Published in Nat Rev Mol Cell Biol on September 01, 2006
Regulation of LncRNA For Breg in Patients With Thymoma and Autoimmune Diseases | NCT02948855
The canonical Notch signaling pathway: unfolding the activation mechanism. Cell (2009) 14.72
Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen. J Exp Med (2007) 5.09
An Oct4-centered protein interaction network in embryonic stem cells. Cell Stem Cell (2010) 5.00
Direct inhibition of the NOTCH transcription factor complex. Nature (2009) 4.82
Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease. Nat Med (2012) 3.96
Tissue damage-induced intestinal stem cell division in Drosophila. Cell Stem Cell (2009) 3.43
Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity (2007) 3.19
Cis-interactions between Notch and Delta generate mutually exclusive signalling states. Nature (2010) 3.06
Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing. Nat Cell Biol (2008) 2.93
Dimorphic effects of Notch signaling in bone homeostasis. Nat Med (2008) 2.82
The Notch signalling system: recent insights into the complexity of a conserved pathway. Nat Rev Genet (2012) 2.77
Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways. Immunity (2008) 2.62
Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine. Immunity (2011) 2.61
Notch-responsive cells initiate the secondary transition in larval zebrafish pancreas. Mech Dev (2009) 2.57
The many facets of Notch ligands. Oncogene (2008) 2.57
Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development. Proc Natl Acad Sci U S A (2008) 2.55
Building muscle: molecular regulation of myogenesis. Cold Spring Harb Perspect Biol (2012) 2.52
Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors. Nucleic Acids Res (2007) 2.51
The mammalian ovary from genesis to revelation. Endocr Rev (2009) 2.31
Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex. Neuron (2008) 2.31
Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus. Proc Natl Acad Sci U S A (2007) 2.31
Notch tumor suppressor function. Oncogene (2008) 2.26
Lentiviral transduction of mammary stem cells for analysis of gene function during development and cancer. Cell Stem Cell (2008) 2.24
Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases. Blood (2008) 2.24
Notch1 regulates the fate of cardiac progenitor cells. Proc Natl Acad Sci U S A (2008) 2.22
Notch activation stimulates transient and selective binding of Su(H)/CSL to target enhancers. Genes Dev (2007) 2.19
NOTCH3 expression is induced in mural cells through an autoregulatory loop that requires endothelial-expressed JAGGED1. Circ Res (2009) 2.15
Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors. Cell (2016) 2.15
Ex vivo expansion of human hematopoietic stem and progenitor cells. Blood (2011) 2.12
Spatial organization of transmembrane receptor signalling. EMBO J (2010) 2.03
Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion. Blood (2007) 2.01
Epidermal Notch signalling: differentiation, cancer and adhesion. Curr Opin Cell Biol (2008) 1.99
Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling. Mol Cell Biol (2009) 1.97
cis-Inhibition of Notch by endogenous Delta biases the outcome of lateral inhibition. Curr Biol (2009) 1.93
Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity. Nat Neurosci (2009) 1.93
Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways. Proc Natl Acad Sci U S A (2008) 1.93
Numb regulates post-endocytic trafficking and degradation of Notch1. J Biol Chem (2009) 1.89
Signaling mechanisms controlling cell fate and embryonic patterning. Cold Spring Harb Perspect Biol (2012) 1.89
Emerging role of Notch in stem cells and cancer. Cancer Lett (2008) 1.88
EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer. Nat Cell Biol (2008) 1.88
Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T. Proc Natl Acad Sci U S A (2007) 1.87
A Notch updated. J Cell Biol (2009) 1.86
NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer. Cancer Res (2010) 1.85
TNF primes endothelial cells for angiogenic sprouting by inducing a tip cell phenotype. Blood (2008) 1.83
A role for the primary cilium in Notch signaling and epidermal differentiation during skin development. Cell (2011) 1.83
Tumor and host factors that may limit efficacy of chemotherapy in non-small cell and small cell lung cancer. Crit Rev Oncol Hematol (2010) 1.82
Conformational locking upon cooperative assembly of notch transcription complexes. Structure (2012) 1.79
Crosstalk of Notch with p53 and p63 in cancer growth control. Nat Rev Cancer (2009) 1.79
The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation. PLoS Biol (2010) 1.77
PAR-1 phosphorylates Mind bomb to promote vertebrate neurogenesis. Dev Cell (2009) 1.76
Notch signaling at a glance. J Cell Sci (2013) 1.76
