposite the oxidized guanosine lesions spiroiminodihydantoin and guanidinohydantoin and DNA synthesis past the lesions using Escherichia coli DNA polymerase I (Klenow fragment). Biochemistry (2002) 1.60
Stability of intrastrand hairpin structures formed by the CAG/CTG class of DNA triplet repeats associated with neurological diseases. Nucleic Acids Res (1996) 1.59
Protection against methylation-induced cytotoxicity by DNA polymerase beta-dependent long patch base excision repair. J Biol Chem (2000) 1.58
DNA damage and repair in telomeres: relation to aging. Proc Natl Acad Sci U S A (1995) 1.56
Genetic effects of oxidative DNA damages: comparative mutagenesis of the imidazole ring-opened formamidopyrimidines (Fapy lesions) and 8-oxo-purines in simian kidney cells. Nucleic Acids Res (2006) 1.51
Oxidation of 7,8-dihydro-8-oxoguanine affords lesions that are potent sources of replication errors in vivo. Biochemistry (2002) 1.48
Oxidation of the sugar moiety of DNA by ionizing radiation or bleomycin could induce the formation of a cluster DNA lesion. Proc Natl Acad Sci U S A (2007) 1.47
DNA damage induced in cells by gamma and UVA radiation as measured by HPLC/GC-MS and HPLC-EC and Comet assay. Chem Res Toxicol (2000) 1.45
Measurement of DNA oxidation in human cells by chromatographic and enzymic methods. Free Radic Biol Med (2003) 1.43
Substrate channeling in mammalian base excision repair pathways: passing the baton. J Biol Chem (2010) 1.43
Analysis of nucleotide insertion and extension at 8-oxo-7,8-dihydroguanine by replicative T7 polymerase exo- and human immunodeficiency virus-1 reverse transcriptase using steady-state and pre-steady-state kinetics. Biochemistry (1997) 1.42
Formation of 13C-, 15N-, and 18O-labeled guanidinohydantoin from guanosine oxidation with singlet oxygen. Implications for structure and mechanism. J Am Chem Soc (2003) 1.42
Oxidative DNA damage associated with combination of guanine and superoxide radicals and repair mechanisms via radical trapping. J Biol Chem (2004) 1.37
Coordination between polymerase beta and FEN1 can modulate CAG repeat expansion. J Biol Chem (2009) 1.37
Nei deficient Escherichia coli are sensitive to chromate and accumulate the oxidized guanine lesion spiroiminodihydantoin. Chem Res Toxicol (2005) 1.37
Removal of hydantoin products of 8-oxoguanine oxidation by the Escherichia coli DNA repair enzyme, FPG. Biochemistry (2000) 1.36
Incorporation and replication of 8-oxo-deoxyguanosine by the human mitochondrial DNA polymerase. J Biol Chem (2006) 1.29
Replication inhibition and miscoding properties of DNA templates containing a site-specific cis-thymine glycol or urea residue. Chem Res Toxicol (1998) 1.29
Insertion of dGMP and dAMP during in vitro DNA synthesis opposite an oxidized form of 7,8-dihydro-8-oxoguanine. Nucleic Acids Res (1999) 1.29
Monomeric base damage products from adenine, guanine, and thymine induced by exposure of DNA to ultraviolet radiation. Biochemistry (1995) 1.28
Redox ribonucleosides. Isolation and characterization of 5-hydroxyuridine, 8-hydroxyguanosine, and 8-hydroxyadenosine from Torula yeast RNA. J Biol Chem (1992) 1.28
Gel electrophoretic detection of 7,8-dihydro-8-oxoguanine and 7, 8-dihydro-8-oxoadenine via oxidation by Ir (IV). Nucleic Acids Res (1998) 1.28
Steady-state and pre-steady-state kinetic analysis of 8-oxo-7,8-dihydroguanosine triphosphate incorporation and extension by replicative and repair DNA polymerases. Biochemistry (1998) 1.26
In vitro DNA synthesis opposite oxazolone and repair of this DNA damage using modified oligonucleotides. Nucleic Acids Res (2000) 1.25
