Tools for GPCR drug discovery.

Emerging targets in cancer management: role of the CXCL12/CXCR4 axis. Onco Targets Ther (2013) 1.44

Structure-Activity Relationship Studies of N- and C-Terminally Modified Secretin Analogs for the Human Secretin Receptor. PLoS One (2016) 1.39

Identification of Novel G Protein-Coupled Receptor 143 Ligands as Pharmacologic Tools for Investigating X-Linked Ocular Albinism. Invest Ophthalmol Vis Sci (2017) 0.97

Identifying ligands at orphan GPCRs: current status using structure-based approaches. Br J Pharmacol (2016) 0.90

Large-scale polymorphism discovery in macaque G-protein coupled receptors. BMC Genomics (2013) 0.84

Multiplex single-molecule interaction profiling of DNA-barcoded proteins. Nature (2014) 0.83

Localized Surface Plasmon Resonance Biosensing: Current Challenges and Approaches. Sensors (Basel) (2015) 0.81

The stem cell-expressed receptor Lgr5 possesses canonical and functionally active molecular determinants critical to β-arrestin-2 recruitment. PLoS One (2013) 0.81

A rapid and affordable screening platform for membrane protein trafficking. BMC Biol (2015) 0.80

CB2 cannabinoid receptor agonist enantiomers HU-433 and HU-308: An inverse relationship between binding affinity and biological potency. Proc Natl Acad Sci U S A (2015) 0.79

Fluorescence anisotropy (polarization): from drug screening to precision medicine. Expert Opin Drug Discov (2015) 0.79

17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(4'-pyridylcarboxamido)morphinan (NAP) Modulating the Mu Opioid Receptor in a Biased Fashion. ACS Chem Neurosci (2016) 0.78

Differential Phosphorylation Provides a Switch to Control How α-Arrestin Rod1 Down-regulates Mating Pheromone Response in Saccharomyces cerevisiae. Genetics (2016) 0.78

A new era for GPCR research: structures, biology and drug discovery. Acta Pharmacol Sin (2012) 0.78

Pancreatic polypeptide is recognized by two hydrophobic domains of the human Y4 receptor binding pocket. J Biol Chem (2013) 0.78

Understanding cadherin EGF LAG seven-pass G-type receptors. J Neurochem (2014) 0.77

Intercellular Lipid Mediators and GPCR Drug Discovery. Biomol Ther (Seoul) (2013) 0.77

Using Bioluminescence Resonance Energy Transfer (BRET) to Characterize Agonist-Induced Arrestin Recruitment to Modified and Unmodified G Protein-Coupled Receptors. Curr Protoc Pharmacol (2015) 0.76

Small Molecule Inhibited Parathyroid Hormone Mediated cAMP Response by N-Terminal Peptide Binding. Sci Rep (2016) 0.76

Somatostatin receptor type 2 contributes to the self-renewal of murine embryonic stem cells. Acta Pharmacol Sin (2014) 0.76

Dynamic mass redistribution reveals diverging importance of PDZ-ligands for G protein-coupled receptor pharmacodynamics. Pharmacol Res (2016) 0.76

Isothermal chemical denaturation to determine binding affinity of small molecules to G-protein coupled receptors. Anal Biochem (2014) 0.76

Intensity interrogation near cutoff resonance for label-free cellular profiling. Sci Rep (2016) 0.76

Epigenetic assays for chemical biology and drug discovery. Clin Epigenetics (2017) 0.75

Analysis of Chemokine Receptor Trafficking by Site-Specific Biotinylation. PLoS One (2016) 0.75

Characterization of 12 GnRH peptide agonists - a kinetic perspective. Br J Pharmacol (2015) 0.75

Discovery of Small-Molecule Modulators of the Human Y4 Receptor. PLoS One (2016) 0.75

Dynamic monitoring of Gi/o-protein-mediated decreases of intracellular cAMP by FRET-based Epac sensors. Pflugers Arch (2017) 0.75

