Published in Dev Biol on January 13, 2012
Membrane bending by protein-protein crowding. Nat Cell Biol (2012) 2.27
Notch ligand endocytosis generates mechanical pulling force dependent on dynamin, epsins, and actin. Dev Cell (2012) 1.35
Endocytosis and control of Notch signaling. Curr Opin Cell Biol (2012) 1.05
Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits. Elife (2014) 0.94
Ubiquitinations in the notch signaling pathway. Int J Mol Sci (2013) 0.86
Caenorhabditis elegans reveals a FxNPxY-independent low-density lipoprotein receptor internalization mechanism mediated by epsin1. Mol Biol Cell (2012) 0.84
Epsin is required for Dishevelled stability and Wnt signalling activation in colon cancer development. Nat Commun (2015) 0.84
Drosophila Tel2 is expressed as a translational fusion with EpsinR and is a regulator of wingless signaling. PLoS One (2012) 0.78
Mechanism of Notch Pathway Activation and Its Role in the Regulation of Olfactory Plasticity in Drosophila melanogaster. PLoS One (2016) 0.76
Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis. Neuron (1999) 17.62
Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol (2006) 13.12
Curvature of clathrin-coated pits driven by epsin. Nature (2002) 8.03
Pathways of clathrin-independent endocytosis. Nat Rev Mol Cell Biol (2007) 6.48
A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins. Nature (2002) 6.22
Clathrin-independent endocytosis of ubiquitinated cargos. Proc Natl Acad Sci U S A (2005) 5.37
Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis. Nature (1998) 4.24
Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis. Nat Cell Biol (2002) 3.94
Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis. Science (2001) 3.67
Adaptors for clathrin coats: structure and function. Annu Rev Cell Dev Biol (2004) 3.41
A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation systems. Trends Biochem Sci (2001) 3.24
Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. Genes Dev (1997) 3.01
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The Drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates. Cell (1990) 2.83
The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate. Development (1997) 2.79
Neuronal differentiation in Drosophila ommatidium. Dev Biol (1987) 2.70
A structural explanation for the binding of multiple ligands by the alpha-adaptin appendage domain. Cell (1999) 2.65
Double-sided ubiquitin binding of Hrs-UIM in endosomal protein sorting. Nat Struct Mol Biol (2006) 2.47
The roles of receptor and ligand endocytosis in regulating Notch signaling. Development (2005) 2.33
Role of Drosophila alpha-adaptin in presynaptic vesicle recycling. Cell (1997) 2.25
Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch. Development (2004) 2.25
Epsin 1 is a polyubiquitin-selective clathrin-associated sorting protein. Traffic (2006) 2.20
Structure and ubiquitin binding of the ubiquitin-interacting motif. J Biol Chem (2003) 2.19
Yeast epsins contain an essential N-terminal ENTH domain, bind clathrin and are required for endocytosis. EMBO J (1999) 2.18
Frizzled regulation of Notch signalling polarizes cell fate in the Drosophila eye. Nature (1999) 2.09
DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur. J Cell Biol (2007) 2.09
Developmental compartmentalization in the dorsal mesothoracic disc of Drosophila. Dev Biol (1976) 2.06
Molecular basis of oligoubiquitin-dependent internalization of membrane proteins in Mammalian cells. Traffic (2006) 1.96
The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module. J Biol Chem (1999) 1.91
Epsin 1 is a cargo-specific adaptor for the clathrin-mediated endocytosis of the influenza virus. Proc Natl Acad Sci U S A (2008) 1.88
Identification of a novel domain shared by putative components of the endocytic and cytoskeletal machinery. Protein Sci (1999) 1.84
The association of epsin with ubiquitinated cargo along the endocytic pathway is negatively regulated by its interaction with clathrin. Proc Natl Acad Sci U S A (2005) 1.78
Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells. Development (2004) 1.74
Notch signaling--constantly on the move. Traffic (2007) 1.71
Asymmetric Notch activation specifies photoreceptors R3 and R4 and planar polarity in the Drosophila eye. Nature (1999) 1.68
A specific protein substrate for a deubiquitinating enzyme: Liquid facets is the substrate of Fat facets. Genes Dev (2002) 1.66
The yeast Epsin Ent1 is recruited to membranes through multiple independent interactions. J Biol Chem (2003) 1.65
Xenopus neuralized is a ubiquitin ligase that interacts with XDelta1 and regulates Notch signaling. Dev Cell (2001) 1.65
Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development. J Cell Biol (2007) 1.64
Results from high-throughput DNA cloning of Arabidopsis thaliana target genes using site-specific recombination. J Struct Funct Genomics (2005) 1.64
Distinct roles for Mind bomb, Neuralized and Epsin in mediating DSL endocytosis and signaling in Drosophila. Development (2005) 1.63
The function of the Drosophila fat facets deubiquitinating enzyme in limiting photoreceptor cell number is intimately associated with endocytosis. Development (2000) 1.61
The fat facets gene is required for Drosophila eye and embryo development. Development (1992) 1.59
Epsin binds to clathrin by associating directly with the clathrin-terminal domain. Evidence for cooperative binding through two discrete sites. J Biol Chem (2000) 1.57
The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster. Genes Dev (1990) 1.53
The ubiquitin-interacting motifs target the endocytic adaptor protein epsin for ubiquitination. Curr Biol (2002) 1.53
Epsin N-terminal homology domains perform an essential function regulating Cdc42 through binding Cdc42 GTPase-activating proteins. Proc Natl Acad Sci U S A (2006) 1.50
Decoding vectorial information from a gradient: sequential roles of the receptors Frizzled and Notch in establishing planar polarity in the Drosophila eye. Development (1999) 1.48
Functional analysis of Cdc42 in actin filament assembly, epithelial morphogenesis, and cell signaling during Drosophila development. Dev Biol (2000) 1.45
The ENTH domain. FEBS Lett (2002) 1.45
Decoding ubiquitin sorting signals for clathrin-dependent endocytosis by CLASPs. J Cell Sci (2007) 1.44
Analysis of the role of ubiquitin-interacting motifs in ubiquitin binding and ubiquitylation. J Biol Chem (2004) 1.41
Epsin 1 is involved in recruitment of ubiquitinated EGF receptors into clathrin-coated pits. Traffic (2008) 1.39
Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis. EMBO J (2006) 1.39
Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice. Proc Natl Acad Sci U S A (2009) 1.38
Fringe, Notch, and making developmental boundaries. Curr Opin Genet Dev (1999) 1.38
Recognition specificity of individual EH domains of mammals and yeast. EMBO J (1998) 1.36
Either part of a Drosophila epsin protein, divided after the ENTH domain, functions in endocytosis of delta in the developing eye. Curr Biol (2003) 1.33
Dorsal-ventral signaling in limb development. Curr Opin Cell Biol (1997) 1.32
Endocytic internalization routes required for delta/notch signaling. Curr Biol (2010) 1.24
A ubiquitin-interacting motif (UIM) is essential for Eps15 and Eps15R ubiquitination. J Biol Chem (2002) 1.23
The Arp2/3 complex and WASp are required for apical trafficking of Delta into microvilli during cell fate specification of sensory organ precursors. Nat Cell Biol (2009) 1.23
Epsin potentiates Notch pathway activity in Drosophila and C. elegans. Development (2004) 1.16
Endocytosis of membrane receptors: two pathways are better than one. Proc Natl Acad Sci U S A (2005) 1.15
The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity. Proc Natl Acad Sci U S A (2008) 1.13
Drosophila melanogaster auxilin regulates the internalization of Delta to control activity of the Notch signaling pathway. J Cell Biol (2006) 1.12
Notch ligand ubiquitylation: what is it good for? Dev Cell (2011) 1.09
