Published in Proc Natl Acad Sci U S A on June 16, 2009
Nuclear calcium signalling in the regulation of brain function. Nat Rev Neurosci (2013) 1.44
Sialic acids in the brain: gangliosides and polysialic acid in nervous system development, stability, disease, and regeneration. Physiol Rev (2014) 1.32
Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice. Proc Natl Acad Sci U S A (2012) 1.17
The plasma membrane Ca²+ ATPase and the plasma membrane sodium calcium exchanger cooperate in the regulation of cell calcium. Cold Spring Harb Perspect Biol (2011) 1.09
It's a lipid's world: bioactive lipid metabolism and signaling in neural stem cell differentiation. Neurochem Res (2012) 0.94
Nuclear sphingolipid metabolism. Annu Rev Physiol (2011) 0.89
Mice lacking major brain gangliosides develop parkinsonism. Neurochem Res (2011) 0.88
Nucleoplasmic calcium signaling and cell proliferation: calcium signaling in the nucleus. Cell Commun Signal (2013) 0.87
Nuclear Na+/K+-ATPase plays an active role in nucleoplasmic Ca2+ homeostasis. J Cell Sci (2012) 0.86
Waves of calcium depletion in the sarcoplasmic reticulum of vascular smooth muscle cells: an inside view of spatiotemporal Ca2+ regulation. PLoS One (2013) 0.81
The interplay between bioactive sphingolipids and steroid hormones. Steroids (2010) 0.81
Effective killing of leukemia cells by the natural product OSW-1 through disruption of cellular calcium homeostasis. J Biol Chem (2012) 0.80
Decoding calcium signaling across the nucleus. Physiology (Bethesda) (2014) 0.78
Interorganellar membrane microdomains: dynamic platforms in the control of calcium signaling and apoptosis. Cells (2013) 0.78
Experimental colitis is associated with transcriptional inhibition of Na+/Ca2+ exchanger isoform 1 (NCX1) expression by interferon γ in the renal distal convoluted tubules. J Biol Chem (2015) 0.78
Therapeutic targeting of the pathological triad of extrasynaptic NMDA receptor signaling in neurodegenerations. J Exp Med (2017) 0.76
A new cell-penetrating peptide that blocks the autoinhibitory XIP domain of NCX1 and enhances antiporter activity. Mol Ther (2014) 0.76
Inhibition of β-Glucocerebrosidase Activity Preserves Motor Unit Integrity in a Mouse Model of Amyotrophic Lateral Sclerosis. Sci Rep (2017) 0.75
Dynamic and quantitative Ca2+ measurements using improved cameleons. Proc Natl Acad Sci U S A (1999) 6.63
Bcl-2-mediated alterations in endoplasmic reticulum Ca2+ analyzed with an improved genetically encoded fluorescent sensor. Proc Natl Acad Sci U S A (2004) 4.46
A novel isothiourea derivative selectively inhibits the reverse mode of Na+/Ca2+ exchange in cells expressing NCX1. J Biol Chem (1996) 2.50
Sodium-calcium exchange: a molecular perspective. Annu Rev Physiol (2000) 2.40
The nucleus is insulated from large cytosolic calcium ion changes. Nature (1994) 2.02
ATP-dependent accumulation and inositol trisphosphate- or cyclic ADP-ribose-mediated release of Ca2+ from the nuclear envelope. Cell (1995) 1.97
Calcium release from the nucleus by InsP3 receptor channels. Neuron (1995) 1.86
Calcium-mediated mechanisms in chemically induced cell death. Annu Rev Pharmacol Toxicol (1992) 1.82
NAADP mobilizes Ca2+ from a thapsigargin-sensitive store in the nuclear envelope by activating ryanodine receptors. J Cell Biol (2003) 1.80
Mutually exclusive and cassette exons underlie alternatively spliced isoforms of the Na/Ca exchanger. J Biol Chem (1994) 1.25
New aspects of nuclear calcium signalling. J Cell Sci (2004) 1.18
Traveling for the glycosphingolipid path. Glycoconj J (2001) 1.16
Induction of calcium influx through TRPC5 channels by cross-linking of GM1 ganglioside associated with alpha5beta1 integrin initiates neurite outgrowth. J Neurosci (2007) 1.15
