Published in Development on October 06, 2004
Tickets to ride: selecting cargo for clathrin-regulated internalization. Nat Rev Mol Cell Biol (2009) 3.98
Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling. Cell (2008) 3.09
The many facets of Notch ligands. Oncogene (2008) 2.57
Endosomal entry regulates Notch receptor activation in Drosophila melanogaster. J Cell Biol (2008) 2.32
Exploring systemic RNA interference in insects: a genome-wide survey for RNAi genes in Tribolium. Genome Biol (2008) 2.25
Numb regulates post-endocytic trafficking and degradation of Notch1. J Biol Chem (2009) 1.89
Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling. J Clin Invest (2012) 1.87
Differential stability of flamingo protein complexes underlies the establishment of planar polarity. Curr Biol (2008) 1.78
The association of epsin with ubiquitinated cargo along the endocytic pathway is negatively regulated by its interaction with clathrin. Proc Natl Acad Sci U S A (2005) 1.78
Notch signaling at a glance. J Cell Sci (2013) 1.76
The molecular logic of Notch signaling--a structural and biochemical perspective. J Cell Sci (2008) 1.65
Regulated trafficking of the MSP/Eph receptor during oocyte meiotic maturation in C. elegans. Curr Biol (2008) 1.64
Canonical and non-canonical Notch ligands. Curr Top Dev Biol (2010) 1.62
Endocytosis and signaling: cell logistics shape the eukaryotic cell plan. Physiol Rev (2012) 1.61
Endocytic regulation of Notch signaling. Curr Opin Genet Dev (2009) 1.59
Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila. PLoS Biol (2005) 1.43
Regulation of the epithelial sodium channel by membrane trafficking. Am J Physiol Renal Physiol (2008) 1.41
Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis. EMBO J (2006) 1.39
Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice. Proc Natl Acad Sci U S A (2009) 1.38
Notch ligand endocytosis generates mechanical pulling force dependent on dynamin, epsins, and actin. Dev Cell (2012) 1.35
Ero1L, a thiol oxidase, is required for Notch signaling through cysteine bridge formation of the Lin12-Notch repeats in Drosophila melanogaster. J Cell Biol (2008) 1.32
Why is delta endocytosis required for effective activation of notch? Dev Dyn (2006) 1.27
Endocytic internalization routes required for delta/notch signaling. Curr Biol (2010) 1.24
The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila. BMC Dev Biol (2008) 1.24
The Arp2/3 complex and WASp are required for apical trafficking of Delta into microvilli during cell fate specification of sensory organ precursors. Nat Cell Biol (2009) 1.23
Riding the DUBway: regulation of protein trafficking by deubiquitylating enzymes. J Cell Biol (2006) 1.22
Notch ligand endocytosis: mechanistic basis of signaling activity. Semin Cell Dev Biol (2012) 1.14
The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity. Proc Natl Acad Sci U S A (2008) 1.13
Drosophila melanogaster auxilin regulates the internalization of Delta to control activity of the Notch signaling pathway. J Cell Biol (2006) 1.12
ADAM proteases: ligand processing and modulation of the Notch pathway. Cell Mol Life Sci (2008) 1.12
Crumbs is required to achieve proper organ size control during Drosophila head development. Development (2010) 1.10
Notch ligand ubiquitylation: what is it good for? Dev Cell (2011) 1.09
Structure-function analysis of delta trafficking, receptor binding and signaling in Drosophila. Genetics (2006) 1.09
USP9X enhances the polarity and self-renewal of embryonic stem cell-derived neural progenitors. Mol Biol Cell (2009) 1.08
Genome-wide expression profiling in the Drosophila eye reveals unexpected repression of notch signaling by the JAK/STAT pathway. Dev Dyn (2009) 1.06
Optical tweezers studies on Notch: single-molecule interaction strength is independent of ligand endocytosis. Dev Cell (2012) 1.06
Structural requirements for PACSIN/Syndapin operation during zebrafish embryonic notochord development. PLoS One (2009) 1.05
Endocytosis and control of Notch signaling. Curr Opin Cell Biol (2012) 1.05
Single-cell gene expression profiling reveals functional heterogeneity of undifferentiated human epidermal cells. Development (2013) 1.04
Neuralized promotes basal to apical transcytosis of delta in epithelial cells. Mol Biol Cell (2010) 1.03
Kuz and TACE can activate Notch independent of ligand. Cell Mol Life Sci (2008) 1.03
Epigenetic regulation of stem cell maintenance in the Drosophila testis via the nucleosome-remodeling factor NURF. Cell Stem Cell (2010) 1.00
Multiple O-glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling. Development (2011) 1.00