The differential effects of low and high doses of apelin through opioid receptors on the blood pressure of rats with renovascular hypertension. Hypertens Res (2017) 0.75

Crystal structure of rhodopsin: A G protein-coupled receptor. Science (2000) 28.60

Inositol trisphosphate and calcium signalling. Nature (1993) 25.57

The GTPase superfamily: conserved structure and molecular mechanism. Nature (1991) 19.64

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor. Nature (2007) 14.06

Crystal structure of the β2 adrenergic receptor-Gs protein complex. Nature (2011) 13.92

The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist. Science (2008) 11.74

Seven-transmembrane receptors. Nat Rev Mol Cell Biol (2002) 11.50

Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science (2010) 10.30

The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Mol Pharmacol (2003) 9.99

Transduction of receptor signals by beta-arrestins. Science (2005) 9.87

Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nat Med (2004) 6.16

Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist. Science (2010) 5.86

The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals. J Cell Sci (2002) 5.04

Beta-arrestin-biased ligands at seven-transmembrane receptors. Trends Pharmacol Sci (2007) 4.35

Micromotion of mammalian cells measured electrically. Proc Natl Acad Sci U S A (1991) 3.51

Structure of the human histamine H1 receptor complex with doxepin. Nature (2011) 3.48

The genetic design of signaling cascades to record receptor activation. Proc Natl Acad Sci U S A (2007) 3.11

Electrical method for detection of endothelial cell shape change in real time: assessment of endothelial barrier function. Proc Natl Acad Sci U S A (1992) 3.00

Bioluminescent assays for high-throughput screening. Assay Drug Dev Technol (2007) 2.90

Monitoring fibroblast behavior in tissue culture with an applied electric field. Proc Natl Acad Sci U S A (1984) 2.89

Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization. Nat Methods (2008) 2.88

Drug design strategies for targeting G-protein-coupled receptors. Chembiochem (2002) 2.86

High content screening: seeing is believing. Trends Biotechnol (2010) 2.63

A morphological biosensor for mammalian cells. Nature (1993) 2.57

Real-time monitoring of morphological changes in living cells by electronic cell sensor arrays: an approach to study G protein-coupled receptors. Anal Chem (2006) 2.32

Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1. J Biol Chem (2005) 2.09

Discovery of new GPCR biology: one receptor structure at a time. Structure (2009) 2.08

FRET imaging reveals that functional neurokinin-1 receptors are monomeric and reside in membrane microdomains of live cells. Proc Natl Acad Sci U S A (2006) 2.04

Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay. J Biol Chem (2009) 1.91

Efficacy at G-protein-coupled receptors. Nat Rev Drug Discov (2002) 1.76

Redistribution of GABAB(1) protein and atypical GABAB responses in GABAB(2)-deficient mice. J Neurosci (2004) 1.66

Highly sensitive fluorescence detection technology currently available for HTS. Drug Discov Today (2003) 1.62

High-throughput screening of G protein-coupled receptor antagonists using a bioluminescence resonance energy transfer 1-based beta-arrestin2 recruitment assay. J Biomol Screen (2005) 1.61

The [35S]GTPgammaS binding assay: approaches and applications in pharmacology. Life Sci (2003) 1.47

HTRF: A technology tailored for drug discovery - a review of theoretical aspects and recent applications. Curr Chem Genomics (2009) 1.39

Receptor heteromerization and drug discovery. Trends Pharmacol Sci (2010) 1.37

Label-free cell-based assays with optical biosensors in drug discovery. Assay Drug Dev Technol (2006) 1.35

Radioreceptor assay of adrenocorticotropic hormone: new approach to assay of polypeptide hormones in plasma. Science (1970) 1.35

Exploring a role for heteromerization in GPCR signalling specificity. Biochem J (2011) 1.31