DNA polymerase V allows bypass of toxic guanine oxidation products in vivo. J Biol Chem (2007) 1.25
Steady-state and pre-steady-state kinetic analysis of dNTP insertion opposite 8-oxo-7,8-dihydroguanine by Escherichia coli polymerases I exo- and II exo-. Biochemistry (1996) 1.22
Structure-dependent DNA damage and repair in a trinucleotide repeat sequence. Biochemistry (2009) 1.22
Synthesis and characterization of oligodeoxynucleotides containing formamidopyrimidine lesions and nonhydrolyzable analogues. J Am Chem Soc (2002) 1.20
DNA CTG triplet repeats involved in dynamic mutations of neurologically related gene sequences form stable duplexes. Nucleic Acids Res (1995) 1.20
Peroxynitrite-induced oxidation and nitration products of guanine and 8-oxoguanine: structures and mechanisms of product formation. Nitric Oxide (2005) 1.19
Possible cause of G-C-->C-G transversion mutation by guanine oxidation product, imidazolone. Chem Biol (2001) 1.17
Factors that influence telomeric oxidative base damage and repair by DNA glycosylase OGG1. DNA Repair (Amst) (2010) 1.17
Effect of the oxidized guanosine lesions spiroiminodihydantoin and guanidinohydantoin on proofreading by Escherichia coli DNA polymerase I (Klenow fragment) in different sequence contexts. Biochemistry (2003) 1.17
MutYH (MYH) and colorectal cancer. Biochem Soc Trans (2005) 1.16
Long-patch base excision DNA repair of 2-deoxyribonolactone prevents the formation of DNA-protein cross-links with DNA polymerase beta. J Biol Chem (2005) 1.14
Exposing the MYtH about base excision repair and human inherited disease. Hum Mol Genet (2003) 1.14
Synthesis of 2'-deoxy-7,8-dihydro-8-oxoguanosine and 2'-deoxy-7,8-dihydro-8-oxoadenosine and their incorporation into oligomeric DNA. Chem Res Toxicol (1992) 1.12
Fapy.dG instructs Klenow exo(-) to misincorporate deoxyadenosine. J Am Chem Soc (2002) 1.11
Comparative analysis of baseline 8-oxo-7,8-dihydroguanine in mammalian cell DNA, by different methods in different laboratories: an approach to consensus. Carcinogenesis (2002) 1.10
Germline mutations in the MYH gene in Swedish familial and sporadic colorectal cancer. Genet Test (2005) 1.10
Influence of sequence context and length on the structure and stability of triplet repeat DNA oligomers. Biochemistry (2004) 1.08
Techniques used to study the DNA polymerase reaction pathway. Biochim Biophys Acta (2009) 1.07
Structural and thermodynamic features of spiroiminodihydantoin damaged DNA duplexes. Biochemistry (2005) 1.06
Studies on the replication of the ring opened formamidopyrimidine, Fapy.dG in Escherichia coli. Biochemistry (2007) 1.06
Insight into the roles of tyrosine 82 and glycine 253 in the Escherichia coli adenine glycosylase MutY. Biochemistry (2005) 1.06
Incidence and persistence of 8-oxo-7,8-dihydroguanine within a hairpin intermediate exacerbates a toxic oxidation cycle associated with trinucleotide repeat expansion. DNA Repair (Amst) (2011) 1.04
Spiroiminodihydantoin and guanidinohydantoin are the dominant products of 8-oxoguanosine oxidation at low fluxes of peroxynitrite: mechanistic studies with 18O. Chem Res Toxicol (2004) 1.04
Trinucleotide repeat DNA alters structure to minimize the thermodynamic impact of 8-oxo-7,8-dihydroguanine. Biochemistry (2011) 0.86
Rapid isolation of host-independent Bdellovibrio bacteriovorus. J Microbiol Methods (2008) 0.84
AGG/CCT interruptions affect nucleosome formation and positioning of healthy-length CGG/CCG triplet repeats. BMC Biochem (2013) 0.80