Current evidence suggests independent regulation of nuclear calcium. Cell Calcium (1998) 1.07
Active nuclear import and export is independent of lumenal Ca2+ stores in intact mammalian cells. J Gen Physiol (1999) 1.05
Enhanced susceptibility to kainate-induced seizures, neuronal apoptosis, and death in mice lacking gangliotetraose gangliosides: protection with LIGA 20, a membrane-permeant analog of GM1. J Neurosci (2005) 1.04
Ganglioside function in calcium homeostasis and signaling. Neurochem Res (2002) 0.98
The calcium store in the nuclear envelope. Cell Calcium (1998) 0.97
Potentiation of a sodium-calcium exchanger in the nuclear envelope by nuclear GM1 ganglioside. J Neurochem (2002) 0.91
Na,K-ATPase in the nuclear envelope regulates Na+: K+ gradients in hepatocyte nuclei. J Membr Biol (2002) 0.90
G-protein-coupled receptors, channels, and Na+-H+ exchanger in nuclear membranes of heart, hepatic, vascular endothelial, and smooth muscle cells. Can J Physiol Pharmacol (2006) 0.89
Susceptibility of cerebellar granule neurons from GM2/GD2 synthase-null mice to apoptosis induced by glutamate excitotoxicity and elevated KCl: rescue by GM1 and LIGA20. Glycoconj J (2004) 0.89
Isoform-specific regulation of the Na+/Ca2+ exchanger in rat astrocytes and neurons by PKA. J Neurosci (1998) 0.89
Presence of sodium-calcium exchanger/GM1 complex in the nuclear envelope of non-neural cells: nature of exchanger-GM1 interaction. Neurochem Res (2004) 0.87
The Na+/Ca2+ exchanger inhibitor, KB-R7943, blocks a nonselective cation channel implicated in chemosensory transduction. J Neurophysiol (2008) 0.86
Induced and spontaneous neuritogenesis are associated with enhanced expression of ganglioside GM1 in the nuclear membrane. J Neurosci (1995) 0.86
Evidence for stereospecific inositol 1,3,4,5-[3H]tetrakisphosphate binding sites on rat liver nuclei. Delineating inositol 1,3,4,5-tetrakisphosphate interaction in nuclear calcium signaling process. J Biol Chem (1993) 0.86
Upregulation of nuclear GM1 accompanies axon-like, but not dendrite-like, outgrowth in NG108-15 cells. J Neurosci Res (1999) 0.83
C6 cells express a sodium-calcium exchanger/GM1 complex in the nuclear envelope but have no exchanger in the plasma membrane: comparison to astrocytes. J Neurosci Res (2004) 0.82
Mutant NG108-15 cells (NG-CR72) deficient in GM1 synthase respond aberrantly to axonogenic stimuli and are vulnerable to calcium-induced apoptosis: they are rescued with LIGA-20. J Neurochem (2001) 0.82
GM1 in the nuclear envelope regulates nuclear calcium through association with a nuclear sodium-calcium exchanger. J Neurochem (2007) 0.82
Gangliosides of the nuclear membrane: a crucial locus of cytoprotective modulation. J Cell Biochem (2006) 0.81
Nuclear pore ion channel activity in live syncytial nuclei. Pflugers Arch (2002) 0.79
Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proc Natl Acad Sci U S A (2007) 3.37
Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex. Science (2013) 3.17
Interface-induced superconductivity and strain-dependent spin density waves in FeSe/SrTiO3 thin films. Nat Mater (2013) 2.15
COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis. Nature (2012) 2.11
Preoperative alpha blockade for normotensive pheochromocytoma: is it necessary? J Hypertens (2011) 1.50
Microsurgical anatomy of the greater superficial petrosal nerve. World Neurosurg (2011) 1.45
Novel mutations of the FRMD7 gene in X-linked congenital motor nystagmus. Mol Vis (2007) 1.45
A robust homogeneous binding assay for alpha4beta2 nicotinic acetylcholine receptor. Acta Pharmacol Sin (2005) 1.43
COUP-TFII regulates tumor growth and metastasis by modulating tumor angiogenesis. Proc Natl Acad Sci U S A (2010) 1.43
A nonpeptidic agonist of glucagon-like peptide 1 receptors with efficacy in diabetic db/db mice. Proc Natl Acad Sci U S A (2007) 1.43