Radioligand binding methods: practical guide and tips. Am J Physiol (1993) 1.29

Fluorophore-tagged GPCR ligands. Curr Opin Chem Biol (2005) 1.29

Non-invasive optical biosensor for assaying endogenous G protein-coupled receptors in adherent cells. J Pharmacol Toxicol Methods (2006) 1.25

Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptors. Curr Pharm Des (2010) 1.20

Comparing label-free biosensors for pharmacological screening with cell-based functional assays. Assay Drug Dev Technol (2010) 1.20

Principles: extending the utility of [35S]GTP gamma S binding assays. Trends Pharmacol Sci (2003) 1.20

High throughput screening technologies for direct cyclic AMP measurement. Assay Drug Dev Technol (2003) 1.19

cAMP detection methods in HTS: selecting the best from the rest. Nat Rev Drug Discov (2004) 1.18

AT1R-CB₁R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II. EMBO J (2011) 1.18

The BRET2/arrestin assay in stable recombinant cells: a platform to screen for compounds that interact with G protein-coupled receptors (GPCRS). J Recept Signal Transduct Res (2002) 1.17

Scintillation proximity assays in high-throughput screening. Assay Drug Dev Technol (2008) 1.13

Label-free whole-cell assays: expanding the scope of GPCR screening. Drug Discov Today (2010) 1.12

Optical biosensor provides insights for bradykinin B(2) receptor signaling in A431 cells. FEBS Lett (2005) 1.10

Dynamic and label-free monitoring of natural killer cell cytotoxic activity using electronic cell sensor arrays. J Immunol Methods (2006) 1.08

Evaluation of cellular dielectric spectroscopy, a whole-cell, label-free technology for drug discovery on Gi-coupled GPCRs. J Biomol Screen (2007) 1.06

The cellular distribution of fluorescently labeled arrestins provides a robust, sensitive, and universal assay for screening G protein-coupled receptors. Assay Drug Dev Technol (2002) 1.06

A homogeneous enzyme fragment complementation-based beta-arrestin translocation assay for high-throughput screening of G-protein-coupled receptors. J Biomol Screen (2008) 1.06

Luciferase Reporter Assay System for Deciphering GPCR Pathways. Curr Chem Genomics (2010) 1.05

Probing cytoskeleton modulation by optical biosensors. FEBS Lett (2005) 1.01

Application of laser-scanning fluorescence microplate cytometry in high content screening. Assay Drug Dev Technol (2006) 1.00

Comparison on functional assays for Gq-coupled GPCRs by measuring inositol monophospate-1 and intracellular calcium in 1536-well plate format. Curr Chem Genomics (2008) 0.99

Cellular dielectric spectroscopy: a powerful new approach to label-free cellular analysis. J Biomol Screen (2004) 0.95

Duplexed label-free G protein--coupled receptor assays for high-throughput screening. J Biomol Screen (2008) 0.93

Evaluation of dynamic mass redistribution technology for pharmacological studies of recombinant and endogenously expressed g protein-coupled receptors. Assay Drug Dev Technol (2008) 0.92

Cellular dielectric spectroscopy: a label-free comprehensive platform for functional evaluation of endogenous receptors. Assay Drug Dev Technol (2006) 0.92

A 100K well screen for a muscarinic receptor using the Epic label-free system--a reflection on the benefits of the label-free approach to screening seven-transmembrane receptors. J Recept Signal Transduct Res (2009) 0.91

Improved donor/acceptor BRET couples for monitoring beta-arrestin recruitment to G protein-coupled receptors. Biotechnol J (2009) 0.91

G Protein-Coupled Receptors: target-based in silico screening. Curr Pharm Des (2009) 0.90

A homogeneous fluorescent live-cell assay for measuring 7-transmembrane receptor activity and agonist functional selectivity through beta-arrestin recruitment. J Biomol Screen (2009) 0.90

Using quantitative BRET to assess G protein-coupled receptor homo- and heterodimerization. Methods Mol Biol (2011) 0.90