Competition between Delta and the Abruptex domain of Notch. BMC Dev Biol (2008) 0.99
Presenilin-based genetic screens in Drosophila melanogaster identify novel notch pathway modifiers. Genetics (2006) 0.99
Endogenously tagged rab proteins: a resource to study membrane trafficking in Drosophila. Dev Cell (2015) 0.99
Regulation of membrane localization of Sanpodo by lethal giant larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organs. Mol Biol Cell (2005) 0.98
Notch signaling and Notch signaling modifiers. Int J Biochem Cell Biol (2011) 0.97
Regulation of Commissureless by the ubiquitin ligase DNedd4 is required for neuromuscular synaptogenesis in Drosophila melanogaster. Mol Cell Biol (2006) 0.97
Role of glycans and glycosyltransferases in the regulation of Notch signaling. Glycobiology (2010) 0.97
Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organs. Nat Cell Biol (2015) 0.97
Regulation of Notch and Wingless signalling by phyllopod, a transcriptional target of the EGFR pathway. EMBO J (2009) 0.95
γ-secretase-dependent cleavage initiates notch signaling from the plasma membrane. Traffic (2010) 0.95
Identification of genes that interact with Drosophila liquid facets. Genetics (2006) 0.94
New positive regulators of lin-12 activity in Caenorhabditis elegans include the BRE-5/Brainiac glycosphingolipid biosynthesis enzyme. Genetics (2005) 0.94
Sanpodo: a context-dependent activator and inhibitor of Notch signaling during asymmetric divisions. Development (2009) 0.94
The intracellular region of Notch ligands: does the tail make the difference? Biol Direct (2007) 0.93
The epsin family of endocytic adaptors promotes fibrosarcoma migration and invasion. J Biol Chem (2010) 0.93
The functions of auxilin and Rab11 in Drosophila suggest that the fundamental role of ligand endocytosis in notch signaling cells is not recycling. PLoS One (2011) 0.93
The clathrin-binding motif and the J-domain of Drosophila Auxilin are essential for facilitating Notch ligand endocytosis. BMC Dev Biol (2008) 0.93
Distinct intracellular motifs of Delta mediate its ubiquitylation and activation by Mindbomb1 and Neuralized. J Cell Biol (2011) 0.93
La FAM fatale: USP9X in development and disease. Cell Mol Life Sci (2015) 0.92
An extracellular region of Serrate is essential for ligand-induced cis-inhibition of Notch signaling. Development (2013) 0.92
The NHR1 domain of Neuralized binds Delta and mediates Delta trafficking and Notch signaling. Mol Biol Cell (2006) 0.91
Ubiquitin-dependent endocytosis, trafficking and turnover of neuronal membrane proteins. Mol Cell Neurosci (2011) 0.89
dEHBP1 controls exocytosis and recycling of Delta during asymmetric divisions. J Cell Biol (2012) 0.88
Ral GTPase promotes asymmetric Notch activation in the Drosophila eye in response to Frizzled/PCP signaling by repressing ligand-independent receptor activation. Development (2011) 0.88
Epsins' novel role in cancer cell invasion. Commun Integr Biol (2011) 0.87
Endocytosis and signaling during development. Cold Spring Harb Perspect Biol (2014) 0.87
Force-induced unfolding simulations of the human Notch1 negative regulatory region: possible roles of the heterodimerization domain in mechanosensing. PLoS One (2011) 0.87
Delta activity independent of its activity as a ligand of Notch. BMC Dev Biol (2005) 0.86
Ubiquitinations in the notch signaling pathway. Int J Mol Sci (2013) 0.86
The cell giveth and the cell taketh away: an overview of Notch pathway activation by endocytic trafficking of ligands and receptors. Acta Histochem (2010) 0.86
The role of Adams in Notch signaling. Adv Exp Med Biol (2012) 0.86
Drosophila liquid facets-Related encodes Golgi epsin and is an essential gene required for cell proliferation, growth, and patterning. Dev Biol (2009) 0.86
The epsin protein family: coordinators of endocytosis and signaling. Biomol Concepts (2012) 0.85
A mutational analysis of the endophilin-A N-BAR domain performed in living flies. PLoS One (2010) 0.84
Caenorhabditis elegans reveals a FxNPxY-independent low-density lipoprotein receptor internalization mechanism mediated by epsin1. Mol Biol Cell (2012) 0.84
C. elegans as a model for membrane traffic. WormBook (2014) 0.84
Both inhibition and activation of Notch signaling rely on a conserved Neuralized-binding motif in Bearded proteins and the Notch ligand Delta. Dev Biol (2009) 0.84
Epsin is required for Dishevelled stability and Wnt signalling activation in colon cancer development. Nat Commun (2015) 0.84