The nuclear orphan receptor COUP-TFII plays an essential role in adipogenesis, glucose homeostasis, and energy metabolism. Cell Metab (2009) 1.38
COUP-TFs regulate eye development by controlling factors essential for optic vesicle morphogenesis. Development (2010) 1.23
Tools for GPCR drug discovery. Acta Pharmacol Sin (2012) 1.22
Induction of calcium influx through TRPC5 channels by cross-linking of GM1 ganglioside associated with alpha5beta1 integrin initiates neurite outgrowth. J Neurosci (2007) 1.15
HIV-1 Tat protein increases the permeability of brain endothelial cells by both inhibiting occludin expression and cleaving occludin via matrix metalloproteinase-9. Brain Res (2011) 1.14
Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells. Cell Res (2011) 1.13
Cross-linking of GM1 ganglioside by galectin-1 mediates regulatory T cell activity involving TRPC5 channel activation: possible role in suppressing experimental autoimmune encephalomyelitis. J Immunol (2009) 1.13
Antiasthmatic drugs targeting the cysteinyl leukotriene receptor 1 alleviate central nervous system inflammatory cell infiltration and pathogenesis of experimental autoimmune encephalomyelitis. J Immunol (2011) 1.11
Bone morphogenetic protein-4 mediates cardiac hypertrophy, apoptosis, and fibrosis in experimentally pathological cardiac hypertrophy. Hypertension (2012) 1.08
Structural characterization of full-length NSF and 20S particles. Nat Struct Mol Biol (2012) 1.08
Enhanced susceptibility to kainate-induced seizures, neuronal apoptosis, and death in mice lacking gangliotetraose gangliosides: protection with LIGA 20, a membrane-permeant analog of GM1. J Neurosci (2005) 1.04
Blocking A2B adenosine receptor alleviates pathogenesis of experimental autoimmune encephalomyelitis via inhibition of IL-6 production and Th17 differentiation. J Immunol (2012) 1.02
Establishment of an ELISA system for determining soluble LAIR-1 levels in sera of patients with HFRS and kidney transplant. J Immunol Methods (2004) 0.98
Cantharidin and norcantharidin inhibit the ability of MCF-7 cells to adhere to platelets via protein kinase C pathway-dependent downregulation of α2 integrin. Oncol Rep (2013) 0.96
The antiepileptic drug valproic acid restores T cell homeostasis and ameliorates pathogenesis of experimental autoimmune encephalomyelitis. J Biol Chem (2012) 0.94
Novel object recognition as a facile behavior test for evaluating drug effects in AβPP/PS1 Alzheimer's disease mouse model. J Alzheimers Dis (2012) 0.92
Proliferation rate of somatic cells affects reprogramming efficiency. J Biol Chem (2013) 0.92
GPNMB enhances bone regeneration by promoting angiogenesis and osteogenesis: potential role for tissue engineering bone. J Cell Biochem (2013) 0.92
N-Acetylaspartate synthase is bimodally expressed in microsomes and mitochondria of brain. Brain Res Mol Brain Res (2004) 0.92
Stereospecific induction of nuclear factor-kappaB activation by isochamaejasmin. Mol Pharmacol (2005) 0.91
Potentiation of a sodium-calcium exchanger in the nuclear envelope by nuclear GM1 ganglioside. J Neurochem (2002) 0.91
Role of Src in ligand-specific regulation of delta-opioid receptor desensitization and internalization. J Neurochem (2008) 0.91
Myelin lipid abnormalities in the aspartoacylase-deficient tremor rat. Neurochem Res (2008) 0.91
Rapid discrimination and quantification of alkaloids in Corydalis Tuber by near-infrared spectroscopy. J Pharm Biomed Anal (2011) 0.90
Stress-mediated p38 activation promotes somatic cell reprogramming. Cell Res (2012) 0.90
G protein-coupled receptors as therapeutic targets for multiple sclerosis. Cell Res (2012) 0.90