Evaluation of FLIPR Calcium 3 Assay Kit--a new no-wash fluorescence calcium indicator reagent. J Biomol Screen (2003) 0.89

Muscarinic receptor-mediated GTP-Eu binding in the hippocampus and prefrontal cortex is correlated with spatial memory impairment in aged rats. Neurobiol Aging (2006) 0.89

Using a radioalloster to test predictions of the cooperativity model for gallamine binding to the allosteric site of muscarinic acetylcholine M(2) receptors. Mol Pharmacol (1999) 0.88

A 1536-well cAMP assay for Gs- and Gi-coupled receptors using enzyme fragmentation complementation. Assay Drug Dev Technol (2004) 0.88

A time-resolved fluorescent lanthanide (Eu)-GTP binding assay for chemokine receptors as targets in drug discovery. Methods Mol Biol (2009) 0.87

Screening G protein-coupled receptors: measurement of intracellular calcium using the fluorometric imaging plate reader. Methods Mol Biol (2009) 0.87

Nonradioactive GTP binding assay to monitor activation of g protein-coupled receptors. Assay Drug Dev Technol (2003) 0.87

G protein-coupled receptor internalization assays in the high-content screening format. Methods Enzymol (2006) 0.86

First structure-activity relationship study on dopamine D3 receptor agents with N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamide structure. J Med Chem (2005) 0.85

Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to G protein-coupled receptor oligomerization. Methods Mol Biol (2011) 0.84

Beta galactosidase enzyme fragment complementation as a novel technology for high throughput screening. Comb Chem High Throughput Screen (2003) 0.84

Kappa opioid receptor screen with the Tango beta-arrestin recruitment technology and characterization of hits with second-messenger assays. J Biomol Screen (2009) 0.84

Enhanced selectivity screening of GPCR ligands using a label-free cell based assay technology. Comb Chem High Throughput Screen (2009) 0.84

FLIPR assays of intracellular calcium in GPCR drug discovery. Methods Mol Biol (2009) 0.84

Photoproteins: important new tools in drug discovery. Assay Drug Dev Technol (2008) 0.83

A 1,536-well [(35)S]GTPgammaS scintillation proximity binding assay for ultra-high-throughput screening of an orphan galphai-coupled GPCR. Assay Drug Dev Technol (2008) 0.82

Europium-labeled GTP as a general nonradioactive substitute for [(35)S]GTPgammaS in high-throughput G protein studies. Anal Biochem (2009) 0.82

Analysis of GPCR localization and trafficking. Methods Mol Biol (2011) 0.82

Visualizing receptor endocytosis and trafficking. Methods Mol Biol (2011) 0.81

High-throughput confocal microscopy for beta-arrestin-green fluorescent protein translocation G protein-coupled receptor assays using the Evotec Opera. Methods Enzymol (2006) 0.81

Assessing activation of the human neuropeptide FF2 receptor with a non-radioactive GTP binding assay. Peptides (2004) 0.81

G protein coupled receptors -in silico drug discovery and design. Curr Top Med Chem (2010) 0.81

A novel bioluminescent protease assay using engineered firefly luciferase. Curr Chem Genomics (2008) 0.80

Identification of orphan G protein-coupled receptor ligands using FLIPR assays. Methods Mol Biol (2005) 0.80

A fully automated [35S]GTPgammaS scintillation proximity assay for the high-throughput screening of Gi-linked G protein-coupled receptors. Assay Drug Dev Technol (2003) 0.80

Time resolved FRET strategy with fluorescent ligands to analyze receptor interactions in native tissues: application to GPCR oligomerization. Methods Mol Biol (2011) 0.80

QSAR modeling of GPCR ligands: methodologies and examples of applications. Ernst Schering Found Symp Proc (2006) 0.78

The ligand-independent translocation assay: an enabling technology for screening orphan G protein-coupled receptors by arrestin recruitment. Methods Enzymol (2006) 0.77