Structure-function analysis of delta trafficking, receptor binding and signaling in Drosophila. Genetics (2006) 1.09
Notch signaling: endocytosis makes delta signal better. Curr Biol (2003) 1.06
Identification of genes that interact with Drosophila liquid facets. Genetics (2006) 0.94
Ubiquitin-interacting motifs of Epsin are involved in the regulation of insulin-dependent endocytosis. J Biochem (2005) 0.94
Homeotic selector genes control the patterning of seven-up expressing cells in the Drosophila dorsal vessel. Mech Dev (2005) 0.93
Auxilin is essential for Delta signaling. Development (2008) 0.93
Drosophila TRAP230/240 are essential coactivators for Atonal in retinal neurogenesis. Dev Biol (2007) 0.93
The clathrin-binding motif and the J-domain of Drosophila Auxilin are essential for facilitating Notch ligand endocytosis. BMC Dev Biol (2008) 0.93
The functions of auxilin and Rab11 in Drosophila suggest that the fundamental role of ligand endocytosis in notch signaling cells is not recycling. PLoS One (2011) 0.93
Drosophila Past1 is involved in endocytosis and is required for germline development and survival of the adult fly. J Cell Sci (2009) 0.89
Interaction of HIV-1 gp41 core with NPF motif in Epsin: implication in endocytosis of HIV. J Biol Chem (2008) 0.89
Notch signaling: Fringe really is a glycosyltransferase. Curr Biol (2000) 0.88
Ubiquitin binding in endocytosis--how tight should it be and where does it happen? Traffic (2006) 0.86
KASH 'n Karry: the KASH domain family of cargo-specific cytoskeletal adaptor proteins. Bioessays (2005) 2.14
The functions of Klarsicht and nuclear lamin in developmentally regulated nuclear migrations of photoreceptor cells in the Drosophila eye. Mol Biol Cell (2003) 1.93
Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells. Development (2004) 1.74
A specific protein substrate for a deubiquitinating enzyme: Liquid facets is the substrate of Fat facets. Genes Dev (2002) 1.66
Drosophila klaroid encodes a SUN domain protein required for Klarsicht localization to the nuclear envelope and nuclear migration in the eye. Fly (Austin) (2009) 1.62
Either part of a Drosophila epsin protein, divided after the ENTH domain, functions in endocytosis of delta in the developing eye. Curr Biol (2003) 1.33
A Drosophila model for Angelman syndrome. Proc Natl Acad Sci U S A (2008) 1.21
Notch ligand ubiquitylation: what is it good for? Dev Cell (2011) 1.09
On the roles of the Drosophila KASH domain proteins Msp-300 and Klarsicht. Fly (Austin) (2008) 0.99
Identification of genes that interact with Drosophila liquid facets. Genetics (2006) 0.94
The Drosophila SUN protein Spag4 cooperates with the coiled-coil protein Yuri Gagarin to maintain association of the basal body and spermatid nucleus. J Cell Sci (2010) 0.93
Auxilin is essential for Delta signaling. Development (2008) 0.93
The functions of auxilin and Rab11 in Drosophila suggest that the fundamental role of ligand endocytosis in notch signaling cells is not recycling. PLoS One (2011) 0.93
Ral GTPase promotes asymmetric Notch activation in the Drosophila eye in response to Frizzled/PCP signaling by repressing ligand-independent receptor activation. Development (2011) 0.88
Identification and characterization of a novel cancer/testis antigen gene CAGE-1. Biochim Biophys Acta (2003) 0.88
Identification of autoantibodies associated with systemic lupus erythematosus. Biochem Biophys Res Commun (2002) 0.86
Drosophila liquid facets-Related encodes Golgi epsin and is an essential gene required for cell proliferation, growth, and patterning. Dev Biol (2009) 0.86
A P element transformation vector for high levels of gene expression in germ-line cells of the ovary and undifferentiated cells in the developing eye of Drosophila. Plasmid (2002) 0.78
Drosophila Tel2 is expressed as a translational fusion with EpsinR and is a regulator of wingless signaling. PLoS One (2012) 0.78
Ral inhibits ligand-independent Notch signaling in Drosophila. Small GTPases (2012) 0.76