Urinary TNF-α and NGAL are correlated with the progression of nephropathy in patients with type 2 diabetes. Exp Ther Med (2013) 0.89
Susceptibility of cerebellar granule neurons from GM2/GD2 synthase-null mice to apoptosis induced by glutamate excitotoxicity and elevated KCl: rescue by GM1 and LIGA20. Glycoconj J (2004) 0.89
iPSCs and small molecules: a reciprocal effort towards better approaches for drug discovery. Acta Pharmacol Sin (2013) 0.89
Bromfenac sodium 0.1%, fluorometholone 0.1% and dexamethasone 0.1% for control of ocular inflammation and prevention of cystoid macular edema after phacoemulsification. Ophthalmologica (2013) 0.88
Lipopolysaccharide up-regulates the expression of Fcalpha/mu receptor and promotes the binding of oxidized low-density lipoprotein and its IgM antibody complex to activated human macrophages. Atherosclerosis (2009) 0.88
Mice lacking major brain gangliosides develop parkinsonism. Neurochem Res (2011) 0.88
(4-[6-(4-isopropoxyphenyl)pyrazolo [1,5-a]pyrimidin-3-yl] quinoline) is a novel inhibitor of autophagy. Br J Pharmacol (2014) 0.88
Deficiency of ganglioside GM1 correlates with Parkinson's disease in mice and humans. J Neurosci Res (2012) 0.87
Presence of sodium-calcium exchanger/GM1 complex in the nuclear envelope of non-neural cells: nature of exchanger-GM1 interaction. Neurochem Res (2004) 0.87
Philinopside E, a new sulfated saponin from sea cucumber, blocks the interaction between kinase insert domain-containing receptor (KDR) and alphavbeta3 integrin via binding to the extracellular domain of KDR. Mol Pharmacol (2007) 0.87
Silencing of GPNMB by siRNA inhibits the formation of melanosomes in melanocytes in a MITF-independent fashion. PLoS One (2012) 0.86
Physiological role of N-acetylaspartate: contribution to myelinogenesis. Adv Exp Med Biol (2006) 0.85
Significance of heparanase-1 and vascular endothelial growth factor in adrenocortical carcinoma angiogenesis: potential for therapy. Endocrine (2011) 0.85
The immunosuppressant cyclosporin A antagonizes human formyl peptide receptor through inhibition of cognate ligand binding. J Immunol (2006) 0.84
Toll-like receptor-9 induced by physical trauma mediates release of cytokines following exposure to CpG motif in mouse skin. Immunology (2003) 0.83
Podophyllotoxin induces CREB phosphorylation and CRE-driven gene expression via PKA but not MAPKs. Mol Cells (2009) 0.83
Characterization of cholera toxin B subunit-induced Ca(2+) influx in neuroblastoma cells: evidence for a voltage-independent GM1 ganglioside-associated Ca(2+) channel. J Neurosci Res (2002) 0.83
Serine 363 of the {delta}-opioid receptor is crucial for adopting distinct pathways to activate ERK1/2 in response to stimulation with different ligands. J Cell Sci (2010) 0.83
Sialidase occurs in both membranes of the nuclear envelope and hydrolyzes endogenous GD1a. J Neurochem (2009) 0.82
Bone morphogenetic protein-2 antagonizes bone morphogenetic protein-4 induced cardiomyocyte hypertrophy and apoptosis. J Cell Physiol (2014) 0.82
C6 cells express a sodium-calcium exchanger/GM1 complex in the nuclear envelope but have no exchanger in the plasma membrane: comparison to astrocytes. J Neurosci Res (2004) 0.82
Lateral photovoltaic effect and electron transport observed in Cr nano-film. Opt Express (2014) 0.82
Bryostatin-5 blocks stromal cell-derived factor-1 induced chemotaxis via desensitization and down-regulation of cell surface CXCR4 receptors. Cancer Res (2008) 0.82
Artesunate induces G2/M cell cycle arrest through autophagy induction in breast cancer cells. Anticancer Drugs (2014) 0.82
A novel therapeutic drug for colon cancer: EpCAM scFv-truncated protamine (tp)-siRNA. Cell Biol Int (2013) 0.81
Engineering tubular bone using mesenchymal stem cell sheets and coral particles. Biochem Biophys Res Commun (2013) 0.81