Comparison of G-protein coupled receptor desensitization-related beta-arrestin redistribution using confocal and non-confocal imaging. Comb Chem High Throughput Screen (2006) 0.76

Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proc Natl Acad Sci U S A (2007) 3.37

Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex. Science (2013) 3.17

Interface-induced superconductivity and strain-dependent spin density waves in FeSe/SrTiO3 thin films. Nat Mater (2013) 2.15

COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis. Nature (2012) 2.11

Preoperative alpha blockade for normotensive pheochromocytoma: is it necessary? J Hypertens (2011) 1.50

Microsurgical anatomy of the greater superficial petrosal nerve. World Neurosurg (2011) 1.45

Novel mutations of the FRMD7 gene in X-linked congenital motor nystagmus. Mol Vis (2007) 1.45

A nonpeptidic agonist of glucagon-like peptide 1 receptors with efficacy in diabetic db/db mice. Proc Natl Acad Sci U S A (2007) 1.43

COUP-TFII regulates tumor growth and metastasis by modulating tumor angiogenesis. Proc Natl Acad Sci U S A (2010) 1.43

A robust homogeneous binding assay for alpha4beta2 nicotinic acetylcholine receptor. Acta Pharmacol Sin (2005) 1.43

The nuclear orphan receptor COUP-TFII plays an essential role in adipogenesis, glucose homeostasis, and energy metabolism. Cell Metab (2009) 1.38

COUP-TFs regulate eye development by controlling factors essential for optic vesicle morphogenesis. Development (2010) 1.23

HIV-1 Tat protein increases the permeability of brain endothelial cells by both inhibiting occludin expression and cleaving occludin via matrix metalloproteinase-9. Brain Res (2011) 1.14

Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells. Cell Res (2011) 1.13

Antiasthmatic drugs targeting the cysteinyl leukotriene receptor 1 alleviate central nervous system inflammatory cell infiltration and pathogenesis of experimental autoimmune encephalomyelitis. J Immunol (2011) 1.11

Bone morphogenetic protein-4 mediates cardiac hypertrophy, apoptosis, and fibrosis in experimentally pathological cardiac hypertrophy. Hypertension (2012) 1.08

Structural characterization of full-length NSF and 20S particles. Nat Struct Mol Biol (2012) 1.08

Enhanced susceptibility to kainate-induced seizures, neuronal apoptosis, and death in mice lacking gangliotetraose gangliosides: protection with LIGA 20, a membrane-permeant analog of GM1. J Neurosci (2005) 1.04

Blocking A2B adenosine receptor alleviates pathogenesis of experimental autoimmune encephalomyelitis via inhibition of IL-6 production and Th17 differentiation. J Immunol (2012) 1.02

Establishment of an ELISA system for determining soluble LAIR-1 levels in sera of patients with HFRS and kidney transplant. J Immunol Methods (2004) 0.98

Cantharidin and norcantharidin inhibit the ability of MCF-7 cells to adhere to platelets via protein kinase C pathway-dependent downregulation of α2 integrin. Oncol Rep (2013) 0.96

The antiepileptic drug valproic acid restores T cell homeostasis and ameliorates pathogenesis of experimental autoimmune encephalomyelitis. J Biol Chem (2012) 0.94

Novel object recognition as a facile behavior test for evaluating drug effects in AβPP/PS1 Alzheimer's disease mouse model. J Alzheimers Dis (2012) 0.92

Proliferation rate of somatic cells affects reprogramming efficiency. J Biol Chem (2013) 0.92

GPNMB enhances bone regeneration by promoting angiogenesis and osteogenesis: potential role for tissue engineering bone. J Cell Biochem (2013) 0.92

Stereospecific induction of nuclear factor-kappaB activation by isochamaejasmin. Mol Pharmacol (2005) 0.91

Sodium-calcium exchanger complexed with GM1 ganglioside in nuclear membrane transfers calcium from nucleoplasm to endoplasmic reticulum. Proc Natl Acad Sci U S A (2009) 0.91