Loss of PTB or negative regulation of Notch mRNA reveals distinct zones of Notch and actin protein accumulation in Drosophila embryo. PLoS One (2011) 0.83
Tools and methods for studying Notch signaling in Drosophila melanogaster. Methods (2014) 0.82
Notch is required in adult Drosophila sensory neurons for morphological and functional plasticity of the olfactory circuit. PLoS Genet (2015) 0.81
Disruption of zebrafish cyclin G-associated kinase (GAK) function impairs the expression of Notch-dependent genes during neurogenesis and causes defects in neuronal development. BMC Dev Biol (2010) 0.81
Delta-like 1-Lysine613 regulates notch signaling. Biochim Biophys Acta (2011) 0.81
Notch and delta mRNAs in early-stage and mid-stage drosophila embryos exhibit complementary patterns of protein-producing potentials. Dev Dyn (2010) 0.81
O-fucose monosaccharide of Drosophila Notch has a temperature-sensitive function and cooperates with O-glucose glycan in Notch transport and Notch signaling activation. J Biol Chem (2014) 0.81
Interaction of Notch signaling modulator Numb with α-Adaptin regulates endocytosis of Notch pathway components and cell fate determination of neural stem cells. J Biol Chem (2012) 0.80
Intracellular trafficking in Drosophila visual system development: a basis for pattern formation through simple mechanisms. Dev Neurobiol (2011) 0.80
Steroid signaling promotes stem cell maintenance in the Drosophila testis. Dev Biol (2014) 0.79
Epsin 1 Promotes Synaptic Growth by Enhancing BMP Signal Levels in Motoneuron Nuclei. PLoS One (2013) 0.79
Drosophila Tel2 is expressed as a translational fusion with EpsinR and is a regulator of wingless signaling. PLoS One (2012) 0.78
Cellular stress induces TRB3/USP9x-dependent Notch activation in cancer. Oncogene (2016) 0.77
The endocytic adaptor Eps15 controls marginal zone B cell numbers. PLoS One (2012) 0.77
Transcriptome analysis of the zebrafish mind bomb mutant. Mol Genet Genomics (2008) 0.77
Mechanism of Notch Pathway Activation and Its Role in the Regulation of Olfactory Plasticity in Drosophila melanogaster. PLoS One (2016) 0.76
Ral inhibits ligand-independent Notch signaling in Drosophila. Small GTPases (2012) 0.76
Functional analysis of the NHR2 domain indicates that oligomerization of Neuralized regulates ubiquitination and endocytosis of Delta during Notch signaling. Mol Cell Biol (2012) 0.75
Planar cell polarity: one or two pathways? Nat Rev Genet (2007) 2.90
Two separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity. Development (2006) 2.50
A feed-forward circuit linking wingless, fat-dachsous signaling, and the warts-hippo pathway to Drosophila wing growth. PLoS Biol (2010) 2.08
Cell interactions and planar polarity in the abdominal epidermis of Drosophila. Development (2004) 1.95
Developmental compartments and planar polarity in Drosophila. Curr Biol (2002) 1.83
Distinct roles for Mind bomb, Neuralized and Epsin in mediating DSL endocytosis and signaling in Drosophila. Development (2005) 1.63
Towards a model of the organisation of planar polarity and pattern in the Drosophila abdomen. Development (2002) 1.55
Reading the Hedgehog morphogen gradient by measuring the ratio of bound to unbound Patched protein. Nature (2004) 1.31
Recruitment of cells into the Drosophila wing primordium by a feed-forward circuit of vestigial autoregulation. Development (2007) 1.30
Retracted Evidence that Armadillo transduces wingless by mediating nuclear export or cytosolic activation of Pangolin. Cell (2002) 1.29
Planar cell polarity: A bridge too far? Curr Biol (2008) 1.17
Evidence that the cysteine-rich domain of Drosophila Frizzled family receptors is dispensable for transducing Wingless. Proc Natl Acad Sci U S A (2004) 1.14
Do the protocadherins Fat and Dachsous link up to determine both planar cell polarity and the dimensions of organs? Nat Cell Biol (2008) 1.13
Subdivision of the Drosophila wing imaginal disc by EGFR-mediated signaling. Development (2002) 1.12
Dpp signaling and the induction of neoplastic tumors by caspase-inhibited apoptotic cells in Drosophila. Proc Natl Acad Sci U S A (2005) 1.03
Control of growth and patterning of the Drosophila wing imaginal disc by EGFR-mediated signaling. Development (2002) 1.03
Control of Drosophila wing growth by the vestigial quadrant enhancer. Development (2007) 1.02
Three distinct roles for notch in Drosophila R7 photoreceptor specification. PLoS Biol (2011) 0.96
DSL-Notch signaling in the Drosophila brain in response to olfactory stimulation. Neuron (2011) 0.95
Evidence that Armadillo transduces wingless by mediating nuclear export or cytosolic activation of Pangolin. Cell (2004) 0.75