The expression, regulation and adhesion function of a novel CD molecule, CD226, on human endothelial cells. Life Sci (2003) 0.81
Development of a universal high-throughput calcium assay for G-protein- coupled receptors with promiscuous G-protein Galpha15/16. Acta Pharmacol Sin (2008) 0.81
Organocatalytic tandem Morita-Baylis-Hillman-Michael reaction for asymmetric synthesis of a drug-like oxa-spirocyclic indanone scaffold. Chem Commun (Camb) (2013) 0.80
Glucagon receptor mediates calcium signaling by coupling to G alpha q/11 and G alpha i/o in HEK293 cells. J Recept Signal Transduct Res (2009) 0.80
Gold-catalyzed cyclization of alkynylaziridines as an efficient approach toward functionalized N-phth pyrroles. J Org Chem (2010) 0.80
A stress response pathway in mice upregulates somatostatin level and transcription in pancreatic delta cells through Gs and β-arrestin 1. Diabetologia (2014) 0.80
Permeability and concentration of levofloxacin in epithelial lining fluid in patients with lower respiratory tract infections. J Clin Pharmacol (2009) 0.80
Curcumin inhibits hERG potassium channels in vitro. Toxicol Lett (2011) 0.80
A cell-based high-throughput assay for the screening of small-molecule inhibitors of p53-MDM2 interaction. J Biomol Screen (2011) 0.79
Bimodal occurrence of aspartoacylase in myelin and cytosol of brain. J Neurochem (2007) 0.79
Application of the soluble salt-assisted route to scalable synthesis of ZnO nanopowder with repeated photocatalytic activity. Nanotechnology (2012) 0.79
Preparation and evaluation of hydrophilic C18 monolithic sorbents for enhanced polar compound retention in liquid chromatography and solid phase extraction. J Chromatogr A (2011) 0.79
Development of a high-throughput assay for screening of gamma-secretase inhibitor with endogenous human, mouse or Drosophila gamma-secretase. Molecules (2009) 0.79
Ganglioside GM1 deficiency in effector T cells from NOD mice induces resistance to regulatory T-cell suppression. Diabetes (2011) 0.79
Structural optimization and biological evaluation of substituted bisphenol A derivatives as beta-amyloid peptide aggregation inhibitors. J Med Chem (2010) 0.78
Gold-catalyzed efficient synthesis of 2,4-disubstituted furans from aryloxy-enynes. Org Biomol Chem (2012) 0.78
Fabrication and characterization of nuclear localization signal-conjugated glycol chitosan micelles for improving the nuclear delivery of doxorubicin. Int J Nanomedicine (2012) 0.78
Stable transfection of GM1 synthase gene into GM1-deficient NG108-15 cells, CR-72 cells, rescues the responsiveness of Trk-neurotrophin receptor to its ligand, NGF. Neurochem Res (2002) 0.78
[Application of Metaphase-Fluorescence in Situ Hybridization to the Diagnosis of Acute Promyelocytic Leukemia and the Detection of Minimal Residual Disease] Zhongguo Shi Yan Xue Ye Xue Za Zhi (2000) 0.78
Development of a quantitative, cell-based, high-content screening assay for epidermal growth factor receptor modulators. Acta Pharmacol Sin (2007) 0.78
Comparative proteomic analyses reveal that the regulators of G-protein signaling proteins regulate amino acid metabolism of the rice blast fungus Magnaporthe oryzae. Proteomics (2014) 0.78
Gold-catalyzed oxidative rearrangement involving 1,2-acyl migration: efficient synthesis of functionalized dihydro-γ-carbolines from α-(2-indolyl) propargylic alcohols and imines. Angew Chem Int Ed Engl (2013) 0.78
Magnesium Lithospermate B Protects Cardiomyocytes from Ischemic Injury Via Inhibition of TAB1-p38 Apoptosis Signaling. Front Pharmacol (2010) 0.78
Induction of matrix metalloproteinase-3 (MMP-3) expression in the microglia by lipopolysaccharide (LPS) via upregulation of glycoprotein nonmetastatic melanoma B (GPNMB) expression. J Mol Neurosci (2014) 0.78