Role of Src in ligand-specific regulation of delta-opioid receptor desensitization and internalization. J Neurochem (2008) 0.91

Rapid discrimination and quantification of alkaloids in Corydalis Tuber by near-infrared spectroscopy. J Pharm Biomed Anal (2011) 0.90

Stress-mediated p38 activation promotes somatic cell reprogramming. Cell Res (2012) 0.90

G protein-coupled receptors as therapeutic targets for multiple sclerosis. Cell Res (2012) 0.90

Susceptibility of cerebellar granule neurons from GM2/GD2 synthase-null mice to apoptosis induced by glutamate excitotoxicity and elevated KCl: rescue by GM1 and LIGA20. Glycoconj J (2004) 0.89

Urinary TNF-α and NGAL are correlated with the progression of nephropathy in patients with type 2 diabetes. Exp Ther Med (2013) 0.89

iPSCs and small molecules: a reciprocal effort towards better approaches for drug discovery. Acta Pharmacol Sin (2013) 0.89

Bromfenac sodium 0.1%, fluorometholone 0.1% and dexamethasone 0.1% for control of ocular inflammation and prevention of cystoid macular edema after phacoemulsification. Ophthalmologica (2013) 0.88

Lipopolysaccharide up-regulates the expression of Fcalpha/mu receptor and promotes the binding of oxidized low-density lipoprotein and its IgM antibody complex to activated human macrophages. Atherosclerosis (2009) 0.88

(4-[6-(4-isopropoxyphenyl)pyrazolo [1,5-a]pyrimidin-3-yl] quinoline) is a novel inhibitor of autophagy. Br J Pharmacol (2014) 0.88

Philinopside E, a new sulfated saponin from sea cucumber, blocks the interaction between kinase insert domain-containing receptor (KDR) and alphavbeta3 integrin via binding to the extracellular domain of KDR. Mol Pharmacol (2007) 0.87

Silencing of GPNMB by siRNA inhibits the formation of melanosomes in melanocytes in a MITF-independent fashion. PLoS One (2012) 0.86

Significance of heparanase-1 and vascular endothelial growth factor in adrenocortical carcinoma angiogenesis: potential for therapy. Endocrine (2011) 0.85

The immunosuppressant cyclosporin A antagonizes human formyl peptide receptor through inhibition of cognate ligand binding. J Immunol (2006) 0.84

Serine 363 of the {delta}-opioid receptor is crucial for adopting distinct pathways to activate ERK1/2 in response to stimulation with different ligands. J Cell Sci (2010) 0.83

Podophyllotoxin induces CREB phosphorylation and CRE-driven gene expression via PKA but not MAPKs. Mol Cells (2009) 0.83

Toll-like receptor-9 induced by physical trauma mediates release of cytokines following exposure to CpG motif in mouse skin. Immunology (2003) 0.83

Characterization of cholera toxin B subunit-induced Ca(2+) influx in neuroblastoma cells: evidence for a voltage-independent GM1 ganglioside-associated Ca(2+) channel. J Neurosci Res (2002) 0.83

Lateral photovoltaic effect and electron transport observed in Cr nano-film. Opt Express (2014) 0.82

Artesunate induces G2/M cell cycle arrest through autophagy induction in breast cancer cells. Anticancer Drugs (2014) 0.82

Bone morphogenetic protein-2 antagonizes bone morphogenetic protein-4 induced cardiomyocyte hypertrophy and apoptosis. J Cell Physiol (2014) 0.82

Bryostatin-5 blocks stromal cell-derived factor-1 induced chemotaxis via desensitization and down-regulation of cell surface CXCR4 receptors. Cancer Res (2008) 0.82

Engineering tubular bone using mesenchymal stem cell sheets and coral particles. Biochem Biophys Res Commun (2013) 0.81

Development of a universal high-throughput calcium assay for G-protein- coupled receptors with promiscuous G-protein Galpha15/16. Acta Pharmacol Sin (2008) 0.81