Apoptosis and the target genes of microRNA-21. Chin J Cancer (2011) 1.74
Distinct TCR signaling pathways drive proliferation and cytokine production in T cells. Nat Immunol (2013) 1.74
Eloquent silence: developmental functions of Class I histone deacetylases. Curr Opin Genet Dev (2008) 1.74
Targeting breast cancer stem cells. Mol Oncol (2010) 1.72
Roles of Pofut1 and O-fucose in mammalian Notch signaling. J Biol Chem (2008) 1.71
The association of Notch2 and NF-kappaB accelerates RANKL-induced osteoclastogenesis. Mol Cell Biol (2008) 1.70
From fly wings to targeted cancer therapies: a centennial for notch signaling. Cancer Cell (2014) 1.70
Not(ch) just development: Notch signalling in the adult brain. Nat Rev Neurosci (2011) 1.69
Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL. Blood (2008) 1.69
Role of A-type lamins in signaling, transcription, and chromatin organization. J Cell Biol (2009) 1.68
The molecular logic of Notch signaling--a structural and biochemical perspective. J Cell Sci (2008) 1.65
Vascular niche factor PEDF modulates Notch-dependent stemness in the adult subependymal zone. Nat Neurosci (2009) 1.64
Notch signaling and morphogenesis of single-cell tubes in the C. elegans digestive tract. Dev Cell (2008) 1.64
Evidence for increased exposure of the Notch1 metalloprotease cleavage site upon conversion to an activated conformation. Structure (2011) 1.64
Canonical and non-canonical Notch ligands. Curr Top Dev Biol (2010) 1.62
Notch signaling in the vasculature. Curr Top Dev Biol (2010) 1.62
The different faces of Notch in T-helper-cell differentiation. Nat Rev Immunol (2009) 1.61
Experimental selection of hypoxia-tolerant Drosophila melanogaster. Proc Natl Acad Sci U S A (2011) 1.60
Notch signaling activation in human embryonic stem cells is required for embryonic, but not trophoblastic, lineage commitment. Cell Stem Cell (2008) 1.60
Endocytic regulation of Notch signaling. Curr Opin Genet Dev (2009) 1.59
Targeting Notch signaling pathway to overcome drug resistance for cancer therapy. Biochim Biophys Acta (2010) 1.59
Notch signaling regulates bile duct morphogenesis in mice. PLoS One (2008) 1.59
Regulation of innate and adaptive immunity by Notch. Nat Rev Immunol (2013) 1.58
Hindsight mediates the role of notch in suppressing hedgehog signaling and cell proliferation. Dev Cell (2007) 1.58
Notch signaling specifies megakaryocyte development from hematopoietic stem cells. Cell Stem Cell (2008) 1.58
Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice. J Clin Invest (2011) 1.58
Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity. Nat Med (2014) 1.57
Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2. PLoS One (2009) 1.57
Down-regulation of the notch pathway in human airway epithelium in association with smoking and chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2008) 1.57
A gp130-Src-YAP module links inflammation to epithelial regeneration. Nature (2015) 1.56
GSK-3 as potential target for therapeutic intervention in cancer. Oncotarget (2014) 1.56
Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition. PLoS One (2008) 1.56
Notch signaling contributes to the pathogenesis of human osteosarcomas. Hum Mol Genet (2009) 1.56
Different levels of Notch signaling regulate quiescence, renewal and differentiation in pancreatic endocrine progenitors. Development (2012) 1.55
How are T(H)1 and T(H)2 effector cells made? Curr Opin Immunol (2009) 1.54
In search of adrenocortical stem and progenitor cells. Endocr Rev (2009) 1.51
Heterozygous Loss-of-Function Mutations in DLL4 Cause Adams-Oliver Syndrome. Am J Hum Genet (2015) 1.50
Role of Notch and its oncogenic signaling crosstalk in breast cancer. Biochim Biophys Acta (2010) 1.50
Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation. Nat Cell Biol (2016) 1.49
Immune mechanisms in medium and large-vessel vasculitis. Nat Rev Rheumatol (2013) 1.48
Transcriptional control of stem cell maintenance in the Drosophila intestine. Development (2010) 1.48
Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11. PLoS Biol (2014) 1.48
Targeting epigenetic regulation of miR-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells. PLoS One (2011) 1.48
Notch and disease: a growing field. Semin Cell Dev Biol (2012) 1.48
A functional Notch-survivin gene signature in basal breast cancer. Breast Cancer Res (2008) 1.46
RAM-induced allostery facilitates assembly of a notch pathway active transcription complex. J Biol Chem (2008) 1.45
Pathogenic stimulation of intestinal stem cell response in Drosophila. J Cell Physiol (2009) 1.45
The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer. Nat Cell Biol (2009) 1.44
Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex. Genes Dev (2010) 1.44