Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer.

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Published in Elife on October 01, 2014

Authors

Young Seok Ju1, Ludmil B Alexandrov1, Moritz Gerstung1, Inigo Martincorena1, Serena Nik-Zainal1, Manasa Ramakrishna1, Helen R Davies1, Elli Papaemmanuil1, Gunes Gundem1, Adam Shlien1, Niccolo Bolli1, Sam Behjati1, Patrick S Tarpey1, Jyoti Nangalia1, Charles E Massie1, Adam P Butler1, Jon W Teague1, George S Vassiliou1, Anthony R Green2, Ming-Qing Du2, Ashwin Unnikrishnan3, John E Pimanda3, Bin Tean Teh4, Nikhil Munshi5, Mel Greaves6, Paresh Vyas7, Adel K El-Naggar8, Tom Santarius2, V Peter Collins2, Richard Grundy9, Jack A Taylor10, D Neil Hayes11, David Malkin12, ICGC Breast Cancer Group, ICGC Chronic Myeloid Disorders Group, ICGC Prostate Cancer Group, Christopher S Foster13, Anne Y Warren2, Hayley C Whitaker14, Daniel Brewer6, Rosalind Eeles6, Colin Cooper6, David Neal14, Tapio Visakorpi15, William B Isaacs16, G Steven Bova15, Adrienne M Flanagan17, P Andrew Futreal1, Andy G Lynch14, Patrick F Chinnery18, Ultan McDermott1, Michael R Stratton1, Peter J Campbell1

Author Affiliations

1: Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom.
2: Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
3: Lowy Cancer Research Centre, University of New South Wales, Sydney, Australia.
4: Laboratory of Cancer Epigenome, National Cancer Centre, Singapore, Singapore.
5: Department of Hematologic Oncology, Dana-Farber Cancer Institute, Boston, United States.
6: Institute of Cancer Research, Sutton, London, United Kingdom.
7: Weatherall Institute for Molecular Medicine, University of Oxford, Oxford, United Kingdom.
8: Department of Pathology, MD Anderson Cancer Center, Houston, United States.
9: Children's Brain Tumour Research Centre, University of Nottingham, Nottingham, United Kingdom.
10: National Institute of Environmental Health Sciences, National Institute of Health, Triangle, North Carolina, United States.
11: Department of Internal Medicine, University of North Carolina, Chapel Hill, United States.
12: Hospital for Sick Children, University of Toronto, Toronto, Canada.
13: Department of Molecular and Clinical Cancer Medicine, University of Liverpool, London, United Kingdom.
14: Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.
15: Institute of Biosciences and Medical Technology - BioMediTech and Fimlab Laboratories, University of Tampere and Tampere University Hospital, Tampere, Finland.
16: Department of Oncology, Johns Hopkins University, Baltimore, United States.
17: Department of Histopathology, Royal National Orthopaedic Hospital, Middlesex, United Kingdom.
18: Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Newcastle-upon-tyne, United Kingdom.

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