The expression, regulation and adhesion function of a novel CD molecule, CD226, on human endothelial cells. Life Sci (2003) 0.81

A novel therapeutic drug for colon cancer: EpCAM scFv-truncated protamine (tp)-siRNA. Cell Biol Int (2013) 0.81

Permeability and concentration of levofloxacin in epithelial lining fluid in patients with lower respiratory tract infections. J Clin Pharmacol (2009) 0.80

A stress response pathway in mice upregulates somatostatin level and transcription in pancreatic delta cells through Gs and β-arrestin 1. Diabetologia (2014) 0.80

Gold-catalyzed cyclization of alkynylaziridines as an efficient approach toward functionalized N-phth pyrroles. J Org Chem (2010) 0.80

Curcumin inhibits hERG potassium channels in vitro. Toxicol Lett (2011) 0.80

Glucagon receptor mediates calcium signaling by coupling to G alpha q/11 and G alpha i/o in HEK293 cells. J Recept Signal Transduct Res (2009) 0.80

Organocatalytic tandem Morita-Baylis-Hillman-Michael reaction for asymmetric synthesis of a drug-like oxa-spirocyclic indanone scaffold. Chem Commun (Camb) (2013) 0.80

Development of a high-throughput assay for screening of gamma-secretase inhibitor with endogenous human, mouse or Drosophila gamma-secretase. Molecules (2009) 0.79

A cell-based high-throughput assay for the screening of small-molecule inhibitors of p53-MDM2 interaction. J Biomol Screen (2011) 0.79

Preparation and evaluation of hydrophilic C18 monolithic sorbents for enhanced polar compound retention in liquid chromatography and solid phase extraction. J Chromatogr A (2011) 0.79

Application of the soluble salt-assisted route to scalable synthesis of ZnO nanopowder with repeated photocatalytic activity. Nanotechnology (2012) 0.79

Induction of matrix metalloproteinase-3 (MMP-3) expression in the microglia by lipopolysaccharide (LPS) via upregulation of glycoprotein nonmetastatic melanoma B (GPNMB) expression. J Mol Neurosci (2014) 0.78

Comparative proteomic analyses reveal that the regulators of G-protein signaling proteins regulate amino acid metabolism of the rice blast fungus Magnaporthe oryzae. Proteomics (2014) 0.78

[Application of Metaphase-Fluorescence in Situ Hybridization to the Diagnosis of Acute Promyelocytic Leukemia and the Detection of Minimal Residual Disease] Zhongguo Shi Yan Xue Ye Xue Za Zhi (2000) 0.78

Synthesis and SAR study of opioid receptor ligands: mono- and bis-indolomorphinans. Chem Biol Drug Des (2009) 0.78

Structural optimization and biological evaluation of substituted bisphenol A derivatives as beta-amyloid peptide aggregation inhibitors. J Med Chem (2010) 0.78

Development of a quantitative, cell-based, high-content screening assay for epidermal growth factor receptor modulators. Acta Pharmacol Sin (2007) 0.78

Gold-catalyzed efficient synthesis of 2,4-disubstituted furans from aryloxy-enynes. Org Biomol Chem (2012) 0.78

Magnesium Lithospermate B Protects Cardiomyocytes from Ischemic Injury Via Inhibition of TAB1-p38 Apoptosis Signaling. Front Pharmacol (2010) 0.78

Fabrication and characterization of nuclear localization signal-conjugated glycol chitosan micelles for improving the nuclear delivery of doxorubicin. Int J Nanomedicine (2012) 0.78

Gold-catalyzed oxidative rearrangement involving 1,2-acyl migration: efficient synthesis of functionalized dihydro-γ-carbolines from α-(2-indolyl) propargylic alcohols and imines. Angew Chem Int Ed Engl (2013) 0.78

Synthesis and opioid receptor activity of indolopropellanes. Bioorg Med Chem Lett (2009) 0.77

Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 2: Discovery of highly potent anti-HIV agents. Bioorg Med Chem Lett (2010) 0.77

Epidemiology of herpes zoster among adults aged 50 and above in Guangdong, China. Hum Vaccin Immunother (2015) 0.77

Discovery of a novel CCR5 antagonist lead compound through fragment assembly. Molecules (2008) 0.77

(Z)-4-bromo-5-(bromomethylene)-3-methylfuran-2(5H)-one sensitizes Escherichia coli persister cells to antibiotics. Appl Microbiol Biotechnol (2013) 0.77

Human foreskin fibroblast produces interleukin-6 to support derivation and self-renewal of mouse embryonic stem cells. Stem Cell Res Ther (2012) 0.77

Expression of FGF4 mRNA is mediated by mating behaviours in mice. Cell Biochem Funct (2012) 0.77

Identification of a novel small-molecule agonist for human G protein-coupled receptor 3. J Pharmacol Exp Ther (2014) 0.77

Estrogen decreases anoikis of ovarian cancer cell line Caov-3 through reducing release of Bit1. DNA Cell Biol (2014) 0.77

Gold(I)-catalyzed 1,4- and/or 1,5-heteroaryl migration reactions through regiocontrolled cyclizations. Chemistry (2014) 0.77

The transcription co-repressor TLE1 interacted with the intracellular region of gpl30 through its Q domain. Mol Cell Biochem (2002) 0.77

Facile synthesis of fully substituted dihydro-β-carbolines via Brønsted acid promoted cascade reactions of α-indolyl propargylic alcohols with nitrones. Org Lett (2012) 0.77

Folic acid conjugated glycol chitosan micelles for targeted delivery of doxorubicin: preparation and preliminary evaluation in vitro. J Biomater Sci Polym Ed (2012) 0.77

Highly expressed MT-ND3 positively associated with histological severity of hepatic steatosis. APMIS (2013) 0.76

Rediocide A, an Insecticide, induces G-protein-coupled receptor desensitization via activation of conventional protein kinase C. J Nat Prod (2012) 0.76

Aurintricarboxylic acid ameliorates experimental autoimmune encephalomyelitis by blocking chemokine-mediated pathogenic cell migration and infiltration. J Immunol (2012) 0.76

Selaginellin M, a new selaginellin derivative from Selaginella pulvinata. J Asian Nat Prod Res (2011) 0.76

Discovery of benzhydrylpiperazine derivatives as CB1 receptor inverse agonists via privileged structure-based approach. Eur J Med Chem (2009) 0.76

The four reprogramming factors and embryonic development in mice. Cell Reprogram (2010) 0.76

A poly(glycerol-sebacate-curcumin) polymer with potential use for brain gliomas. J Biomed Mater Res A (2012) 0.76

Studies on the structure-activity relationship of 1,3,3,4-tetra-substituted pyrrolidine embodied CCR5 receptor antagonists. Part 1: Tuning the N-substituents. Bioorg Med Chem Lett (2010) 0.76

The positively charged residues in the fragment 71 - 77 of complexin is required for its binding to SNARE complex. IUBMB Life (2007) 0.75

Gold(I)-catalyzed furan-yne cyclizations involving 1,2-rearrangement: efficient synthesis of functionalized 1-naphthols and its application to the synthesis of wailupemycin G. Chemistry (2014) 0.75

Intact MDM2 E3 ligase activity is required for the cytosolic localization and function of β-arrestin2. Mol Biol Cell (2011) 0.75

COUP-TFII regulates satellite cell function and muscular dystrophy. J Clin Invest (2016) 0.75

Pd/Cu-catalyzed cascade Sonogashira coupling/cyclization reactions to highly substituted 3-formyl furans. Org Biomol Chem (2011) 0.75

Consideration of dual characters of exosomes in the tumour immune response. Cell Biol Int (2014) 0.75